Barbara Hollunder

Barbara Hollunder
Charité Universitätsmedizin Berlin | Charité · Department of Neurology with Chair in Experimental Neurology/BNIC

Master of Science

About

11
Publications
6,742
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Citations
Introduction
Barbara currently pursues a PhD at the Department of Neurology at Charité Universitätsmedizin Berlin as a fellow of the Einstein Center for Neurosciences and the Berlin School of Mind and Brain. Her research interests include symptom-specific connectomic DBS for the treatment of neurological and psychiatric circuitopathies, patient-centered precision neuromodulation, optimal DBS circuit stimulation target modeling and comparative studies across disorders.

Publications

Publications (11)
Article
Introduction: Neurocircuits are involved in the motor, cognitive, and affective dysfunctions of multiple brain disorders. Functional segregation into these domains has been widely defined on a fronto-cortical basis. However, despite considerable interaction, these functional domains remain partitioned to some extent at (sub)thalamic levels (1). To...
Article
Full-text available
At the group-level, deep brain stimulation leads to significant therapeutic benefit in a multitude of neurological and neuropsychiatric disorders. At the single-patient level, however, symptoms may sometimes persist despite “optimal” electrode placement at established treatment coordinates. This may be partly explained by limitations of disease-cen...
Article
Tourette syndrome (TS) constitutes a childhood-onset brain disorder with the defining presence of tic behaviors. Tics are repetitive movements or sounds that resemble voluntary actions but appear without embedment to discernable context (1). Effective therapy is complicated by phenotypical hetero-geneity, which arises not only from a wide variabili...
Preprint
Full-text available
At the group-level, deep brain stimulation leads to significant therapeutic benefit in a multitude of neurological and neuropsychiatric disorders. At the single-patient level, however, symptoms may sometimes persist despite "optimal" electrode placement at established treatment coordinates. This may be partly explained by limitations of disease-cen...
Book
Full-text available
The book is available here: https://www.elsevier.com/books/connectomic-deep-brain-stimulation/horn/978-0-12-821861-7
Article
Full-text available
Obsessive-compulsive disorder is among the most disabling psychiatric disorders. Although deep brain stimulation is considered an effective treatment, its use in clinical practice is not fully established. This is, at least in part, due to ambiguity about the best suited target and insufficient knowledge about underlying mechanisms. Recent advances...
Article
Full-text available
Background: Multiple deep brain stimulation (DBS) targets have been proposed for treating intractable obsessive-compulsive disorder (OCD). Here, we investigated whether stimulation effects of different target sites would be mediated by one common or several segregated functional brain networks. Methods: Seeding from active electrodes of four patien...
Chapter
Full-text available
In light of heterogeneous phenotypes across pathologies and patients, the treatment of network disorders via neuromodulation techniques -amongst them deep brain stimulation (DBS)- is largely complicated. This emphasizes the need for more precisely tailoring these techniques to the individual patient. The approach of this chapter to the topic of per...
Article
Full-text available
Dysregulation of physiological stress reactivity plays a key role in the development and relapse risk of alcohol dependence. This article reviews studies investigating physiological responses to experimentally induced acute stress in patients with alcohol dependence. A systematic search from electronic databases resulted in 3641 articles found and...

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Projects

Project (1)
Project
Work on a book about connectomic deep brain stimulation for Academic Press. https://www.elsevier.com/books/connectomic-deep-brain-stimulation/horn/978-0-12-821861-7