Barry Bryant

Johns Hopkins Medicine | JHUSOM · Department of Psychiatry and Behavioral Sciences

Introduction: Traumatic brain injury (TBI) may alter dementia progression, although co-occurring neuropsychiatric symptoms (NPS) have received less attention. Originally designed to evaluate behavioral disruption prior to dementia diagnosis, the mild behavioral impairment (MBI) construct relates NPS to underlying neural circuit disruptions, with p...

Objective To complete a systematic review of the literature examining neuroimaging findings unique to co-occurring syndromal depression in the setting of TBI. Methods A PRISMA compliant literature search was conducted in PubMed (MEDLINE), PsychINFO, EMBASE, and Scopus databases for articles published prior to April of 2022. The database query yiel...

Neuroimaging is widely utilized in studying traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). The risk for PTSD is greater after TBI than non-TBI trauma, and PTSD is associated with worse outcomes after TBI. Studying the neuroimaging correlates of TBI-related PTSD may provide insights into the etiology of both conditions and h...

Introduction Neuroimaging has been a highly utilized technique for studying traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) independently of one another, however, neuroimaging has increasingly been identified as a useful tool in better understanding TBI-related psychiatric conditions, such as PTSD. Objectives To complete a s...

Introduction Traumatic brain injury (TBI) may alter dementia progression, although co-occurring neuropsychiatric symptoms (NPS) have received less attention. The mild behavioral impairment (MBI) construct relates NPS to underlying neural circuit disruptions, representing an important area of inquiry regarding TBI and dementia. Objectives (1) to ex...

Introduction Sleep disturbances are common following traumatic brain injury (TBI) worsening morbidity and other neuropsychiatric symptoms. Post-TBI alterations in sleep architecture require further study. Objectives (1) To evaluate polysomnographic measures of sleep architecture in participants with history of TBI compared to controls and as meta-...

Background Behavioral and emotional dyscontrol commonly occur following traumatic brain injury (TBI). Neuroimaging and electrophysiological correlates of dyscontrol have not been systematically summarized in the literature to date. Objective To complete a systematic review of the literature examining neuroimaging and electrophysiological findings...

Objective The objective of this study was to determine whether individuals who began fighting competitively at a younger age experienced adverse brain health outcomes compared to fighters who began competing at an older age. Background Established literature has made clear that fighting sports such as boxing and mixed martial arts can lead to head...

Objective To evaluate the relationship between professional fighter weight class and neuropsychiatric outcomes. Background Traumatic brain injury (TBI) is a common source of functional impairment among athletes, military personnel, and the general population. Professional fighters in both boxing and mixed martial arts (MMA) are at particular risk...

Lateral humeral condyle fractures in children are treated with several approaches, yet it is unclear which has the best treatment outcomes. We hypothesized that functional outcomes would be equivalent between treatment types, reduction approaches, and fixation types. Our purpose was to assess patient-reported outcomes and complications by treatment...

Background Traumatic brain injury (TBI) can precipitate new-onset psychiatric symptoms or worsen existing psychiatric conditions. To elucidate specific mechanisms for this interaction, neuroimaging is often used to study both psychiatric conditions and TBI. This systematic review aims to synthesize the existing literature of neuroimaging findings a...

Background Increasing neurological disease burden and advancing treatment options require clinical trials to expand the evidence base of clinical care. We aimed to characterize neurology clinical trials registered between October 2007 and April 2018 and identify features associated with early discontinuation and results reporting. Methods We compa...

Traumatic brain injury (TBI) is a common source of functional impairment among athletes, military personnel, and the general population. Professional fighters in both boxing and mixed martial arts (MMA) are at particular risk for repetitive TBI and may provide valuable insight into both the pathophysiology of TBI and its consequences. Currently, ef...

Background: Many patients with spastic quadriplegic cerebral palsy (CP) and severe scoliosis develop hip displacement, whereas others do not. We investigated demographic characteristics, risk factors for CP, and imaging findings associated with nondisplaced hips in patients with CP and severe scoliosis. Methods: We retrospectively analyzed recor...

Introduction: Traumatic brain injury (TBI) may alter the course of neuropsychiatric symptom (NPS) onset during dementia development. The connection among TBI, NPS, and dementia progression is of increasing interest to researchers and clinicians. Methods: Incidence of NPS was examined in participants with normal cognition who progressed to all-ca...

Introduction: Once pulmonary disease progresses to end-stage pulmonary disease, treatment options are very limited. An important advance in the field is the development of a bioartificial lung derived from a generic matrix scaffold populated with patients' own cells. Significant progress has already been made in the engineering of bioartificial lu...

Objective Little is known about the importance of an applicant's research productivity in terms of matching into a highly-ranked orthopaedic residency. We characterized the research of orthopaedic residents who matched in 2017 to determine whether 1) program tiers differed by their residents’ research; and 2) discrete increases in applicants’ resea...

OBJECTIVE The objectives of the study were to determine, among patients with adult spinal deformity (ASD), the following: 1) how preoperative opioid use, dose, and duration of use are associated with long-term opioid use and dose; 2) how preoperative opioid use is associated with rates of postoperative use from 6 weeks to 2 years; and 3) how postop...

Background: Depressive symptoms are common sequelae of traumatic brain injury (TBI) and neuroimaging has been a highly utilized technique for studying TBI and depression independently of each other. Objective: To complete a systematic review of the literature examining imaging findings unique to co-occurring depressive symptoms in the setting of TB...

Traumatic brain injury (TBI) and Alzheimer’s disease (AD) bear a complex relationship, potentially increasing risk of one another reciprocally. However, recent evidence suggests post-TBI dementia exists as a distinct neurodegenerative syndrome, confounding AD diagnostic accuracy in clinical settings. This investigation sought to evaluate TBI’s impa...

It has long been established that fighting sports such as boxing and mixed martial arts can lead to head injury. Prior work from this group on the Professional Fighters Brain Health Study found that exposure to repetitive head impacts is associated with lower brain volumes and decreased processing speed in fighters. Current and previously licensed...

BACKGROUND CONTEXT A potential limitation of staging surgery in adult spinal deformity (ASD) patients is delayed functional recovery; however, this finding has not been well demonstrated. PURPOSE Our purpose was to demonstrate that ASD patients who undergo staged surgery have equivalent timeline to functional recovery compared to patients who have...

BACKGROUND CONTEXT Long-term opioid use is common among ASD patients, and it is a cause of significant morbidity. PURPOSE This study aims to evaluate whether opioid use at 6 and 12 months post-surgery are predictive of long-term use at 2 years following surgery. STUDY DESIGN/SETTING Retrospective cohort study. PATIENT SAMPLE Retrospective review...

BACKGROUND CONTEXT Opioid use is prevalent among adult spinal deformity patients. Long-term opioid use can result in negative effects on health and quality of life. Preoperative opioid use has been linked to long-term postoperative use, but there is little data whether dose and duration are significant contributors to this effect in this population...

Mycobacterium tuberculosis-infected macrophages and dendritic cells are limited in their ability to present antigen to CD4+ T cells suggesting that other mechanism of antigen presentation are driving the robust T cell response observed during an M. tuberculosis infection. These mechanisms could include antigens present in apoptotic bodies, necrotic...

We demonstrate the chemical transformation of layered, two-dimensional (2D) SnS2 to non-layered Cu2SnS3 via cation exchange. Resulting Cu2SnS3 nanosheets (NSs) retain the overall starting morphology of their parent, few-layer SnS2 templates. Specifically, they possess micron-sized dimensions and have controlled thicknesses dictated by the number of...