Balint Kincses

Balint Kincses
University Hospital Essen | UK Essen

Doctor of Medicine, Bachelor of Physics

About

24
Publications
2,370
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173
Citations
Introduction
My current and main interest is pain processing in the human brain. How painful experience arise from brain connectivity? How are these connections altered in diseases such as migraine? I use structural and functional MR images to investigate connectivity changes related to pain perception.

Publications

Publications (24)
Article
Full-text available
Visual dysfunction is a recognized early symptom of Parkinson's disease (PD) that partly scales motor symptoms, yet its background is heterogeneous. With additional deficits in visuospatial attention, the two systems are hard to disentangle and it is not known whether impaired functional connectivity in the visual cortex is translative in nature or...
Preprint
Pain sensitivity is known to considerably vary across individuals. While the variability in pain has been linked to structural neural correlates, it is still unclear how well these findings replicate in independent data and whether they are powerful enough to provide reliable pain sensitivity predictions on the individual level. In this study, we c...
Article
Full-text available
Objective Recent studies suggested that CSF-mediated factors contribute to periventricular (PV) T2-hyperintense lesion formation in multiple sclerosis (MS) and this in turn correlates with cortical damage. We thus investigated if such PV-changes are observable microstructurally in early-MS and if they correlate with cortical damage. Methods We ass...
Article
Full-text available
Laterality patterns of resting state networks (RSN) change in various neuropsychiatric conditions. Multiple sclerosis (MS) causes neuro-cognitive symptoms involving dysfunctional large-scale brain networks. Yet, whether healthy laterality patterns of RSNs are maintained in MS and whether altered laterality patterns explain disease symptoms has not...
Article
Objective: Lateralization of visuospatial attention in healthy people, known as pseudoneglect, results in leftward bias during the Landmark or line bisection tasks. Cognitive dysfunctions in patients with multiple sclerosis (MS) might affect the visuospatial attentional abilities as well. In this study, we aimed to examine the association between...
Article
Background Cognitive decline is a prominent symptom of MS. Clear connection between cognitive status and white matter microstructural changes has not been unequivocally observed to date. Objective To characterise the relationship between white matter microstructure and cognitive performance a partial least squares (PLS) approach was used. Methods...
Article
Full-text available
Previous studies have described the structure and function of the insular cortex in terms of spatially continuous gradients. Here we assess how spatial features of insular resting state functional organization correspond to individual pain sensitivity. From a previous multicenter study, we included 107 healthy participants, who underwent resting st...
Article
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An amendment to this paper has been published and can be accessed via the original article.
Article
Full-text available
Background: Hypointense lesions on T1-weighted images have important clinical relevance in multiple sclerosis patients. Traditionally, spin-echo (SE) sequences are used to assess these lesions (termed black holes), but Fast Spoiled Gradient-Echo (FSPGR) sequences provide an excellent alternative. Objective: To determine whether the contrast differ...
Article
Full-text available
Background SYNE1 ataxia is an autosomal recessive hereditary condition, the main characteristic features of which are gait and limb ataxia and cerebellar dysarthria. Reports have revealed that the clinical phenotype of SYNE1 ataxia is more complex than the first published cases with pure cerebellar signs indicated. The aim of this study was to char...
Article
Background: Multiple sclerosis may damage cognitive performance in several domains, including attention. Although attention network deficits were described during rest, studies that investigate their function during task performance are scarce. Objective: To investigate connectivity within and between task-related networks in multiple sclerosis...
Preprint
Full-text available
Background SYNE1 ataxia is an autosomal recessive hereditary condition, the main characteristic features of which are gait and limb ataxia and cerebellar dysarthria. Previous reports revealed that the clinical phenotype of SYNE1 ataxia is more complex than the first published cases with pure cerebellar signs. The aim of this study was to characteri...
Article
Full-text available
BACKGROUND AND PURPOSE Diffusion tensor imaging (DTI) is a promising approach to detect the underlying brain pathology. These alterations can be seen in several diseases such as multiple sclerosis. Tract‐based spatial statistics (TBSS) is an easy to use and robust way for analyzing diffusion data. The effect of acquisition parameters of DTI on TBSS...
Article
Full-text available
Individual differences in pain perception are of interest in basic and clinical research as altered pain sensitivity is both a characteristic and a risk factor for many pain conditions. It is, however, unclear how individual sensitivity to pain is reflected in the pain-free resting-state brain activity and functional connectivity. Here, we identify...
Article
This study aims to investigate whether intra-network dynamic functional connectivity and causal interactions of the salience network is altered in the interictal term of migraine. 32 healthy controls, 37 migraineurs without aura and 20 migraineurs with aura were recruited. Participants underwent a T1-weighted scan and resting-state fMRI protocol in...
Article
Full-text available
Background: Migraine research is booming with the rapidly developing neuroimaging tools. Structural and functional alterations of the migrainous brain were detected with MRI. The outcome of a research study largely depends on the working hypothesis, on the chosen measurement approach and also on the subject selection. Against all evidence from the...
Preprint
Full-text available
Individual differences in pain perception are of key interest in basic and clinical research as altered pain sensitivity is both a characteristic and a risk factor for many pain conditions. It is, however, unclear how individual susceptibility to pain is reflected in the pain-free resting-state brain activity and functional connectivity. Here, we i...
Article
Full-text available
Introduction: Brain structure and function were reported to be altered in migraine. Importantly our earlier results showed that white matter diffusion abnormalities and resting state functional activity were affected differently in the two subtypes of the disease, migraine with and without aura. Resting fluctuation of the BOLD signal in the white m...
Preprint
Full-text available
In a recent study, Dadi and colleagues make recommendations on optimal parameters for functional connectome-based predictive models. While the authors acknowledge that “optimal choices of parameters will differ on datasets with very different properties”, some questions regarding the universality of the recommended “default values” remain unanswere...
Article
Full-text available
Eye movement deficits are frequently noted in multiple sclerosis during bedside clinical examination, but subtle dysfunction may remain undetected and might only be identified with advanced approaches. While classical neurology provides insight into the complex functional anatomy of oculomotor functions, little is known about the structural backgro...
Article
Full-text available
Next to the disseminated clinical symptoms, cognitive dysfunctions are common features of multiple sclerosis (MS). Over the recent years several different MRI measures became available representing the various features of the pathology, but the contribution to various clinical and cognitive functions is not yet fully understood. In this multiparame...
Article
Objective: To examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine. Methods: Interictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent dif...
Article
Full-text available
Background: Formerly white matter abnormalities in a mixed group of migraine patients with and without aura were shown. Here, we aimed to explore white matter alterations in a homogeneous group of migraineurs with aura and to delineate possible relationships between white matter changes and clinical variables. Methods: Eighteen patients with aura,...

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