B Jeevana Jyothi

Sri Padmavati Mahila Visvavidyalayam | SPVV · Department of Pharmaceutical Sciences

The objective of the present study was to formulate and evaluate an oral, time-controlled drug delivery system of Zafirlukast. Zafirlukast belongs to BCS class II drugs as it has poor aqueous solubility and good permeability. Hence an attempt has been made to improve its aqueous solubility by solid dispersion technique so that its dissolution, bioa...

Objectives: The main objective of the present work includes extraction of cellulose from Oryza sativa (OS), characterization of cellulose, development of controlled release tablet dalfampridine using cellulose of OS, and in vitro evaluation. Methods: Dry powdered OS husk sample was extracted with a mixture of hexane and methanol (2:1, v/v) using so...

Losartan potassium (LSP) is an angiotensin II receptor blocker used for long treatment of hypertension. Commercial preparations are usually available as oral tablets or capsules. Even though it is soluble in water it exhibits poor oral bioavailability due to first pass effect. Hence the present work was aimed at preparation of highly patient conven...

The aim of the present research work was to prepare curcumin nanocrystals and to assess GI absorption in comparison with pure curcumin and turmeric powder, an INDIAN food ingredient. Eight formulations of nanocrystals of curcumin were prepared in two steps involving homogenization and lyophillization each containing 500 mg of curcumin. polyvinylpyr...

Drug delivery systems that precisely control the release rates or target drugs to a specific site have an enormous impact on health care system. In the modern era of treatment many new approaches have been evolved for more efficient administration of drugs. One such approach is the administration of drugs at times at which they are most effective a...

Drug delivery systems that precisely control the release rates or target drugs to a specific site have an enormous impact on health care system. In the modern era of treatment many new approaches have been evolved for more efficient administration of drugs. One such approach is the administration of drugs at times at which they are most effective a...

Propranolol HCl, an antihypertensive drug was formulated as transdermal prolonged release proniosomal gel due its drawback of short life when given through oral route. Nine formulations of proniosomes were prepared using different polymers viz. Maltodextrin, span 40, span 60 and cholesterol by slurry, slow stirring method. All were in turn prepared...

Now-a-days, the emphasis of pharmaceutical researchers is turned towards the development of more efficacious drug delivery systems with already existing molecule. However, in recent applications, Multiparticulate drug delivery systems (MDDS) are gaining much favor over single- unit dosage forms because of their potential benefits like predictable g...

Proniosome powders proved to be the potential carriers for efficient oral delivery of lipophilic or amphiphilic drugs. Henceforth, an attempt was made to improve the oral delivery of valsartan by loading into maltodextrin based proniosome powders. The proniosome powders were prepared by varying the ratio of span 60 and cholesterol and evaluated for...

Flutamide (FLT) is an antiandrogen drug for the treatment of prostate cancer. It has the drawback of poor water solubility and needs enhancement of its dissolution rate in simulated gastric fluids. Hence, it is prepared as self-nanoemulsifying drug delivery systems (SNEDDS) with an aim to enhance its dissolution rate. The objectives of the study ar...

A validated reverse phase HPLC method was developed for the estimation fexofenadine hydrochloride in rat plasma to determine pharmacokinetic parameters such as peak plasma concentration (Cmax), peak time (t max), area under the curve (AUC0-24) and biological half-life (t1/2). The samples were chromatographed on a reverse phase column, Luna C18 (250...

A validated reverse phase HPLC method was developed for the estimation of cefpodoxime proxetil in rat plasma to determine pharmacokinetic parameters such as peak plasma concentration (Cmax), peak time (tmax), area under the curve (AUC0-24), absorption rate constant K a and biological half-life (t1/2). The samples were chromatographed on a reverse p...

Glibenclamide (GLB) is a second generation anti-diabetic drug used for the treatment of Type -II Diabetes. The drawback of the drug is, it is practically insoluble in water and so possesses poor solubility, GI absorption and bioavailability. Hence the objective of the work is to develop fast dissolving tablets of Glibenclamide using Crospovidone (C...