Ayşe Ağbaş

Ayşe Ağbaş
Istanbul University-Cerrahpasa · Pediatric Nephrology

MD

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51
Publications
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388
Citations

Publications

Publications (51)
Article
Full-text available
Background This study aims to identify epidemiological and clinical characteristics of patients and report our experience with eculizumab treatment during an outbreak of hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli (STEC) in Istanbul in 2015. Methods Thirty-two children (21 females, median age 3.25 years) were i...
Article
Background: Hypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce. Methods: The HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialys...
Article
Full-text available
Objective: The kidney is the second most commonly affected organ by severe acute respiratory syndrome coronavirus-2, characterized by hematuria, proteinuria, and acute kidney injury. There are few studies describing renal involvement in pediatric cases. Materials and methods: This retrospective study evaluated the prevalence of hematuria, protei...
Article
Full-text available
We evaluated the demographic features, etiologic risk factors, treatment strategies, and outcome of the infants and children with urolithiasis (UL). A retrospective multicenter study was conducted including 23 Pediatric Nephrology centers in Turkey. The medical records of 2513 children with UL were reviewed. One thousand, three hundred and four boy...
Article
Background The “HDF-Heart-Height” study showed that haemodiafiltration (HDF) is associated with improved growth compared to conventional haemodialysis (HD). We report a post-hoc analysis of this study assessing the effect of extracorporeal dialysis therapies on nutritional indices. Methods 107 children were included in the baseline cross-sectional...
Article
Full-text available
Background: Our aim was to identify acute kidney injury (AKI) and subacute kidney injury using both KDIGO criteria and urinary biomarkers in children with mild/moderate COVID-19. Methods: This cross-sectional study included 71 children who were hospitalized with a diagnosis of COVID-19 from 3 centers in Istanbul and 75 healthy children. We used...
Article
Full-text available
Predictors of early diagnosis and severe infection in children with coronavirus disease 2019 (COVID-19), which has killed more than 4 million people worldwide, have not been identified. However, some biomarkers, including cytokines and chemokines, are associated with the diagnosis, pathogenesis and severity of COVID-19 in adults. We examined whethe...
Article
Background: The phenotypic and genotypic spectrum and kidney outcome of PLCε1-related kidney disease are not well known. We attempted to study 25 genetically confirmed cases of PLCε1-related kidney disease from 11 centers to expand the clinical spectrum and to determine the relationship between phenotypic and genotypic features, kidney outcome, an...
Article
Full-text available
Aim:It can be challenging to distinguish between influenza and coronavirus disease-2019 (COVID-19) during the influenza season. Therefore, we aimed to compare the clinical symptoms, laboratory findings, and outcomes of these two diseases in children.Materials and Methods:Thirty-two children with COVID-19 and 22 children with influenza who were hosp...
Article
Various molecular and cellular processes are involved in renal fibrosis, such as oxidative stress, inflammation, endothelial cell injury, and apoptosis. Heat shock proteins (HSPs) are implicated in the progression of chronic kidney disease (CKD). Our aim was to evaluate changes in urine and serum HSP levels over time and their relationships with th...
Article
Full-text available
Vitamin D has an immunomodulating property that regulates the inflammatory response. In this study, the aim was to evaluate the relationship between vitamin D levels and clinical severity and inflammation markers in children and adolescents with COVID-19. The clinical and laboratory records of 103 pediatric cases with COVID-19, whose vitamin D leve...
Article
Background Children are one of the most vulnerable groups in conflict zones, especially those with chronic diseases. This study aimed to investigate kidney disease profiles and problems during follow-up in a population of Syrian refugee children residing in Turkey.Methods Syrian refugee children aged between 0 and 18 years were included in the stud...
Article
Full-text available
Background Patients on dialysis have a high burden of bone related comorbidities including fractures. We report a post-hoc analysis of the prospective cohort study “HDF-Heart-Height” to determine the prevalence and risk factors for CKD-related bone disease in children on hemodiafiltration(HDF) and conventional hemodialysis(HD). Design 144 children...
Article
Background: Nephrocalcinosis (NC) is defined as calcium deposition in the kidney parenchyma and tubules. This study aims to determine the etiology, risk factors and follow-up results of patients with NC in Turkey. Materials and methods: Patients diagnosed with NC in the Pediatric Nephrology Department Units of 19 centers from all geographical re...
Article
Full-text available
What is Known?• Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection• Vitamin D binding protein (DBP) is the key transport protein which, along with albumin, binds over 99% of the circulating vitamin D metabolitesWhat is New?• Lower 25 OH vitamin D levels were associated with higher inflammation mark...
Article
Background: Hypertension is prevalent in children on dialysis and associated with cardiovascular disease. We studied the blood pressure (BP) trends and the evolution of BP over 1 year in children on conventional hemodialysis (HD) vs. hemodiafiltration (HDF). Methods: This is a post hoc analysis of the "3H - HDF-Hearts-Height" dataset, a multicen...
Article
Background Although similar factors play a role in both PTA and anemia in patients with CKD, additional risk factors exist in the pathogenesis of PTA. The present study aimed at comparing anemia and inflammation‐related parameters between RTx recipients and CKD patients and elucidating the risk factors of PTA. Methods This single‐centered, cross‐s...
Article
Full-text available
Objective Cardiovascular morbidity is high in patients with coarctation of aorta even after successful repair. This study aimed to assess the frequency of late hypertension and the relationship between ambulatory hypertension and cardiovascular target organ damage in children and adolescents after early and successful repair of coarctation of the a...
Poster
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Background and Aims Alport syndrome (AS) is an inherited glomerular basement membrane disease caused by mutations in COL4A3, COL4A4 or COL4A5 genes. Recently, it has been reported that focal segmental glomerulosclerosis (FSGS) can be seen in AS and COL4A mutations can be detected in FSGS. In this study, we aimed to define the clinical characteristi...
Article
Background Alport syndrome (AS) is an inherited glomerular disease caused by mutations in COL4A3, COL4A4, or COL4A5. Associations between clinical manifestations and genotype are not yet well defined. Our study aimed to define clinical and genetic characteristics, establish genotype–phenotype correlations, and determine prognosis of AS in children....
Article
Introduction: The objectives of this study were to determine the incidence of congenital anomalies of the kidney and urinary tract (CAKUT) in asymptomatic first-degree relatives of patients with a CAKUT diagnosis and to evaluate the benefits of such screening. Methods: Files of patients who were followed up at Cerrahpaşa Faculty of Medicine, Ped...
Article
The original version of this article unfortunately contained a mistake. The answer to question 3 was presented incorrectly. The correct answer is given below.
Article
Background: This study aimed to evaluate the cardiometabolic risk factors in normotensive obese and hypertensive obese (HT-obese) children by comparison of anthropomorphic measurements, fat distribution, carotid artery intima-media thickness (CIMT), and inflammatory markers. Methods: Fifty-three obese patients 10-18 years of age with a BMI-for-age...
Article
Background: Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment and long-term outcome. Methods: We contacted paediatric and adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic and clinical data in an online form. Re...
Article
Full-text available
Background: Cardiovascular disease is prevalent in children on dialysis and accounts for almost 30% of all deaths. Randomised trials in adults suggest that haemodiafiltration (HDF) with high convection volumes is associated with reduced cardiovascular mortality compared to high-flux haemodialysis (HD); however paediatric data are scarce. We design...
Article
Full-text available
Background: This study aimed to evaluate plasma concentrations of leptin and total ghrelin in children with chronic kidney disease (CKD) and assess their roles in protein-energy wasting (PEW). Methods: This study consisted of three different CKD populations [CKD group (20 patients with non-dialysis CKD), dialysis group (39 patients on dialysis),...
Data
Comparison of the biochemistry data of the patients on HD and HDF. (PDF)
Data
Comparison of the inflammatory, oxidative stress and endothelial markers between HD and HDF in incident and prevalent patients. (PDF)
Data
Comparison of the inflammatory, oxidative stress and endothelial markers between HD and HDF. (PDF)
Article
Background and objectives: Autosomal dominant polycystic kidney disease is the most common inheritable kidney disease, frequently thought to become symptomatic in adulthood. However, patients with autosomal dominant polycystic kidney disease may develop signs or symptoms during childhood, in particular hypertension. Although ambulatory BP monitori...
Article
Objective: To evaluate and compare the accuracy of the Onal and Dogan nomograms for prediction of stone-free rate after shock-wave lithotripsy (SWL) in children. Methods: We retrospectively analyzed the medical records of children <18 years old who had been treated with SWL for kidney stone in our department between January 2014 and December 201...
Article
Full-text available
Background: There are limited data on infants with atypical hemolytic uremic syndrome (aHUS). The aim of this study was to determine the clinical and laboratory features, and to evaluate treatment modalities and outcomes in infants with aHUS. Materials and methods: Relevant data on patients with onset of aHUS at age <2 years were obtained from t...
Article
Full-text available
Systemic lupus erythematosus and Sjögren’s syndrome are chronic auto-inflammatory disorders which can lead to serious organ damage. Although systemic lupus erythematosus and Sjögren’s syndrome were previously considered two forms of the same disease because of presence of clinical coexistence of these two conditions, the view that they are two diff...
Article
Atypical hemolytic uremic syndrome (aHUS) is mostly linked to defects in the regulation of alternative complement pathway, but a rare form is caused by an inherited defect of cobalamin 1 metabolism. Cobalamin C (cblC) deficiency is an autosomal recessive disorder of vitamin B12 metabolism that results from mutations in methylmalonic aciduria and ho...
Article
Background Cardiovascular disease (CVD) is an important complication of chronic kidney disease (CKD) in children. However, it is not well known when and how cardiovascular alterations start. Methods This cross-sectional, controlled study consisted of 25 patients and 28 healthy controls. 24-h ambulatory blood pressure monitoring, aortic pulse wave v...
Conference Paper
Full-text available
Giriş Üreter taşlarına etkinliği bilinse de, çocukluk çağı böbrek taşlarında doksazosin kullanımı ve etkinliğine dair yapılmış çalışma yoktur. Bu çalışmanın amacı 1 cm’den küçük böbrek taşı saptanan çocuk hastalarda, doksazosinin taş düşürme süresi ve oranı üzerine olan etkisini incelemektir. Gereç-Yöntem Ocak 2013- Ağustos 2015 tarihleri arasında,...
Article
Full-text available
Primary Sjögren syndrome (pSS) is an uncommon disease in childhood. Childhood pSS might have different clinical manifestations than adult pSS. We describe a 13-year-old girl with multiple episodes of bilateral parotid swelling lasting 2 years. Her history included severe arthralgia, local edema, and purpura episodes since 9 years of age. During her...

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