Ayse Demirel

Gazi University · Laboratory Animal Breeding and Experimental Research Center

Amaç: Bu çalışmanın amacı Koenzim Q10’ nun sıçanlarda asetik asitle indüklenmiş deneysel kolit modelinde mukoza, goblet hücre yoğunluğu ve sıkı bağlantı proteinleri üzerine olan etkisinin araştırılmasıdır. Gereç ve Yöntem: Çalışmada 24 adet, 10 haftalık dişi Wistar albino sıçan kullanıldı ve Kontrol grubu (n=4), Kolit grubu (n=10) ve Kolit+Koenzim...

The aim of this study was to evaluate the effects of coenzyme Q10 in the treatment of endometriosis rat models. Twenty seven Sprague Dawley rats were divided into four groups; Control Group (n = 7; Endometriosis group), Reference Group (n = 6; Endometriosis + Buserelin acetate, 20 mg/kg), CoQ10 Group-I (n = 7; Endometriosis + CoQ10, 50 mg/kg) and C...

Medicinal plants have a long history of use as food and remedy in traditional and modern societies, as well as have been used as herbal drugs and sources of novel bioactive compounds. They provide a wide array of chemical compounds, many of which can not be synthesized via current synthesis methods. Natural products may provide aromatase inhibitory...

This study aims to show the changing effects of Androctonus crassicauda venom and A.crasicauda spesific antivenom during pregnancy in brain tissue of dams and their pups. Totally, 12 pregnant-Wistar Albino rats were randomly divided into two groups as venom-antivenom administration (n=6) and control groups (n=6). In venom-antivenom administration g...

Objectives:Ligation during ovariohysterectomy (OHE) or surgical operations of the ovary affect the integrity and structure of the tissue. Evaluation of the ovarian follicle appearance and structures become important, especially if the removed ovaries are to be frozen and thawed and re-transplanted in patients receiving chemotherapy/radiotherapy. Ac...

Endometritis is characterized by inflammation of the endometrial lining that leads to reduced reproductive potential. Restoring the impaired hormonal balance is an important component of endometritis treatment. The purpose of the current study was to evaluate the effects of resveratrol on estrogen and progesterone hormone status in endometritis. Ma...

Background Rumex crispus L. (Polygonaceae), known as “Labada” in Turkey, was reported to be used for the treatment of gynecological diseases such as postpartum complications and infertility in folk medicine. Earlier studies on R. crispus have shown that leaf, fruit and root extracts have anti-inflammatory and antioxidant activities and are used for...

Article history: The aim of the present study was to investigate the therapeutic effects of Teucrium chamaedrys L. (Lamiaceae) in the experimentally induced endometriosis in rats. Endometrial tissue was implanted into the abdominal wall of thirty Sprague Dawley rats; the rats with endometriosis were randomized into five groups and treatment procedu...

Endometriosis is an estrogen-dependent diseases associated with pain and infertility with features of most frequently symptoms according chronic inflammation, dysmenorrhoea, deep dyspareunia, dyschezia and dysuria. Functional endometrial and stromal tissue implants exist outside the uterine cavity and causes inflammatory processes. Therefore, sever...

The uterus in sheep is more resistant to invasion of microorganisms after parturition and bacterial elimination can occur rapidly compared to other animal species. In spite of this feature of the uterus, the distocia, assisted delivery, stillbirth or the infection-induced abortions, uterine prolapse and unhygienic environmental conditions are predi...

Abstract: The aim of this study was firstly to determine the relationship between estrous cycle and oxidative stress in reproductive tissues in bitches. This research was performed in twenty-nine healthy bitches from different breeds and of varied ages (the range was 2-5 years) that were brought to the clinic for routine ovariohysterectomy. The sta...

Endometritis is an inflammatory disorder of the endometrial lining of the uterine tissue in postpartum stage. Endometritis mostly progresses subclinically and causes infertility through the disruption of the hormonal balance. It has been shown in many studies that resveratrol has anti-inflammatory and antioxidant properties. However, the possible b...

Incidents of scorpion stings are common in Turkey. These cases can cause severe envenomation and so represent an important public health problem. In Turkey, the most venomous species are Leiurus abdullahbayrami and Androctonus crassicauda. There has been no study on the effects of A. crassicauda stings on pregnant rats. Consequently, we investigate...

The aim of this study was to determine the short-, mid- and long-term effects of cloprostenol (a synthetic analogue of prostoglandin F2α, PG) and equine chorionic gonadotropin (E) administration on reproductive organs (uterine tissue and ovaries) in female rats. Three different groups, PG, E, and control (C), were created, as well as six subgroups...

Ovarian tissue (OT) cryopreservation is a promising approach for fertility preservation. The objective of this study was to investigate the effect of “needle immersed vitrification” technique for cryopreservation of dog OT. The OT (n= 40 dogs) were collected by elective ovariohysterectomy procedure and each OT was divided into 2 pieces as fresh con...

The vitrification of ovarian tissue has the potential to preserve the fertility. The purpose of the present study was to reveal the effects of cryoprotectant agent temperature on the morphological and ultrastructural features of follicle in dog ovarian tissue. The ovarian tissues were classified as control and two vitrification groups. The forty ti...

The object of this study was to compare the histopathologic change in uterus as well as the findings of clinical and bacteriological of twentyfour bitches with pyometra. Uterine lesions were grouped as acute endometritis, subacute endometritis, acute metritis, subacute metritis. Complete blood-count, blood biochemical parameters and toxin levels we...

Researchers have been investigating new treatment strategies for the management of pseudopregnancy, due to some long term causes of this disease including mastitis and mammary tumor. Owing to the side effects of hormone therapy, much attention has been focused on more tolerable treatment options including natural remedies. In the present study, we...

In this study, the efficiency of the ‘‘Needle Immersed Vitrification’’ technique was tested on cryopreserved feline ovarian tissue. For vitrification, ovarian fragments (0.5–1.5 mm2) from each ovary were collected; the grafts were exposed to 7.5–15% ethylene glycol and 7.5–15% dimethyl sulfoxide at room temperature and stored in liquid nitrogen at...

Gynecologic cancers are among the most common cancers in humans and animals. Treatment success depends on several factors including stage at diagnosis, tumor type, origin and metastasis. Currently, surgery, chemotherapy, and radiotherapy are preferred in the treatment of these cancers. However, many anticarcinogenic drugs can cause severe adverse e...

Özet: İntra-abdominal adezyon, başta jinekolojik operasyonlar olmak üzere pek çok abdominal cerrahi girişim sonrası ortaya çıkan; ağrı, intestinal veya üretral tıkanma gibi klinik semptomlarla kendini gösteren önemli bir komplikasyondur. Abdominal boşlukta fibrin oluşumu adezyon patofizyolojisinin temelini oluşturmaktadır. İntra-abdominal adezyonla...

This report describes a case of spontaneous abortion in a 4-year-old Golden Retriever dog with ovarian endometriosis. Clinical findings indicated that there was not any senstivity in the abdomen and the viability parameters were within the reference values. On vaginal examination, serosanguineous discharge was determined. Ultrasonographic examinati...

Objective: Sea buckthorn (Hippophae rhamnoides L.) and St. John's wort (Hypericum perforatum L.) are used as an emmenagog and for the treatment of other gynecological disorders including uterus inflammation and endometriosis. The aim of the present study is to investigate the potential of a mixture of sea buckthorn and St. John's wort oils (HrHp oi...

The present case report describes a 6-year-old, mixed-breed bitch that was referred due to anorexia, polyuria, polydipsia, and lethargy for 2 weeks. The bitch had been spayed 4 years previously at a different clinic. Vaginal inspection by speculum and cytology was not possible because the vaginal canal had been closed surgically. Stump pyometra was...

Ethnopharmacological relevance: Endometriosis is a gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. The fruits of Viburnum opulus L. have been used to treat gynecological disorders including primary and secondary dysmenorrhea and ovarian cysts. Materials and methods: Air-dried and powdered fr...

Abstract: In this case report it was described that 3 years old Siamese female cat which was bred four times but could not get pregnant, is brought to our clinic for ovariohysterectomy. On clinical examination, the cat was in good general condition, viability parameters were between reference values, and vaginal discharge was not observed. Ovariohy...

This report describes a case of a typical serous borderline tumor of the ovary in a 6-year-old Pointer dog. Although ovarian tumors are rare in dogs, epithelial tumors are the most frequently diagnosed ovarian tumors. A borderline tumor, which is an epithelial tumor of the ovary, was initially identified in a badger. This case is the first publishe...

Gonadotropin salici hormon (GnRH), on hipofizden folikul uyarici hormon (FSH) ve luteinlestirici hormon (LH) salinimini uyararak, ovaryum fonksiyonlarini kontrol eder. Dogal GnRH molekulunde bulunan aminoasit yapilarinin degistirilmesi sonucu gelistirilen GnRH analoglari, endojen GnRH’ya gore daha guclu ve etkilidir. Genellikle ostrusun uyarilmasi...

The aim of the present study was to assess the activity of the hazelnut oil in the treatment of polycystic ovary syndrome in rats. Serum follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, testosterone, serum lipid parameters, leptin and glucose levels were evaluated. Moreover, antioxidant activity was tested using superoxid...

The aim of this study was to determine the effectiveness of dry-off antibiotic therapy and teat sealant on somatic cell count (SCC) in Saanen goats. The goats were randomly divided into 3 groups. In Groups I (n = 50) and II (n = 50), the goats were treated with intramammary antibiotics and a combination of intramammary antibiotics and internal teat...

The aim of this study was to determine the risk factors for subclinical heifer mastitis and to create a model that can predict the prevalence of subclinical mastitis of pregnant heifers in farms in Turkey. Lacteal secretion samples were taken from 439 pregnant (6–9 months) heifers and bacteriological analyses were performed. In this study, 37.47% o...

Thuja occidentalis L. (Cupressaceae) has been used in folk medicine for the treatment of rheumatism, amenorrhea, cystitis, and uterine carcinomas, and as an abortifacient and contraceptive. The present study aimed to determine whether T. occidentalis oil and α-thujone could be beneficial in the treatment of polycystic ovary syndrome (PCOS). T. occi...

The aim of the present study is to evaluate the treatment potential of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in the experimentally induced endometriosis model in rats. Endometriosis was surgically induced in rats by autotransplanting endometrial tissue to abdominal wall. Thirty-six rats were randomly divided into six groups...

The aim of the present research is to evaluate the antiurolithiatic effect of the various extracts prepared from the fruits of Viburnum opulus L., in regard to its ethnobotanical record. To induce urolithiasis, 70 mg/kg sodium oxalate was injected to the rats which were housed individually in metabolic cages. The test materials were applied during...

Background: Feline mastitis is an uncommon infl ammation of mammary gland that is caused by bacterial infection of lactating gland or during pseudopregnancy. Milk accumulation may cause acute septic mastitis due to congestion of milk. It is believed that the microorganisms gain entrance via fi ssures in the nipples and adjacent skin or spread by wa...

In this study, uterine rupture and postoperative process were described in a pregnant queen who referred to clinic due to trauma. On clinical examination, a brownish vaginal discharge, abdominal pain and tenderness were observed. Transabdominal ultrasonography revealed that increased intraperitoneal fluid and a linear anechoic area extended to ante...

Ovarian remnant syndrome (ORS) is the presence of functional ovarian tissue with signs of oestrus as a complication after ovariohysterectomy (OHE) or ovariectomy. Stump pyometra is another complication that can be observed after OHE. However, there are few reports about ORS and stump pyometra in queens. In this report, three queens with recurrent o...

zet: Bu çalışmada, köpeklerde pyometra hastalığının teşhisinde, bazı kan parametreleri değerlerine göre optimal pozitiflik eşiğinin (kesim noktası) ROC eğrisi yöntemiyle belirlenmesi amaçlanmıştır. Uygulamadaki veriler, Ankara Üniversitesi Veteriner Fakültesi Doğum ve Jinekoloji Kliniği'ne pyometra şüphesi ile gelen köpeklerden elde edilmiştir. Çal...

zet: Pyometra, tanısının geciktiği olgularda ölümcül olabilen bir hastalıktır. Geliştirilen birçok tanı yöntemi, hastalığın hem erken dönemde teşhis edilmesi hem de prognozu hakkında bilgi vererek tedavi seçeneklerinin ortaya konmasını sağlamıştır. Sunulan bu derlemede, pyometralı köpeklerde tanı yöntemleri ve bununla ilgili son yıllardaki çalışmal...

The aim of this study was to determine the incidence and levels of the gram negative bacterial endotoxin, and to investigate the effects of antiendotoxemic treatment along with operation. Thirty bitches with pyometra were used in this study. The bitches were randomly allocated into two groups as Group I (treated with polymyxin E-ampisillin) and Gro...

The aim of this study was to investigate the prognosis, the risk status and the death reasons in dead and recovered bitches with pyometra after the operative approach by comparing serum biochemical, and haematological parameters, as well as bacteriological and clinical findings. Bitches with pyometra (n=30) were ovariohysterectomized. Eight bitches...