Bamigboye Taiwo

Bamigboye Taiwo
Obafemi Awolowo University | OAU · Department of Pharmaceutical Chemistry

Ph.D

About

21
Publications
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206
Citations
Introduction
In my laboratory, 1. we have been investigating Nigerian medicinal plants for lead compounds in anticancer drug discovery and development. 2. We have been investigating medicinal herbs used locally for the treatment of uterine fibroid with the aim of developing alternative therapeutic intervention to surgery. 3. We are exploring our medicinal herbs for compounds that can selectively bind delta opioid receptors 4. We are building a small molecule repository from our medicinal herbs.

Publications

Publications (21)
Article
Full-text available
Background: Diabetes mellitus (DM) is a serious public health challenge, projected by WHO to be one of the 7 leading cause of death by 2030. Medicinal plants have been demonstrated to be useful in DM local management because of polyphenols present in these plants. For an alternative treatment approach especially with polyphenols-rich herbs, knowled...
Article
Abelmoschus esculentus (okra) is used in the traditional treatment of cancer, hyperlipidaemia and hyperglycaemia. We, therefore, investigated its composition and potential cytotoxic or antioxidant properties that might underlie its phytotherapeutic applications. Its methanolic fruit extract yielded compounds 1, 2 and 3, identified through NMR, UV a...
Article
Full-text available
Background: The leaf of Anacardium occidentale L. has been a component of many herbal recipes in South-Western Nigeria. The work reported herein, therefore, explored the phytochemical composition of this plant and the potential anti-cancer activity of an isolated chemical constituent. Methods: Phytochemical methods (including chromatographic ana...
Article
Schistosomiasis, a chronic neglected tropical disease caused by the Schistosoma spp. parasite, is associated with disabling patient symptoms. The new focus of the WHO roadmap on 'transmission control, wherever possible’ offers drug development opportunities for intermediate-host control to prevent human-to-snail-to-human parasite transmission. Repo...
Article
Introduction: Nigerian medicinal plants have been demonstrated to be veritable source of lead compounds for drug discovery efforts. One such example is mangiferin. Mangiferin was originally isolated from the Nigerian plant Ceiba pentandra (Mombacaceae), after which its structure was elucidated with the aid of spectroscopy. Mangiferin, a xanthone g...
Article
Cancer is now the second-leading cause of mortality and morbidity, behind only heart disease, necessitating urgent development of (chemo)therapeutic interventions to stem the growing burden of cancer cases and cancer death. Plants represent a credible source of promising drug leads in this regard, with a long history of proven use in the indigenous...
Article
Full-text available
Background: Mondia whitei L. (Hook. F.) Skeels (Periplocaceae) is a medicinal plant used locally in managing pain, fever, loss of appetite and as an aphrodiasc in the South-Western states of Nigeria. However, the fruit is consumed habitually in the South-Eastern states of Nigeria, leading to speculation that it may possess some central nervous syst...
Article
Full-text available
Chromatographic fractionation of the methanolic extract of Corchorus olitorious (L.) (Tiliaceae), on silica gel yielded two polyphenolic compounds. The structures of the compounds were elucidated as Methyl-1,4,5-tri-O-caffeoyl quinate and Trans-3-(4-Hydroxy-3-methoxyphenyl) acrylic anhydride, based on extensive use of spectroscopic techniques such...
Article
Full-text available
Background: Solenostemon monostachys Briq. (Lamiaceae) is a weed widely used in ethno medicine to treat infections and inflammatory conditions but the active compounds are yet to be identified. This study isolated and identified the radical scavenging compounds from S. monostachys crude extract using diphenyl-1, 1-picryl hydrazyl (DPPH) to monitor...
Article
Full-text available
Background: Ficus exasperata Vahl-Holl (Moraceae) leaves are used for infectious and inflammatory conditions in many West African Countries. However, there is need for more phytochemical studies to justify the ethnomedicinal uses of the plant. Material and methods: The crude 50% aqueous ethanolic extract of the leaves was partitioned successivel...
Article
Full-text available
Unlabelled: The leaves of Ritchiea capparoides var. longipedicellata (Capparidaceae) is used in ethnomedicine in South-Western Nigeria to treat infectious and parasitic diseases. This study was aimed at identifying the compound(s) that are responsible for the antimicrobial and antiplasmodial activities of the leaves and also to contribute to the c...
Conference Paper
Three flavonoids: apigenin, luteolin and apigenin-7-O-B-glucuronic acid and their radical scavenging properties were reported for the first time in S. monostachys.
Article
Full-text available
The concentrations of 15 elements and heavy metals in the stem bark of Harungana madagascariensis were determined using an energy-dispersive X-ray fluorescence (EDXRF) spectrometer. The anti-anemic activity was done using the changes in hematological parameters (PCV, RBC and Hb) influenced by phenylhydrazine HCL (80 mg/kg) and malaria parasites-ind...
Article
Full-text available
The stem bark extract of H. madagascariensis, its 5 fractions and some isolated compounds obtained from the n-hexane fraction were assesed for their anti – anaemia property, anti-malarial and anti-trichomonal activities on Plasmodium and Trichomonads species respectively. The sample pellet of the extract was also analysed to detect its elemental co...
Article
Full-text available
Ten Nigerian plants suggested from their ethnomedical uses to possess antimicrobial and antioxidant activities were studied for their anti-microbial and anti-oxidant properties. Antimicrobial activity was tested against Escherichia coli NCTC 10418, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Candida albicans, Candida pseudotro...

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