Bárdur Sigurgeirsson

Bárdur Sigurgeirsson
University of Iceland | HI · Faculty of Medicine, Department of Dermatology

MD, PhD

About

147
Publications
34,740
Reads
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13,581
Citations
Citations since 2016
32 Research Items
5670 Citations
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
Additional affiliations
September 1993 - present
University of Iceland
Position
  • Professor (Associate)
January 1988 - March 1992
Karolinska University Hospital
Position
  • Medical Doctor
January 1988 - January 1992
Karolinska Institutet
Position
  • Medical Doctor

Publications

Publications (147)
Article
Full-text available
Convenient administration is an important factor for treatment adherence in patients with psoriasis. MATURE study reports the efficacy, safety, tolerability, and pharmacokinetics of secukinumab 300 mg 2 mL autoinjector (AI) from MATURE trial (NCT03589885). Eligible patients were randomized to secukinumab 300 mg 2 mL AI or 2x 1 mL pre-filled syringe...
Article
Introduction L’étude MATURE a évalué l’efficacité, la sécurité, la tolérance et la pharmacocinétique de l’auto-injecteur (AI) 2 mL de sécukinumab 300 mg chez les patients atteints de psoriasis en plaques modéré à sévère. Nous rapportons ici les résultats de l’analyse du critère principal jusqu’à la semaine 16. Matériel et méthodes MATURE est un es...
Article
Atopic dermatitis is a chronic inflammatory skin disease characterised by eczematous skin lesions and intense pruritus. It is often associated with other atopic diseases such as allergic rhinitis and conjunctivitis, bronchial asthma and eosinophilic oesophagitis. Dupilumab is the first biologic approved for the treatment of moderate-to-severe atopi...
Article
Psoriasis is an autoimmune disease driven by a Th17 response linked to the antimicrobial peptide (AMP) LL‐37 that has been connected to the induction and chronicity of psoriasis. We show that keratinocytes secrete various immune biomarkers with a direct link to psoriasis immunopathogenesis. Under pro‐inflammatory microenvironmental conditions LL‐37...
Article
Full-text available
Background: Evidence shows good tolerability in patients for subcutaneous injection volumes up to 3 mL. Objectives: We investigated efficacy, pharmacokinetics, and tolerability of secukinumab 300 mg/2 mL pre-filled syringe (PFS) in patients with moderate to severe plaque psoriasis. Methods: ALLURE was a 52-week, multicenter, randomized (1:1:1)...
Article
Background Dermatophytosis is a world‐wide distributed common infection. Antifungal drug resistance in dermatophytosis used to be rare, but unfortunately the current Indian epidemic of atypical widespread recalcitrant and terbinafine‐resistant dermatophytosis is spreading and has sporadically been reported in Europe. Objectives To explore the occu...
Article
The success of genome-wide association studies (GWAS) in identifying common, low-penetrance variant-cancer associations for the past decade is undisputed. However, discovering additional high-penetrance cancer mutations in unknown cancer predisposing genes requires detection of variant-cancer association of ultra-rare coding variants. Consequently,...
Article
Full-text available
Autoimmune thyroid disease is the most common autoimmune disease and is highly heritable1. Here, by using a genome-wide association study of 30,234 cases and 725,172 controls from Iceland and the UK Biobank, we find 99 sequence variants at 93 loci, of which 84 variants are previously unreported2–7. A low-frequency (1.36%) intronic variant in FLT3 (...
Article
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Cutaneous squamous cell carcinoma (SCC) is one of the most common cancers in the United States. Previous genome-wide association studies (GWAS) have identified 14 single nucleotide polymorphisms (SNPs) associated with cutaneous SCC. Here, we report the largest cutaneous SCC meta-analysis to date, representing six international cohorts and totaling...
Article
Full-text available
Aims: The aim of the study was to compare the pharmacokinetics, safety and tolerability of secukinumab with different devices for subcutaneous (s.c.) administration of 2 mL. Methods: A phase 1 study in healthy subjects with six devices to administer 2 mL injection volumes was conducted to evaluate the serum pharmacokinetics (PK), safety and tole...
Article
Background: Most pathogenic mutations in the BRCA2 gene carry a high risk of hereditary breast and ovarian cancer (HBOC). However, a stop-gain mutation, K3326* (rs11571833), confers risk of lung cancer and cancers of the upper-aero-digestive tract but only a modest risk of breast or ovarian cancer. The Icelandic population provides an opportunity...
Chapter
The history of onychomycosis is short and parallels that of tinea pedis and the invasion of dermatophyte Trichophyton rubrum into the Western world. T. rubrum is today the major cause of onychomycosis worldwide. Onychomycosis is so common today that every dermatologist examines several cases a week or even several a day. The medical treatment of on...
Chapter
Onychomycosis is the most common nail disease in adults, representing over 50% of all nail disorders and is often associated with tinea pedis. Some patients respond poorly to treatment, while others are cured after a standard course of an oral antifungal drug. Examining known prognostic factors may help clinicians to identify these patients before...
Chapter
Onychomycosis should be considered a medical problem, rather than a cosmetic one. In most cases, except the mildest one and in children systemic treatment is needed. Choice of treatment is based on several factors such as the organism isolated, type of onychomycosis, concomitant disorders and possibility of drug interactions. Terbinafine is the dru...
Article
Full-text available
A meta-analysis of publicly available summary statistics on multiple sclerosis combined with three Nordic multiple sclerosis cohorts (21,079 cases, 371,198 controls) revealed seven sequence variants associating with multiple sclerosis, not reported previously. Using polygenic risk scores based on public summary statistics of variants outside the ma...
Article
Full-text available
Patient adherence is a key consideration in the choice of a topical regimen for the treatment of onychomycosis. The objective of this study was to investigate patient-reported outcomes (treatment utilisation, adherence and satisfaction) in onychomycosis treated with once-weekly amorolfine 5% nail lacquer versus once-daily ciclopirox 8% nail lacquer...
Article
Clinical trials of biologic therapies in psoriasis usually evaluate fixed dosing regimens. It is well-known, however, that patients prescribed biologics may occasionally need to interrupt therapy for reasons such as surgery, changes in healthcare coverage, or pregnancy.(1) Consequently, dermatologists need to know whether interruption of biologic t...
Article
Full-text available
Psoriasis is a chronic inflammatory skin disease with profound effects on patients' health-related quality of life (HRQoL). Twenty-nine patients with plaque psoriasis and a history of streptococcal-associated psoriasis exacerbations were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and followed for 24 months. Patients were...
Chapter
Onychomycosis is a chronic fungal infection of the nail and may involve the nail bed, the nail plate, and the matrix. It is difficult to treat and relapses, and reinfections are common. The diagnosis can be made only when both positive laboratory and clinical criteria are present [1]. It can be caused by dermatophytes, yeasts, or non-dermatophyte m...
Chapter
The medical treatment of fungal infections affecting the skin has changed considerably over the past 200 years from the application of crude astringent or emollient dressings to the current use of active and specific antifungal agents. Indeed in the early part of the nineteenth century, there was still a debate over the need to treat fungal infecti...
Article
Full-text available
Background Secukinumab, a fully human anti-interleukin 17A monoclonal antibody, has demonstrated rapid, strong, and sustained efficacy in moderate-to-severe plaque psoriasis. Objective To measure treatment effect on psoriasis-related itching, pain, and scaling during the first 12 weeks of treatment. Methods ERASURE and FIXTURE were double-blind,...
Article
Background: Carriage of the HLA-Cw*0602 allele is associated with a particular set of clinical features and treatment responses in psoriasis. Tonsillectomy can improve psoriasis. Objectives: We sought to evaluate whether HLA-Cw*0602 predicts a favorable outcome after tonsillectomy of patients with psoriasis. Methods: This prospective case seri...
Article
Full-text available
Streptococcal throat infections are known to trigger or exacerbate psoriasis, and several studies support the benefit of tonsillectomy. To evaluate the potential of tonsillectomy as a treatment, we used a retrospective study-specific questionnaire to assess the proportion of psoriasis patients with sore throat-associated psoriasis exacerbations. Ou...
Article
Full-text available
As onychomycosis is unsightly, this study clinically evaluated whether the antifungal efficacy of amorolfine 5% nail lacquer (NL) was affected by a masking, natural-coloured, cosmetic nail varnish applied 24 h later; in vitro investigations were also performed. Subjects with mild-to-moderate distal subungual toenail onychomycosis were randomised to...
Article
Background: Secukinumab is a human interleukin-17A antagonist indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy. The objective of this analysis was to measure the treatment response on psoriasis-related itching, pain, and scaling via the Psoriasis Symptom Diary (PSD...
Article
Interleukin (IL)-17A is a key cytokine in the pathogenesis of psoriatic disease of the skin and joints. In phase 3 trials, secukinumab, a fully human anti-IL-17A monoclonal antibody, demonstrated robust efficacy in psoriasis, with rapid onset, high response rates, and durable response. To evaluate the efficacy of secukinumab in subjects with psori...
Article
Full-text available
In an ongoing screen for DNA sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conduct a genome-wide association study (GWAS) of 24,988,228 SNPs and small indels detected through whole-genome sequencing of 2,636 Icelanders and imputed into 4,572 BCC patients and 266,358 controls. Here we show the discovery of four new B...
Article
Full-text available
Atopic dermatitis (AD) primarily affects infants and young children. Although topical corticosteroids (TCSs) are often prescribed, noncorticosteroid treatments are needed because compliance with TCSs is poor due to concerns about their side effects. In this longest and largest intervention study ever conducted in infants with mild-to-moderate AD, p...
Article
Full-text available
Background: Interleukin-17A is considered to be central to the pathogenesis of psoriasis. We evaluated secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe plaque psoriasis. Methods: In two phase 3, double-blind, 52-week trials, ERASURE (Efficacy of Response and Safety of Two Fixed Secukinumab...
Article
Background The incidence of cutaneous melanoma increased dramatically in Iceland during the last two decades of the 20th century.Objective The aim of this study was to investigate the trend in Breslow's tumour thickness during the years 1980-2009.Methods The population-based Icelandic Cancer Registry provided information on all cutaneous melanomas...
Article
Background Secukinumab has been shown to significantly improve plaque psoriasis and physical functioning in subjects with psoriasis and concomitant psoriatic arthritis (PsA) [1]. High sensitivity C-reactive protein (hsCRP) is an indicator of skin and joint inflammation and hsCRP levels >3 mg/L are indicative of increased cardiovascular risk [2]. Ob...
Article
Full-text available
To search for new sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conducted a genome-wide association study of 38.5 million SNPs and small indels identified through whole genome sequencing of 2,230 Icelanders. We imputed genotypes for 4,208 BCC patients and 109,408 controls using Illumina SNP chip typing data, carried...
Article
Full-text available
Onychomycosis is a common disorder, and high prevalence figures are commonly cited in the literature. Evaluate the prevalence of onychomycosis based on published studies. Relevant studies were identified in Medline by using specific search criteria. Eleven population-based and 21 hospital-based studies were identified. The mean prevalence in Europe...
Article
A combined treatment with saltwater baths and narrow-band ultraviolet-B (NB-UVB) is a known treatment for psoriasis. This study evaluates and compares two treatment regimens including bathing in geothermal seawater combined with NB-UVB therapy and a NB-UVB monotherapy. Sixty-eight psoriasis patients were randomly assigned to bathing in geothermal s...
Article
It is known that NB-UVB therapy can suppress a broad range of immune cells but the additional effect of bathing in geothermal seawater still remains unclear. To study the influence of treatment on the expression of circulating immune cells contributing to the pathogenesis of psoriasis, six psoriasis patients were treated with bathing in geothermal...
Article
Background: Onychomycosis is effectively treated with terbinafine and itraconazole. However, frequent repeated dosing is required, and hepatic and cardiac adverse events may occur. Objectives: Evaluate efficacy and safety of albaconazole, a novel triazole, for once-weekly treatment of distal subungual onychomycosis of the great toenail. Methods...
Article
Full-text available
We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and...
Article
Full-text available
Background Interleukin (IL)-17A has major proinflammatory activity in psoriatic lesional skin. Objectives To assess the efficacy and safety of secukinumab, a fully human IgG1κ monoclonal anti-IL-17A antibody, in moderate-to-severe plaque psoriasis in a phase II regimen-finding study. Methods A total of 404 patients were randomized to subcutaneous p...
Article
Background Conventional systemic therapies for plaque psoriasis have not fully met the needs of patients, and although current biologic treatments are generally well tolerated, concerns exist with respect to long-term safety. Interleukin (IL)-17A is believed to be an important effector cytokine in the pathogenesis of psoriasis and is produced by Th...
Article
Background: Interleukin-17A has major proinflammatory activity in psoriatic lesional skin. Objectives: Assess the efficacy and safety of secukinumab, a fully human IgG1κ monoclonal anti–interleukin-17A antibody, in moderate-to-severe plaque psoriasis in a phase II regimen-finding study. Methods: 404 patients were randomised to subcutaneous placebo...
Article
Full-text available
Introduction: Current topical treatments for onychomycosis are unsatisfactory. New topical agents that offer efficacy without the potential adverse effects of oral antifungal therapy would benefit patients with this condition and encourage a greater treatment rate. Areas covered: Currently available topical therapies are reviewed, and new approa...
Article
Full-text available
Exacerbation of chronic psoriasis can be associated with streptococcal throat infections, and T cells that respond to peptide sequences common to streptococcal M proteins and skin keratins have been detected in patients' blood. To our knowledge, we have conducted the first blinded, prospective study to assess the impact of tonsillectomy on psoriasi...
Article
Full-text available
Background Terbinafine nail solution (TNS) was developed for the treatment of onychomycosis. Objective To assess the efficacy of TNS vs. vehicle and amorolfine 5% nail lacquer. Methods Subjects with mild-to-moderate toe onychomycosis (25% to ≤75% nail-involvement, matrix uninvolved) were randomized to receive either TNS or vehicle in two double-bli...
Article
Full-text available
To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-wide association study of 16 million SNPs identified through whole-genome sequencing of 457 Icelanders. We imputed genotypes for 41,675 Illumina SNP chip-typed Icelanders and their relatives. In the discovery phase, the strongest signal came from rs78378222[C] (...
Article
Full-text available
The UV-index is an international standard measurement of the strength of erythemogenic ultraviolet radiation. It is often published in the media and then refers to the highest expected UV radiation for that day. The highest UV-index value measured in Iceland is seven. Although this is similar to the maximum values from southern Scandinavia, the ave...
Article
Full-text available
To measure erythemogenic UV radiation in Iceland. Material and methods: Erythemogenic UV radiation was measured during the period from April through September 2010. We used a UV sensor that measures the Erythema Action Spectrum as has been defined by the Commission Internationale de l'Eclairage (CIE) as the standard representation of the average sk...
Article
Full-text available
Since 1980, sunbed use and travel abroad have dramatically increased in Iceland (64°-66°N). The authors assessed temporal trends in melanoma incidence by body site in Iceland in relation to sunbed use and travel abroad. Using joinpoint analysis, they calculated estimated annual percent changes (EAPCs) and identified the years during which statistic...
Article
Standard treatment for onychomycosis often results in less than half of subjects achieving disease-free nails. Onychomycosis is even more challenging to treat as relapses and re-infections are common. To determine if a prophylactic effect exists when a treatment with amorolfine nail lacquer (ANL), with half the frequency of the standard regimen, is...
Article
Full-text available
Effects of susceptibility variants may depend on from which parent they are inherited. Although many associations between sequence variants and human traits have been discovered through genome-wide associations, the impact of parental origin has largely been ignored. Here we show that for 38,167 Icelanders genotyped using single nucleotide polymorp...
Article
To examine if host baseline factors and week 24 mycology results are associated with mycological and clinical cure in patients with onychomycosis treated with oral terbinafine. Open pilot study to determine prognostic factors in the treatment of onychomycosis. Outpatient dermatology clinic. A total of 199 patients from the Icelandic arm of a trial...
Article
Full-text available
In a follow-up to our previously reported genome-wide association study of cutaneous basal cell carcinoma (BCC), we describe here several new susceptibility variants. SNP rs11170164, encoding a G138E substitution in the keratin 5 (KRT5) gene, affects risk of BCC (OR = 1.35, P = 2.1 x 10(-9)). A variant at 9p21 near CDKN2A and CDKN2B also confers su...
Article
Full-text available
The common sequence variants that have recently been associated with cancer risk are particular to a single cancer type or at most two. Following up on our genome-wide scan of basal cell carcinoma, we found that rs401681[C] on chromosome 5p15.33 satisfied our threshold for genome-wide significance (OR = 1.25, P = 3.7 x 10(-12)). We tested rs401681...
Article
To search for new sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conducted a genome-wide SNP association study of 930 Icelanders with BCC and 33,117 controls. After analyzing 304,083 SNPs, we observed signals from loci at 1p36 and 1q42, and replicated these associations in additional sample sets from Iceland and East...
Article
Full-text available
Fair color increases risk of cutaneous melanoma (CM) and basal cell carcinoma (BCC). Recent genome-wide association studies have identified variants affecting hair, eye and skin pigmentation in Europeans. Here, we assess the effect of these variants on risk of CM and BCC in European populations comprising 2,121 individuals with CM, 2,163 individual...
Article
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We present results from a genome-wide association study for variants associated with human pigmentation characteristics among 5,130 Icelanders, with follow-up analyses in 2,116 Icelanders and 1,214 Dutch individuals. Two coding variants in TPCN2 are associated with hair color, and a variant at the ASIP locus shows strong association with skin sensi...