Baishakhi Dey

• M.Pharm (Tech), Phd Post doc
• PostDoc Position at Indian Institute of Technology Kharagpur

The study reports the fortification of vitamin A and D2 (fortificants) in soymilk (fortifying vehicle) by sustained emulsification, after previously encapsulating the two fortificants in emulsified form. The process parameters for fortification of the encapsulated fortificants into the fortifying vehicle were initially predicted by D-optimal mixtur...

Food fortification is an effective intervention strategy for combating micronutrient deficiencies. Vitamin A can be fortified in a wide range of food vehicles. In this research work, vitamin A in the form of palmitate (VAP) have been microencapsulated by emulsion technology intended for fortification purposes. D-optimal mixture design approach was...

This research work presents the physicochemical and nutritional evaluation of soymilk and soymilk based products like tofu and its by-product okhara and soy yoghurt and a comparative study of their effect on blood gluco-lipid profile in both animal models and Type 2 diabetic patient volunteers. Their nutritional effect were also assessed amongst ch...

Background Coronavirus disease 2019 (COVID-19), named by WHO, is a public health disaster of the third millennium. This acute respiratory distress syndrome (ARDS) has severe complications like pneumonitis, respiratory failure, shock, multi-organ failure, and finally, death. Despite repurposing of broad-spectrum antivirals, vaccinations, use of mask...

The study reports the microencapsulation of ergocalciferol (vitamin D2) by emulsification technique, the experimental process parameters being chemometrically optimized by D-optimal mixture design approach followed by physico-chemical characterization of the resultant emulsion. Basing on desirability ramp function graph and lab experimentation resu...

Nutraceutical products and dietary supplements are playing a vital adjunctive role in treating several ailments. Value addition and product diversification is an important strategy in food and beverage industries. Many tea diversification products are available in global nutraceutical market. This study reports the formulation of a value-added blac...

Background Milk, the fluid secreted by the female of all mammalian species, fulfills the complete nutritional and energy requirements. Being enriched in physiologically important proteins and peptides, enzymes, enzyme inhibitors, immunoglobulins, growth factors, hormones, and antibacterial agents, milk is a single balanced diet. Milk can be convert...

Environmental issues, limited landfill space, and exhaustion of resources call for the adoption of greener and cleaner technologies, so as to attain zero waste economy. Nanotechnology is considered “green” in the sense that it develops products and follows processes that are eco-friendly, uses natural resources that are not depleted or renewable, e...

Background Background: Food fortification is an effective intervention strategy to combat micronutrient malnutrition, hidden hunger, and improvement of public health and nutritional status. Choice of a cost-effective, widely consumed, compatible, and stable candidate vehicle is essential for a successful fortification. Objective Objective: This co...

The massive surge in global population is expected to surpass 9 billion by 2050. Though hi-tech agri practices and modern food processing techniques are producing enough food for the entire population, still incidences of malnutrition, poverty, hunger question the food supply and security. There is enormous food wastage every year in the food suppl...

Spilanthol (affinin), a plant bioactive, is an F3M1 N-alkylamide (2E,6Z,8E)-N-isobutyl-2,6,8-decatrienamide, first isolated from Heliopsis longipes. However, spilanthol or its homologs have been found in plant family of Asteraceae, especially Spilanthes species. Spilanthol has been labeled as principle bioactive of Spilanthes acmella; the plant spe...

Background This research article aims to study at molecular level by in silico GRIP docking the effectivity of the detected compounds in value added black tea or VABT, prepared in a chemometrically optimized ratio of Black tea:Cinnamon (Cinnamomum zeylanicum):Ginger (Zingiber officinale):Cardamom (Elettaria cardamomum) in combating diabesity. Resu...

Tea is a popular refreshing beverage and its popularity is also due to its multidimensional health benefits. The health effects of tea are due to its polyphenolic contents, viz. catechins, and methyl xanthenes like caffeine etc. The variance in concentration of these secondary metabolites both in fresh tea leaves and processed black tea owing to se...

Plant bioactives have a great role in combating multifactorial disease conditions like metabolic syndrome (MetS). This research work aims to develop a standardized plant extract combination and formulate it to tablets with nutraceutical potentials. The extract was prepared from the bark powder of Ficus religiosa, seed powder of Syzigium cumini and...

Climatic changes have great impact on the crops and agro-eco systems and such changes influences the concentration of secondary metabolites. IIT Kharagpur, India is a non-traditional tea growing zone where Tocklai Vegetative 25 variety was used as the research material. This study reports the development of a chemometrics assisted HPLC method valid...

Background: The application of in silico tools in the development of anti cancer drugs. Objective: The summing of different computer aided drug design approaches that have been applied in the development of anti cancer drugs. Method: Structure based, ligand based, hybrid protein-ligand pharmacophore methods, Homology modeling, molecular dockin...

The aim of drug delivery is primarily focused on the optimum bioavailability at the targeted site of action over a defined period of time. Nanoparticle plays significant role in the drug delivery as it can be designed as target based, with improved stability, increased drug stability as well as can offer constant rate in the drug delivery. Nanopart...

This article reports the formulation and quality evaluations of tulsi tea tablets prepared for better applicability. Tulsi-tea extracts (TTE) were prepared by mixing black tea: tulsi in the w/w ratios of 70:30 and tablets were formulated by a combination of wet granulation and direct compression. Micromeritic properties of the powder blend of TTE a...

This article aims at reviewing the effectiveness of compounds in black tea in combating neuroinflammation in Alzheimer’s disease (AD). Detailed chemo profiling of black tea showed the presence of theaflavins, different catechins, and amino acids viz., L-theanine and methylxanthines. A literature search showed a multitude of pharmacological activiti...

Tea is a very popular commercial crop and India is the world's largest consumer of tea in the world and the second largest producer of tea. Black tea is mostly preferred in Indian context and its multifaceted health benefits are being largely explored. This research article made a comparative study of antioxidant, hypoglycemic and hypolipidemic eff...

Background: This work reports the safety profiling, in vivo hypoglycemic and pharmacokinetic studies of three phytoceuticals viz. conventional and sustained release tablets and microspheres each containing a polyherbal product phytocomposite (PHC) as the active ingredient. PHC is prepared from the leaf extracts of Ficus benghalensis: Syzigium cumi...

This study reports the development of solid oral phytoceutical formulations with Phytocomposite (PHC), an antidiabetic poly herbal preparation as the active core material. Spherical, monolithic PHC microspheres of size range (10 -100 µm) were obtained with Hausner ratio, Carr’s index and angle of repose of 1.141± 0.010, 12.418±0.769 and 25.17±0.96...

Background: The world has witnessed growing complexities in disease scenario influenced by the drastic changes in host-pathogen- environment triadic relation. Pharmaceutical R&Ds are in constant search of novel therapeutic entities to hasten transition of drug molecules from lab bench to patient bedside. Extensive animal studies and human pharmaco...

This study reports the identification and characterization of pharmacologically active compounds present in a polyherbal product phytocomposite (PHC) prepared from the leaf powders of Ficus benghalensis (Banyan), Syzigium cumini (Jamun) and Ocimum sanctum (Tulsi) and explore the binding affinities of the compounds in PHC in inhibiting α-amylase and...

Background: Streblusol E, a phenolic phytoconstituents of Streblus asper is a potential antihepatitis B viral agent. Objective: Current study is to mechanistically analyze the probable site of action for streblusol E. Material and methods: Streblusol E has been docked with EF3-CaM adenylyl cyclase(1PK0), deoxycytidine kinase(2NOA), human nucleoside...

Background: Tulsi, Banyan, and Jamun are popular Indian medicinal plants with notable hypoglycemic potentials. Now the work reports chemo-profiling of the three species with in-vitro screening approach for natural enzyme inhibitors (NEIs) against enzymes pathogenic for type 2 diabetes. Further along with the chemometrics optimized extraction proce...

Aim of the study is to chemometrically optimize the extraction procedure of tea polyphenolics, evaluate antioxidant potentials of fresh tea leaves and made tea grown in the non-traditional tea zone of IIT Kharagpur by in vitro assays, in silico docking studies and in vitro AChE inhibitory assays. Total tea polyphenolics, flavonoids and volatile co...

Despite tremendous strides in modern medicine stringent control over insulin resistance or restoration of normoglycemia has not yet been achieved. With the growth of molecular biology, omics technologies, docking studies, and in silico pharmacology, modulators of enzymes and receptors affecting the molecular pathogenesis of the disease are being co...

Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bio-availability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies usi...

3-Dimensional printing (3DP) constitutes a raft of technologies, based on different physical mechanisms, that generate a 3-dimensional physical object from a digital model. Because of its rapid fabrication and precise geometry, 3DP has gained a prominent focus in biomedical and nanobiomaterials research. Despite advancements in targeted, controlled...

The current research focuses on the estimation of bulk density and angle of repose of tea leaves at different moisture content and size and development of a mathematical model for bulk density and angle of repose using response surface methodology followed by numerical optimization of responses using desirability functions. Further work was done on...

3D printing (3DP), constitutes a raft of technologies, based on different physical mechanisms which desires to generate a 3D physical object from a digital model. Due to its rapid fabrication and precise geometry, 3DP has gained a prominent focus in biomedical and nano-biomaterials research. Despite advancements in targeted, controlled and pulsatil...

Design of experiment (DOE) approach reinforces the robustness of the method being developed. This was employed for UV-visible (200-400 nm and 400-800 nm respectively) and RP-HPLC method development using C 18 inertsil column and optimization of variables for ambrisentan (ABN) estimation in bulk and formulations. A two-level full factorial design as...

Impurity profiling has also become an important phase of pharmaceutical research, where both spectroscopic and chromatographic methods find applications. The analytical methodology needs to be very sensitive, specific and precise which will separate and determine the impurity of interest at 0.1% level. Current research reports a validated RP-HPLC m...

To investigate the presence and potency of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays. The leaf extracts of the three different Eucalyptus species [E. globulus (EG), E. citriodora (EC), E. camaldulensis (ECA)] were subjected to in vitro assay procedures to explore the prevalence of natural enzy...

Analytical method development is a vital part of pre-formulation and formulation development research. Development of validated, robust, cost-effective methodologies for routine drug estimations is the urgent need of the pharmaceutical R&Ds. Quality is an essential attribute in any pharmaceutical product and impurity profiling offers a broad scope...

The current research aims to formulate Venlafaxine Sustained Release (VHL-SR) tablets using hydrophilic-hydrophobic polymers combination blends by melt granulation technique which highlights the novelty. The polymers selected for the present study have matrix forming properties. Results of FTIR studies have shown that there were no interactions bet...

The current research paper reports a validated UV and RP-HPLC method for routine estimations of CFTX in bulk and unit dosage formulations. For the UV estimation of CFTX, using ammonium acetate buffer as the solvent, λmax was set at 241.5 nm and linearity range obtained in the concentration range of 2-10 µg/mL. The optimized RP-HPLC conditions for C...

Eucalyptus is well represented in different Pharmacopeias for its variant pharmacology and depicts a wide range of photochemicals like triterpenoids, flavonoids, polyphenols, gallotannins and macrocarpals both in its volatile and nonvolatile fractions. Hot aqueous leaf decoctions of Eucalyptus have been recommended as ‘herbal tea’ in different regi...

Present study aims at comparative evaluation of drug release and permeability of diclofenac sodium loaded ethylcellulose (EC), cellulose acetate (CA) and eudragit (EU) microspheres. Microspheres of EC, CA and EU containing diclofenac sodium were prepared by an emulsification-solvent evaporation (oil-in-oil, o/o) method and were investigated for a c...

Diabetes is becoming one of the major killers of mankind after cancer and AIDS. Despite tremendous strides in modern medicine and availability of insulin therapy, restorations to normoglycemia without adverse consequences have not yet been achieved. Diabetes is found to be multi-factorial from the pathogenic point of view. Apart from conventional t...

Prescription auditing, a sort of vigilance activity is an important tool in pharmaco-epidemiological studies to get a clear picture about rational usage of drug, widely prescribed drugs, extent of polypharmacy, and the most prevalent diseases in a particular area. With the changing dynamics of the lifestyle, behavioral pattern, socioeconomic and ed...

Constant escalations in the number of diabetics world-wide and the failure of conventional therapy to restore normoglycemia without adverse effects, in spite of tremendous strides in modern medicine, calls for naturopathy and alternative medicine. Because diabetes is multi-factorial and has secondary complications, prevention of hyperglycemia is th...

Analytical method development being a vital part of pre formulation-formulation research and development obviates the need to develop reliable, effective, eco friendly and cost effective methodologies for routine analysis of active pharmaceutical ingredients. UV spectroscopy is one of the earliest, yet of wide applications in drug analysis in diffe...

Oxidative damage to neurons has a significant role in the pathogenesis of AD; hence antioxidant therapy to prevent oxidative injury can be effective in preventing or retarding the progress of AD. Extracts from Ginko biloba named as Egb761 have been found to show cognitive improvement in AD patients and in those with multi-infarct dementia. Similarl...

Constant escalations in the number of diabetics’ worldwide, associated complications and financial implications, failure of conventional the rapy regimen to restore normoglycemia has brought to limelight the non-pharmacologic mean s like lifestyle and dietary interventions as one of the effective aids to combat type 2 diabetes. Economy, education,p...

Hospital is the medical institution where sick or injured people are given medical or surgical care irrespective of their socio-economic status. Health care givers and administrators are considered as health care professionals. The form of hospital services, their organization, development, operation and administration have undergone significant...

Health care management has really become a burning question of the day and the current health scenario of our rural India is a story of utter deprivation. On one side there are hi-tech medical facilities and use of state-of-art-medical technologies with five star deluxe facilities in a few urban centers’ but in the rural counterpart the stories of...

To investigate the effect of lifestyle interventions in the non-pharmacological management of type 2 diabetes via a mechanistic approach. A randomized controlled trial was carried out on 60 type 2 diabetic male and female volunteers that fulfilled the inclusion criteria, with their proper consent and permission of the International Electrotechnical...

The main aim in the drug therapy of any disease is to attain the desired therapeutic concentration of the drug in plasma or at the site of action and maintain it for the entire duration of treatment. A drug on being used in conventional dosage forms leads to unavoidable fluctuations in the drug concentration leading to under medication or overmedic...

The latest breakthroughs in computer-aided drug design, drug delivery systems, and enabling technologies. Computer Aided Drug Design (CADD) and Delivery Systems offers an in-depth discussion of the computer-assisted techniques used to discover, design, and optimize new, effective, and safe drugs. Recent technological developments in biochemistry, b...