Balázs Egyed

Balázs Egyed
Eötvös Loránd University · Department of Genetics

Assistant Professor

About

56
Publications
14,896
Reads
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819
Citations
Additional affiliations
October 2009 - present
Eötvös Loránd University
Position
  • Professor (Assistant)
January 2009 - present
Eötvös Loránd University Budapest, Hungary
Position
  • Eötvös Loránd University
December 2006 - present
Pázmány Péter Catholic University
Position
  • Invited lecturer
Description
  • Invited lecturer in the course of "Criminalistics, identification" dedicated for Forensic Law students

Publications

Publications (56)
Preprint
Background Aging is the most significant risk factor in many diseases and for mortality alike, and it is known to be influenced by both genetic and environmental factors. Due to dogs’ importance in human societies, the study of aging in companion dogs is worthwhile in its own right. Still, dogs could also be ideal translational model animals for hu...
Article
Full-text available
Most of the early Hungarian tribes originated from the Volga-Kama and South-Ural regions, where they were composed of a mixed population based on historical, philological, and archaeological data. We present here the uniparental genetic makeup of the medieval era of these regions that served as a melting pot for ethnic groups with different linguis...
Preprint
The domestication of dogs from their shared ancestors with wolves occurred around 25,000 years ago and affected many characteristics of the species, including its appearance and behavior. Comparative RNA sequencing experiments can help shed light on the delicate details of gene expression regulation responsible for the variance in complex traits be...
Preprint
Full-text available
Most of the early Hungarian tribes originated from the Volga-Kama and South-Ural regions, where they were composed of a mixed population based on historical, philological and archaeological data. Here we present the uniparental genetic makeup of the medieval era of these regions that served as a melting pot for ethnic groups with different linguist...
Preprint
Full-text available
In this study we report 20 ancient shotgun genomes from present-day Western Hungary (3530 – 1620 cal BCE), mainly from previously understudied Baden, Somogyvár-Vinkovci, Kisapostag, and Encrusted Pottery archaeological cultures. Besides analysing archaeological, anthropological and genetic data, ¹⁴ C and strontium isotope measurements complemented...
Conference Paper
Full-text available
The archeological transformation in the Hungarian Conquest Period of the Carpathian Basin is intensively investigated, while there is not much genetic data from this period. The impact of the arrival of the Hungarians could be measured by monitoring the genetic continuity in this region. For this purpose, we have included archeologically well-descr...
Article
Full-text available
Describing evolutionary conserved physiological or molecular patterns, which can reliably mark the age of both model organisms and humans or predict the onset of age-related pathologies has become a priority in aging research. The age-related gene-expression changes of the Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) gene have been well-documented...
Article
Full-text available
The ancient Hungarians originated from the Ural region of Russia, and migrated through the Middle-Volga region and the Eastern European steppe into the Carpathian Basin during the ninth century AD. Their Homeland was probably in the southern Trans-Ural region, where the Kushnarenkovo culture was disseminated. In the Cis-Ural region Lomovatovo and N...
Conference Paper
Full-text available
Around 895 AD new people appeared in the Carpathian Basin: the Hungarians. According to our current knowledge the first relics from archaeological cultures that are most probably connected with the early Hungarians were found in the Central and Southern Urals. The Hungarians migrated westwards from here through the Middle-Volga region and the East-...
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Preprint
Full-text available
The ancient Hungarians originated from the Ural region of Russia, and migrated through the Middle-Volga region and the Eastern European steppe into the Carpathian Basin during the 9th century AD. Their Homeland was probably in the southern Trans-Ural region, where the Kushnarenkovo culture disseminated. In the Cis-Ural region Lomovatovo and Nevolin...
Article
Full-text available
Aging is the largest risk factor in many diseases and mortality alike. As the elderly population is expected to increase at an accelerating rate in the future, these phenomena will pose a growing socio-economic burden on societies. To successfully cope with this challenge, a deeper understanding of aging is crucial. In many aspects, the companion d...
Article
Full-text available
In dogs, the social and spatial restriction associated with living in a kennel environment could lead to chronic stress and the development of abnormal behaviors ("kennel-dog syndrome"). However, little is known about how kenneled dogs differ from their conspecifics living as pets in human families. In the current study, using a test battery exposi...
Article
Full-text available
After 568 AD the Avars settled in the Carpathian Basin and founded the Avar Qaganate that was an important power in Central Europe until the 9th century. Part of the Avar society was probably of Asian origin; however, the localisation of their homeland is hampered by the scarcity of historical and archaeological data. Here, we study mitogenome and...
Article
Full-text available
After 568 AD the Avars settled in the Carpathian Basin and founded the Avar Qaganate that was an important power in Central Europe until the 9th century. Part of the Avar society was probably of Asian origin; however, the localisation of their homeland is hampered by the scarcity of historical and archaeological data. Here, we study mitogenome and...
Article
The emergence of Massively Parallel Sequencing technologies enabled the analysis of full mitochondrial (mt)DNA sequences from forensically relevant samples that have, so far, only been typed in the control region or its hypervariable segments. In this study, we evaluated the performance of a commercially available multiplex-PCR-based assay, the Pre...
Preprint
Full-text available
After 568 AD the Avars settled in the Carpathian Basin and founded the Avar Qaganate that was an important power in Central Europe until the 9 th century. Part of the Avar society was probably of Asian origin, however the localisation of their homeland is hampered by the scarcity of historical and archaeological data. Here, we study mitogenome and...
Conference Paper
Full-text available
Although linguists, historians, archaeologists have been researching it for a long time, the exact origin, route and chronology of the early Hungarians’ migration is still unclear. According to our current knowledge the first relics from archaeological cultures that are most probably connected with Hungarians’ ancestors were found in the Central an...
Article
Full-text available
SUMMARY: Background: Recently, wildlife poaching as a part of wildlife crime caused a serious decline for several species. Integration of novel methods or specific applications into forensic sciences increases the range of available actions against these global activities. objectives: The goal of our paper is to present some recent challenges and l...
Conference Paper
Many scientific theories exist about the origin of Hungarians and their migration from Northern Central Asia to Europe in the 8th–¬9th centuries AD. Ethnic heterogeneity of the Hungarian Conquerors is attested by a number of historical and archaeological evidence due to their associated migration with other populations from the Ural region through...
Poster
Full-text available
Red deer poaching Red deer is of the most important and valuable game mammals in Hungary. About 35-40000 animals are legally taken per year, but the population is affected by illegal activities. In our case a trunked corpse of a Red deer was discovered in the forest. From the belongings (knife, paper handkerchiefs, trouser, shirt) of the suspected...
Article
Full-text available
Rare mitochondrial lineages with relict distributions can sometimes be disproportionately informative about deep events in human prehistory. We have studied one such lineage, haplogroup R0a, which uniquely is most frequent in Arabia and the Horn of Africa, but is distributed much more widely, from Europe to India. We conclude that: (1) the lineage...
Conference Paper
Full-text available
Dog hairs are often found at crime scenes as evidence material, and in many cases investigation of animal traces can solve a crime. Shed hairs recovered as evidence are usually telogen phase and contain minimal amount or no nuclear DNA, and therefore in such cases mtDNA can be examined because of its high copy number in hairs. There are several pop...
Article
Full-text available
In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570,...
Article
Red deer is the most valuable game of the fauna in Hungary, and there is a strong need for genetic identification of individuals. For this purpose, 10 tetranucleotide STR markers were developed and amplified in two 5-plex systems. The study presented here includes the flanking region sequence analysis and the allele nomenclature of the 10 loci as w...
Article
Identification of vaginal fluids is an important step in the process of sexual assaults confirmation. Advances in both microbiology and molecular biology defined technical approaches allowing the discrimination of body fluids. These protocols are based on the identification of specific bacterial communities by microfloraDNA (mfDNA) amplification. A...
Data
According to the opinion of a plaintiff (Mrs. B) and a co-plaintiff (Mrs. A), two samples had been exchanged during cytogenetic investigation of foetal chorionic villi (CV), because the child of Mrs. A was born with Down syndrome in spite of the negative CV result (46, XY). The CV investigation of Mrs. B had given a positive result (47, XY, + 21),...
Article
Allele frequencies for 10 short tandem repeats (STRs) were determined using the StockMarks® Dog Genotyping Kit (Applied Biosystems) from a pool of 668 unrelated dogs, consisting of 79 different breeds or breed variants from the Hungarian canine population. For the comparative statistical analysis, four pure bred, one mixed group - all individuals e...
Article
The primary application of STR markers is going to be a tool of high fidelity in forensic genetics, for instance identifying the cognate animal from traces. The microsatellite marker set also helps in the protection of red deer stocks from poaching in Hungary. Moreover, increasing interests of red deer farms have appeared to develop DNA based diagn...
Article
As dogs are widespread and popular pets they have overriding importance from criminal point of view. The relevancy exists not only in cases of dog attacks or in traffic accidents, but also the scattered, shaded hairs can often provide indirect evidence in crime scene—person relation as well.
Article
One hundred and seventy three entire mtDNA control region sequences were generated and analyzed in a population sample from Ashkenazi Jews living in Hungary. The control region was amplified in one piece and sequenced with different sequencing primers. Sequence evaluation was performed twice and validated by a third senior scientist. Phylogenetic a...
Article
Transylvania's ethnic mosaic is composed of Romanians, German Saxons and Hungarians. The ethnic groups of the Hungarian minority that settled in Romania show differences in dialects, customs and religious affiliations. In this study entire mtDNA control region sequences from 360 individuals of Hungarian ethnicity from two populations (the Csángó an...
Article
Full-text available
To facilitate forensic mtDNA testing in Hungary, we have generated control region databases for two Hungarian populations: 211 individuals were sampled from the urban Budapest population and 208 individuals were sampled from a Romani ("gypsy") population in Baranya county. Sequences were generated using a highly redundant approach to minimize poten...
Article
To assess the mitochondrial DNA polymorphisms of the Hungarian population in the Carpathian basin and to facilitate forensic mtDNA testing a collection of control region sequences were generated from two population samples from Hungary and from two Hungarian speaking populations from Transylvania (Romania). Entire control region sequencing was perf...
Article
Our study provides population genetic data on two population samples collected in a Hungarian speaking region of Transylvania, Romania. Allele frequency and profile databases were generated on 17 autosomal STR loci (D2S1338, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, D21S11, VWA, FGA, TH01, TPOX, CSF1PO, Penta E and Penta...
Article
Previous studies have shown that population analyses in Hungary can be of great importance from the viewpoint of the examination of population differentiation. This study provides additional population genetic data of the Hungarian population on the thirteen CODIS core STR loci and on two penta STRs (PentaE, PentaD). Allele frequency and profile da...
Article
Hungarian population. Allele frequency and profile database for the STR loci D2S1338, D19S433 and SE33 (ACTBP2) were obtained from a population sample of 224 unrealed individuals living in the Budapest area of Central Hungary. One sample showed a three-allele pattern at the SE33 locus.
Conference Paper
According to the opinion of a plaintiff (Mrs. B) and a co-plaintiff (Mrs. A), two samples had been exchanged during cytogenetic investigation of foetal chorionic villi (CV), because the child of Mrs. A was born with Down syndrome in spite of the negative CV result (46, XY). The CV investigation of Mrs. B had given a positive result (47, XY, +21), s...
Article
Hungary has an old long cynophilic and cynologic tradition, and a significantly high canine population. However, during the last years, several (even lethal) attacks to man were observed. In some cases, the human remains on the dog's body or stomach content can prove the animal as perpetrator. Lacking this evidence, the availability of certain cani...
Article
Full-text available
In a case of the death of a 7-year-old boy, the police investigations revealed a possible dog attack contrary to the witness testimonies. DNA investigations were carried out from hairs, saliva and bloodstains with 10 canine-specific STR loci by the use of fluorescently labelled multiplex PCR and the ABI PRISM 310 genetic analyzer. The analysis of o...
Article
Full-text available
Several animal carcasses were found in the paddocks of a Hungarian County Zoo during 1 week. The 14 animals killed were thought to be the victims of a dogfight training. The primary suspect was the security guard of the Zoo with his guard dogs. DNA tests were carried out on hairs and bloodstains and 10 canine-specific STR loci were analysed by fluo...
Article
Full-text available
A case of disputed paternity in dogs is reported. DNA examinations were carried out from hair samples of the individuals several months after the death of the putative sire. Ten short tandem repeat (STR) loci were analysed by fluorescence-labelled multiplex PCR using ABI PRISM 310 Genetic Analyser. Based on the results the candidate sire was includ...
Article
STRs have become almost the exclusive tool of genetic scientists in forensic typing work. Consequently, large numbers of samples are genotyped and the detection of rare abnormalities is to be expected. We found rare losses of alleles, also known as drop-out, at the two STR loci D13S317 and CD4. Drop-out at D13S317 was accidentally found in typing o...
Article
A multiplex reaction for the eight STR loci D3S1358, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820 was used to generate allele frequency databases for two Hungarian population samples, Caucasians from the Budapest area and Romanies from Baranya county. During the analysis two intermediate-sized alleles and a sequence variant allele were obs...

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Projects

Projects (4)
Project
We are studying changes of retrotransposon activity and gene expressions in several tissues in dogs.
Archived project
Application of approach and methodology of human forensic DNA analysis in animal related cases. (Wildlife and domestic animal forensic genetics.)
Project
generate population genetic data