Banshi Saboo

• M.D.
• Medical Doctor at DiaCare

Closed-loop insulin delivery systems, also known as automated insulin delivery (AID) integrate CGM, insulin pumps, and control algorithms to automate real-time insulin delivery, effectively reducing glycemic variability in diabetes management [1]. • Type 1 Diabetes (T1D) affects an estimated 8.4 million individuals globally (2021), with 500,000 new...

Controversies in journal publications remain in the mainstream of scientific discussions globally. Concerning the significance of avoiding controversies with publications, the article spans some of the factors that may lead to controversies and the widely discussed controversial studies in diabetes including the rosiglitazone study, the association...

Assessing the clinical and biochemical profiles of patients with type-2 diabetes (T2D) is vital for understanding the disease characteristics and improving disease management. This study aimed to assess the profiles of adults (> 18 years old) with T2D enrolled in a one-year diabetes management program in Pune, India. This cross-sectional study retr...

Highlights •Asian Indians with Type 2 Diabetes should undergo mandatory screening for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) using non-invasive tools like Fibrosis-4 Index (FIB-4) or vibration-controlled transient elastography for disease assessment and progression monitoring. •Lifestyle modifications through culturally ap...

Diabetes is a growing global health concern with a high prevalence in the Asian and Western Pacific regions. Effective diabetes management mainly relies on self-care practices. However, glycemic control remains poor, especially in developing nations where healthcare access is limited. Low physician density and minimal healthcare funding exacerbate...

Rising prevalence of Type 2 Diabetes (T2D) among young Asians has emerged as a public health crisis that threatens the long-term health, economic stability, and productivity of nations across Asia (1). Early-onset T2D poses unique challenges, including higher rates of undiagnosed cases, more aggressive disease progression, an increased risk of chro...

Schools, workplaces, and society play a critical role in providing a safe and supportive environment to individuals with type 1 diabetes mellitus (T1DM). However, for many people with T1DM in India, this still remains elusive. This white paper, led by distinguished experts from TiEUP, a national conclave for T1DM in India, thoroughly summarizes the...

Background: Type 2 diabetes (T2D) is the leading cause of chronic kidney disease (CKD) worldwide. Identifying clinical and laboratory associations with CKD in T2D can assist physicians in targeting modifiable risk factors. In light of limited data from India, the CITE (CKD in Indian T2D Evaluation) study was conducted. Methods: The multicenter, cro...

Vaccination is one of the most cost-effective public health strategies. Millions of adults globally suffer from diseases preventable by vaccines. Vaccination in persons with diabetes mellitus is crucial for enhancing immunity, protecting against new infectious agents, and boosting the efficacy of childhood vaccines. It also reduces the community...

OBJECTIVE: This study aims to explore the perspectives, practices, and challenges faced by healthcare professionals (HCPs) in India in managing type 1 diabetes (T1D) during pregnancy, focusing on preconception care, glucose control, and adherence to clinical guidelines. MATERIALS AND METHODS: To collect anonymous data, a Google form was circulated...

OBJECTIVE: In 1923, while India was engaged in the Flag Satyagraha movement for independence, the medical community witnessed the discovery of insulin and the early recognition of metabolic syndrome (MetS) by Swedish physician Eskil Kylin. This article draws parallels between the historical Satyagraha movement and the current fight against MetS, ad...

People with diabetes are at increased risk for infections, and vaccine-preventable diseases such as pneumococcal and influenza infections pose serious complications, including increased mortality rates. Despite the benefits of vaccinations in preventing such infections and their complications, vaccine uptake among individuals with diabetes remains...

Effective management of diabetes warrants accurate and regular monitoring of glucose levels to prevent serious diabetes-associated complications and long-term health consequences. Hence, achieving target glucose levels and maintaining adequate glycemic control is essential in diabetes to prevent episodes of hypoglycemia. Multiple glucose monitoring...

Background Pakistan’s collaboration with the World Diabetes Foundation (WDF) introduced a pioneering and unparalleled initiative to enhance maternal and child healthcare. The mass media campaign for the detection of hyperglycemia in pregnancy (HIP) via screening, management, and prevention is a significant component of this collaboration to reduce...

Background Type 2 diabetes (T2D) is a chronic metabolic disorder that has a notable influence on mental well-being, contributing to elevated morbidity and mortality rates. Depression and anxiety disorders are the most common mental health concerns among patients with T2D worldwide. Therefore, the present study aimed to assess the impact of an onlin...

OBJECTIVE: The escalation of type 2 diabetes (T2D) as a global health crisis necessitates a shift towards personalized medicine to optimize treatment efficacy and minimize adverse drug reactions (ADRs). This review article underscores the significant role of pharmacogenomics in refining T2D management. We explore the influence of genetic variations...

The Indian Society of Hypertension (InSH) highlights the urgency for India-specific guidelines on hypertension management. Hypertension affects over one billion people worldwide, with India bearing a significant burden due to its population, diversity, and demographics. In India, hypertension affects 21% of women and 24% of men, while pre-hypertens...

The care of the aged becomes a critical priority in the ever-changing field of healthcare, requiring a specialized, and sensitive approach. This population is at the intersection of medical innovation and ethical care, as they are susceptible to the compounding effects of various drugs and complex health issues. In this regard, the Clinical Pharmac...

Introduction Hypogonadism is a common comorbidity associated with several metabolic disorders including type 2 diabetes (T2D) that can remain undetected without proper screening. Here, we evaluated the prevalence of hypogonadism in Indian male patients with T2D with or without obesity. Methods In this prospective, observational study, male patient...

Polypharmacy is increasingly prevalent among elderly populations due to multimorbidity and the expansion of pharmaceutical options. This case report explores the adverse effects of polypharmacy in an elderly patient, emphasizing the importance of appropriate medication management and the role of clinical pharmacologists. A 78-year-old male with mul...

Diabetes presents a significant public health challenge globally, with India emerging as a hotspot for the disease burden. The International Diabetes Federation (IDF) Diabetes Atlas 2021 highlights India with 1 in 7 adults affected with diabetes. Given the heightened susceptibility of individuals with diabetes to vaccine-preventable diseases, vacci...

Introduction Evidence on the prevalence of foot problems among people with diabetes in India at a national level is lacking. Hence, this study was aimed to assess the burden of high-risk (HR) feet in people with diabetes across India. Research design and methods A cross-sectional national-level project ‘Save the Feet and Keep Walking’ campaign was...

Backround: Recent advances in insulin research open new avenues for treatment, both, for type 1 and type 2 diabetes. In developed countries, standardized “ultra-rapid-acting insulins” are now also used in addition to rapid-acting insulins. First- and second-generation basal analogs are available. Third generation basal analogs, which only need to b...

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contac...

Type 1 diabetes (T1D) is characterized by the progressive loss of pancreatic beta cells, resulting in insulin deficiency. This condition requires exogenous insulin therapy to prevent fatal complications caused by hyperglycemia. Effective management of T1D also includes structured diabetes education, proper nutrition, addressing psychosocial issues,...

Type 1 diabetes (T1D) is characterized by the progressive loss of pancreatic beta cells, resulting in insulin deficiency. This condition requires exogenous insulin therapy to prevent fatal complications caused by hyperglycemia. Effective management of T1D also includes structured diabetes education, proper nutrition, addressing psychosocial issues,...

Background The global rise in diabetes, particularly in India, poses a significant public health challenge, with factors such as limited awareness, financial strain, and cultural considerations hindering its effective management. Although lifestyle changes have shown promising results, their consistent implementation and maintenance continue to pos...

Overweight and obesity are increasingly recognized as potential targets for early intervention. Unlike injectable treatments, oral formulations are more easily accepted by people with diabetes. In Asian Indians, BMI ≥ 25 kg/m2 is considered obesity. Study participants were de-identified from the electronic medical records of a comprehensive diabete...

Aim: To assess the impact of Smit.fit’s CGM-powered Diabetes Care program on reducing HbA1c levels and increasing Time in Range (TIR) for T2DM patients at health clinics. Method: A single group design study of repeated measures evaluated Smit.fit’s 4-month Diabetes Care program deployed at partner health clinics across 50 cities in India. The inter...

This comprehensive review explores the intricate connections between mind, body, and diabetes, with a particular focus on the profound impact of emotional stress on individuals managing this chronic condition. Drawing on a wealth of research spanning the intersection of psychology, physiology, and diabetes care, the review delves into the multiface...

Several studies have reported the rising prevalence of diabetes in young adults globally. ADA currently recommends routine screening for diabetes starting at the age of 35 years. Indians are known to develop diabetes at a younger age, although there is a scarcity of large studies looking at the prevalence of diabetes in Young Indians. Objective of...

Introduction Type 1 diabetes (T1D), especially in children, demands continuous attention and support from parents. Managing T1D can be a herculean task, which could even affect parenting. These challenges could become intense when the child reaches adulthood. In this study, we aim to understand the emotional and social dimensions experienced by par...

With the advent of ever more sophisticated technologies, the notion of conventional glucose monitoring has been transforming. The potential benefits of continuous glucose monitoring have been touted since its introduction more than 20 years back. People with diabetes are now well aware of the multitude of benefits they can harness with continuous g...

Background The increasing incidence of type 2 diabetes (T2D) in India underscores the pressing need for effective management strategies. Meeting the American Diabetes Association (ADA) ABC targets for diabetes (glycated hemoglobin (HbA1c), blood pressure, and serum low-density lipoprotein cholesterol (LDL-C)) is crucial for effectively managing T2D...

The Oral Glucose Tolerance Test (OGTT) remains a gold standard for diagnosis of diabetes and prediabetes all over the world and also in India. The original OGTT was a five sample test which included fasting, 30, 60, 90, and 120 min. Later, the test was modified in the US to two sample test 0 and 120 min, i.e., fasting and 2 h after 75 g glucose and...

Optimal diabetes management demands the monitoring of blood glucose (BG) at specified intervals. Self-monitoring of BG has now become an integral part of maintaining the recommended target level and has gained wide acceptance among the diabetes community as a standard tool for glycemic management. The technological advancements in diabetology have...

Introduction The use of complementary and alternative medicine (CAM) among individuals with diabetes has seen a significant surge. Estimates show that 80% of people in developing countries still prefer CAM for the treatment of health conditions. CAM encompasses various medical practices outside mainstream medicine and is increasingly employed for t...

Background and Aim Hypoglycemia, marked by low blood glucose levels, presents significant challenges in diabetes care. This review outlines the evidence-based recommendations formulated by the DGENius Experts Consensus Group for managing hypoglycemia in people with diabetes. The goal was to furnish well-defined, evidence-based recommendations for a...

OBJECTIVE: To investigate the efficacy of insulin degludec/insulin aspart (IDegAsp) co-formulation versus insulin glargine U300 (IGlarU300) in insulin-naïve individuals with type 2 diabetes (T2D) who had inadequate glycemic control with three oral antidiabetic drugs. MATERIALS AND METHODS: In this multicenter, retrospective, observational study, in...

A BSTRACT Cerebrospinal fluid (CSF) flow plays a critical role in clearing metabolic waste from the brain. The flow depends on several factors, including cardiac and respiratory oscillations. The process of CSF pulsations also follows a circadian pattern and plays a central role in maintaining the homeostasis of the brain and the central nervous sy...

Background Over the past two decades, insulin glargine 100 U/mL (Gla-100) has emerged as the “standard of care” basal insulin for the management of type 1 diabetes mellitus (T1DM). Both formulations, insulin glargine 100 U/mL (Gla-100) and glargine 300 U/mL (Gla-300) have been extensively studied against various comparator basal insulins across var...

Festivals are integral to our cultural tapestry, uniting communities in celebration. However, for individuals living with diabetes, these vibrant occasions can present challenges to glycemic control. This review explores the intricate relationship between festivals and diabetes management. It highlights the need for awareness and knowledge dissemin...

Diabetes mellitus, a global health concern, is characterized by complex pathophysiology and presents diverse clinical challenges. Effective management of diabetes hinges on key principles such as glycemic control, lifestyle modifications, and adherence. In non-insulin-requiring Type 2 diabetes (T2D), persistent elevated HbA1c levels remain a challe...

Insulin plays a crucial role in the treatment of individuals with both type 1 diabetes mellitus and the majority of those with type 2 diabetes mellitus. However, obstacles such as injection-related discomfort and financial limitations can impede the initiation of treatment and adherence to it. To overcome these challenges and improve patient outcom...

Glucagon has been an important hormone for nearly a century, as it was first discovered in 1923. Over the years, research on glucagon has provided valuable insights into its function and its role in glucose homeostasis. Glucagon receptors have indeed been identified in cardiac tissue as well. This discovery indicates that glucagon might exert direc...

The intricate relationship between the gut and the brain has long captured the imagination of scientists, philosophers, and clinicians alike. Over the past few decades, research has unveiled a complex and bidirectional communication network that connects these seemingly distinct organs, giving rise to the concept of the gut–brain axis. This axis re...

This review article looks at the historical journey of the discovery of glucagon and the initial stages of research that paved the way for a comprehensive understanding of its physiological significance. Glucagon, an essential peptide hormone produced by the pancreas, plays a pivotal role in maintaining glucose homeostasis. Tracing the trajectory o...

Background and Aims The current pandemic of diabetes warrants the use of clinical strategies to circumvent clinician inertia on doseescalation with oral antidiabetic drugs (OADs). precluded by progressive decline of beta-cell function andinsulin resistance in almost all of the cases. The cardiovascular safety evidence for these agents often limitsc...

Disclosure: P. Shamanna: None. J. Mohammed: None. M. Mohamed: None. T. Poon: None. M. Dharmalingam: None. B. Saboo: None. S. Damodharan: None. A. Vadavi: None. M. Thajudeen: None. A. Keshavamurthy: None. S. Bhonsley: None. B. R: None. S. Joshi: None. Background and Aims: The aim was to study the effect of a personalized diet using the Digital Twin...

Disclosure: S.R. Joshi: None. J. Mohammed: None. M. Mohamed: None. T. Poon: None. M. Dharmalingam: None. B. Saboo: None. S. Damodharan: None. A. Vadavi: None. M. Thajudeen: None. A. Keshavamurthy: None. S. Bhonsley: None. B. R: None. P. Shamanna: None. Background and Aims: The aim was to study the effect of a personalized diet using the Digital Twi...

Background: Heart rate varies during breathing and the heart rate variability (HRV) facilitates the autonomic homeostatic capacity. The maximum HRV was observed at around 10 s of prolonged respiration as per HRV biofeedback literature. However, there is a gap in understanding the variations in HRV by different respiration lengths during simple Bhr...

Finerenone is a nonsteroidal mineralocorticoid receptor antagonist, which is used to retard the progression of chronic kidney disease in persons with type 2 diabetes. This communication describes the various aspects of patient counseling needed to ensure safe and effective usage of the molecule. It utilizes the 5C checklist: Confirmation of clinica...

Aim/hypothesis Five subgroups were described in European diabetes patients using a data driven machine learning approach on commonly measured variables. We aimed to test the applicability of this phenotyping in Indian individuals with young-onset type 2 diabetes. Methods We applied the European-derived centroids to Indian individuals with type 2 di...

Background and Objectives: Hypertension (HT) is a leading risk factor for blood vessel diseases worldwide and its prevalence is increasing among adolescents. Lifestyle changes cause increased obesity, thereby increasing the risk of developing HT. In this study, the prevalence of HT and associated risk factors were assessed in adolescents in Gujarat...

Background and Aim: Type 2 diabetes (T2D) remission is widely reported across the world. However, there are no large-scale cohort studies that report the effectiveness of lifestyle intervention on T2D remission, especially in Indian population. The study aimed to evaluate the effectiveness of a one-year lifestyle modification program-Holistic Trans...

Background: India is predicted to have over 27 million children with obesity, representing over half of the children with obesity in the region and 1 in 10 of all children globally. Aim: To study Obesity prevalence in Adolescents and making timely interventions for healthier lifestyle adoption in urban and rural Ahmedabad. Methodology: A team of ph...

Rationale: Drug prescribing studies can suggest modifications in the current prescribing practices, which in turn will reduce the treatment cost, non-compliance and complications. Purpose: To identify the prescription patterns in patients with type 2 diabetes mellitus with respect to the duration of the disease. Methods: Patients with type 2 diabet...

Background and Aim­: Type 2 diabetes (T2D) remission through calorie and carbohydrate restriction has been reported. We conducted a pilot trial to observe whether oral Glucose tolerance test (OGTT) clearance is possible in T2D patients who underwent remission through a lifestyle modification program. Methods: A total of 3689 patients who had previo...

Background: Type 2 diabetes (T2D) is a chronic metabolic disorder that has a significant impact on the mental health of an individual, which in turn results in increased morbidity and mortality. Objective: To evaluate the effect of holistic lifestyle intervention in improving mental health outcomes in patients with T2D. Materials and Methods: In th...

Clinical empathy is one of the most essential tools of medical practice, and it is an act of correctly acknowledging the emotional state of another without experiencing that state oneself. Empathy comprises four components. Mounting evidence exists to support the use of clinical empathy as a tactic for effective health care. Resolving the multi-fol...

Background: Non-communicable disease (NCD) rates are rapidly increasing in India with wide regional variations. We aimed to quantify the prevalence of metabolic NCDs in India and analyse interstate and inter-regional variations. Methods: The Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study, a cross-sectional population-based...

Objectives: To suggest how continuous glucose monitoring (CGM) may be used intermittently in individuals with type 2 diabetes (T2D). Materials and methods: The use of CGM is largely in those with type 1 diabetes (T1D), in whom it makes sense to use CGM continuously as CGM provides a valuable tool to not only adjust their insulin doses but also t...

Aims: This study aimed to provide a global insight into initiatives in type 1 diabetes care driven by the COVID-19 pandemic and associations with glycemic outcomes. Methods: An online questionnaire regarding diabetes care before and during the pandemic was sent to all centers (n=97, 66,985 youth with type 1 diabetes) active in the SWEET registry...

Objective Twin Precision Treatment (TPT) is a novel Whole-Body Digital Twin (WBDT) enabled precision nutrition for reversing diabetes, that uses AI and the Internet of Things, to integrate multidimensional data, from non-invasive sensors, to give precision nutrition and health recommendations via the TPT app and by coaches. Methods We conducted a p...

Objective In this study, our goal was to understand the comparative impact of humming, physical activity, emotional stress, and sleep on several heart rate variability (HRV) parameters, including the stress index (SI), and to assess the effectiveness of humming (simple Bhramari) as a stress buster based on the HRV parameters. Methods This pilot st...

Male hypogonadism (MH) is a clinical and biochemical syndrome caused by inadequate synthesis of testosterone. Untreated MH can result in long-term effects, including metabolic, musculoskeletal, mood-related, and reproductive dysfunction. Among Indian men above 40 years of age, the prevalence of MH is 20%–29%. Among men with type 2 diabetes mellitus...

Background: There is a bidirectional relationship between COVID-19 and diabetes. New-onset diabetes and severe metabolic complications of pre-existing diabetes in patients with COVID-19 have been observed. Steroids are medications used for treatment of several diseases, including COVID-19. Its pharmacological action increases blood glucose and pose...