Azat Gainutdinov

Kazan Federal University · Department of Human and Animal Physiology

The developing entorhinal–hippocampal system is embedded within a large-scale bottom-up network, where spontaneous myoclonic movements, presumably via somatosensory feedback, trigger hippocampal early sharp waves (eSPWs). The hypothesis, that somatosensory feedback links myoclonic movements with eSPWs, implies that direct somatosensory stimulation...

Hippocampal theta oscillations are pivotal for hippocampal functions of spatial navigation, learning and memory. In the behaving animals in vivo, hippocampal theta oscillations display bilateral synchronization. Internally generated oscillations in the theta frequency range have also been described in the intact hippocampus preparation in vitro. Ho...

Anoxic spreading depolarization (aSD) is a hallmark of ischemic injury in the cerebral cortex. In adults, aSD is associated with rapid and nearly complete neuronal depolarization and loss of neuronal functions. While ischemia also evokes aSD in the immature cortex, developmental aspects of neuronal behavior during aSD remain largely unknown. Here,...

In the present study we explored neuronal survival during oxygen-glucose deprivation (OGD) in slices of the barrel cortex using whole-cell patch clamp recordings and concomitant extracellular recordings of local field potential (LFP) ,and optical intrinsic signal (OIS). To this aim we used two types of neuronal survival assessment. In the first app...

Anoxic spreading depolarization (aSD) has been hypothesized as a terminal event during oxygen–glucose deprivation (OGD) in submerged cortical slices in vitro. However, mechanical artifacts caused by aSD-triggered edema may introduce error in the assessment of neuronal viability. Here, using continuous patch-clamp recordings from submerged rat corti...

Cerebral edema is a major, life threatening complication of ischemic brain damage. Previous studies using brain slices have revealed that cellular swelling and a concomitant increase in tissue transparency starts within minutes of the onset of metabolic insult in association with collective anoxic spreading depolarization (aSD). However, the dynami...

Anoxic depolarization (AD) is a hallmark of ischemic brain damage. AD is associated with a spreading wave of neuronal depolarization and an increase in light transmittance. However, initiation and spread of AD across the layers of the somatosensory cortex, which is one of the most frequently affected brain regions in ischemic stroke, remains largel...

AD propagation in a slice with a cut through L4 (related to Figure 4C). Left, OIS and right, AD front. 5× playback speed.

Double-side propagating AD (related to Figure 3D). Left, OIS and right, AD front. 5× playback speed.

Single-barrel AD initiation pattern (related to Figure 3A). Left, OIS and right, AD front. 5× playback speed.

AD propagation in a slice with a cut above L4 (related to Figure 4A). Left, OIS and right, AD front. 5× playback speed.

Multiple-barrel AD initiation (related to Figure 3B). Left, OIS and right, AD front. 5× playback speed.

One side propagating AD (related to Figure 3C). Left, OIS and right, AD front. 5× playback speed.

AD propagation in a slice with a cut below L4 (related to Figure 4B). Left, OIS and right, AD front. 5× playback speed.