Babatunji Emmanuel Oyinloye

Afe Babalola University · Department of Biochemistry

This study investigated the effects of flavonoid-rich extract from Hibiscus sabdariffa L. (Malvaceae) leaves on liver damage in streptozotocin-induced diabetic rats by evaluating various biochemical parameters, including the molecular gene expressions of Nrf-2 and HO-1 as well as histological parameters. The extract was found to significantly reduc...

Citation: Ejeje, J.N.; Agbebi, E.A.; Mathenjwa-Goqo, M.S.; Oje, O.A.; Agboinghale, P.E.; Ebe, I.T.; Obafemi, T.O.; Adewole, E.; Omaka, O.N.; Onikanni, S.A.; et al. Computational Investigation of the Therapeutic Potential of Detarium senegalense in the Management of Erectile Dysfunction. Abstract: Erectile dysfunction (ED) is a multifactorial social...

Parkia biglobosa (PB) is among the various underexploited nutritious plants. A comparative study was conducted on the effect processing PB has on the amino and fatty acid composition. Fermented (FPB), defatted (DPB), and protein isolates (PI) samples were prepared from Parkia biglobosa seeds using various processing methods, and evaluated using sta...

Cardiac damage resulting from diabetes poses a significant health risk, underscoring the need to investigate potential therapeutic interventions. This study investigates the potential cardioprotective effects of flavonoid-rich extracts from Hibiscus sabdariffa leaves in streptozotocin-induced diabetic rats. The study involved diabetic rats administ...

Background Studies suggest that medicinal plant extracts can help reduce the neuron degeneration associated with diabetes. In this study, the neuroprotective effect of the alkaloid-rich extract from the leaves of Lannea egregia was assessed in rats with diabetes induced by streptozotocin (STZ). Methods Lannea egregia alkaloid-rich analysis was car...

Poly (ADP-ribose) polymerase 1 is a versatile enzyme that is deeply involved in diverse cellular processes. It exerts influence on pivotal activities such as DNA repair, transcriptional regulation, and cell death. PARP1 is crucial due to its susceptibility to posttranslational modifications, each of which has distinct roles in shaping its functiona...

The neuroprotective ability of alkaloid-rich leaf extract of Dalbergiella welwitschii in streptozotocin-induced type 2 diabetic rats were investigated in this study. Dalbergiella welwitshii leaf alkaloid-rich extract was obtained using standard procedure. Streptozotocin was injected into the experimental animals intraperitoneally at a dose of 45 mg...

Prostate cancer (PCa) is a complex and biologically diverse disease with no curative treatment options at present. This study aims to utilize computational methods to explore potential anti-PCa compounds based on differentially expressed genes (DEGs), with the goal of identifying novel therapeutic indications or repurposing existing drugs. The meth...

Currently, there is no known cure for diabetes. Different pharmaceutical therapies have been approved for the management of type 2 diabetes mellitus (T2DM), some are in clinical trials and they have beenclassified according to their route or mechanism of action. Insulin types, sulfonylureas, biguanides, alpha-glucosidase inhibitors, thiazolidinedio...

Diabetes is a group of medical conditions characterized by the body’s inability to effectively control blood glucose levels, due to either insufficient insulin synthesis in type 1 diabetes or inadequate insulin sensitivity in type 2 diabetes. According to this research, the PI3K/AKT pathway of Ocimum gratissimum leaf flavonoid-rich extracts in stre...

The burden of human schistosomiasis, a known but neglected tropical disease in Sub-Saharan Africa, has been worrisome in recent years. It is becoming increasingly difficult to tackle schistosomiasis with praziquantel, a drug known to be effective against all Schistosoma species, due to reports of reduced efficacy and resistance. Therefore, this stu...

O. gratissimum is one of the most common medicinal plants in every community in Nigeria. This plant has been presumed to be useful in the management of diseases including breast cancer, which is one the commonest cancers affecting women globally. Hence, this study aimed to computationally investigate the phytochemicals present in O. gratissimum by...

Alzheimer’s disease (AD) accounts for a major statistic among the class of neurodegenerative diseases. A number of mechanisms have been identified in its pathogenesis and progression which include the amyloid beta (Aβ) aggregation, hyperphosphorylation of tau protein, oxidative stress, endoplasmic reticulum (ER) stress and apoptosis. These processe...

The use of medicinal plants as food and medicine has been a common practice in the world, especially in tropical African countries. One such plant in West Africa is Uvaria chamae, also known as Bush banana, renowned for its diverse ethnomedicinal applications and, more recently, for its pharmacological activities attributed to a rich array of phyto...

Background This mini review aims to provide an overview of the role of telemedicine in preventing multi-drug resistant tuberculosis (MDR-TB) in Nigeria. The specific objectives include examining the potential benefits of telemedicine, identifying the challenges associated with its implementation, and highlighting the importance of addressing infras...

Background: Methyl cellosolve (METC) is a widely used industrial solvent due to its amphipathic nature. It is found in household materials such as liquid soaps, dyes, inks, brake fluids, herbicides, etc. This makes exposure in humans incessant and indiscriminate. The PI3K-Akt-mTOR and the intrinsic apoptotic pathways are very important cellular act...

Hepatocellular carcinoma is a prevalent form of liver cancer that is life threatening. Many chemically synthesized anti-cancer drugs have various degrees of side effects. Hence, this study investigated the effect of FEAC interventions on NDEA-CCl 4-induced HCAR in male Wistar rats. HCAR was induced by intraperitoneal administration of 200 mg/kg of...

Cervical cancer remains a major public health problem accounting for continuous female death in developing countries. Cervical cancer is the second most common cancer in women globally with an estimated number of 500,000 new cases of cervical cancer and 273,000 mortalities annually. Cervical screening is the best cancer screening test in the histor...

Spondias mombin ( S. mombin ), a prominent botanical resource, has garnered recognition within folkloric therapy. Parkinson's disease (PD), characterized by dopaminergic neuron attrition in the substantia nigra, manifests as motor anomalies like tremors, rigidity, and bradykinesia. This study capitalizes on S. mombin 's reservoir of 100 characteriz...

Skin aging and wrinkle formation are processes that are largely influenced by the overexpression of enzymes like tyrosinase, elastase, and collagenase. This study aimed to validate the skin anti-aging properties of phytochemicals from Peperomia pellucida (PP) as well as its attendant mechanism of action. Compounds previously characterized from PP w...

Citation: Oyinloye, B.E.; Agbebi, E.A.; Agboola, O.E.; Ubah, C.S.; Owolabi, O.V.; Aruleba, R.T.; Onikanni, S.A.; Ejeje, J.N.; Ajiboye, B.O.; Omotuyi, O.I. Skin Anti-Aging Abstract: Skin aging and wrinkle formation are processes that are largely influenced by the overex-pression of enzymes like tyrosinase, elastase, and collagenase. This study aimed...

This experiment was conducted to evaluate the Dalbergiella welwitschia alkaloid-rich extracts on liver damage in streptozotocin-induced diabetic rats. Hence, to induce diabetes, 45 mg/kg body weight of streptozotocin was intraperitoneally injected into the Wistar rats. Subsequently, 5 % (w/v) of glucose water was given to the induced animals for 24...

Breast cancer remains the most frequently diagnosed cancer worldwide. Several drugs have been identified and found to be active against the pathogenesis of breast cancer, however, the uniqueness each tumor cell exhibit remains a major issue. The difference in the phenotypes of tumor cells and the high metastatic activity they exhibit have heightene...

Citation: Onikanni, S.A.; Lawal, B.; Munyembaraga, V.; Bakare, O.S.; Taher, M.; Khotib, J.; Susanti, D.; Oyinloye, B.E.; Noriega, L.; Famuti, A.; et al. Profiling the Antidiabetic Potential of Compounds Identified from Fractionated Extracts of Entada africana toward Glucokinase Stimulation: Computational Insight. Molecules 2023, 28, 5752. https://...

Syringic acid (SACI) is an emerging nutraceutical and antioxidant used in modern Chinese medicine. It has potential neuroprotective, anti-hyperglycemic, and anti-angiogenic properties. Methyl cellosolve (MCEL) has been reported to induce tissue inflammation in the testis, kidney, liver, and lung. This study aimed to investigate the effect and proba...

Combination therapy has birthed improved treatment possibilities for a number of complex and degenerative diseases in the world, which include cancer, diabetes and cardiovascular disease, and has been encouraged for use in the treatment of Alzheimer’s disease (AD), as a result of its complex pathological pathways. The combination of memantine and d...

Glucokinase has play an important role in regulating blood glucose level and serves as one essential therapeutic target in type 2 diabetes management. Entada africana , medicinal plant and highly rich source of bioactive ligands with potency to develop new target drug for glucokinase such as diabetes and obesity. Therefore, the study explored compu...

Ethnopharmacological relevance: Syringic acid (SAC) is a phenolic compound and an antioxidant that has been identified in honey, grapes, red wine, marigold and sugar apple. Due to its potent antioxidant prowess, SAC possesses hepatoprotective, nephroprotective, neuroprotective, cardioprotective and anti-inflammatory activities. Aim of the study: Ju...

Introduction Syringic acid (SYRAC) isolated from Ban Lan Gen or Isatis root, a famous Chinese traditional medicine is known to possess antiendotoxic effect. Methyl cellosolve (MCE) on the other hand, is an important constituent of car brake fluids, pesticides, inks, paints, and liquid soaps, rendering humans inevitable to its exposure. Methods Thi...

The African nutmeg (Monodora myristica) is a medically useful plant. We, herein, aimed to critically examine whether bioactive compounds identified in the extracted oil of Monodora myristica could act as antimicrobial agents. To this end, we employed the Schrödinger platform as the computational tool to screen bioactive compounds identified in the...

The development of clinically actionable pharmaceuticals against coronavirus disease (COVID-19); an infectious disease caused by the SARS-CoV-2 virus is very important for ending the pandemic. Coronavirus spike glycoprotein (GP)-Receptor Binding Domain (RBD) and its interaction with host receptor angiotensin converting enzyme 2 (ACE2) is one of the...

Diabetes mellitus (DM) is by far the most common metabolic disease impacting human health, and Type II diabetes (T2DM) accounts for almost all occurrences of diabetes. This work examined the anti-diabetic efficacy of Brachystegia eurycoma compounds against druggable proteins associated with T2DM and its complications. Fourteen proteins were identif...

Mitochondria malfunction is linked to the development of β-cell failure and a variety of neurodegenerative disorders. Pancreatic β-cells are normally configured to detect glucose and other food secretagogues in order to adjust insulin exocytosis and maintain glucose homeostasis. As a result of the increased glucose level, mitochondria metabolites a...

Methyl cellosolve (MTC) is an established gonadotoxic and hematotoxic compound that is commonly and universally utilized in herbicide, liquid soap, stain, dye, paint, and brake fluid manufacturing industries as a solvent. Due to its wide range usage, this study therefore investigated the effect of syringic acid (SYAC) on hematological indices, sper...

Aldose reductase and glycogen synthase kinase 3β (GSK3β) represent two of the ideal drug targets in diabetes due to their role in the pathogenesis of diabetes. Studies have shown that plant compounds provide therapeutics in diabetes management. This study identified some compounds in S. mombin as dual inhibitors of aldose reductase and GSK3β. S. mo...

Methyl cellosolve (MECEL) is an industrial solvent with widespread use. Some of the products that have been known to contain MECEL include paints, nail polish, inks for printing, varnish, anti-icing agents in jet fuel, liquid soaps, and so on. Tissues affected by exposure to MECEL include the thymus, fetus, testes, and blood. Recent studies have al...

Background Lannea egregia leaf has been reported to be effective in the management/treatment of different ailments.Objectives Antioxidant and modulatory effect of alkaloid-rich extract of Lannea egregia leaf (AELE) on gluconeogenic and nucleotide-hydrolyzing enzyme activities in isolated psoas muscles (ex vivo) were investigated.Methods Five male a...

The book is an evidence-based reference about biochemical mechanisms of action of plant secondary metabolites. It conveys an understanding about how plant-based therapies work, and explains their role in the treatment of complementary and alternative medicine for in the treatment of diabetes, cancer, neurodegenerative disorders, microbial infection...

Background: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods:...

Diabetes mellitus (DM) is a metabolic disease that affects millions of individuals, both male and female, around the world. Nanomedicine has significantly improved the health of diabetic patients through the provision of non-obstructive systems for the treatment of diseases such as DM. This technique has provided several advanced insulin delivery s...

The antioxidant, cholinergic, monoaminergic, and purinergic activities of flavonoid-rich extract from Dalbergiella welwitschii leaf (FEDW) were investigated on oxidative testicular injury (ex vivo) due to the local report on the use of this plant as anti-testicular injury. Flavonoid extract was obtained from FEDW using a standard procedure. Five ma...

The antioxidant, cholinergic, monoaminergic, and purinergic activities of flavonoid-rich extract from Dalbergiella welwitschii leaf (FEDW) were investigated on oxidative testicular injury (ex vivo) due to the local report on the use of this plant as anti-testicular injury. Flavonoid extract was obtained from FEDW using a standard procedure. Five ma...

Coronavirus spike glycoprotein (GP)-Receptor Binding Domain (RBD) and its interaction with host receptor angiotensin converting enzyme 2 (ACE2) is one of the most structurally understood but therapeutically untapped aspect of COVID-19 pathogenesis. In this study, Fragment-based lead discovery was conducted to identify potential lead anti-SARS-COV-2...

Aim: To confirm their use in the management of diabetes and to determine the numerous phytochemicals present that may be connected to the active performance of the plants, the fractionated extracts of Leptadenia hastata and Entada africana were subjected to an in vitro experiment. Material and methods: The plant leaves were dried, pulverized with...

Background This study assessed the hepatoprotective potential of flavonoid-rich extracts from Gongronema latifolium Benth on diabetes-induced type 2 rats via Fetuin-A and tumor necrosis factor-alpha (TnF-α). Methods In a standard procedure, the flavonoid-rich extract was prepared. For experimental rats, streptozotocin was injected intraperitoneall...

In this research, the beneficial roles of aqueous leaf extract of Solanum macrocarpon (SM) on diabetic cardiomyopathy were evaluated. Diabetic rats (induced with alloxan) were given varying doses of SM aqueous leaves extract for 28 days, and the animals were sacrificed. A series of diabetic cardiomyopathy parameters were determined. Diabetic rats s...

The increasing global burden of diabetes mellitus has called for the search for a therapeutic alternative that offers better activities and safety than conventional chemotherapy. Herein, we evaluated the neuroprotective and antioxidant properties of different fractions (ethyl acetate, N-butanol and residual aqueous) of Clompanus pubescens leaves in...

Background The genus Pennisetum contains remarkable natural bioactive components, and its 140 species are widely distributed in tropical and subtropical countries, where they are frequently used for therapeutic purposes such as the treatment of dysentery, fever, diabetes, and abdominal pain by indigenous people. However, the available information f...

The treatment of diabetes involves the use of herbal plants, attracting interest in their cost-effectiveness and efficacy. An aqueous extract of Persea americana seeds (AEPAS) was explored in this study as a possible therapeutic agent in rats with diabetes mellitus. The induction of diabetes in the rats was achieved by injecting 65 mg/kg body weigh...

The worldwide expanding increment in cancer pervasiveness is disturbing and this disease ranks among the main causes of mortality in both developing and developed countries. Unfortunately, available treatment options come with serious side effects and do not guarantee complete success. Although numerous models have been proposed for the development...

SARS-CoV-2, the causative virus for COVID-19 has now super-mutated into the Omicron (Om) variant. On its spike (S) glycoprotein alone, more than 30 substitutions have been characterized with 15 within the receptor binding domain (RBD); It therefore calls to question the transmissibility and antibody escapability of Omicron. This study was setup to...

Diabetes mellitus (DM) is the most predominant group of metabolic disorders wreaking havoc on the wellbeing of man, with type 2 diabetes mellitus (type 2 DM) accounting for most DM related cases. This study, hence, investigated the antidiabetic potential of Gongronema latifolium leaf fractionated compounds against proteins implicated in different m...

Introduction The present study access the effect of the flavonoid-rich isolate from Gongronema latifolium against cardiomyopathy in a streptozotocin-rich extract. Material and methods The flavonoid-rich isolate from G. latifolium leaf (FREGL) was prepared using a standard method. A single injection of streptozotocin was induced into the experiment...

Background SARS-CoV-2, the causative virus for COVID-19 has now super-mutated into the Omicron ( Om ) variant. On its spike glycoprotein alone, more than 30 substitutions have been characterized with 15 within the receptor binding domain (RBD); It therefore calls to question the transmissibility and antibody escapability of Omicron. This study was...

Sterculia tragacantha (ST) Lindl leaf is commonly used locally in the management of diabetes mellitus (DM) and its complications. This study was aimed at assessing the valuable effects of ST leaf on streptozotocin-diabetic cardiomyopathy (DCM). Streptozotocin was administered intraperitoneally to the experimental animals to induce DM, and hence, pl...

African nations which are often categorized as either developing or underdeveloped economy has agriculture and industrialization as the mainstay for their economy. Industrialization in most African nations is usually faced with the problem of releasing untreated effluents and wastes into the environment. As a result of these, most of the arable lan...

Cadmium is a toxic metal and poses a high environmental risk to animals and humans, alike. It is thus pertinent to search for medicinal plants in protecting against cadmium toxicity. This study aims at investigating the ability of aqueous extract of Persea americana seeds (AEPA) in ameliorating the toxic effects of cadmium in the kidneys of cadmium...