Azadeh Nadjarzadeh

Shahid Sadoughi University of Medical Sciences and Health Services | SSU · Nutrition

Background olycystic ovary syndrome (PCOS) is an endocrine disorder that can lead to major reproductive and metabolic complications. Management of glycemic parameters is an important step to improve the symptoms of PCOS. Objective This study aims to evaluate the effects of the dietary approaches to stop hypertension (DASH) diet and curcumin (Cur)...

Background The fast spread of the coronavirus disease 2019 (COVID-19) epidemic and its high mortality were quickly considered by the health community. Dietary patterns play an important role in strengthening or weakening the immune system and thus incidence of diseases. Aim The present study can provide a comprehensive picture of the association b...

Background: Anxiety is one of the most prevalent mental illnesses globally. While there are long-established, separate, and bidirectional connections between nutrition, excess body weight, and anxiety, it is still unclear how these variables interact and affect anxiety state. The aim of the current investigation was to determine whether there was a...

Background Type 2 diabetes mellitus (T2DM) is often linked to chronic inflammation, which can be influenced by both lifestyle and dietary choices. However, the relationship between the inflammatory potential of diet and lifestyle factors and the risk of developing T2DM remains unclear. The present study aimed to investigate the associations of the...

Background Polycystic ovary syndrome (PCOS) is the most common ovarian dysfunction. Recent studies showed the effectiveness of licorice on metabolic profiles with inconsistent findings. So, we investigated the effect of licorice on obesity indices, glycemic indices, and lipid profiles in women with PCOS. Methods This randomized, double-blind, plac...

Background As the most common endocrine disorder, type 2 diabetes is the main cause of more than 4% of deaths worldwide, West Asia and especially Iran is known as one of the regions in the world where the incidence of diabetes has increased significantly in recent years. Failure to control diabetes can cause side effects which reduce the patient's...

Background Growing research underscores the significance of diet quality in the development of Metabolic Syndrome (MetS). Our study investigates the correlation between the Global Diet Quality Score (GDQS) and MetS, along with its components, in Iranian adults. Methods This study utilizes data from the Yazd Health Study (YaHS) and includes a final...

Background: COVID-19 has caused a high health burden worldwide and increased the need to identify factors affecting its risk. Fruits and vegetables are essential for a healthy diet and immune system function. This study investigated the associations between fruit and vegetable intake and COVID-19 incidence in a large sample of Iranian adults. Meth...

Background Nigella sativa (NS) oil has been found to have advantageous benefits in the management of inflammation and obesity. This study investigated the effect of NS supplementation on blood mRNA expressions and serum levels of IL-1β, IL-6, leptin, and insulin concentrations in overweight/obese women. Methods In a crossover design, participants...

Aim Evidence indicates there are still conflicts regarding CETP Taq1B polymorphism and coronary artery disease risk factors. Current findings about whether dietary patterns can change the relationship of the Taq1B on lipid profile and the severity of coronary arteries stenosis appears to be limited. The present research made an attempt to investiga...

The association of CETP Taq1B polymorphism with some metabolic traits is still controversial. The interaction of adherence to dietary indices with this polymorphism on the severity of coronary artery stenosis and serum lipid parameters needs to be investigated. This study aimed to test this hypothesis. This cross‐sectional study included 453 patien...

Background Polycystic ovary syndrome (PCOS) is an endocrine disorder that can lead to major reproductive and metabolic complications, including infertility and insulin resistance. Management of glycemic parameters is an important step to improve the symptoms of PCOS. Lifestyle-based treatments, including interventions with healthy eating patterns a...

Aim Non-alcoholic fatty liver disease (NAFLD) is a condition characterized by the accumulation of fat in the liver without excessive alcohol consumption. Lifestyle modifications, such as adopting a healthy diet, represent the standard treatment for NAFLD. However, the impact of the Dietary Approaches to Stop Hypertension (DASH) diet on oxidative st...

Purpose Recent evidence suggests that adherence to dietary approaches to stop hypertension (DASH) diet can be effective in managing non-alcoholic fatty liver disease (NAFLD). We investigated the effect of DASH diet on hepatic fibrosis, steatosis and liver enzymes in patients with NAFLD. Methods This 12-week randomized controlled trial was conducte...

Introduction Genetic and environmental factors are involved in the pathogenesis of cardiovascular diseases (CVDs). The aim of the study was to investigate between the genotype of the NFKB1 gene and the cardiometabolic risk factor in patients undergoing coronary angiography. Methods This cross-sectional study was conducted on 462 adults (male and w...

Coronary artery disease (CAD) is one of the most important cardiovascular diseases. Lifestyle and genetic factors play important roles in the development of CAD. The aim of the study is to examine the interaction of dietary patterns and genes on the likelihood of abnormal lipid profile and coronary artery stenosis in Iranians undergoing coronary an...

Background: Serum insulin levels and insulin sensitivity can impact mental disorders. This study investigates the association of the insulinemic potential of diet calculated using the empirical dietary indices for insulin resistance (EDIR) and hyperinsulinemia (EDIH) with psychological disorders, including depression, anxiety, and stress. Methods...

Background: Studies have shown that children’s food preferences play a main role in the formation of long-term eating habits and nutritional patterns in their future lives. This study aimed to investigate food preferences of primary students in Yazd, Iran. Methods: This cross-sectional study was conducted on 420 primary school students of Yazd, bot...

Background: Previous studies have shown that insulin directly affects the risk of type 2 diabetes mellitus (T2DM) but the relationship between insulinaemic potential of diet and lifestyle and the T2DM risk is still unknown. Accordingly, we aimed to investigate the relationship between the insulinaemic potential of diet and lifestyle based on indic...

Aim: Evidence indicates there are still conflicts regarding CETP Taq1B polymorphism and coronary artery disease risk factors. Current knowledge about whether dietary patterns can change the relationship of the Taq1B on lipid profile and the severity of coronary arteries stenosis is limited. Present research aimed to investigate this hypothesis. Met...

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases with major reproductive and metabolic complications with an impact on public health. Hyperandrogenism and chronic inflammation have been suggested as the leading cause of pathophysiology and clinical manifestations associated with PCOS. It seems that the alte...

Background: Cardiovascular diseases (CVDs) are recognized as one of the leading causes of death worldwide. Studies have shown the impact of genetic predisposition and dietary factors on developing these diseases. Dietary patterns and genetic factors such as polymorphisms related to the level of adiponectin may also interact with each other and pro...

Vitamin B12 affects and modify the function of multiple organ systems. Its deficiency may cause psychiatric symptoms in addition to hematologic, gastrointestinal, and neurologic manifestations. The present case study aims to report a patient with vitamin B12 deficiency who coexisted with resistant and persistent depression, and experienced mania ph...

some studies have suggested that vitamin C deficiency may play a role in the etiology of depression although the efficient dose and time of prescription is not clear now. Also, it is not known which antidepressant drugs could be more efficient in augmentation with vitamins. Nowadays, due to the importance and more prevalence of psychiatric disorder...

Background: Healthy nutrition is a part of a healthy pregnancy. Having a poor food attitude towards healthy nutrition often leads to unfavorable consequences for the mother and her baby. Health care providers need to be aware of these attitudes, so that they can focus their attention on pregnant women during this critical period. Therefore, the pre...

Background & aims To examine the association between dietary whole and refined grains and their replacement and psychological disorders. Methods This cross-sectional study was carried out on the recruitment phase of YaHS-TAMYZ prospective study (Yazd, Iran). Data on demographic characteristics, dietary intakes, and potential confounders were gathe...

Introduction: excessive consumption of salt is one of the unhealthy eating habits and is one of the factors in the high prevalence of cardiovascular diseases and the resulting mortality. Using swot tool is one of the effective measures in understanding the society, planning and new solutions for behavior modification. So, the aim of this study was...

Background The preoperative period is a good time to improve nutrition status, compensate for nutrient deficiencies, and optimize immune function in patients’ underlying surgery. In some medical conditions, supplementation with a combination of l -glutamine (Gln), β-hydroxy-β-methylbutyrate (HMB), and l -arginine (Arg) had promising effects on impr...

Background: Beneficial effects of vitamins and dietary supplements in the prevention and treatment of metabolic syndrome (MS) are controversial. This study aims to evaluate the association between dietary supplements intake and MS. Methods: This analytical cross-sectional analysis was conducted on 9539 people aged 35-70 years who participated in th...

Background: Flaxseed has rich content of alpha linolenic acid for preventing pro inflammatory process. The aim of present study is exploring the effect of flaxseed oil supplementation on inflammatory biomarkers and body composition in overweight adults with pre-diabetes. Material and methods: this double-blind randomized clinical trial conducted...

Background The diet’s role in developing psychological disorders has been considered by researchers in recent years. Objective To examine the association between major dietary patterns and severe mental disorders symptoms in a large sample of adults living in Yazd city, central Iran. Methods This cross-sectional study used the baseline data of a...

Background Psychological disorders including depression, anxiety, and stress comprise a huge public health problem. The aim of this cross-sectional study is to assess the relationship between dietary glycemic index (DGI) and glycemic load (DGL) and mental disorders. Method Participants (n = 10,000) aged 20–69 were randomly selected from 200 cluste...

Adipocyte expansion through adipogenesis can offset the adverse metabolic effects of obesity. Nigella sativa (NS)(black seed) oil is shown to have therapeutic features in the management of obesity. NS oil might have beneficial changes in obese populations through mediating serum levels of adipogenesis-related parameters and relative transcriptional...

Background: Among non-communicable diseases, cardiovascular diseases (CVDs) account for 44% of all deaths. Among natural alternatives, Nigella sativa (NS) exert beneficial effects on cardio-metabolic factors. This is the first systematic review and meta-analysis protocol aimed to identify all the findings relevant to the effects of NS on cardio-met...

Background: Little observational studies have been conducted on the association between diet and sleep. We conducted a cross-sectional study to evaluate the associations of dietary patterns with sleep duration in an Iranian population. Methods: This study was conducted on the baseline data of two population-based Iranian cohorts: the YaHS-TAMYS...

PurposePolycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-age women. Insulin resistance and dyslipidemia are linked to PCOS. l-Carnitine supplementation as a management strategy for women with PCOS has been proposed. The effect of l-carnitine supplementation on insulin resistance, sex hormone-binding globulin (SHBG)...

Background: Some studies have shown that Socioeconomic Status (SES) is positively related to insulin resistance among different population groups, except for pregnant women. Therefore, we examined the relationship between SES and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) index as well as mediating variables. Materials and methods:...

Abstract Background: Some studies have shown that Socioeconomic Status (SES) is positively related to insulin resistance among different population groups, except for pregnant women. Therefore, we examined the relationship between SES and Homeostasis Model Assessment‑Insulin Resistance (HOMA‑IR) index as well as mediating variables. Materials and M...

Previous multiple-choice food-based food frequency questionnaires (FFQs) were not validated against weighed dietary records (WDRs) in Iran. This study investigated the validity and reproducibility of a multiple-choice semiquantitative food frequency questionnaire (SQ-FFQ) in adults living in central Iran. Patients with diabetes and their spouses we...

Background: Psychological disorders including depression, anxiety, and stress comprise a huge public health problem. The aim of this cross-sectional study is to assess the relationship between dietary glycemic index (DGI) and glycemic load (DGL) and mental disorders. Method: Participants (n = 10,000) aged 20-69 were randomly selected from 200 clust...

Background Cardiac surgery is associated with a widespread inflammatory response, by an additional release of free radicals. Due to the importance of these patient’s nutritional status, the present study was designed to evaluate the effectiveness of supplementation with a combination of glutamine, β-hydroxy-β-methylbutyrate (HMB) and arginine in pa...

Sleep disorders are linked to obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). The evidence suggests that dietary carbohydrate content may be related to sleep duration. We designed a study to investigate the association between a low-carbohydrate diet (LCD) with long sleep duration (> 8 h) and short sleep duration (< 5 h)....

Purpose: Since obesity is a risk factor for various diseases and is associated with increased oxidative stress conditions, some herbs are considered to be effective in reducing obesity and its complications. Methods: This secondary analysis investigates the effect of Nigella sativa (N.S) oil supplement on total antioxidant capacity (TAC) and mal...

Purpose Established data revealed a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. There are conflicting data regarding the association between adherence of dietary approach to stop hypertension (DASH) and obesity. Therefore, this study aims to investigate this relationship among a large sample...

Background Oxidative stress is related to many chronic diseases such as type 2 diabetes, cancers, hypertension, and heart diseases. Antioxidant activity of pomegranate due to high content of polyphenols, flavonoids, and several other types of antioxidant compounds has been of interest; however, the findings on its antioxidant effects are inconsiste...

Background: Follow-up studies have shown an increased risk of thyroid dysfunction in individuals with normal serum thyroid-stimulating hormone (TSH) levels. Furthermore, the possible consequences of minor differences in thyroid function (without achieving poor thyroid function) in the risk of weight gain during pregnancy are questionable, too. The...

Background: It seems that 14-25% of the women retain at least 5 kg weight from 6 to 12 months after delivery and gestational weight gain is the most important reason of weight retention. Thus, we assessed the effect of prenatal nutrition education program on the retained weights at 8, 26, and 52 weeks after delivery in primiparous women. Methods:...

Background Despite the protective effects of foods being rich in phytochemicals against chronic diseases, this issue is still poorly understood. The aim of this study was to investigate the association between Dietary Phytochemical Index (DPI) and metabolic syndrome (MetS) and its components. Methods This cross-sectional study focused on adults ag...

Background: Exceeded weight during the first 1000 days of life can lead to adulthood obesity and health-related problems. In the present study, we aimed to find the prevalence of overweight and obesity and their related demographic factors in the first year of life in Yazd. Methods: In a cross-sectional study, recorded data of 600 infants were coll...

Objectives: Data demonstrated a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. Inconsistent data regarding the association between adherence of Healthy Eating Index-2015 (HEI-2015) and obesity is identified. Thus, this study intends to address this relationship among a large sample of both urban...

Objectives: Data demonstrated a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. Inconsistent data regarding the association between adherence of Healthy Eating Index-2015 (HEI-2015) and obesity is identified. Thus, this study intends to address this relationship among a large sample of both urban...

Objective Data demonstrated a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. Inconsistent data regarding the association between adherence of Healthy Eating Index-2015 (HEI-2015) and obesity is identified. Thus, this study intends to address this relationship among a large sample of both urban a...

Objective Assessing the relationship between low-carbohydrate diet (LCD) score and metabolic syndrome (Mets) in Iranian adults. Design Cross-sectional study Setting Yazd Health Study and Taghzieh Mardom-e-Yazd study. Participants Data of 2074 participants were used. Dietary intakes were assessed by a validated semi-quantitative FFQ. LCD score wa...

PurposeEstablished data revealed a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. There are conflicting data regarding the association between adherence of Dietary Approach to Stop Hypertension (DASH) and obesity. Therefore, this study intends to investigate this relationship among a large sampl...

Dietary patterns are considered as a modifiable risk factor for metabolic syndrome (MetS). Therefore, the present study aimed to evaluate the association between the Dietary Approaches to Stop Hypertension (DASH) and Mediterranean (MED) dietary patterns and MetS. This cross-sectional study was conducted on the data from recruitment phase of prospec...

Purpose Dietary intake is a modifiable risk factor for metabolic syndrome (MetS). Therefore, this study aims to evaluate the association between the Healthy Eating Index-2015 (HEI-2015) and MetS. Design/methodology/approach MetS was diagnosed among 2,326 adults. Dietary intake was assessed by a validated food frequency questionnaire. The HEI-2015...

Purpose: To assess the effect of Nigella sativa (N.S) oil supplements on CVD risk factors in a crossover design for the first time. Methods: Obese and overweight healthy women were randomized to receive N.S oil (2000 mg/day) and placebo. This intervention period lasted for 8 weeks and separated by a 4-week washout period. An iso-caloric diet was...

Objectives: Established data revealed a relationship between obesity and increasing the risk of mortality and morbidity of chronic diseases. There are conflicting data regarding the association between adherence of Dietary Approach to Stop Hypertension (DASH) and obesity. Therefore, this study intends to investigate this relationship among a large...

Background: Hibiscus sabdariffa linnaeus (HSL) is a tropical plant with a high content of anthocyanin, traditionally found to have beneficial biological activities. This randomized, double-blind, placebo-controlled, and parallel trial was conducted to assess some renal and cardiovascular effects of supplementation with HSL in patients with diabetic...

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Background: The purpose of this study is to investigate the amount of salt consumed by the people living in Yazd, Iran and its related factors based on previous investigations. materials and methods: A general search was performed on electronic databases of Daneshgostar Barakat system, Magiran, SID and English databases such as Scopus, PubMed, Web...

Introduction Over consumption of salt adversely affects health and is associated with some diseases. Salt over consumption has been reported to be higher in Asian countries including Iran. This research aimed to identify the facilitative factors of reduced salt consumption among 20–65 year-old women to develop effective educational interventions. M...

Introduction: During the pregnancy, a woman as a healthy person grows another human being in her body and needs more cares due to changes in psychological and physical needs. This study aimed to explore the nutritional beliefs of pregnant women in Yazd city. Methods: This was a qualitative study conducted with a conventional content analysis app...

Objective The aim of this study was to evaluate the effect of hypocaloric high-protein, low-carbohydrate weight loss diet supplemented with fennel on anthropometric and androgen indices in overweight and obese women with polycystic ovary syndrome (PCOS). Methods A randomized controlled trial with a factorial design was performed on sixty-four over...

Objectives Obesity is a global concern which is associated with several complications and disease. Design Present study is the first crossover, double-blind, placebo-controlled, randomized clinical trial aimed to evaluate the effect of Nigella Sativa (N. sativa) intervention on anthropometric and body composition parameters as well as dietary inta...

Background: There is growing agreement that plant foods-based phytochemicals have a protective role against chronic diseases. Current study was to appraise Dietary Phytochemical Index (DPI) with the risk of metabolic syndrome (MetS) and its components. Methods: A cross sectional study of 1097 men , 1220 women and aged 20-70 years assessed dietary i...

Purpose Increased dietary salt content is one of the effective factors of hypertension and a major public health challenge globally. Although the positive effects of dietary salt reduction on health are universally accepted, people can hardly reduce their salt intake. The purpose of this study is to identify the inhibitory factors of dietary salt r...

Background: The role of diet in developing psychological disorders has been considered by researchers in recent years. Objective: To examine the association between major dietary patterns and severe mental disorders in a large sample of adults living in Yazd city, central Iran. Methods: This cross-sectional study used the baseline data of a populat...

Background: Obesity is considered as the greatest cause of chronic diseases worldwide. The prevalence rate of obesity and overweight should be recognized in the community for planning and prioritizing health problems. The aim of this study was to investigate the prevalence of obesity and overweight and its related factors among residents of Yazd ci...

Background: Polycystic ovarian syndrome (PCOS), one of the most common causes of endocrine disorders with irregular menstruation, is accompanied by an increase in androgen and polycystic ovarian. The aim of this study was to evaluate the effect of weight loss regimen with and without supplementation. L-carnitine affects lipid profile, insulin, and...

Background and Aim: Over the past few decades, different epidemiological studies have been conducted on the relationship between mental disorders and hypertension. However, conflicting results have been reported. This research aimed to evaluate the relationship between symptoms of depression, anxiety and stress with hypertension in a large populati...

Introduction Considering the progressive trend of pre-diabetes and limited evidence regarding the effectiveness of flaxseed supplement in improving glycemic indices, the aim of this study was to evaluate the effect of flaxseed oil supplementation on insulin resistance (IR) indices and inflammatory indices in overweight pre-diabetes patients. Metho...

Background: Phytochemicals are natural non-nutritive bioactive compounds in plant foods. There is growing agreement that plant foods-based phytochemicals have a protective role against chronic diseases. The purpose of current study was to appraise Dietary Phytochemical Index (DPI) with the risk of metabolic syndrome (MetS) and its components. Metho...

Background: Conflicting results have been obtained from the studies on the hypoglycemic effect of cinnamon in patients with diabetes mellitus type II (T2DM). Objectives: This research aimed at assessing the effect of applying the syndrome differentiation model based on traditional Persian medicine (TPM) to identify the patients who benefit more fro...

Background: To the best of our knowledge, no study has tried to develop and validate a multiple-choice food-based FFQ in Iran using weighed dietary records.This study aimed to investigate the validity and reproducibility of a multiple-choice semi-quantitative food frequency questionnaire (SQ-FFQ)in adults living in central Iran. Methods: Participan...