Barbara Ferry

Barbara Ferry
Lyon Neuroscience Research Center · UMR 5292

Ph.D. Neuroscience

About

98
Publications
22,127
Reads
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2,324
Citations
Citations since 2017
17 Research Items
749 Citations
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2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
Introduction
Fondamental : 1) The role of the interactions between the olfactory bulb and associative areas (amygdala, hippocampus and entorhinal cortex) in simple and complex olfactory learnings ; 2) The role of NE, Glu, GABA and orexin in olfactory learning and memory; 3) Characterization of the role of attention and emotion in various pathological context (eating disorders; Alzheimer disease); 4) Forensic science : identification of the volatile organic compounds that characterize human scent; 5) complex scents identification by police dogs
Additional affiliations
December 2017 - present
Forensic Research Institute of the Gendarmerie Nationale, France
Position
  • Senior Researcher
Description
  • Chemical composition of human scents
November 2017 - present
Université du Québec à Trois-Rivières
Position
  • Research Associate
Description
  • New techniques in crime scene investigation
June 2008 - present
Lyon Neuroscience Research Center
Position
  • Senior Researcher
Description
  • Role of the noradrenergic system in the basolateral amygdala in modulating olfactory memory processes underlying olfactory associative learning tasks

Publications

Publications (98)
Article
Full-text available
The hippocampal formation has been extensivelydescribed asa keycomponent forobject recognition in conjunction with place and context. The present study aimed at describing neural mechanisms in the hippocampal formation that support olfactory–tactile (OT) object discrimination in a task where space and context were not taken into account. The task c...
Article
Full-text available
Human scent identification is based on a matching-to-sample task in which trained dogs are required to compare a scent sample collected from an object found at a crime scene to that of a suspect. Based on dogs’ greater olfactory ability to detect and process odours, this method has been used in forensic investigations to identify the odour of a sus...
Article
Full-text available
In a natural environment, avoidance of a particular food source is mostly determined by a previous intake experience during which sensory stimuli such as food odor, become aversive through a simple associative conditioned learning. Conditioned odor aversion learning (COA) is a food conditioning paradigm that results from the association between a t...
Research
Full-text available
Odorology is a technique that uses specially-trained dogs to identify human scent. It is used in police investigations to establish that an individual has been at the scene of a crime. However, there is no international norm on how these dogs are trained. At the Centre de recherche en neurosciences de Lyon (CNRS/Université Claude Bernard Lyon 1/Ins...
Article
Full-text available
Techniques of stereotaxic surgery are commonly used in research laboratories by a range of students, technicians, and researchers. To meet the evolving requirements imposed by international legislation, and to promote the implementation of 3R rules (replacement, reduction, and refinement) by reducing experimental error, animal morbidity, and mortal...
Article
Epileptic seizures constitute a significant comorbidity of Alzheimer’s Disease (AD), which are recapitulated in transgenic mouse models of amyloidogenesis. Here, we sought to evaluate the potential role of Tau pathology regarding seizure occurrence. To this end, we performed intra-hippocampal electroencephalogram (EEG) recordings and PTZ (pentylene...
Article
A scent lineup is generally a procedure whereby a dog's alerting behavior is used to establish that the dog detects two scents, one from a crime scene and one from a suspect, as deriving from the same person. The aim of this article is to compare methodologies of using dogs in scent lineups as a means of identifying perpetrators of crimes. It is ho...
Article
Previous work has shown that β-adrenergic and GABAergic systems in the basolateral amygdala (BLA) are involved in the acquisition of conditioned odor aversion (COA) learning. The involvement of α2-adrenoreceptors, however, is poorly documented. In a first experiment, male Long-Evans rats received infusions of 0.1 μg of the selective α2-antagonist D...
Chapter
Full-text available
A large variety of behaviors that are essential for animal survival depend on the processing and perception of surrounding smells present in the natural environment. In particular, food-search behavior, which is conditioned by hunger, is directly driven by the perception of odors associated with food, and feeding status modulates olfactory sensitiv...
Article
Full-text available
Post-traumatic stress disorder (PTSD) is a common consequence of exposure to a life-threatening event. Currently, pharmacological treatments are limited by high rates of relapse, and novel treatment approaches are needed. We have recently demonstrated that propranolol, a β-adrenergic antagonist, inhibited aversive memory reconsolidation in animals....
Data
Manuscript dataset. The first sheet of the document provides the percentage of freezing during contextual and cued fear conditioning tests. Sheets 2 and 3 provide latencies (in sec) before entering each compartments during respectively the familiarization and the test phases of the “city-like” experiment, and sheet 4 provides the total duration (in...
Article
Full-text available
L’odorologie est une méthode d’identification des odeurs humaines qui est utilisée depuis 2003 par les services de la police judiciaire pour identifier la présence d’un individu sur une scène de crime. Cette méthode repose sur la capacité de chiens à comparer une odeur prélevée sur un objet de la scène d’effraction (odeur de référence) à celle de p...
Article
Full-text available
Odorology is a forensic method based that enables to identify the presence of a suspect at a crime scene. It is used by the Sous-direction de la Police Technique et Scientifique (SDPTS) in Ecully since 2003. This article first describes the physiology of the olfactory sensory processing in the dog. Then, the different phases of the dog’s training a...
Book
Among the components of the limbic system, the amygdala is a fascinating structure that is involved in the processes of liking and disliking and in the ways our emotions drive our actions and affect the strength of our memories. Over these last twenty years, advances in techniques for examining brain activity have led to new insights into the func...
Article
Full-text available
Odorology is a forensic method based on a comparison between an olfactory sample collected from an object found at a crime scene that has been in contact with a human individual and that of a suspect. Based on the greater olfactory ability of dogs to detect and process odors, this method has been used in criminal investigation by the Direction Cent...
Article
Full-text available
L’odorologie est une technique d’identification mise en oeuvre dans les enquêtes criminelles et délictuelles par la Direction Centrale de la Police Judiciaire (Sous-Direction de la Police Technique et Scientifique, SDPTS) à Ecully depuis 2003. Elle permet, grâce aux capacités olfactives de chiens spécialement entraînés, de démontrer la présence de...
Research
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Article on the publication in plos one
Research
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Publication found in France Inter journal
Research
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Publication found in France Info Journal
Research
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Publication in the "Inside Science" Journal
Research
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Publication in the "IFL Science" Journal
Research
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Publication of an article in the Daily Science
Research
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Publication in the "Daily Science" Journal
Research
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Publication in "Le Devoir" Canadian journal
Research
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Publication in "SINC" spanish journal
Research
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Publication found in "2 interest"
Research
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Publication found in "Radio Scoop"
Research
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Pulblication found in the journal France Soir
Research
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Media publication found in Ici Radio Canada
Research
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Media publication found in the journal "pourquoi Docteur"
Research
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Media coverage found in "24 matins.fr"
Research
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Reoprt based on the AFP communication ; Media file found in the Journal "La Depêche" :
Research
Full-text available
L’odorologie est une technique d’identification des odeurs humaines par des chiens spécialement entraînés. Elle est utilisée dans les enquêtes policières pour démontrer la présence d’un individu sur une scène d’infraction. Cependant, il n’existe à l’heure actuelle aucun standard international concernant l’entraînement des chiens. Au Centre de reche...
Data
Summary of the data (mean S.E.M.) obtained during successive phases of intitial learning. These data refer to Fig 2. (XLSX)
Data
Summary of the data (mean S.E.M.) obtained during the 10 periods of continuous training. These data refer to Fig 3 and Table 1. (XLSX)
Article
Erratum for A2A adenosine receptor deletion is protective in a mouse model of Tauopathy
Article
In a natural environment, avoidance of a particular food source is mostly determined by a previous intake experience during which sensory stimuli such as food odor, become aversive through a simple associative conditioned learning. Conditioned odor aversion learning (COA) is a food conditioning paradigm that results from the association between a t...
Article
Full-text available
Full text: http://www.nature.com/mp/journal/vaop/ncurrent/pdf/mp2014151a.pdf Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer's disease (AD) in humans and mitigates both amyloid and Tau burden in transgenic mouse models. However, the impact of selective A2AR blockade on the...
Article
Full-text available
Alzheimer’s disease (AD) is characterized by extracellular amyloid deposits and intraneuronal neurofibrillary tangles, made of aggregated hyper- and abnormally phosphorylated Tau proteins. The latter, referred to as “Tau pathology”, contribute to synaptic impairments leading to memory deficits in AD patients. Previous epidemiological studies reveal...
Article
Full-text available
While the olfactory and tactile vibrissal systems have been extensively studied in the rat, the neural basis of these cross-modal associations is still elusive. Here we tested the hypothesis that the lateral entorhinal cortex (LEC) could be particularly involved. In order to tackle this question, we have developed a new behavioral paradigm which co...
Article
Full-text available
A large variety of behaviors that are essential for animal survival depend on the perception and processing of surrounding smells present in the natural environment. In particular, food-search behavior, which is conditioned by hunger, is directly driven by the perception of odors associated with food, and feeding status modulates olfactory sensitiv...
Book
Stereotaxic neurosurgery in rodents is used by a variety of people working at research laboratories (research staff, technicians, students at animal facilities...). The present handbook presents all the steps necessary to complete a stereotaxic neurosurgery protocol in accordance with current animal welfare guidelines. This book will guide surgeons...
Article
Full-text available
To test the selectivity of the orexin A (OXA) system in olfactory sensitivity, the present study compared the effects of fasting and of central infusion of OXA on the memory processes underlying odor-malaise association during the conditioned odor aversion (COA) paradigm. Animals implanted with a cannula in the left ventricle received ICV infusion...
Article
Full-text available
Electrochemical methods are very often used to detect catecholamine and indolamine neurotransmitters separated by conventional reverse-phase high performance liquid chromatography (HPLC). The present paper presents the development of a chromatographic method to detect monoamines present in low-volume brain dialysis samples using a capillary column...
Chapter
Far from being fully understood, the multiple functions of the brain still require in site investigations through invasive captors or probes placed in direct contact with the cerebral matter. In order to reach both an optimal precision and a safe outcome of the procedure, a responsible practice of brain surgery requires a perfect knowledge of the a...
Chapter
Full-text available
Techniques of stereotaxic surgery are commonly used today in research laboratories. To meet the evolving requirements imposed by international legislation and to promote the implementation of the 3Rs (Replacement, Reduction, and Refinement) by reducing experimental error, animal morbidity, and mortality, it is essential that standard technical proc...
Chapter
For addressing the specific objectives of a proposed study, stereotaxic surgery is often used in combination with other techniques. These techniques can include in vivo experimental procedures for activating or inactivating brain structures or transmitter systems, permanent selective lesioning, functional neuroanatomy using tracers and activity mar...
Chapter
Full-text available
This chapter addresses the issue of legislative frameworks applicable to the use of animals for scientific purpose. After a short introduction on the rationale of law and regulations, a first part covers the latest European Directive (2010/63/UE), which enforces the implementation of the 3Rs principle (Replacement, Reduction, Refinement) as well as...
Chapter
This chapter covers the use of a stereotaxic atlas and cranial landmarks to determine the spatial coordinates of a brain structure and the handling of a stereotaxic apparatus. From a short definition of stereotaxy, the reader, already familiar with the three-dimensional reference system described in Chap. 2, is first guided through a presentation o...
Chapter
At the end of an experiment in which a stereotaxic surgery has been used to manipulate the activity of a particular brain target structure, postmortem examination of the brain is necessary to validate the experimental data. The different steps including euthanasia, autopsy and removal of the brain, treatments specific to organ fixation, sectioning,...
Chapter
With essential elements of functional neuroanatomy, this chapter completes the anatomical basis developed in Chap. 2, with a systematic description of the major neurotransmitter systems, including ways to experimentally influence them. The amino acids, such as glutamate and gamma-aminobutyric acid (GABA), and the monoamines such as noradrenaline an...
Book
Among the components of the limbic system, the amygdala is a fascinating structure that is involved in the processes of liking and disliking and in the ways our emotions drive our actions and affect the strength of our memories. Combined with new conceptual breakthroughs, the very latest data obtained by leading world experts in amygdala function t...
Article
The present study aimed to create a direct bridge between observations on peripheral and central responses to odorant mixtures and their components. Three experiments were performed using mixtures of fruity (isoamyl acetate; ISO) and woody (whiskey lactone; WL) odorants known to contribute to some of the major notes in Burgundy red wine. These expe...
Article
Full-text available
The importance of central beta-adrenergic system has been essentially investigated in aversive/emotional learning tasks. However, recent data suggest that the beta-adrenergic system is also required for incidental taste learning. In the present study we evaluated in rats whether beta-adrenergic receptor activity is required for taste habituation, a...
Article
Full-text available
These experiments investigated the role of the alpha(2)-adrenoceptors of the basolateral nucleus of the amygdala (BLA) in modulating the retention of inhibitory avoidance (IA). In Experiment 1, male Sprague Dawley rats implanted with bilateral cannulae in the BLA received microinfusions of a selective alpha(2)-adrenoceptor antagonist idazoxan 20 mi...
Article
Full-text available
Conditioned odor aversion (COA) is the avoidance of an odorized-tasteless solution (the conditioned stimulus, CS), the ingestion of which precedes toxicosis. Previous works have shown that the basolateral nucleus of the amygdala (BLA) is involved in the acquisition, and more precisely, the control of the CS memory trace, of COA. Since catecholamine...
Article
Full-text available
Conditioned odor aversion (COA) corresponds to the avoidance of an odorized-tasteless solution (conditioned stimulus, CS) previously paired with toxicosis. COA occurs only when the interstimulus interval (ISI) is kept short, suggesting that the memory trace of the odor is subject to rapid decay. Previous experiments have shown that the entorhinal c...
Article
Full-text available
In Alzheimer's disease (AD), cognitive decline is linked to cholinergic dysfunctions in the basal forebrain (BF), although the earliest neuronal damage is described in the entorhinal cortex (EC). In rats, selective cholinergic BF lesions or fiber-sparing EC lesions may induce memory deficits, but most often of weak magnitude. This study investigate...
Article
Full-text available
Evidence from the effect of aspiration lesions of the entorhinal cortex (EC) has shown that this region is involved in conditioned odor-aversion (COA) learning--that is, the avoidance of an odorized tasteless solution the ingestion of which precedes toxicosis--by rendering COA tolerant to long odor-toxicosis delay. The present study examined whethe...
Article
Full-text available
This study investigates which forebrain structures show Fos protein expression during conditioned taste aversion (CTA) acquisition and whether Fos expression depends on the aversion strength. A novel taste paired with an intraperitoneal injection of a low dose of the malaise-inducing agent lithium chloride (LiCl) induced a weak CTA, whereas associa...
Article
Full-text available
Recent studies have shown that the integrity of the entorhinal cortex (EC) is not required for simple contextual conditioning. In background contextual conditioning, i.e., when a phasic cue is present during training, the involvement of the EC is still a matter of debate. Therefore, the present work further examines whether the EC is required for b...
Article
Full-text available
Systemic or intracerebral administration of glucocorticoids enhances memory consolidation in several tasks. Previously, we reported that these effects depend on an intact basolateral nucleus of the amygdala (BLA) and efferents from the BLA that run through the stria terminalis (ST). The BLA projects directly to the nucleus accumbens (NAc) via this...
Article
Full-text available
Systemic or intracerebral administration of glucocorticoids en- hances memory consolidation in several tasks. Previously, we reported that these effects depend on an intact basolateral nucleus of the amygdala (BLA) and efferents from the BLA that run through the stria terminalis (ST). The BLA projects directly to the nucleus accumbens (NAc) via thi...
Article
Full-text available
In the taste-potentiated odor aversion (TPOA) paradigm, animals acquire a strong aversion to an odor that is followed by delayed intoxication only if a gustatory stimulus is presented with the odor during conditioning. Although previous work has shown that N-methyl-D-aspartate (NMDA) receptors in the basolateral nucleus of the amygdala (BLA) play a...
Article
Full-text available
There is extensive evidence indicating that the noradrenergic system of the amygdala, particularly the basolateral nucleus of the amygdala (BLA), is involved in memory consolidation. This article reviews the central hypothesis that stress hormones released during emotionally arousing experiences activate noradrenergic mechanisms in the BLA, resulti...
Article
Full-text available
There is extensive evidence indicating that the noradrenergic system of the amygdala, particularly the basolateral nucleus of the amygdala (BLA), is involved in memory consolidation. Infusions of norepinephrine or beta-adrenoceptor agonists into the BLA enhance memory for inhibitory avoidance as well as water maze training. Other findings show that...
Article
Full-text available
The present study examined the effects of post-training infusions of the specific beta2-adrenergic agonist clenbuterol into the basolateral nucleus of the amygdala (BLA), on inhibitory avoidance retention. Male Sprague-Dawley rats were surgically implanted with cannulae aimed at the BLA. Animals were microinfused with different doses of clenbuterol...