Azin Ayatollahi

Center For Research And Training In Skin Diseases And Leprosy

Androgenetic alopecia (AGA) is the leading etiology for scalp hair loss in both genders. Apart from the limited approved pharmaceuticals, there are several suggested nonsurgical-nondrug therapies, including scalp injectables enriched with polynucleotides, however, limited data exists and is mostly limited to one gender. This study evaluates the eff...

Onychomycosis is a frequent fungal nail disease that is hard to treat and, in most cases, needs long-term therapy with oral agents. Traditionally, oral agents are favored over topical agents, but it should not be overlooked that they come with broad adverse effects and concomitant drug interactions, which can be unsuitable for many individuals. The...

Introduction: Despite the considerably high prevalence of cutaneous warts, no optimally effective and safe treatment is available. Leaves of date palm (Phoenix dactylifera L.; Arecaceae) have long been used in Iran's folk medicine as a remedy for warts. Methods: To assess the state-of-the-art evidence on using P. dactylifera L. for warts, we con...

Objective: The present study was designed to evaluate the effects of seven common preservatives used in Iranian cosmetic products on facial skin microflora. Methods: Fifteen healthy volunteers, aged 20 to 35 years, were recruited. Three symmetrical sites from the cheeks of each volunteer were selected and samples were collected. DNA was extracte...

Background: Injection of botulinum toxin for cosmetic purposes is a well-established practice. Objectives: This study was conducted to compare the safety and efficacy of Dyston® (investigational biosimilar abobotulinumtoxinA) with Dysport® (abobotulinumtoxinA, Ipsen) in the treatment of moderate to severe glabellar lines. Methods: Out of 193 s...

Candida parapsilosis is a non-albicans Candida spp. associated with bloodstream infections in critically ill patients. Failure to treat it effectively due to delay in diagnosis often leads to serious illnessess. The present research aimed to investigate the antifungal activities of nanoparticles (NPs) against fluconazole-resistant C. parapsilosis s...

Background While soaps are the most commonly used cleansing agents for human skin, they also damage the epidermal barrier and potentially increase the risk of disorders such as contact dermatitis. Aims This study set out to compare the potential skin irritancy of four types of soaps and their effects on the skin barrier function and biophysical pa...

Introduction Dandruff and seborrheic dermatitis [SD] are similar skin conditions but have different severities. Because the current therapies are not able to completely remove dandruff, herbal extracts with better effectiveness and fewer side effects are being used in the pharmaceutical and cosmetic industries. Due to the adverse effects of chemica...

As COVID-19 vaccination has started worldwide to control this pandemic, dermatologists may face various challenges with these new vaccines. In this manuscript, we review different types of available COVID-19 vaccines and their various production platforms. Vaccination considerations in patients with skin diseases, especially those using immunomodul...

Background Spironolactone is an effective treatment for female patients with acne vulgaris. However, topical spironolactone could be a valuable treatment option in both male and female acne patients due to the less possibility of systemic side effects with its topical formulation. Objective To evaluate the efficacy and safety of 5% spironolactone...

The article's abstract is not available.

Background The global spread of terbinafine‐resistant Trichophyton mentagrophytes with point mutations in the squalene epoxidase (SQLE) gene is a big concern. Aim The present study presents a series of unusual familial cases of generalized dermatophytosis caused by multidrug‐resistant T. mentagrophytes genotype VIII. Methods Initially, the skin s...

Coronavirus disease 2019 (COVID-19) is a highly infectious respiratory illness caused by SARS-CoV-2. Not much is yet known about this new viral disease. In our early encounter with the COVID-19, before the pandemic and during the early days of dealing with this novel viral disease in our country, we saw some cases of anosmia in patients infected by...

High-intensity focused ultrasound (HIFU) is widely used for skin rejuvenation and tightening. The aim of this study was to determine the safety and efficacy of HIFU for face and neck rejuvenation. A systematic search of peer reviewed articles published before December 2017 was performed using Medline, Web of Science, and Scopus databases. Retrieved...

Background Skin boosting with small particles of hyaluronic acid (HA) is a new method of skin rejuvenation. Aim Here we aim to evaluate the efficacy and safety of booster injections of non‐cross‐linked HA in improving the facial skin quality. Methods 20 men and women age 40.15 ± 6.63 years were treated with 3 injections of non‐cross‐linked HA (1‐...

The aim of this study was to compare the efficacy and safety of a novel diode system emitting 755 nm wavelength with conventional 755 nm alexandrite laser in skin types III and IV. It was a randomized, right-left comparison, assessor-blind, clinical study. Sixteen female volunteers age 29.52 ± 9.52 were randomly assigned to receive six treatment se...

Introduction: Leprosy is an infectious disease which primarily affect skin and peripheral nerves. Mycobacterium leprae and Mycobacterium lepromatosis that are the acid-fast bacillus are known to be cause of leprosy. Genetic factors and immunological function have some roles in susceptibility of developing leprosy. There are some cases of familial l...

Background: Melasma is the most common pigmentary skin disorder, especially in females and those with darker complexion. The current study evaluated the safety and efficacy of a triple combination cream containing hydroquinone 4%+tretinoin 0.05%+fluocinolone acetonide 0.01% (Januluma® cream produced by Janus Pharmaceutical Co, Tehran, Iran) in the...

Background Various tests have been carried out to determine the irritant potential of soaps/cleansers. Objectives This study was carried out to compare the effects of four different soap formulations on biophysical parameters of the skin, including trans‐epidermal water loss (TEWL) and erythema index. Methods Four different soap formulations (cre...

Background Application of topical moisturizers is an essential part of the management of atopic dermatitis (AD). Linoleic acid (LA), the most abundant fatty acid in the epidermis, and its derivatives have an essential role in the structure and function of the epidermal barrier, and their defects are prominent in AD. The aim of this study was to com...

Introduction and Objective Platelet-rich plasma (PRP) is an autologous preparation of platelets in concentrated plasma. The platelet is a natural source of different growth factors and cytokines. These growth factors act on stem cells in the bulge area of the follicles and stimulate the development of new follicles, and promote neovascularization....

Background: Although there are many studies showing the role of platelet rich plasma (PRP) in bone grafts, teeth osteosynthesis, and wound healing, there have been little peer reviewed studies about the safety and efficacy of PRP application in the treatment of hair loss. Materials and methods: In this systematic review, we searched Ovid Medline...

Hereditary hypotrichosis simplex of the scalp is a genetic disorder, characterized by sparse or absent scalp hair without structural defects, in the absence of other ectodermal or systemic abnormalities. Structural hair defects may be presented with a genetic disorder affecting hair growth or part of a congenital syndrome or may indicate underlying...

Striae distensae (SD) are a frequent skin condition for which treatment remains a challenge. The 1540-nm non-ablative fractional laser (Star Lux 500) has been shown to improve atrophic scars by increasing the amount of dermal collagen. To assess the safety and efficacy of the Star Lux 500 laser in the treatment of mature hypopigmented striae in Per...

Background: Pemphigus vulgaris is an autoimmune blistering skin disease with unknown etiology. Drugs such as angiotensin-converting enzyme (ACE) inhibitors may contribute in the pathogenesis of pemphigus. Objective: We plan this essay to evaluate the serum ACE level in pemphigus vulgaris patients in comparison with healthy controls to recognize it...

Leprosy is one of the most primitive diseases with which human beings have been confronted for thousands of years. It primarily affects skin and peripheral nervous system. The cause of disease, Mycobacterium leprae, was discovered by Armauer Hansen in 1873. After the introduction of Multi Drug Therapy (MDT ) by WHO in 1982 as the first effective tr...

Early detection of skin cancers by screening could be very beneficial to decrease their morbidity or mortality. There is limited study about skin cancer screening in Iran. This essay was planned as a pilot skin cancer screening campaign in Tehran, Iran to evaluate its profit and failure and further design large-scale screening program more definite...

Multiple sclerosis (MS) is a demyelinating disease which can cause many disabilities for the patient. Recent data suggests that MS patients have higher risk for osteoporosis. This study was performed to investigate if the osteoporosis prevalence is higher in MS patients and to determine the possible factors affecting bone mineral density (BMD). 51...

Background: To our knowledge, there is a hypothesis regarding the association of vitiligo with other autoimmune disorders. Organ-specific autoantibodies are found more frequently in the serum of vitiligo patients. Recent studies have demonstrated the role of alterations in serum transforming growth factor-beta (TGF-beta) released from regulatory T...

Pemphigus foliaceus is an autoimmune blistering disease, which affects the skin but rarely affects the mucosae. There are two variants of pemphigus foliaceus : endemic and sporadic. Erythroderma due to pemphigus foliaceus is unusual and its occurrence in a child is very rare. We describe a case of erythrodermic pemphigus foliaceus in a 12- year- ol...

Background: Recent studies suggest that psoriasis may be a pathogenic factor for the metabolic syndrome and atherosclerosis. The aim of our study was to investigate the metabolic state in psoriatic patients in order to clarify the association between psoriasis and insulin resistance. Methods: This single-centre, case- control study was performed be...

A 45-year-old man presented with multiple ulcerated and erythematous nodules on his scalp. The first lesion appeared on his vertex as an erythematous plaque five years ago and there was gradual increase in size and number of the lesions ever since. He was otherwise healthy. Physical examination showed multiple erythematous nodules, some were cruste...

Background: Lichen planus is a common inflammatory disease that can involve the skin, nails, mucous membrane, and hair follicles. There is a long list of topical and systemic therapies for its treatment. Methotrexarte has some characteristics that make it a good choice for generalized lichen planus. Aim: The goal of this study was to assess the eff...

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Langerhans cell histiocytosis (LCH) is a rare disease and generally affects children under 15 years of age. Adult onset form and cutaneous features at presentation are uncommon. There are some options for treatment of the skin lesions of LCH such as topical and intralesional corticosteroid, nitrogen mustard, etc., which are not completely curative....

According to the English literature, various lasers and light sources (i,g. argon ion lasers, pulsed KTP lasers, diode lasers and Nd:YAG lasers, pulsed dye laser(PDL), intense pulsed light sources (IPLS) are applicable for the treatment of different vascular lesions. These conditions are the most important indication for laser therapy. This review...

Background: Adequate control of acne is difficult, regardless of the various conventional modalities. Intense Pulsed Light (IPL) system is one of the emerging options that are become increasingly useful. Methods: To achieve the best IPL parameters we evaluated the efficacy and tolerability of IPL at 752-nm wavelength, 35 j/cm2 fluence, 55-ms pulse...

According to the English literature, various lasers and light sources (i,g. argon ion lasers, pulsed KTP lasers, diode lasers and Nd:YAG lasers, pulsed dye laser(PDL), intense pulsed light sources (IPLS) are applicable for the treatment of different vascular lesions. These conditions are the most important indication for laser therapy. This review...

Porokeratosis is a rare disorder of keratinization with unknown etiology. It exhibits both sporadic and autosomal dominant inheritance. The lesions are sharply demarcated, hyperkeratotic, and annular with distinct keratotic edges. The cornoid lamella is the histological hallmark of porokeratosis. Porokeratosis lesions on the face may have a superfi...

Background: Adequate control of acne is difficult, regardless of the various conventional modalities. Intense Pulsed Light (IPL) system is one of the emerging options that are become increasingly useful. Methods: To achieve the best IPL parameters we evaluated the efficacy and tolerability of IPL at 752-nm wavelength, 35 j/cm2 fluence, 55-ms pulse...