Barry J Plant

Barry J Plant
University College Cork | UCC · Department of Medicine

About

191
Publications
14,188
Reads
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2,634
Citations
Additional affiliations
September 2007 - present
Cork University Hospital
Position
  • Director Adult Cf Centre & Consultant Respiratory Physician

Publications

Publications (191)
Article
Full-text available
Objectives The objectives of this article are to list the most commonly prescribed Oral Nutritional Supplements in the UK and Ireland and their sugar content; and to raise awareness among the dental profession regarding their uses and potential dental risks involved. Background Many older patients benefit from Oral Nutritional Supplements. Prescri...
Article
Purpose of review: At many institutions, the Covid-19 pandemic made it necessary to rapidly change the way services are provided to patients, including those with cystic fibrosis (CF). The purpose of this review is to explore the past, present and future of telehealth and virtual monitoring in CF and to highlight certain challenges/considerations...
Article
Background Dyspnea is a common symptom in patients with end-stage kidney disease being treated with dialysis. This study aimed to ascertain the level of respiratory disability in patients after kidney transplantation through assessing a cohort of kidney allograft recipients for respiratory compromise and thereby identifying a potential target for t...
Article
Full-text available
Thoracic computed tomography (CT) is the imaging reference method in the diagnosis, assessment and management of lung disease. In the setting of cystic fibrosis (CF), CT demonstrates increased sensitivity compared with pulmonary function tests and chest radiography, and findings correlate with clinical outcomes. Better understanding of the aetiolog...
Article
Background Treatment with Ivacaftor provides a significant clinical benefit in people with cystic fibrosis (PWCF) with the class III G551D-CFTR mutation. This study determined the effect of CFTR modulation with ivacaftor on the lung microbiota in PWCF. Methods Using both extended-culture and culture-independent molecular methods, we analysed the l...
Article
Background Tezacaftor–ivacaftor is an approved cystic fibrosis transmembrane conductance regulator (CFTR) modulator shown to be efficacious and generally safe and well tolerated over 8–24 weeks in phase 3 clinical studies in participants aged 12 years or older with cystic fibrosis homozygous for the Phe508del CFTR mutation (F/F; study 661-106 [EVOL...
Article
Full-text available
Background Several medical procedures involving the respiratory tract are considered ‘aerosol generating’. Aerosols from these procedures may be inhaled by bystanders and there are consequent concerns regarding infection transmission, or, specific to nebulised therapy, secondary drug exposure. Aims Assess the efficacy of a proprietary HEPA-filteri...
Article
Full-text available
AIM To assess the utility of a volumetric low-dose computed tomography (CT) thorax (LDCTT) protocol at a dose equivalent to a posteroanterior (PA) and lateral chest radiograph for surveillance of cystic fibrosis (CF) patients. MATERIALS AND METHODS A prospective study was undertaken of 19 adult patients with CF that proceeded to LDCTT at 12 and 24...
Article
Purpose Clostridium difficile has been reported to occur in the gastrointestinal tract of 50% of Cystic Fibrosis (CF) subjects, however, clinical C. difficile infection (CDI) is a rare occurrence in this cohort despite the presence of toxigenic and hypervirulent ribotypes. Here, we present the first longitudinal, multicentre analysis of C. difficil...
Article
Poorly performing diagnostic tests can impact patient safety. Clinical investigations must have good precision and diagnostic accuracy before widespread use in clinical practice. Transient elastography (TE) measures liver stiffness, a surrogate marker of liver fibrosis in adults and children. Studies to evaluate its repeatability and reproducibilit...
Article
Cystic fibrosis (CF) is the most common life-limiting autosomal recessive genetic disorder among Caucasian populations. The majority of CF cases are diagnosed in childhood; however, increasing numbers of adults are being diagnosed with the condition. We present the case of a 65-year-old Irish woman presenting with a chronic cough and a history of r...
Article
Background: It is suggested that airway fungi, in particular Aspergillus may impinge on clinical phenotype in asthma. Indeed the term severe asthma with fungal sensitisation (SAFS) has been coined. We aimed to ascertain whether the presence of fungi, in particular Aspergillus fumigatus, in the airway correlated with asthma severity and control. Fu...
Article
Full-text available
Background Several treatment approaches in cystic fibrosis (CF) aim to correct CF transmembrane conductance regulator (CFTR) function; the efficacy of each approach is dependent on the mutation(s) present. A need remains for more effective treatments to correct functional deficits caused by the F508del mutation. Methods Two placebo-controlled, pha...
Article
Rationale: Patient registries have the potential to collect and analyze high-quality postauthorization data on new medicines. Objectives: We used cystic fibrosis (CF) registry data to assess outcomes after the initiation of ivacaftor, a CF transmembrane conductance regulator (CFTR) potentiator approved for the treatment of CF with a defective ga...
Article
Background The next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector VX-659, in triple combination with tezacaftor and ivacaftor (VX-659–tezacaftor–ivacaftor), was developed to restore the function of Phe508del CFTR protein in patients with cystic fibrosis. Methods We evaluated the effects of VX-659–tezacaftor–ivacaf...
Article
Full-text available
Background Pirfenidone is a novel anti-fibrotic agent in idiopathic pulmonary fibrosis with proven clinical benefit. Better human tissue models to demonstrate the immunomodulatory and anti-fibrotic effect of pirfenidone are required. Objectives The purpose of the study was to use transbronchial lung cryobiopsy (TBLC), a novel technique which provid...
Article
A 40‐year‐old male with Cystic Fibrosis developed a sudden onset choking, cough, dyspnea and hemoptysis after using his inhaler. He presented to A&E. CT scan located a foreign body in his right bronchus intermedius (RBI). Rigid bronchoscopy was performed and removed a plastic rawl plug with screw from his RBI. He made a rapid recovery. On questioni...
Article
Full-text available
Background: We have recently shown that human epididymis protein 4 (HE4) levels correlate with the severity of cystic fibrosis (CF) lung disease. However, there are no data on how HE4 levels alter in patients receiving CFTR modulating therapy. Methods: In this retrospective clinical study, 3 independent CF patient cohorts (US-American: 29, Austr...
Chapter
Life expectancy for some Cystic Fibrosis (CF) patients is rising and new complications and procedures are predicted. Subsequently there is need for education and management interventions that can benefit CF adults. This paper proposes a CF patient passport to record basic medical information through a smartphone application (app), giving the patien...
Article
Background In the investigation of lung cancer, current practice in many healthcare systems would support bronchoscopy regardless of CT findings in patients with hemoptysis. We sought to identify the cause, the diagnostic yield of CT and bronchoscopy and the requirement for bronchoscopy in at risk patients with hemoptysis with a normal CT scan thro...
Article
Full-text available
Developments in managing CF continue to drive dramatic improvements in survival. As newborn screening rolls-out across Europe, CF centres are increasingly caring for cohorts of patients who have minimal lung disease on diagnosis. With the introduction of mutation-specific therapies and the prospect of truly personalised medicine, patients have the...
Article
Exercise-Induced Bronchoconstriction (EIB) is an acute, transient airway narrowing occurring after exercise which may impact athletic performance. Studies report 10% of the general population and up to 90% of asthmatics experience EIB. Ninety-two players from three elite hurling squads underwent a spirometric field-based provocation test with real-...
Article
Full-text available
Cystic Fibrosis (CF) and its treatment result in an altered gut microbiota composition compared to non-CF controls. However, the impact of this on gut microbiota functionality has not been extensively characterised. Our aim was to conduct a proof-of-principle study to investigate if measurable changes in gut microbiota functionality occur in adult...
Article
Background: Ivacaftor produces significant clinical benefit in patients with cystic fibrosis (CF) with the G551D mutation. Prevalence of this mutation at Cork CF Centre is 23%. This study assessed the impact of CFTR modulation on multiple modalities of patient assessment. Methods: Thirty three patients with the G551D mutation were assessed at ba...
Article
Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed ubiquitously throughout the body. Thus, while respiratory manifestations dominate much of cystic fibrosis (CF) care, there are prominent multi-organ manifestations and comorbidities. In the general population, the number of comorbidities increases with aging. Few illnesses have...
Article
Full-text available
Background: Studies are required that evaluate real-world outcomes of inhaled aztreonam lysine in patients with cystic fibrosis (CF). Methods: Our treatment-evaluator tool assessed the effectiveness of inhaled aztreonam in routine practice in 117 CF patients across four time periods (6-12 (P2) and 0-6months (P1) pre-initiation, and 0-6 (T1) and...
Article
Full-text available
Background Cystic Fibrosis (CF) is an autosomal recessive disease that affects the function of a number of organs, principally the lungs, but also the gastrointestinal tract. The manifestations of cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction in the gastrointestinal tract, as well as frequent antibiotic exposure, undoubtedl...
Article
Background: Many asthmatics remain sub-optimally controlled despite current treatments. Reasons include comorbidities that could aggravate asthma, including gastro-esophageal reflux (GER). We aimed to investigate whether aspiration occurs in asthmatic patients and if so does it correlate with asthma control. Methods: Patients had ACQ-7, FeNO, an...
Chapter
Since the commercialization of antibiotics in the 1940s, life expectancy has increased in parallel with their discovery. However, concerns regarding the collateral effects of antibiotic therapy on gut microbiota composition and functionality within the host have come to the fore. Antibiotic therapy disrupts the normal ecology of the gut microbiome,...
Article
The content for this activity is based on the satellite symposium, "Current Strategies for the Long-term Assessment, Monitoring, and Management for Cystic Fibrosis Patients Treated with CFTR Modulator Therapy" that was presented at the 39th European Cystic Fibrosis Society Conference on June 10, 2016 (Online access: http://courses.elseviercme.com/e...
Poster
Full-text available
Introduction: CF is the most common life limiting genetic disease affecting Caucasians and Ireland has the highest occurrence of this disease in the world. Thanks to recent developments in CF therapy and treatments, life expectancy for these patients is expected to rise. Hence this research presents an mHealth app with well-being questionnaire and...
Conference Paper
This article, presents a smartphone game app for Android devices where the user must blow into the microphone to control the sprite's movements as opposed to tapping. The game also encompasses a questionnaire and web based data tracking system, that is targeted at adult Cystic Fibrosis patients. App data is stored on an external database and saved...
Conference Paper
The use of smartphones technologies and apps in health has become increasing popular in recent years and as such has led to the development of the mobile health (mHealth) sector. However, mobile health applications (apps) are often rejected in app stores or not utilised by the intended audience. This has led to much discussion about the review proc...
Article
Clostridium difficile is an anaerobic Gram-positive, spore-forming, toxin-producing bacillus transmitted among humans through the faecal–oral route. Despite increasing carriage rates and the presence of C. difficile toxin in stool, patients with CF rarely appear to develop typical manifestations of C. difficile infection (CDI). In this study, we ex...
Poster
Full-text available
Cystic Fibrosis (CF) is the most common life limiting genetic disease affecting caucasians, and Ireland has the highest occurrence of CF in the world. Immersive virtual reality (VR) is a nascent field, becoming increasingly popular in education and training. INVIVO Communications presented 3D medical content through the Oculus Rift, which was found...
Conference Paper
Cystic Fibrosis (CF) is a genetic disease which affects multiple organs within the human body. In CF the lungs produce a thick and sticky mucus which can lead to respiratory infections and reduction in airflow. Knowledge of this disease is taught to undergraduate medical students in years 2 and 3, however it is considered that introducing this info...
Article
Full-text available
A 58-year old lady under active follow-up with the respiratory services at our institution for bronchiectasis secondary to hypogammaglobulinaemia presented with hoarseness and haemoptysis. She was also receiving rituximab maintenance therapy for follicular lymphoma. Bronchoscopy demonstrated vesicular lesions on her vocal cords and trachea, confirm...
Article
Full-text available
The usage of salt pipes in respiratory conditions is increasing despite a paucity of clinical evidence and safety data. We conducted a safety study of salt therapy in a small but defined asthma cohort (n=12). Each patient inhaled from the Cisca Easy Saltpipe® for 5 minutes. Serial FEV1 was conducted at intervals after inhaler use. The maximum fall...