Balamurugan K

• M. Pharmacy PhD
• Annamalai University

Introduction: The present study evaluated the individual and combined effect of diosgenin and silymarin against epilepsy in maximal electroshock (MES)-, pentylenetetrazole (PTZ)-, and strychnine (SRY)-induced seizures models in rats. Materials and Methods: Wistar rats were selected and grouped into five (n = 6). Groups I and II were kept as contr...

Bauhinia tomentosa is a traditional medicine used to treat Diuresis, Impotence, Diabetes, Dysentery, Inflammation and Hyperlipidemia. The present study was carried out to investigate the possible neuropharmacological activities of aqueous extract of Bauhinia tomentosa L. leaves in mice. The effects of the extract on Central Nervous System were eval...

The present study was aimed to investigate the combined effect of bioactive compounds, Diosgenin and Silymarin in an animal model of depression. Wistar albino rats of either sex were randomly divided into five groups and treated for 7 days. Groups I and II were served as a control and a standard and groups III, IV and V were treated with Diosgenin...

Oral administration of the non-steroidal anti-inflammatory drug, Diclofenac Diethylamine (DDEA) is often associated with gastrointestinal ulcers, bleeding and extensive first-pass hepatic metabolism. As an alternative to oral administration, formulated microsponges-based gel of DDEA was developed for topical administration, to quantify diclofenac d...

This paper portrays a recently developed, optimized and validated isocratic RP-HPLC strategy for the separation of two anti-diabetic drugs Vildagliptin (VLD) and Metformin (MET).The optimization of the HPLC methodology included several variables, of which the impacts of each was studied. After a sequence of preliminary-screening experiments, the co...

CONTEXT: The acquisition of antibiotic without a prescription by the general population is a typical practice found in community pharmacies across India, which is a notable contributor of antimicrobial resistance. According to the present regulation in India, sale of certain antimicrobials included in schedule H1 without prescription is unlawful. I...

Abstract The present study was aimed to investigate the combined effect of bioactive compounds, Diosgenin and Silymarin in an animal model of depression. Wistar albino rats of either sex were randomly divided into five groups and treated for 7 days. Groups I and II were served as a control and a standard and groups III, IV and V were treated with D...

Introduction: Antimicrobials play a significant role in majority of treatments in clinical settings and are most widely prescribed. The objective of our present study is to describe antimicrobial prescribing patterns in pediatric medicine at a tertiary hospital located in a city of Andhra Pradesh and identify measures to improvement of antimicrobia...

Objective: Evidence is emerging that specific combinations of bioactive compounds may be far more effective in protecting against several diseases as compared to the effect of a single compound. The present study was aimed to investigate the interactive effect of Diosgenin and Silymarin, the bioactive compounds from plant origin in an animal model...

The new investigation in this present work is to develop microsponges constructed novel drug delivery system for sustained action of Flurbiprofen. Quai-emulsion solvent diffusion method was engaged using Ethyl cellulose and Eudragit RS100 with drug: polymer ratio for development of microsponges. For optimization purposes, several factors are consid...

The scientific evaluation of medicinal plants used in the preparation of folk remedies has provided modern medicine with effective pharmaceuticals for the treatment of diseases. The ethanolic extract of Sida rhombifolia Linn (Malvaceae) whole plants were investigated for its hepatoprotective effect on paracetamol (2g/kg/b.wt/p.o suspended in 0.5% C...

Villorita cyprinoides is a black water clam that belongs to a group of the genus Villorita; species cyprinoides (Fam:Corbiculidae) were found in the backwaters of Kerala, mainly in Vembanad backwaters. Clams are considered to be nutritious and delicious and are fished in considerable quantities in some coastal places, known to scavenge and deactiva...

Losartan, an antihypertensive agent which selected for the preparation of transdermal delivery system as it complies with physicochemical properties required to permeate through skin. The preformulation studies involving description, solubility, melting point, partition coefficient of the drug were found to be comparable with the standard. The patc...

The effect of ethanolic extract of the whole plants of leptadenia reticulata has been studied in albino rats to explore it's the anti-implantation and hormonal activities. A strong anti-implantation (inhibition 100%) and uterotropic activity was observed at the dose level of 300 mg /kg. No antiestrogenic activity could be detected.

In the present studies hepatoprotective activity of omega-3-fatty acids against paracetamol induced hepatic damage in albino rats was observed. Hepatic injury was induced by administering 2g/Kg body wt. p.o. of paracetamol, omega-3-fatty acid at dose levels of 100 mg/Kg/day and 300 mg/Kg/day were administered for albino rats altered and proved to b...

In the present study, the protective effect of fish oil against Isoproterenol (IPH)-induced myocardial infarction was studied in male albinoWistar rats. Fish oil was administered orally at 5% v/w for 30 days and IPH (8.5 mg/Kg,s.c) were injected with twice at an interval for 24hrs to induce myocardial infarction at the end of the day, then serum bi...

Objective to evaluate Oecophylla smaragdina (OS) for antitumor activity against Dalton's Lymphoma Ascites (DLA) cells in Swiss mice. Materials and Methods Oecophylla smaragdina (OS)was successively extracted with ethanol for three times and the treatment was started after 24 hours of the tumor inoculation continued once daily for 14 days and the an...

Background: Cardiovascular diseases (CVD) are the leading cause of death throughout world population each and every year. Focus on dyslipidemia management is urgently required in India to halt the rising tide of CVD. The purpose of diabetic dyslipidemia study is a record based one, to find out the effect of Rosuvastatin plus Fenofibrate, in adult T...

This is a collective data for Linagliptin from previously published methods either in alone or in combination with Metformin or Empagliflozine . Many spectroscopic methods like derivative techniques, chromogenic techniques were used for newly developed as well as improved chromatographic methods were reported for biological fluids and pharmaceutica...

To evaluate the effect of Cetylmyristeolate (CMO) in Freund's complete adjuvant induced arthritis in rats. The experimental study was evaluated on male and female Wister rats weighing (150-200gms). 0.5 ml of Freund's complete adjuvant (FCA) in the left tibiotarsal joint (IA) was injected to induce arthritis, CMO-500mg; 1g and CMO100mg + MSM200mg +...

Simple, rapid and reproducible methods were established for quantitative determination of Sitagliptin (SIT) and Metformin (MET) spiked with plasma using an Onyx C18 Monolithic column connected with an Onyx C18 guard cartridge and PDA detection at 210 nm. The mobile phase was MeOH, ACN, 0.01mM KH2PO4 (pH 3.5±0.5), adjusted with freshly prepared 10%...

This review work is a collective data of previously published methods related to the analysis of Sitagliptin either in alone or in combination with other drugs. Many spectroscopic methods like derivative techniques, chromogenic techniques were used for. Newly developed as well as improved chromatographic method also available by using biological fl...

Among the variety of nanoparticles being at present examined by pharmaceutical researchers, lipid nanoparticles have led the pack in view of clear preferences of higher level of biocompatibility and flexibility. Lipid nanoparticles, including solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), lipid-drug conjugates (LDC) and polym...

Bioactive compounds are a type of secondary plant metabolites eliciting pharmacological and toxicological effects in living organism. They are the chemical compounds found in plants and certain foods playing a potential role in human disease and treatment. They have been used in traditional medicine as plant extracts to prevent various maladies inc...

Cinnoline (1, 2 benzodiazine or pyridine) is a novel aromatic bioactive heterocyclic compound which have wide range of pharmacological profiles like antimicrobial activity like antibacterial, antifungal, anti-inflammatory, antihelminthic activity, anti molluscicidal activity, antimalarial, anti-tuberculosis, anti tumor activity etc. Cinnoline has a...

The goal of delivery system is to get optimal therapeutic management. But, it stillremains a challenge in the field of pharmaceuticals for delivery of ionic species and some nonionic. Several transdermal approaches have been used and recently there has been a great attentionin using iontophoretic technique for the transdermal drug delivery of medic...

Achyranthes aspera is an important medicinal plant found throughout India. The antifertility activity of the ethanolic extract of Achyranthes aspera is now being investigated. The activity such as antizygotic activity, blastocystotoxic activity and abortifacient activity were investigated. The data suggests that the Achyranthes aspera extract exert...

Breastfeeding is the optimal form of infant feeding for the first months of an infant’s life, and the majority of healthy women initiate breastfeeding after the birth of their infant. Although the majority of medications are considered to be compatible with breastfeeding, cases of significant infant toxicity exist, suggesting a case by case risk as...

The effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Nail permeability is however quite low and limits topical therapy to early/mild disease states such as onychomycosis (fungal infections of the nail). Current research on nail permeation that focuses on altering the nail plate barrier by means of c...

The present study was designed to investigate whether Sida rhombifolia Linn (Malvaceae), a natural herb, would attenuate the acute myocardial infarction in isoproterenol (ISP)-treated rat model via maintaining cardiac function and activities of endogenous antioxidant enzymes. Heart tissue enzyme analysis in albino (Wistar) male rats, such as LPO, G...

Colorectal cancer (CRC) is the fourth most common type of cancer and the second cause of death by cancer in the Western world. Epidemiologic studies suggest that increased consumption of fruits, vegetables and high total dietary fiber which contains flavonoids reduces the risk of development of colon cancer. Hence the effect of Apigenin a flavone w...

Villorita cyprinoides is a black water clam that belongs to a group of the genus Villorita; species cyprinoides (Fam:Corbiculidae) were found in the backwaters of Kerala, mainly in Vembanad backwaters. Clams are considered to be nutritious and delicious and are fished in considerable quantities in some coastal places, known to scavenge and deactiva...

In this paper we report the effects of crude venom of Conus musicus on the isolated frog heart preparation and hematological parameters of rats. In the episode of administration of the Conus musicus toxin as 10, 20 μg dose attenuated the contractions of the frog heart in a dose dependent manner indicating the depressant action. When toxin co-admini...

In the present studies hepatoprotective activity of Omega-3-fatty acids against paracetamol induced hepatic damage in albino rats was evaluated. Hepatic injury was induced by administering 2g/Kg body wt. p.o of paracetamol. Omega-3-fatty acid at dose levels of 100 and 300 mg/Kg/day were administered for albino rats which reduced serum liver enzymes...

A drug utilization pattern of antibiotics for complicated urinary tract infections in 100 cases above 18years of age was done at Sri Ramachandra Medical College and Research Institute. The antibiotic sensitivity profile of the microorganism causing urinary tract infections was studied in age group between 18-60 yrs of either sex as in patients ward...

The current study was focused to find out the relation of pulmonary function (PFT)in female with Rheumatoid arthritis (RA).The study was carried on 100 females with RA in the age group 20-60 years, who fulfill the Revised American Rheumatism Association Criteria (1988). Patients with respiratory illness, smoking habits, treated with methotrexate we...