Babette Simon

Babette Simon
Paris Descartes, CPSC | Paris 5 · Paris centre

About

71
Publications
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2,401
Citations
Citations since 2016
2 Research Items
228 Citations
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040

Publications

Publications (71)
Book
Full-text available
Wenn die Erde krank ist, kann der Mensch nicht gesund sein. Das Konzept Planetary Health befasst sich mit den Zusammenhängen zwischen der Gesundheit des Menschen und der Gesundheit unseres Planeten. Bereits jetzt hat die zunehmende Zerstörung der Ökosysteme durch die raumgreifende Lebensweise des Menschen negativen Einfluss auf unsere Gesundheit, z...
Chapter
Das endokrine gastroenteropankreatoische System ist das größte endokrine System des Körpers. Die hier gebildeten Hormone sind für die Freisetzung von Verdauungssäften, die Darmmotilität und die Trophik verantwortlich. In gleicher Weise ist aber auch das enterische Nervensystem in diese Aufgaben involviert. Der einzige bekannte klinisch relevante Ma...
Chapter
Für die Nomenklatur der endokrinen Tumoren des Gastrointestinaltrakts werden die in der Übersicht zusammengefassten Begriffe synonym verwendet. Der Terminus »Karzinoid« ist streng genommen den endokrinen Tumoren des Magen-Darm-Trakts (Vorder-, Mittel- und Hinterdarm) und den sich aus dem Vorderdarm abgeleiteten Organsystemen wie dem Bronchialsystem...
Article
The fatality of pancreatic cancer (PC) is mostly caused by an advanced stage of diagnosis for the majority of patients. Nearly 5% of all PC patients exhibit a familial background of the disease. Inherited forms of PC occur in three distinct clinical settings: first, hereditary tumor syndromes revealing primarily a clinical phenotype other than PC w...
Article
CpG islands methylation is the main epigenetic modification found in human tumors leading to transcriptional silencing of certain tumor suppressor genes. Reacquisition of p16/CDKN2A tumor suppressor gene expression by 5-aza-2'-deoxycytidine results in concurrent growth inhibition of neuroendocrine pancreatic tumor cells. However, the growth suppres...
Chapter
Neuroendokrine GEP-Tumoren sind eine heterogene Gruppe seltener Neoplasien, die in 2 Gruppen unterteilt werden: endokrine Pankreastumoren und endokrine Tumoren des Magen-Darmt-Takts (Karzinoide). Gemeinsam ist ihnen die Synthese und Sekretion einer Vielzahl biogener Amine und Peptidhormone. Nach dem klinischen Bild wird zwischen funktionell aktiven...
Chapter
Primäre Dünndarmtumoren sind eine heterogene Gruppe seltener benigner und maligner Neoplasien. Sie werden in epitheliale und nichtepitheliale Tumoren, maligne Lymphome und hamartomatöse oder hyperplastische Polypen unterteilt und müssen von Sekundärtumoren (Metastasen) abgegrenzt werden. Prädisponierende Faktoren sind genetische Syndrome, Alteratio...
Article
Many studies have shown carbohydrate-deficient transferrin (CDT) to be a sensitive and specific marker of chronic alcohol abuse. We present the case of a 23-year-old, healthy professional soccer player who caused a car accident due to alcohol consumption. Several CDT test results were elevated above the laboratory reference range and were considere...
Article
Many studies have shown carbohydrate-deficient transferrin (CDT) to be a sensitive and specific marker of chronic alcohol abuse. We present the case of a 23-year-old, healthy professional soccer player who caused a car accident due to alcohol consumption. Several CDT test results were elevated above the laboratory reference range and were considere...
Article
The INK4a/ARF locus on chromosome 9p21 is one of the important defenses against tumor development and engages both the Rb and the p53 tumor suppressor pathways through its capacity to encode two distinct proteins, p16(INK4a) and p14(ARF). Despite controversial reports, the body of present data suggests that tumor suppressors p16(INK4a) and p14(ARF)...
Chapter
Für die Nomenklatur der endokrinen Tumoren des Gastrointestinaltrakts werden die in der Übersicht zusammengefassten Begriffe synonym verwendet. Der Terminus „Karzinoid“ ist streng genommen den endokrinen Tumoren des Magen-Darm-Trakts (Vorder-, Mittel- und Hinterdarm) und den sich aus dem Vorderdarm abgeleiteten Organsystemen wie dem Bronchialsystem...
Article
This study evaluates the possibility of treating Bon1 and QGP pancreatic neuroendocrine tumor cells with radioactive iodide ((131)I) after stable transfection with the thyroid sodium iodide symporter (NIS). NIS expression was driven either by the strong viral cytomegalovirus promoter or by the tissue-specific chromogranin A promoter. Using either a...
Article
Full-text available
Molecular mechanisms contributing to the tumorigenesis of pancreatic endocrine tumors (PETs) are still not well understood. Allelic deletions at chromosome 22q12.3 were detected in about 30-60% of PETs, suggesting that inactivation of one or more tumor suppressor genes on this chromosomal arm is important for their pathogenesis. Because the putativ...
Article
Human MAGE and GAGE genes encode tumor-specific antigens presented by HLA I molecules recognized on tumor cells by cytolytic T lymphocytes. To determine if pancreatic cancer patients would be suitable for MAGE- or GAGE-based immunotherapy, the expression frequency of MAGE-A1, -A2, -A3, -A4, -A6 and GAGE1-8 genes was assessed in 15 pancreatic tumor...
Article
Full-text available
Functional inactivation of the Rb and p53 pathways appears to be a rite of passage for all cancerous cells. However, p53 and Rb alterations are rare events in neuroendocrine gastroenteropancreatic (GEP) tumors. The CDKN2 locus on chromosome 9p21 sits at the nexus of both pathways harboring tumor suppressor genes, which restrain cell growth by affec...
Article
Germline mutations of the MEN1 gene have been identified as the causative genetic defect of multiple endocrine neoplasia type I (MEN-I), an autosomal dominantly inherited condition. To establish the basis for predictive family screening we evaluated the spectrum of MEN1 gene mutations in MEN-I patients treated at our institution. Relatives at risk...
Article
Primary prevention is the most effective approach to reduce the incidence of pancreatic cancer. Epidemiological studies have contributed to the identification of risk factors for pancreatic cancer, suggesting an association with age, various medical conditions, environmental and lifestyle risk factors, and occupational and genetic conditions. Age i...
Article
Tumors arising from the pancreatic islet cells are rare and represent a heterogeneous group of benign or malignant lesions. Most tumors present with well characterized syndromes, whereas others appear to be nonfunctioning. The clinical features of 11 men and 7 women with nonfunctioning islet cell carcinomas operated on between 1983 and 1998 were re...
Article
Background: Somatostatin and its long-acting analogues are effective in symptom control in patients with functionally active neuroendocrine GEP tumours. Several in vitro and in vivo reports suggest that they are also able to control tumour growth. Methods: Critical review of published data on the effect of long-acting somatostatin analogues on symp...
Article
Infectious agents may directly or indirectly (through the response of the host's immune system) modulate the growth of vascular cells. Local and/or systemic increase of cytokines could influence the extent of (re-)stenosis in the vascular tree. Further studies in this field may identify patients at a high risk for atherogenesis and restenosis. Thei...
Article
A 49-year-old man had a histologically confirmed pancreatic carcinoma with several huge necrotic metastases in the liver. Many cases of increased radionuclide uptake in liver metastases have been reported, but in this case the radionuclide uptake was missing.
Article
The molecular mechanisms contributing to the tumorigenesis of insulinomas are poorly understood. Disruption of the cell cycle due to inactivation of the p16(INK4a) tumor-suppressor gene was identified in a variety of human tumors, including gastrinomas and nonfunctioning endocrine pancreatic carcinomas. In this study the role of p16(INK4a) in the t...
Article
Somatostatin and its long-acting analogues are effective in symptom control in patients with functionally active neuroendocrine GEP tumours. Several in vitro and in vivo reports suggest that they are also able to control tumour growth. Critical review of published data on the effect of long-acting somatostatin analogues on symptom and growth contro...
Chapter
Die beiden zuerst entdeckten gastrointestinalen Hormone sind Sekretin, welches 1902 von Bayliss u. Starling (Bayliss u. Starling 1902) sowie Gastrin, welches 1905 von Edkins (Edkins 1905) beschrieben wurde. Die Strukturaufklärung beider Hormone als Voraussetzung für die Identifizierung ihres zellulären Ursprungs und für den radioimmunologischen Nac...
Article
Mutations of the adenomatous polyposis coli (APC) tumor suppressor gene have been described in a subset of pancreatic carcinomas. The APC gene modulates the beta-catenin-Tcf pathway. The major player in this pathway is the beta-catenin protein encoded by the beta-catenin gene. A variety of different tumors, including colon, prostate, endometrial, a...
Article
The tumor suppressor gene DPC4/Smad4 at 18q21.1 is inactive in about 50% of pancreatic carcinoma xenografts and cell lines. However, the role of DPC4 in the multistep carcinogenesis of primary pancreatic adenocarcinomas remains uncertain. Therefore, we examined 45 primary human pancreatic adenocarcinomas and 12 pancreatic cancer cell lines for DPC4...
Article
Full-text available
Tumors of the endocrine pancreas are extremely rare, and molecular mechanisms leading to their development are not well understood. A candidate tumor suppressor gene, DPC4, located at 18q21, has recently been shown to be inactivated in half of pancreatic adenocarcinoma xenografts. The close anatomical relationship of the exocrine and endocrine panc...
Article
In recent years a large number of coronary artery disease risk factors were discovered. The knowledge of these factors improves the estimate of the coronary artery disease (CAD) risk--however it still remains to be only an "estimate". A perfect prediction of an upcoming CAD event is not possible, despite all high score laboratory technology. Theref...
Article
Mutations in the MEN 1 gene were recently discovered as the causative genetic defect of the autosomal dominantly inherited multiple endocrine neoplasia type 1. It was the aim of this study to evaluate the spectrum of MEN 1 mutations in our own series of patients in order to obtain a basis for predictive family screening. Genomic DNA from peripheral...
Article
Full-text available
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited tumor syndrome characterized by the development of multiple endocrine tumors. The gene responsible for the disease, termed MEN1 gene. has recently been isolated and germline mutations have been described in affected MEN1 individuals. Twelve unrelated (German MEN1 families...
Article
Full-text available
The FHIT gene is localized on chromosome 3p14, a region including a tumor cell-specific, commonly deleted region. To determine the role of the FHIT gene in pancreatic carcinogenesis, 14 pancreatic carcinoma cell lines were analyzed by reverse transcription-PCR and exon-specific PCR amplification of genomic DNA. The full-length FHIT transcript was l...
Article
ZBP-89 is a Krüppel-type zinc finger transcription factor that binds to GC-rich sequences. Overexpression of this factor prevents EGF induction of the gastrin promoter; therefore, we postulated that ZBP-89 may modulate cellular proliferation. To test this hypothesis, ZBP-89 was overexpressed in immortalized (GH4) and malignant (AGS) cell lines. Gro...
Article
Deletion and mutational analyses of the gastrin promoter have identified a binding site for the yeast transcription factor RAP1 relevant for transcriptional activation in islet cells. We here report that the mammalian transcription factors binding to this site in islet cells are the Sp transcription factor members Sp1 and Sp3. Furthermore, function...
Article
Transient expression of pancreatic gastrin corresponds to a period of rapid islet cell development. After birth gastrin expression silencing is coincidental with islet cell terminal differentiation, while persistent expression is accompanied with nesidioblastosis and reexpression observed in islet cell tumors. Experiments with transgenic animals su...
Article
The mechanisms causing progression of fundic gastritis and changes in argyrophil cell morphology in patients undergoing long-term treatment with proton pump inhibitors are unknown. The hypothesis of this study was that Helicobacter pylori is a risk factor for both gastritis and argyrophil cell hyperplasia. Forty-two patients with peptic disorders r...
Article
Tumor cell-induced platelet aggregation (TCIPA) is considered to be a critical step in hematogenous metastasis. TCIPA was studied in vitro in six human pancreatic carcinoma cell lines (PC 3, PC 44, AsPC1, BxPC3, Capan2, Panc1). Whereas all cell lines induced aggregation of washed platelets in the presence of minimal amounts of platelet-poor plasma,...
Article
Gastrin stimulates histidine decarboxylase (HDC) activity and proliferation of enterochromaffin-like (ECL) cells. Furthermore, it has been suggested that gastrin controls HDC gene expression. We therefore analysed the effect of gastrin receptor blockade by PD 136 450 (CAM 1189) on HDC gene expression. The influence of PD 136 450 on gastrin, somatos...
Article
The alpha 6-containing integrin was suggested to be involved in the process of tumor invasion and metastasis. Therefore, the aim of the study was to investigate the expression and function of this adhesion receptor in pancreatic carcinoma. Integrin expression was investigated in pancreatic tissue and tumor cell lines using immunohistochemistry. Rad...
Article
Background/Aims: The α6-containing integrin was suggested to be involved in the process of tumor invasion and metastasis. Therefore, the aim of the study was to investigate the expression and function of this adhesion receptor in pancreatic carcinoma. Methods: Integrin expression was investigated in pancreatic tissue and tumor cell lines using immu...
Article
We performed cytogenetic and fluorescence in situ hybridization (FISH) studies on 29 sporadic or familial tumors associated with von Hippel-Lindau [correction of Landau] disease. Four of five renal cell carcinomas with detectable alterations showed clones with chromosome 3 alterations. These changes led to loss of genetic material visible with cyto...
Article
Gastrin transcription in islet cells is activated by a cis-regulatory sequence containing a binding site for the yeast transcription factor RAP1. The DNA-protein interactions between RAP1 protein and the gastrin DNA element determined by methylation interference assays are identical to those of RAP1 and yeast genes. Point mutations in the gastrin R...
Article
The pathogenesis of pancreatic cancer is poorly understood. The multigenetic nature of carcinogenesis has been best documented in colon cancer. The relevance of this model was suggested for other epithelial tumors. Only advanced stages of pancreatic cancer are usually detected because of late diagnosis. Analysis of accumulated, diverse genetic chan...
Article
Background/aims: The pathogenesis of pancreatic cancer is poorly understood. The multigenetic nature of carcinogenesis has been best documented in colon cancer. The relevance of this model was suggested for other epithelial tumors. Only advanced stages of pancreatic cancer are usually detected because of late diagnosis. Analysis of accumulated, di...
Article
The gastric proton pump H+/K(+)-ATPase in the parietal cell is central to acid secretion into the stomach. We performed the following experiment to examine the pattern of expression of the alpha- and beta-subunits of the H+/K(+)-ATPase at the transcriptional level during 7 days' application of the proton pump inhibitor omeprazole, in relation to th...
Article
Gastrin is transiently expressed in fetal islets during a critical period of their development from protodifferentiated islet precursors in fetal pancreatic ducts. To examine the possible role of gastrin as an islet cell growth factor, postnatal islet growth was studied in transgenic mice which overexpress gastrin and TGF alpha in their pancreas. O...
Article
Here, we give a few examples of weights belonging to the classes Q and Q̃. As an application of the first part, we also give a unified method for the proof of continuous imbeddings for weighted Sobolev spaces. The method we use allows us to estimate the imbedding constants and to get directly, and in a simple way, all the standard equivalent norms.
Article
In this note, we extend the notion of relative rearrangement introduced by J. Mossimo and R. Temam [1] (see also [2–4]) to any measure space. This type of a result finds application in the problems set in weighted spaces (on unbounded domains) or on manifolds [5,6]. As in [7] and [8], we begin by studying the regularity of the monotone rearrangemen...
Article
Brain natriuretic peptide (BNP) is synthesized and released predominantly in the ventricular myocardium whereas atrial natriuretic peptide (ANP) is produced mainly in the atria. This study evaluated whether artificial pacemaker stimulation or left heart catheterization results in specific changes in BNP and ANP plasma levels. Both BNP and ANP respo...
Article
At present at least seven different endocrine cell types have been identified in the stomach. According to their relative frequency and secretion products the antral gastrin producing G cell and somatostatin producing D cell and the fundic histamine producing ECL cell are the best characterized cell types. Total endocrine cell mass is controlled by...
Article
Full-text available
The cell surface antigen, epithelial glycoprotein, defined by the monoclonal antibody HEA 125, is expressed on virtually all epithelial cell membranes but not on mesodermal or neural cell membranes. The cDNA encoding epithelial glycoprotein was isolated by HEA 125 antibody enrichment of colon tumor cDNA expressed transiently in COS cells. The seque...
Article
Many human tumors, particularly those of epithelial origin, appear to express greatly reduced levels of major histocompatibility complex class I antigens on their surface. It has been previously reported that the class I gene H-2Ld, introduced into adenovirus type 12-transformed mouse cells, induces reversal of oncogenesis in immunocompetent BALB/c...
Article
Esterase-16, an esterase present in lung and other tissues of the laboratory rat, has been characterized by its biochemical properties (electrophoretic mobility, substrate pattern, sensitivity to inhibitors) and genetic variation in 107 inbred strains and substrains including 14 RI strains. It was classified as a carboxylesterase (EC 3.1.1.1). The...
Article
The banding pattern of rat liver carboxylesterases (EC 3.1.1.1) was demonstrated following polyacrylamide gel electrophoresis and isoelectric focusing using standardized conditions. Phenotypic variations, occurring in commonly used inbred rat strains, were compared. Separate isozymes were identified using genetic nomenclature. Individual bands were...
Article
The effect of thiamphenicol was studied in 6 groups of adult rabbits, 4 with normal and 2 with stimulated erythropoiesis, and compared with 2 control groups. Thiamphenicol was administered intravenously in daily doses of 30 mg/kg for 10 and 60 days and of 60 mg/kg for 10 and 30 days in the rabbits with normal erythropoiesis. The groups with stimula...
Article
Ferrokinetic studies using radioiron (59Fe) in 19 patients during therapy with thiamphenicol are reported. In 14 patients with administration of radioiron on the 4th day of therapy, only a small decrease in iron utilization and erythrocyte iron turnover could be demonstrated while in the remaining 5 patients with radioiron administration on the las...
Article
For 6 to 18 days, 20 patients were treated with an average dosage of 19.5 g thiamphenicol (TAP). During and up to 3 wk after therapy, erythro, leuco and thrombocytes, hemoglobin, reticulocytes, serum iron and iron binding capacity were regularly examined. In most of the cases there was a significant decrease in the erythropoietic parameters reachin...
Article
20 patients were treated with an average dose of 19.5 g of the chloramphenicol-analogue Thiamphenicol (TAP). Before, during and after therapy, peripheral blood counts, serum iron and total iron binding capacity were controlled continuously. In some of the patients of the group, additional ferrokinetic, cytogenetic and electron microscopic studies o...
Article
To obtain differentiability results for weighted monotone rearrangement, we have introduced in [ibid., 17-31 (1997; reviewed above)], the general classes of weights Q and Q ˜. Here, we give a few examples of weights belonging to these classes. In particular, we show that weights behaving like distance functions belong to Q and Q ˜. As an applicatio...

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