Banu Laila

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Verified

Banu verified their affiliation via an institutional email.

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• MPhil MMEd MS PhD
• Professor at Bangabandhu Sheikh Mujib Medical University

The SARS-CoV-2-induced disease, COVID-19, remains a worldwide public health concern due to its high rate of transmission, even in vaccinated and previously infected people. In the endemic state, it continues to cause significant pathology. To elu- cidate the viral mutational changes and screen the emergence of new variants of concern, we conducted...

Background: Among all breast cancers, 5 to 10% are hereditary and related to mutation of BRCA1 and BRCA2 gene. To date, extensive researches have been carried out for detection of mutations in the exon2 of BRCA1 gene. Genetic study on these two genes from formalin-fixed paraffin-embedded tissue in Bangladeshi population has not been reported so far...

Objectives: The transcription factor 7 like 2 (TCF7L2) gene has been emerged as the most promising T2DM causing gene and the intronic variant rs12255372 of the TCF7L2 gene has demonstrated robust association with T2DM across various ethnic groups. The aim of this study was to determine the frequency of rs12255372 polymorphism in Bangladeshi adult p...

Background: The fifth most prevalent cause of cancer-related death worldwide and the most frequently diagnosed malignancy is breast cancer. Breast cancer is the second most prevalent neoplasm in Bangladesh and it is rising alarmingly among females. Ignorance and illiteracy are contributing factors to mortality due to delayed presentation. This stud...

Introduction COVID-19 pandemic hit Bangladesh with relatively low intensity, unlike its neighbors India and European countries and USA. Methods The present report included data of 8,480 individuals tested for COVID-19 RT-PCR of the workers and officials from readymade garments (RMG) industry in Chandra area in Gazipur. The present data looked into...

Background: While the etiology of type 2 diabetes mellitus (T2DM) is complex, genetic markers for T2DM are surfacing fast, and amidst such markers, the transcription factor 7-like 2 ( TCF7L2 ) gene has been emerged as the most promising T2DM-causing gene. The intronic variant rs12255372 of the TCF7L2 gene has been found to be strongly associated wi...

Introduction: While the etiology of T2DM is complex, genetic markers for T2DM are surfacing fast and amidst such markers, the transcription factor 7 like 2 (TCF7L2) gene has been emerged as the most promising T2DM causing gene. The intronic variant rs12255372 of the TCF7L2 gene has been found to be strongly associated with T2DM in different ethnic...

The objectives of this study were to compare dengue virus (DENV) cases, deaths, case-fatality ratio [CFR], and meteorological parameters between the first and the recent decades of this century (2000-2010 vs. 2011-2022) and to describe the trends, seasonality, and impact of change of temperature and rainfall patterns on transmission dynamics of den...

not available Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 172-173

Background: Vitamin D receptor gene (VDR) polymorphism and its association with various diseases have been previously investigated. But the association of vitamin D receptor gene polymorphism with COPD has not been investigated yet. Objective: To assess the association between vitamin D receptor gene polymorphism (FokI) and COPD. Methods: This cros...

In 1992 a new syndrome was described consisting of syncopal episodes or sudden death in patients with a structurally normal heart and an electrocardiogram characteristic of right bundle branch block with ST segment elevation in leads V1 to V3. Brugada syndrome is an autosomal dominant disorder. It has been shown to be associated with mutations in t...

Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic hereditary cardiomyopathy characterized by sudden cardiac death. Mutations in the MYBPC3 gene are often the most prevalent genetic abnormality in HCM with a prevalence ranging from 20.0 to 42.0%. The mutation spectrum is available for different countries, but such studies are lacking i...

Background: Vitamin D receptor gene (VDR) polymorphism and its association with various diseases have been previously investigated. But the association of vitamin D receptor gene polymorphism with COPD has not been investigated yet. Objective: To assess the association between vitamin D receptor gene polymorphism (TaqI) and COPD. Methods: This cros...

Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic cardiomyopathy characterized by sudden cardiac death. HCM is caused by the mutation in several genes that encode sarcomere proteins. Beta-Myosin Heavy Chain (β-MHC) gene is the one of the most mutated genes responsible for HCM. Studies on mutation spectrum of β-MHC gene are lacking in...

BACKGROUND : Wilson disease (WD) is an autosomal recessive disorder caused by mutation in the Adenosine Triphosphate 7B (ATP7B) gene. The spectrum of ATP7B mutation varies in different populations. The objective of this study was to identify the mutation in exon 8 and exon 14 of ATP7B gene in Bangladeshi children clinically diagnosed as WD. We also...

Recent scientific advancements have sparked an increasing trend of returning to nature. Scientists worldwide prefer natural medical derivatives over synthetic ones due to fewer side effects. Green tea is abundant in bioactive components and vitamins. Although most components of green tea were thought to be absorbed inadequately by oral administrati...

Background: Scattered patient counseling services are available at different public and private institutions in Bangladesh but organized genetic counselling services are either at an early stage of development. Objective: The aim of the study was to develop a genetic counselling evaluation format for adult Bangladeshi patients with AML. Methodology...

A-3-year-old Bangladeshi pediatric patient named Tasin was presented with a diagnosed case of congenital hypothyroidism (CH). This type of hypothyroidism may occur due to the alteration in the nucleotide sequences of the Thyroid transcription factor 2 gene. Few studies are present on the genetic basis of this disease. CH is common in Bangladesh, ma...

Psoriasis is a common, chronic, immune mediated inflammatory disease that involves the innate immunological system (keratinocyte, dendritic cell, histiocytes, mast cells and endothelial cells) and acquired immunological system (T lymphocytes). Essential trace elements like iron (Fe), copper (Cu) undergo redox cycling and have physiological signific...

Context and rationale: Congenital hypothyroidism is a prevalent endocrine disease that may occur due to the alteration in the sequence of nucleotides of the NKX2.5 gene. Though congenital hypothyroidism is quite common among the Bangladeshi pediatric population, there are few studies on the genetic basis of this disease. Objective: This study aimed...

Mutation in Exon2 of BRCA1 Gene in Adult Bengali Bangladeshi Female Patients with Breast Cancer: An Experience from Two Tertiary-Care Hospitals Document Type: Research Articles Authors Sagana Shahreen Chowdhury Marjia Khatun Toufiq Hasan Khan Anjuman Banu Laila Department of Anatomy, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, B...

Background: The occurrence rate of BRCA1 mutations is found to be high in South Asian countries where early onset of breast cancer is common. In Bangladesh, noticeable percentage of patients experience breast cancer in their reproductive ages. The objective of this study was to identify any mutation in exon2 of the BRCA1 gene in adult Bengali Bang...

Psoriasis is a common, chronic, immune mediated inflammatory disease that involves the innate immunological system (keratinocyte, dendritic cell, histiocytes, mast cells and endothelial cells) and acquired immunological system (T lymphocytes). Essential trace elements like iron (Fe), copper (Cu) undergo redox cycling and have physiological signific...

Introduction: Craniofacial anthropometry can be useful for forensic scientist, physical anthropologist, genetic counsellors as well as reconstructive surgery for the purposes of identification of an individuals and understanding human physical variation, gender and ethnicity especially with facial recognition as a tool in recent advances in biometr...

Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder. Due to long term impairment, high genetic component (heritability> 90%), lack of effective prevention and treatment, ASD has been prioritized for genetic studies. Studies on Copy Number Variations (CNV) at chromosome 16p11.2 locus have mostly been conducted in population...

Background:Hypertrophic cardiomyopathy (HCM) is the most frequent type of cardiomyopathy. HCM is a disease of changing cardiac morphology that causes various form of cardiac dysfunction. HCM patients may remain asymptomatic and undiagnosed for a long time. If they become symptomatic, they commonly present with breathlessness, chest discomfort, and...

Background: The nucleophosmin gene (NPM1) has recently been described as one of the most frequent genetic lesions in acute myeloid leukemia (AML). To the best our knowledge, no molecular genetic study on the NPM1 gene mutation in AML patients in adult Bengali Bangladeshi has been reported. It would, therefore, be a great opportunity to modernize ou...

Being prevalent as high as 0.2% (or 1 in 500) in the general population, Hypertrophic Cardiomyopathy (HM) is a disease marked by phenotypic and genotypic heterogeneity and is the most prevalent heritable cardiovascular disease. The heterogeneous nature of HCM can be explained by environmental influences such as exercise, modifier genes, or the pres...

Context: The craniofacial anthropometric norms are essential for establishing the facial identity of a person. The Santal community being one of the major tribes of Bangladesh, there are few recorded data in the literature on the craniofacial anthropometry of that population. Study addressing the craniofacial anthropometry of the adult Santal femal...

Context: Breast cancer is a multi-factorial disease and consistently ranks as one of the top killer cancers in women. The increasing incidence of breast cancer prevailing in Bangladeshi women, especially at a younger age, and their survival rate justifies research on breast cancer epidemiology. Age is the established risk factor for breast cancer....

With the advancement of medical genetics, particular emphasis is given on the genetic counseling worldwide. In Bangladesh, genetic counseling services are not yet developed. Acute myeloid leukemia (AML) is a malignant disease of the myeloid cells of bone marrow. Like other malignant diseases, it may result from a mutation in the DNA. A genetic coun...

English version of the final format of genetic counseling of adult Bangladeshi patients with AML is included as the supplementary material.

Bacteria and archaea possess adaptive immunity against foreign genetic materials through clustered regularly interspaced short palindromic repeat (CRISPR) systems. The discovery of this intriguing bacterial system heralded a revolutionary change in the field of medical science. The CRISPR and CRISPR-associated protein 9 (Cas9) based molecular mecha...

Context: Craniofacial anthropometry is an important stem of anthropometry in which the dimensions of the head and face are measured. Stature being one of the criteria of personal identification has a definite and proportional biological relationship with each and every part of the human body eg. head, face, trunk and extremities. The Santal communi...

Bacteria and archaea possess adaptive immunity against foreign genetic materials through clustered regularly interspaced short palindromic repeat (CRISPR) systems. The discovery of this intriguing bacterial system heralded a revolutionary change in the field of medical science. The CRISPR and CRISPR-associated protein 9 (Cas9) based molecular mecha...

Hypertrophic Cardiomyopathy (HCM) shows considerable clinical heterogeneity, both between and within families. So far 18 genes have been identified and about 1400 different mutations have been found. Among these mutations human beta-Myosin Heavy Chain (β-MHC) and Myosin Binding Protein C (MyBP-C) mutations account for about 50% of cases. In this st...

Gene therapy is a novel approach to treat, cure, or ultimately prevent disease by changing the expression of a person’s gene. Itinvolves the transfer of a therapeutic or working gene copy into specific cells of an individual in order to repair a faulty genecopy. Thus it may be used to replace a faulty gene, or to introduce a new gene whose function...

Death is always dreadful and the diseases those causes sudden death are universal threats in health concern. Brugada syndrom is a recently identified entity of arrhythmia and sudden cardiac death. This genetic and male dominant disorder is prevalent in Southeast Asian region. At least seven genes have been identified to associate with its occurrenc...

Atopic dermatitis (AD) is a chronic, inflammatory skin disease in early childhood. Atopic dermatitis is familial disease, often coexists with other atopic diseases with multiple risk factors associated with atopic eczema. The disease is more frequent in urban areas compared with rural areas. Changes in nutrition and a decrease in infant breast-feed...

Being prevalent as high as 0.2% (or 1 in 500) in the general population, Hypertrophic Cardiomyopathy (HCM) is a disease marked by phenotypic and genotypic heterogeneity and is the most prevalent heritable cardiovascular disease. The heterogeneous nature of HCM can be explained by environmental influences such as exercise, modifier genes, or the pre...

This study examined whether circulating levels of soluble receptor for advanced glycation end products (sRAGE) alter in prediabetes and correlate with insulin resistance (IR) and beta cell function in prediabetes and newly diagnosed type 2 diabetes mellitus (T2DM). Subjects without previous history of diabetes were recruited and grouped as control,...

Many changes have been made in the field of Neuroanatomy teaching and assessment. One important way to know the changes in other country is by analyzing the Neuroanatomy text books and we can compare their reflections in our curriculum by analyzing the assessment system. To analyze the 'Preface's of contemporary Neuroanatomy text books, qualitative...

Curriculum development for Advanced Genetics at BSMMU, Bangladesh

ABSTRACT In 1992 a new syndrome was described consisting of syncopal episodes or sudden death in patients with a structurally normal heart and an electrocardiogram characteristic of right bundle branch block with ST segment elevation in leads V1 to V3. Brugada syndrome is an autosomal dominant disorder. It has been shown to be associated with mutat...

Umbilical cord blood collected at birth is a rich source of stem cells that can be used to treat diseases of the blood and immune system. Cord blood stem cells which have infinite medical potential are currently used in the treatment of several life-threatening diseases, and play an important role in the treatment of blood and immune system related...

Appendicitis is the most common clinical condition of the appendix. Many cases of acute appendicitis result from obstruction of the lumen of the appendix by lymphoid hyperplasia. The vermiform appendix is a worm-like, closed-ended, narrow, small tubular structure, projecting from posteromedial wall of cecum. It is an integral part of the Gut Associ...

The dimensions of the human body are affected by geographical, racial, ethnic, gender and age factors. So, a normative data of pe-riocular measurements based on above factors are indispensable to identify any ocular pathology and to precise determination of the degree of deviations from the normal. The study was descriptive, observational and cross...

It is well accepted that a single standard of craniofacial norms is not appropriate for application to diverse racial and ethnic groups, even for different sex and ages in same ethnic group. So it is necessary to develop craniofacial norms for different groups based on above factors. The present study was designed to establish the baseline measurem...

This observational study was done among the different types of diabetes, gestational diabetes mellitus (GDM). In the present study we looked for the microscopic impacts of GDM on the umbilical cord. This study was carried out in the department of Anatomy, Chittagong Medical College from May 2006 to April 2007. Total fifty umbilical cords with place...

Facial anthropometry has well-known implications in health-related fields. Measurement of human face is used in identification of person in Forensic medicine, Plastic surgery, Orthodontics, Archeology, Hairstyle design and examination of the differences between races and ethnicities. Facial anthropometry provides an indication of the variations in...

Facial anthropometry has well-known implications in health-related fields. Measurement of human face is used in identification of person in Forensic medicine, Plastic surgery, Orthodontics, Archeology, Hair-style design and examination of the differences between races and ethnicities. Facial anthropometry provides an indication of the variations in...

The present descriptive, observational, and cross-sectional study was designed to establish the baseline measurements of the craniofacial anthropometrical parameters and indices of 100 adult Bangladeshi Buddhist Chakma females aged between 25 and 45 years, residing at different locations of Chittagong and Rangamati cities. A total of ten craniofaci...

The analysis of facial soft tissue from the photographic records gives information about the standard nor-mative values of different facial parameters of a specific population group, helps in the diagnosis of any abnormalities of face and also helps for the treatment plan of patients undergoing orthodontic treatment or facial plastic surgery. The a...

Estimation of stature is an important tool in forensic examination especially in unknown, highly decomposed, fragmentary and mutilated human remains. When the evidences are skeletal remains; forensic anthropology has put forward means to estimate the stature from the skeletal and even from fragmentary bones. Sometimes, craniofacial remains are brou...

Background Acne is a common manifestation of hyperandrogenemia. Polycystic ovarian syndrome (PCOS) is a common endocrine abnormality affecting reproductive aged women. In the female, the most common cause of hyperandrogenemia is PCOS. The purpose of our study was to determine the PCOS in women with acne. Patients and methods In this observational,...

Please cite this paper as: Chowdhury S, Banu LA, Chowdhury TA, Rubayet S, Khatoon S. Achieving Millennium Development Goals 4 and 5 in Bangladesh. BJOG 2011;118 (Suppl. 2):36–46. Bangladesh has made commendable progress in achieving Millennium Development Goals (MDGs) 4 and 5. Since 1990, there has been a remarkable reduction in maternal and child...

Ultimately, every cell in the human body can be traced back to a fertilized egg that came into existence from the union of ovum and sperm. But the body is made up of over 200 different types of cells, not just one. All of these cell types come from a pool of cells in the early embryo, called stem cells. DOI: http://dx.doi.org/10.3329/bja.v9i1.8138...

Objective: Clinically the adverse effects of the diabetes on the out come of pregnancy are well established. The present study was designed to look for the impacts of gestational diabetes on the gross and histomorphological features of the umbilical cord. Type of study: A descriptive study having analytical components. Place and period of study: De...

Context: Aiming the effects of severity of diabetes mellitus on human placenta and the neonatal outcome, a quantitative study at the macroscopic level was designed. Material and Methods: Sixty post caesarean section human placentae were studied of which thirty were from mothers having established diabetes mellitus considered as EDM and thirty were...

Context: The thyroid gland is the first endocrine organ to evolve in the vertebrates. It has right and left lobes and connected by narrow median isthmus which lies over the second, third and fourth tracheal rings. A conical pyramidal lobe often ascends towards the hyoid bone from isthmus or the adjacent part of either lobe. It measures about 1.25 c...

Objective: Clinically the adverse effects of the diabetes on the out come of pregnancy are well established. The present study was designed to look for the impacts of gestational diabetes on the gross and histomorphological features of the umbilical cord. Materials: Total fifty (50) umbilical cords with the placenta were collected within 36 th to 4...

Three hundred and thirty four medical students were questioned regarding their views on anatomy as an emerging science and further career option. A questionnaire with 16 statements was given to these students and their answers were compiled. The results of this study were encouraging. 99% of students consider anatomy as an essential pillar of medic...

Context: Preterm birth is the major cause of perinatal mortality and morbidity. For the last few decades, it has become an important issue in public health policies of developing countries. Gestational diabetes mellitus (GDM) is one of the high-risk factors for the preterm birth and altered fetal development. This pregnancy induced disorder leads t...

Context: Body physique is influenced to a greater extent by climatic, hereditary, nutritional and racial factors. Since in Bangladesh variegated ethnic groups inhabit in different conditions, no single anthropometric formula is suitable. The stature prediction occupies relatively a central position in the anthropometric research. And estimation of...

Context: Anatomy is a compulsory subject for postgraduate medical courses of Bangladesh. MD internal medicine is a clinical course run by different universities of Bangladesh. To maintain a standard of medical education a curriculum is essential for a course. Again course content is an essential part of a curriculum. Doctor of Medicine (MD) courses...

Context: Stature is the height of the person in the upright posture. It is an important measure of physical identity. Interrelationships among different body measurements may be used to estimate one from another in case of missing body parts. As any part of the human skeleton can be found as the evidences, there arise a need to investigate whether...

In this experiment defatted Trigonella foenumgraecum (fenugreek seeds/methi seeds) has used as the antidiabetogenic herbal medicine. The experiment was carried out in Bangabandhu Sheikh Mujib Medical University and BIRDEM from 1996 to 1998 on a total of 58 Long Evans rats of either sex. They were 50-60 days young rats with average body weight 72-17...