Bang Zheng

Bang Zheng
Peking University | PKU · Department of Epidemiology and Biostatistics

Doctor of Philosophy

About

57
Publications
18,189
Reads
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443
Citations
Introduction
Skills and Expertise
Additional affiliations
January 2022 - present
London School of Hygiene and Tropical Medicine
Position
  • Assistant professor
June 2021 - January 2022
The University of Edinburgh
Position
  • Senior research fellow
Education
October 2017 - October 2020
Imperial College London
Field of study
  • Neuroepidemiology
September 2015 - July 2017
Peking University
Field of study
  • Epidemiology and Biostatistics

Publications

Publications (57)
Article
Full-text available
Background Practice effects (PE), after repeated cognitive measurements, may mask cognitive decline and represent a challenge in clinical and research settings. However, an attenuated practice effect may indicate the presence of brain pathologies. This study aimed to evaluate practice effects on the Repeatable Battery for the Assessment of Neuropsy...
Article
Purpose To compare submandibular gland (SMG) transplantation with minor salivary glands (MSGs) transplantation for the treatment of different dry eye diseases (DED). Design Retrospective clinical cohort study. Methods Seventy-three refractory DED eyes were divided into three groups. Group A: 35 end-stage DED eyes who underwent SMG transplantation...
Article
Full-text available
Background No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for COVID-19, identify factors associated with patient-perceived recovery, and identify potential therapeutic targets by describing the underlying inflammatory profiles of the...
Article
Reduced rank regression is an extended multivariate linear regression model with the function of dimension reduction. It has been more and more widely used in nutritional epidemiology research to understand people's dietary patterns in recent years. However, there has been no existing Stata package or command to implement reduced rank regression in...
Article
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The present paper examines longitudinally how subjective perceptions about COVID-19, one’s community, and the government predict adherence to public health measures to reduce the spread of the virus. Using an international survey ( N = 3040), we test how infection risk perception, trust in the governmental response and communications about COVID-19...
Article
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Before vaccines for COVID-19 became available, a set of infection prevention behaviors constituted the primary means to mitigate the virus spread. Our study aimed to identify important predictors of this set of behaviors. Whereas social and health psychological theories suggest a limited set of predictors, machine learning analyses can identify cor...
Article
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Anxiety associated with the COVID-19 pandemic and home confinement has been associated with adverse health behaviors, such as unhealthy eating, smoking, and drinking. However, most studies have been limited by regional sampling, which precludes the examination of behavioral consequences associated with the pandemic at a global level. Further, few s...
Article
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Emerging evidence has shown that COVID-19 survivors could suffer from persistent symptoms. However, it remains unclear whether these symptoms persist over the longer term. This study aimed to systematically synthesise evidence on post-COVID symptoms persisting for at least 12 months. We searched PubMed and Embase for papers reporting at least one-y...
Article
Purpose of review: Persistence of symptoms after acute coronavirus disease 2019 (COVID-19), often described as long-COVID, is common and debilitating. In this article, we review the epidemiology, clinical features, and research priorities for long-COVID focusing on the respiratory system. Recent findings: Breathlessness, cough and chest pain wer...
Article
Understanding the determinants of COVID-19 vaccine uptake is important to inform policy decisions and plan vaccination campaigns. The aims of this research were to: (1) explore the individual- and country-level determinants of intentions to be vaccinated against SARS-CoV-2, and (2) examine worldwide variation in vaccination intentions. This cross-s...
Article
Background: Type 2 diabetes (T2D) is an established risk factor for dementia. However, it remains unclear whether the presence of comorbidities could further increase dementia risk in diabetes patients. Objectives: To examine the associations between cardiovascular and non-cardiovascular comorbidities and dementia risk in T2D patients. Design:...
Preprint
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Background There are currently no effective pharmacological or non-pharmacological interventions for Long-COVID. To identify potential therapeutic targets, we focussed on previously described four recovery clusters five months after hospital discharge, their underlying inflammatory profiles and relationship with clinical outcomes at one year. Metho...
Article
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Tightening social norms is thought to be adaptive for dealing with collective threat yet it may have negative consequences for increasing prejudice. The present research investigated the role of desire for cultural tightness, triggered by the COVID-19 pandemic, in increasing negative attitudes towards immigrants. We used participant-level data from...
Article
In the context of ageing and Alzheimer’s disease (AD), factors linked to reserve and resilience may confer protection against impact of underlying neuropathology on cognitive function. Such factors are differentially manifested in men and women, yet limited studies have explored potential divergence in their capacity to moderate cognitive outcomes,...
Article
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Background: Several studies have assessed the impact of COVID-19-related lockdowns on sleep quality across global populations. However, no study to date has specifically assessed at-risk populations, particularly those at highest risk of complications from coronavirus infection deemed “clinically-extremely-vulnerable-(COVID-19CEV)” (as defined by P...
Article
During the initial phase of the COVID-19 pandemic, U.S. conservative politicians and the media downplayed the risk of both contracting COVID-19 and the effectiveness of recommended health behaviors. Health behavior theories suggest perceived vulnerability to a health threat and perceived effectiveness of recommended health-protective behaviors dete...
Preprint
Full-text available
Metformin, an antidiabetic drug, triggers anti-aging cellular responses. Aging is the principal risk factor for dementia, but previous observational studies of the diabetes drugs metformin vs. sulfonylureas have been mixed. We tested the hypotheses that metformin improves survival and reduces the risk of dementia, relative to the sulfonylureas, by...
Article
Full-text available
Background Blood pressure (BP) categories are useful to simplify preventions in public health, and diagnostic and treatment approaches in clinical practice. Updated evidence about the associations of BP categories with cardiovascular diseases (CVDs) and its subtypes is warranted. Methods and findings About 0.5 million adults aged 30 to 79 years we...
Article
Objective: Type 2 diabetes is an established risk factor for dementia. However, the roles of glycemic control and diabetic complications in the development of dementia have been less well substantiated. This large-scale cohort study aims to examine associations of longitudinal HbA1c levels and diabetic complications with the risk of dementia incid...
Article
Full-text available
This paper examines whether compliance with COVID-19 mitigation measures is motivated by wanting to save lives or save the economy (or both), and which implications this carries to fight the pandemic. National representative samples were collected from 24 countries (N = 25,435). The main predictors were (1) perceived risk to contract coronavirus, (...
Article
Full-text available
Background The effective implementation of government policies and measures for controlling the coronavirus disease 2019 (COVID-19) pandemic requires compliance from the public. This study aimed to examine cross-sectional and longitudinal associations of trust in government regarding COVID-19 control with the adoption of recommended health behaviou...
Article
Background Although there are increasing concerns on mental health consequences of the COVID-19 pandemic, no large-scale population-based studies have examined the associations of risk perception of COVID-19 with emotion and subsequent mental health. Methods : This study analysed cross-sectional and longitudinal data from the PsyCorona Survey that...
Article
Background: Reliable, widely accessible and affordable biomarkers for predicting Alzheimer's disease (AD) brain pathology status are a necessity to aid development of prevention strategies in cognitively healthy at-risk older adults, at the right timepoint. Measurements of the key neuropathological hallmark beta-amyloid (Aβ) by PET neuroimaging or...
Article
Practice effects (PE), after repeated cognitive measurements, may mask cognitive decline and remain a major issue in clinical and research settings. However, an attenuated practice effect may indicate cognitive decline or the presence of brain pathologies. Exploring factors that influence PE can inform strategies to distinguish true signal from bia...
Article
Cognitive reserve factors reflecting innate (crystallized intelligence) and derived (educational attainment) cognitive capacity are shown to be associated with preservation of cognitive function and delayed decline. Yet little information is available on how these static measures of reserve themselves are associated with cerebral amyloid burden and...
Article
Dementia risk scores (DRS) for the prediction of Alzheimer’s disease (AD) have the potential to identify at‐risk individuals for secondary prevention trials. To date, risk scores have focused primarily on predicting dementia symptoms rather than AD histopathology. Prediction of biological disease status could inform more precise targeting of at‐ris...
Article
Increasing longevity worldwide has resulted in an unprecedented high burden of dementia. Several lines of research have implicated factors affecting B‐vitamin status among risk factors for cognitive decline and dementia. We aimed to determine the prevalence of vitamin B12 deficiency among cognitively healthy volunteers from the Cognitive Health in...
Preprint
Full-text available
The Coronavirus is highly infectious and potentially deadly. In the absence of a cure or a vaccine, the infection prevention behaviors recommended by the World Health Organization constitute the only measure that is presently available to combat the pandemic. The unprecedented impact of this pandemic calls for swift identification of factors most i...
Preprint
Full-text available
In this work, we study how social contacts and feelings of solidarity shape experiences of loneliness during the COVID-19 lockdown in early 2020. We draw on cross-national data, collected across four time points between mid-March until early May 2020. We situate our work within the public debate on these issues and discuss to what extent the public...
Preprint
Full-text available
According to health behavior theories, perceived vulnerability to a health threat and perceived effectiveness of recommended health-protective behaviors determine motivation to follow these recommendations. Because the U.S. President Trump and U.S. conservative politicians downplayed the risk and seriousness of contracting COVID-19 and the effectiv...
Article
Full-text available
The PsyCorona collaboration is a research project to examine processes involved in the COVID-19 pandemic, such as behavior that curbs virus transmission, which may implicate social norms, cooperation, and self-regulation. The study also examines psychosocial consequences of physical distancing strategies and societal lockdown, such as frustration o...
Article
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Background The clinical outcomes of patients who received distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood. Methods Information from patients und...
Article
Full-text available
Objectives To determine prevalence of vitamin B12 and folate deficiency and associations with cognitive performance in participants recruited for the Cognitive Health in Ageing Register: Investigational, Observational, and Trial Studies in Dementia Research: Prospective Readiness cOhort Study (CHARIOTPRO) SubStudy (CPRO-SS). Design Cross-sectional...
Article
Background: Morning cortisol levels have been reported to be elevated among patients with Alzheimer's disease (AD); yet no meta-analysis has been conducted to confirm the existence and magnitude of this association. It also remains unclear whether hypercortisolism is a risk factor for AD. Methods: PubMed, EMBASE, and PsycINFO were systematically...
Article
Alzheimer's disease (AD) is the most common form of dementia, impacting global cognitive performance, including episodic memory. Semantic clustering is a learning strategy involving grouping words of similar meaning and can improve episodic memory performance, e.g., list learning. As the APOE ε4 allele is the most validated genetic risk factor for...
Preprint
Full-text available
Background: The clinical outcomes of distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) patients have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood. Methods: Information from patients undergoing dist...
Preprint
Full-text available
Background: The clinical outcomes of patients who received distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood. Methods: Information from patients un...
Article
Full-text available
Mapping the Moods of COVID-19: Global Study Uses Data Visualization to Track Psychological Responses, Identify Targets for Intervention
Preprint
Full-text available
This paper examines whether compliance with COVID-19 mitigation measures is motivated by wanting to save lives or save the economy (or both), and which implications this carries to fight the pandemic. National representative samples were collected from 24 countries (N=25,435). The main predictors were (i) perceived risk to contract coronavirus, (ii...
Preprint
Previous studies suggested that public trust in government is vital for implementations of social policies that rely on public's behavioural responses. This study examined associations of trust in government regarding COVID-19 control with recommended health behaviours and prosocial behaviours. Data from an international survey with representative...
Preprint
Full-text available
Previous studies suggested that public trust in government is vital for implementations of social policies that rely on public's behavioural responses. This study examined associations of trust in government regarding COVID-19 control with recommended health behaviours and prosocial behaviours. Data from an international survey with representative...
Article
Full-text available
Background: Cancer-derived immunoglobulin G (CIgG) has been detected in various cancers and plays important roles in carcinogenesis. The present study aimed to investigate its clinical significance in pancreatic ductal adenocarcinoma (PDAC). Methods: Using tissue microarrays (TMAs) and immunohistochemistry, we assessed CIgG expression in 326 patien...
Article
Full-text available
Objectives The present study aimed to examine whether habitual snoring was independently associated with risk of type 2 diabetes among Chinese adults, and to assess the role that adiposity measures play in the snoring–diabetes association, as well as to evaluate the joint influence of snoring and adiposity measures on diabetes. Research design and...
Article
Objective: A differential diagnosis between malignant and benign parathyroid lesions is difficult due to their overlapping clinicopathological characteristics. As such, molecular markers are urgently needed. Cancer-derived immunoglobulin G (CIgG) is a novel molecule plays important roles in carcinogenesis. The present study aimed to investigate th...
Article
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Introduction: The role of TOMM40-APOE 19q13.3 region variants is well documented in Alzheimer's disease (AD) but remains contentious in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). Methods: We dissected genetic profiles within the TOMM40-APOE region in 451 individuals from four European brain banks, including DLB and P...
Article
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Objective: To examine the associations of individual insomnia symptoms with risks of incident cardio-cerebral vascular diseases (CVD) and possible moderating factors among Chinese adults. Methods: The China Kadoorie Biobank is a prospective cohort study that recruited participants from 10 areas across China. Data from 487,200 adults 30 to 79 yea...
Article
Full-text available
Elevated cortisol as a measure of hypothalamic-pituitary-adrenal-axis hyperactivity has emerged as a predictor of clinical progression of Alzheimer's disease (AD), in conjunction with amyloid-β (Aβ) abnormalities. Yet factors exist which have the propensity to delay AD symptomatic expression in the face of an AD-type biomarker-based pathological pr...
Article
Purpose: Submandibular gland (SMG) transplantation improves the tear film and other ocular-surface features for patients with severe dry eye disease (DED). Using the dry eye-related quality of life (QOL) questionnaire, we aimed to evaluate whether DED patients' QOL would benefit from SMG transplantation and determine whether preoperative ophthalmo...
Article
Full-text available
Background: Mixed results have shown the association between sleep behavior and depression, but evidence relating the joint effect of sleep duration and sleep disturbances is limited, especially in Chinese population. Methods: A total of 512,891 adults aged 30-79 years from China Kadoorie Biobank (CKB) were included. Depression was defined by Co...
Article
Full-text available
Background To develop the Chinese version of quality of life scale for dry eye patients based on the Impact of Dry Eye on Everyday Life (IDEEL) questionnaire and to assess the reliability and validity of the developed scale. Methods The original IDEEL was adapted cross-culturally to Chinese language and further developed following standard procedu...
Article
Objective: To investigate the distribution of sleep duration, daytime naps habits, and insomnia-related symptoms among participants from the China Kadoorie Biobank (CKB) study, and to examine the associations between the sleep-associated factors. Methods: A self-designed computer-based questionnaire was adopted to collect social-demographic informa...
Article
Objective: To describe the regional differences and secular trend in age at menarche, height and leg length in adult women aged 30-79 years in 10 areas included in China Kadoorie Biobank study (CKB), and evaluate the association between age at menarche and height and leg length in adult women in China. Methods: A total of 285 187 women, who had dat...
Article
OBJECTIVE: To investigate the sleep quality and related factors among medical students in China, understand the association between dormitory environment and sleep quality, and provide evidence and recommendations for sleep hygiene intervention.

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Projects

Projects (2)
Project
Therapeutic approaches for late-onset dementia (LOD), particularly its most common form, Alzheimer’s disease (AD) have primarily focused on anti-amyloid/ anti-tau strategies. Fewer studies have evaluated the contribution of co-existing pathologies of this multifactorial disease as viable biomarkers, and/ or markers of therapeutic efficacy. Additional to the classical hallmarks of the amyloid cascade hypothesis and related tau abnormalities associated with neuronal loss in AD, a growing body of research suggests that hypothalamic-pituitary-adrenal (HPA) system dysregulation, resulting in hyper-secretion of the axis’s output molecule, the glucocorticoid (GC) hormone (released as cortisol: man/corticosterone: rodents) may contribute to disease development. The HPA system may thus present a readily accessible portal to predict AD-dementia risk, gauge disease severity and extent of pathology; and explore potential as a therapeutic target. The HPA-DEM-PREV programme adopts translational methodologies via high-throughput preclinical (animal model) and clinical (human samples) experimental setting, alongside in-silico methods to fully evaluate the role of glucocorticoids and HPA axis dysregulation in AD etio-pathogensis. The projects will elucidate underlying mechanisms and investigate the therapeutic impact of HPA modulators.
Project
The Cognitive Health in Aging Register: Investigational Observational, and Trial studies in dementia research (CHARIOT): Prospective Readiness cOhort(PRO) (CHARIOT:PRO) Programme – (PI: L. Middleton; co-Investigator: C.Udeh-Momoh; NCT02114372, www.clinicaltrials.gov), featuring almost 2,000 cognitively healthy adults, aged 60-85 years at baseline, was designed & initiated in July 2015 as a single-site study at Imperial College London, to characterize factors and markers influencing cognitive and functional progression clinical AD stages, and validate neuropsychological measures and end-points of progression from the preclinical stage (Udeh-Momoh et al, 2019). The programme represents a unique resource including bio-samples (blood, urine, CSF and saliva), whole genome data (Illumina GSA), battery of traditional clinical biomarkers, detailed medical and lifestyle histories, including detailed information on dietary intake and physical activity, imaging modalities like structural and functional (resting state) MRI scans providing information on brain structure and functional connectivity within specific brain networks, amyloid status based on brain imaging and fluid AD biomarker data (equivalent numbers of amyloid positives and negatives enrolled at baseline) as well as retinal amyloid imaging, and a range of neuropsychological batteries, such as ADCS-PACC, RBANS, NAB. This baseline data has been enriched with regular repeat batteries of cognitive testing (approximately every three to six months), lifestyle questionnaires and recently approved longitudinal Tau PET and structural MRI. This follow-up is funded for 4.5-5 years, with ~250 participants at the 3-year follow-up point as at January 2021. The study has been funded exclusively by Janssen until June 2020. A consortium of funders, involving Merck, Takeda and Gates has now been formed with Janssen remaining as study sponsors. An ancillary study (CPSS-2/Seahorse study) was initiated in 2018 and features 450 older adults with known sub/below-threshold amyloid pathology at baseline. This Imperial College sponsored study runs in parallel with the CPRO study collecting the same clinical and cognitive data, with recent inclusion of a novel voice-based cognitive assessment that can be performed remotely. Both CHARIOT:PRO studies was transitioned to online format due to the Covid-19 pandemic enabling continued longitudinal data collection. With the lifting of restrictions, the studies have reverted back to face-to-face evaluations.