Babatunde A Ogunnaike

Babatunde A Ogunnaike
University of Delaware | UDel UD · Department of Chemical and Biomolecular Engineering

PhD

About

290
Publications
45,357
Reads
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5,566
Citations
Additional affiliations
September 2002 - present
University of Delaware
Position
  • William L. Friend Chaired Professor
June 1989 - August 2002
Dupont
Position
  • Research Associate
July 1988 - June 1989
University of Wisconsin–Madison
Position
  • Professor

Publications

Publications (290)
Article
The extracellular matrix (ECM) is a complex, temporally-regulated environment, and engineered hydrogels are increasingly used as ECM surrogates for probing related cell functions. ECM remodeling events related to injury or disease result in local ECM softening and stiffening (e.g., degradation followed by deposition/crosslinking). Inspired by these...
Article
Full-text available
Rapid breakdown of hepatic glycogen stores into glucose plays an important role during intense physical exercise to maintain systemic euglycemia. Hepatic glycogenolysis is governed by several different liver-intrinsic and systemic factors such as hepatic zonation, circulating catecholamines, hepatocellular calcium signaling, hepatic neuroanatomy, a...
Article
Four organic halide salts of interest to alloyed perovskite solar cell fabrication are characterized using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), powder x-ray diffraction (XRD), and thermogravimetric analysis. The chemical and crystal structures of methylammonium iodide (MAI), methylammonium bromide (MABr),...
Article
The production of monoclonal antibody (mAb) therapeutics, a rapidly growing multi-billion-dollar enterprise in the biopharmaceutical industry, faces major challenges in achieving desired productivity and product quality consistently. These challenges, traditionally addressed by genetic engineering and media recipe development, are now being address...
Book
Full-text available
This collection of twenty papers seeks to provide—under a single cover—a broad spectrum of research results showcasing this quantitative perspective of the physiological processes that subtend life, the diseases that occur when these systems malfunction, and the design of effective treatments for these diseases, specifically using mathematical mode...
Article
Full-text available
Introduction Pregnancy in sickle cell disease is fraught with many complications including pre-eclampsia (PE) and intrauterine growth restriction (IUGR). Previously, we found an abnormality in prostacyclin–thromboxane ratio in sickle cell pregnant women, a situation that is also found in non-sickle pregnancies with PE and unexplained IUGR. Low-dose...
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In manufacturing monoclonal antibodies (mAbs), it is crucial to be able to predict how process conditions and supplements affect antibody productivity and quality attributes, especially glycosylation. Supplemental inputs, such as amino acids and trace metals in the media, have been reported to affect cell metabolism and glycosylation; understanding...
Article
Monoclonal antibodies (mAbs) are critically important biologics as the largest class of molecules used to treat cancers, rheumatoid arthritis, and other chronic diseases. Antibody glycosylation is a critical quality attribute (CQA) that has ramifications for patient safety and physiological efficacy – one that can be modified by such factors as med...
Article
Full-text available
Genes that establish the circadian clock have differential expression with respect to solar time in central and peripheral tissues. Here, we find circadian-time-induced differential expression in a large number of genes not associated with circadian rhythms in two brain regions lacking overt circadian function: the dorsal vagal complex (DVC) and th...
Article
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Vapor deposition processes have shown promise for high-quality perovskite solar cells with potential pathways for scale-up to large area manufacturing. Here, we present a sequential close space vapor transport process to deposit CH3NH3PbI3 (MAPI) perovskite thin films by depositing a layer of PbI2 then reacting it with CH3NH3I (MAI) vapor. We find...
Article
The mammalian organism maintains stable, efficient and “near-optimal” performance and homeostasis in the face of external and internal perturbations via distinct biological systems ranging from the large-scale physiological (nervous, endocrine, immune, cardiovascular, respiratory, etc.), to the cellular (growth and proliferation regulation, DNA dam...
Article
Agarose phantoms are one type of phantom commonly used in developing in vivo brain magnetic resonance elastography (MRE)sequences because they are inexpensive and easy to work with, store, and dispose of; however, protocols for creating agarose phantoms are non-standardized and often result in inconsistent phantoms with significant variability in m...
Article
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Background: Recent results from single cell gene and protein regulation studies are starting to uncover the previously underappreciated fact that individual cells within a population exhibit high variability in the expression of mRNA and proteins (i.e., molecular variability). By combining cellular network modeling, and high-throughput gene expres...
Article
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Dynamics as well as localization of Ca2+ transients plays a vital role in liver function under homeostatic conditions, repair, and disease. In response to circulating hormonal stimuli, hepatocytes exhibit intracellular Ca2+ responses that propagate through liver lobules in a wave-like fashion. Although intracellular processes that control cell auto...
Article
Full-text available
In order to meet desired drug product quality targets, the glycosylation profile of biotherapeutics such as monoclonal antibodies (mAbs) must be maintained consistently during manufacturing. Achieving consistent glycan distribution profiles requires identifying factors that influence glycosylation, and manipulating them appropriately via well-desig...
Article
Traditional process monitoring methods cannot evaluate and grade the degree of harm that faults can cause to an industrial process. Consequently, a process could be shut down inadvertently when harmless faults occur. To overcome such problems, we propose a hierarchical process monitoring method for fault detection, fault grade evaluation and fault...
Article
Full-text available
Single-cell heterogeneity confounds efforts to understand how a population of cells organizes into cellular networks that underlie tissue-level function. This complexity is prominent in the mammalian suprachiasmatic nucleus (SCN). Here, individual neurons exhibit a remarkable amount of asynchronous behavior and transcriptional heterogeneity. Howeve...
Article
Copper indium gallium diselenide, Cu(InGa)Se2 (CIGS) solar cells have achieved efficiencies of 22.3% at the cell level and 17.5% at the module level. CIGS-based modules are also in the early stages of commercialization, with >1 GW annual production capacity. The most common method for producing CIGS in industry is via precursor reaction, which cons...
Article
Patients with immune thrombocytopenic purpura (ITP), a disease featuring abnormally low platelet count, are susceptible to excessive bleeding. One of the more effective treatment regimens is to increase platelet production with romiplostim. However, current romiplostim treatment strategies tend to produce undesirable responses where platelet count...
Article
Glycan distribution has been identified as a "critical quality attribute" for many biopharmaceutical products, including monoclonal antibodies. Consequently, determining quantitatively how process variables affect glycan distribution is important during process development in order to control antibody glycosylation. In this work, we assess the effe...
Article
Objective: The purpose of the present study is to model the dynamics of lobular Ca2+ wave propagation induced by an extracellular stimulus, and to analyze the effect of spatially systematic variations in cell-intrinsic signaling parameters on sinusoidal Ca2+ response. Methods: We developed a computational model of lobular scale Ca2+ signaling th...
Article
Full-text available
Developing high fidelity quantitative models of solid state reaction systems can be challenging, especially in deposition systems where, in addition to the multiple competing processes occurring simultaneously, the solid interacts with its atmosphere. In this work, we develop a model for the growth of a thin solid film where species from the atmosp...
Article
The distribution of droplet sizes produced in a microfluidic T-junction is modeled using the gamma probability distribution. The proposed model is validated using physical insight from the hypothesized mechanism of droplet breakup and statistically using the Anderson-Darling test. Where signal-to-noise ratio is low and the gamma distribution does n...
Research
Full-text available
An integrated engineering control system model of primary and secondary hemostasis, Presentation 72b, presented at the 2015 AIChe Annual Meeting, Salt Lake City USA, November 8-13, 2015
Article
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Background: A hallmark of chronic liver disease is the impairment of the liver's innate regenerative ability. In this work we use a computational approach to unravel the principles underlying control of liver repair following an acute physiological challenge. Methods: We used a mathematical model of inter- and intra-cellular interactions during...
Article
Engineering researchers at the University of Delaware in the US are investigating the use of solar power on UD's fuel cell bus fleet, as a way to reduce operating costs without increasing greenhouse gas emissions.
Article
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Meeting rapidly growing global energy demand—without producing greenhouse gases or further diminishing the availability of non-renewable resources—requires the development of affordable low-emission renewable energy systems. Here, we develop a hybrid renewable energy system (HRES) for automotive applications—specifically, a roof-installed photovolt...
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The primary focus of this paper is the identiication of second-order Volterra models using input sequences that ooer the following three advantages: i they are plant friendly;" ii they simplify the required computations; and iii they can emphasize certain model parameters over others. To provide a quantitative basis for discussing the of these adva...
Article
In this work, we present a method of controlling self-assembly. First, we demonstrate that images of surface morphologies can be decomposed into important features that capture essential properties of the surface. Subsequently, we develop a method for obtaining a low-dimensional representation of the entire feature set and show that this reduced re...
Conference Paper
An important part of designing effective decentralized multivariable control schemes is determining control loop configurations that minimize control loop interactions. Traditionally, the most appropriate control loop configuration is often determined using the relative gain array of a process obtained at a single operating condition, with the conf...
Conference Paper
Following damage, the liver initiates a recovery program inducing hepatocytes to enter the cell cycle and recover lost mass. As early as 30 seconds after injury, signaling cascades become active within the liver. Dynamic molecular changes continue for approximately 1 week following injury, restoring liver mass to the pre-injury levels. The dynamics...
Article
Full-text available
Following partial hepatectomy, the liver initiates a regenerative program involving hepatocyte priming and replication driven by coordinated cytokine and growth factor actions. We investigated the mechanisms underlying Adiponectin's (Adn) regulation of liver regeneration through modulation of these mediators. Adn-/- mice showed delayed onset of hep...
Article
N-linked glycan distribution affects important end-use characteristics such as the bioactivity and efficacy of many therapeutic proteins, (including monoclonal antibodies), in vivo. Yet, obtaining desired glycan distributions consistently during batch-to-batch production can be challenging for biopharmaceutical manufacturers. While an appropriately...
Article
Full-text available
Context: A control engineering perspective provides a framework for representing important mechanistic details of the calcium (Ca) regulatory system efficiently. The resulting model facilitates the testing of hypotheses about mechanisms underlying the emergence of known Ca-related pathologies. Objective: The objective of this work is to develop...
Article
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What is the significance of the extensive variability observed in individual members of a single cell phenotype? This question is particularly relevant to the highly differentiated organization of the brain. In this study, for the first time, we analyze the in vivo variability within a neuronal phenotype in terms of input type. We developed a large...
Article
One major challenge currently facing the biopharmaceutical industry is to understand how MAb micro-heterogeneity affects therapeutic efficacy, potency, immunogenicity and clearance. MAb micro-heterogeneity can result from post-translational modifications such as sialylation, galactosylation, C-terminal lysine cleavage, glycine amidation and tryptop...
Article
Full-text available
To function as intended in vivo, a majority of biopharmaceuticals require specific glycan distributions. However, achieving a precise glycan distribution during manufacturing can be challenging because glycosylation is a non-template driven cellular process, with the potential for significant uncontrolled variability in glycan distributions. As imp...
Article
Optimization of process variables is an important, yet difficult, task for systems-level analysis and design of complex stochastic systems. Here, we introduce the Simplex-Triangulation Optimization (STO) algorithm to optimize stochastic black-box systems efficiently in fewer iterations than other comparable algorithms without requiring gradient inf...
Article
Industrial chemical processes are dynamic, in the sense that their variables are constantly changing with time; yet in most chemical engineering programs, the first and only course that focuses on dynamic behavior is Process Dynamics and Control (PD&C). In this single course, students are expected to acquire an understanding of dynamics (how proces...
Conference Paper
Hemostasis, the physiological process that arrests bleeding and keeps blood within the blood vessel, consists of a set of reactions that can be divided into various functional components. Normal functioning of the components is necessary to achieve a delicate balance between effective hemostasis and pathological conditions such as thrombosis, one o...
Conference Paper
As the body’s main detoxifying organ, the liver is routinely exposed to high levels of toxic compounds. Mature liver cells therefore retain the unique ability to enter the cell cycle and regenerate lost mass following even severe injury without impairing liver function. This tightly controlled response to an experimentally repeatable stress gives a...