Barbara Hinteregger

• Medical University of Graz

Amyotrophic lateral sclerosis (ALS) still depicts an incurable and devastating disease. Drug development efforts are mostly based on superoxide dismutase 1 gene (SOD1)-G93A mice that present a very strong and early phenotype, allowing only a short time window for intervention. An alternative mouse model is available, that is based on the same found...

Background Preclinical Alzheimer’s disease (AD) research strongly depends on transgenic mouse models that display major symptoms of the disease. Although several AD mouse models have been developed representing relevant pathologies, only a fraction of available mouse models, like the Tg4-42 mouse model, display hippocampal atrophy caused by the dea...

Alzheimer’s disease can be modelled by different transgenic mouse strains. To gain deeper insight into disease model mechanisms, the previously described Tg4–42 mouse was analysed for transgene integration. On RNA/DNA level the transgene integration resulted in more than 20 copy numbers and further caused a deletion of exon 2 of the retinoic acid r...

Significance Phosphoenolpyruvate carboxykinase (PEPCK) has a unique position in cell metabolism by allowing the flexible use of nutrients for anabolic biosynthetic reactions. PEPCK activity has just recently been described in cancer cells. It has been shown to promote cancer cell survival under nutrient deprivation, a typical feature in solid cance...