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Introduction
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Publications
Publications (44)
Metabolic reprogramming within the tumor microenvironment (TME) plays a critical role in driving drug resistance in gastrointestinal cancers (GI), particularly through the pathways of fatty acid oxidation and glycolysis. Cancer cells often rewire their metabolism to sustain growth and reshape the TME, creating conditions such as nutrient depletion,...
Though people usually imagine the typical person as a man rather than a woman, the effect is mixed for racial groups and understudied among traditionally male social groups (e.g., police and criminals) and non-U.S. populations. Results from a survey (N > 5000) collected via a globally distributed laboratory network in over 40 regions demonstrated t...
The intricate relationship between chronic lung diseases and viral infections is a significant concern in respiratory medicine. We explore how pre-existing lung conditions, including chronic obstructive pulmonary disease, asthma, and interstitial lung diseases, influence susceptibility, severity, and outcomes of viral infections. We also examine ho...
Chronic obstructive pulmonary disease (COPD) patients often experience reduced physical activity, sleep disturbances, and cognitive impairment. However, reports on measurement of rest-activity rhythm and sleep-wake behavior and their impact on cognitive functions in COPD patients are limited. This study aimed to objectively measure circadian rhythm...
In recent years, remarkable strides have been made in the management of gastrointestinal disorders, transforming the landscape of patient care and outcomes. This article explores the latest breakthroughs in the field, encompassing innovative diagnostic techniques, personalized treatment approaches, and novel therapeutic interventions. Additionally,...
The emergence of COVID-19 caused by SARS-CoV-2 has transformed our understanding of the disease, transcending its initial characterization as a respiratory ailment. Acknowledged now as a multisystem dysfunctional disorder, COVID-19 exhibits a diverse range of symptoms, notably affecting the Gastrointestinal (GI) system. This article delves into the...
Gestational diabetes mellitus (GDM) is a risk to maternal-fetal health due to uncertain diagnostic criteria and treatment options. Luo's study demonstrated the efficacy of customized nutritional therapies in controlling GDM. Tailored strategies led to significant body weight loss, improved glucolipid metabolism, and fewer prenatal and newborn probl...
Lung cancer, characterized by its heterogeneity, presents a significant challenge in therapeutic management, primarily due to the development of resistance to conventional drugs. This resistance is often compounded by the tumor’s ability to reprogram its metabolic pathways, a survival strategy that enables cancer cells to thrive in adverse conditio...
Lung cancer, characterized by its heterogeneity, presents a significant challenge in ther-apeutic management, primarily due to the development of resistance to conventional drugs. This resistance is often compounded by the tumour’s ability to reprogram its metabolic pathways, a survival strategy that enables cancer cells to thrive in adverse condit...
RNA viruses continue to pose significant threats to global public health, necessitating a profound understanding of their pathogenic mechanisms and the development of effective therapeutic interventions. This manuscript provides a comprehensive overview of emerging perspectives on RNA virus-mediated infections, spanning from the intricate intricaci...
Sickle cell disease (SCD) is a complex genetic disorder associated with multiple clinical manifestations, including increased susceptibility to bacterial and viral infections. This review article presents a comprehensive analysis of the current literature obtained from various online databases focusing on the relationship between SCD and infections...
Mental simulation theories of language comprehension propose that people automatically create mental representations of objects mentioned in sentences. Mental representation is often measured with the sentence-picture verification task, wherein participants first read a sentence that implies the object property (i.e., shape and orientation). Partic...
Chronotype is individuals’ endogenous circadian phase which is obvious through preference for scheduling timings of sleep–wake, physical or mental activities at behavior level, as well as differences in circadian phase in biological variables (e.g., body temperature or serum melatonin concentration). Three different chronotypes prevail in human pop...
Background
Sickle cell disease (SCD) is a type of hemoglobinopathy characterized by abnormal hemoglobin molecules, which includes numerous acute and chronic complications. Ischemic stroke, silent cerebral infarction, headache, and neurocognitive impairment are the most common neurological complications associated with SCD.
Summary
Acute anemia bec...
In December 2019, a new strain of coronavirus was discovered in China, and the World Health Organization declared it a pandemic in March 2020. The majority of people with coronavirus disease 19 (COVID-19) exhibit no or only mild symptoms such as fever, cough, anosmia, and headache. Meanwhile, approximately 15% develop a severe lung infection over t...
Purpose
The current study is the first attempt to screen obstructive sleep apnea (OSA) risk in adult populations of Chhattisgarh, India. A few predictors of OSA, such as socio-demographic variables, excessive daytime sleepiness (EDS), behavioral sleep variables, and chronotype were also investigated.
Methods
Five hundred eleven (167 males and 344...
Humans adjust to the diurnally varying light-dark cycle in nature through circadian rhythm, a phenomenon of about 24 h oscillations in biological processes. The circadian rhythm operates at a genetic level that overt in circadian rhythm at biochemical, physiological and behavioral levels. The circadian rhythm is the output of coordinated functions...
Eyewitness identifications play a key role in the justice system, but eyewitnesses can make errors, often with profound consequences. We used findings from basic science and innovative technologies to develop and test whether a novel interactive lineup procedure, wherein witnesses can rotate and dynamically view the lineup faces from different angl...
Physical activity (PA) and nutrition are the essential components of a healthy lifestyle, as they can influence energy balance, promote functional ability of various systems and improve immunity. Infections and their associated symptoms are the common and frequent challenges to human health that are causing severe economic and social consequences a...
Animal Welfare Attitudes (AWA) can be defined as the attitudes of humans
towards the welfare of animals. Although AWA has been previously associated with demographic
factors as gender, one of the main limitations is that few studies applied robust psychometric
questionnaire scales. Moreover, some evidence of cross-cultural variations in AWA have bee...
The commonly observed nocturnal attack of asthma is accompanied by circadian variations in airway inflammation and other physiological variables. It is also documented to present with a significantly higher risk of adverse cardiovascular events that are associated with lower heart rate variability (HRV) and depressed sympathetic and enhanced parasy...
Introduction
Lockdown and stay home order has been imposed on people in many countries including India to prevent the community transmission of COVID-19 pandemic. However this social restriction led to disturbed daily routine and lifestyle behaviour that is needed to be attended for proper therapeutic management of overall health during such crisis...
Concerns about animal welfare are becoming increasingly important. Recent research suggests that age and gender are associated with attitudes toward animal welfare in adolescents. In this study, we analyzed attitudes toward animal welfare in adolescents from five geographic regions: Colombia, France, Germany, and two regions in India (Raipur and Ka...
Background
Chronotype is the circadian time preference for sleep–wake timings. However, its impact on cognitive performance is least explored.
Objective
The present study investigated the effect of chronotype (morning “M” vs. evening “E”) on cognitive measures as a function of time of the day. In addition, the correlation between electroencephalog...
Over the past 10 years, Oosterhof and Todorov’s valence–dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgements of faces. Because this model has primarily been developed and tested in Western regions, it is unclear w...
Background: India, being the third worst affected country from COVID-19 pandemic at the time of study, faced complete lockdown to minimize community transmission that confined people to social isolation for extended durations.
Design and Methods: Therefore, we conducted an online questionnaire-based survey for the Indian population after 37 days o...
Background: Lockdowns to prevent the community transmission of COVID-19 pandemic has confined the people at home and imposed social restrictions, which is expected to cause alterations in circadian driven sleep-wake schedule and its associated lifestyle behaviors.
Design and Methods: An online questionnaire-based survey was conducted to assess the...
Eyewitness identifications play a key role in the justice system, but eyewitnesses make errors, often with profound consequences. Errors are more likely when the witness is of a different race to the suspect, due to a phenomenon called the Own Race Bias (ORB). ORB is characterized as an encoding-based deficit, but has been predominantly tested usin...
Over the last ten years, Oosterhof and Todorov’s valence-dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgments of faces. Because this model has primarily been developed and tested in Western regions, it is unclear w...
Our knowledge on the circadian phenomenon in Jatropha curcas is limited. Therefore, we studied the activity of nitrate reductase (NR) in leaves of J. curcas under light and dark cycles (LD 12:12), continuous light (LL) and constant darkness (DD). We observed a statistically significant circadian rhythm in NR activity in LD. Unlike in DD, the circad...
Concerns about the veracity of psychological research have been growing. Many findings in psychological science are based on studies with insufficient statistical power and nonrepresentative samples, or may otherwise be limited to specific, ungeneralizable settings or populations. Crowdsourced research, a type of large-scale collaboration in which...
We studied patterns in the distribution of chronotype and sleep–wake behavior in a randomly chosen sample population of Indian teenagers consisting 965 school-going children. All of them voluntarily responded on two structured inventories, namely truncated version of the morningness–eveningness questionnaire (MEQ) to assess chronotype and the Munic...
Concerns have been growing about the veracity of psychological findings. Many findings in psychological science are based on studies with insufficient statistical power and non-representative samples, or may otherwise be limited to specific, ungeneralizable settings or populations. Large-scale collaboration, in which one or more research projects a...
We aimed to examine the effects of socio-demographic factors on performance of adolescents on intelligence (intelligence quotient, IQ) task and short interval time estimation. 207 healthy randomly selected adolescent including males and females voluntarily participated in this study. Performance on IQ task was tested using Pass Along Test. Adolesce...
The present study aimed to investigate probability of a possible endogenous circadian rhythm in human cognitive attribute to estimate short intervals. Apparently healthy young males and females were selected for our study. Eight subjects prospectively produced the short-time intervals 10 s and 60 s at 2 hourly intervals in 30 h constant routine (CR...
The primary objective of the present research work is to study and compare the circadian variability in body temperature recorded from different locations of the body during subjects’ normal routines. Temperatures of oral cavity (sublingually), tympanum, forehead, axilla and the elbow pit were measured simultaneously at approximate 1-h intervals fo...
The present study was designed to examine the variability in intelligence quotient (IQ) and short interval time estimates (SITE) in school-going adolescents as function of time of the day and socio-demographic characteristics (age, gender, educational level and type of family). Two hundred seven (N=207) apparently healthy randomly selected adolesce...
Ability to perceive fast-paced events (a range of short intervals) is one of the important cognitive skills in humans. The underlying mechanism of this ability still remains elusive. We designed a study to investigate the subjective perception of short-intervals (10, 20, 60 and 120 s) in a cohort of healthy young male and female university students...
The present study is planned to study the pattern/variation in subjective estimation of an array of short-intervals using two popular methods, time reproduction (TR) and time production (TP) prospectively. In the first study, the subjects estimated the short-intervals 5 s, 10 s, 15 s, 30 s, 60 s, and 120 s with time reproduction (TR). In the second...
Several physiological disorders and impairment of cognition have been ascribed to the effects of noise. In the present study, we assessed the consequence of noise on interval timing – one of the crucial cognitive components in humans. The study was carried out during the five-day State carnival from afternoon to late evening (14:30–21:30). The soun...
Cognitive science is emerging as one of the engaging areas of research in the domain of neurosciences, human behavior and chronobiology. Mechanisms of short-term time perception continue to baffle scientists in these disciplines. The wide arrays of methodologies used to ascertain human abilities to estimate short-time intervals give rise to diverse...
Questions
Questions (3)
Is it possible that the value of circadian amplitude higher than circadian MESOR? or depends upon the variable such as physiological (blood pressure) or biochemical (ex. melatonin)?
Is there a standard statistical test for comparison of skewness of two distributions ?
Is there any report on effect of blood pressure (SBP and DBP) on short-time perception/short-interval time estimation, a cognitive attribute in human?