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Ayhan Filazi

Ayhan Filazi
Ankara University · Department of Pharmacology and Toxicology (Faculty of Veterinary Medicine)

Dr.

About

169
Publications
86,589
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Introduction
Ayhan Filazi currently works at the Department of Pharmacology and Toxicology (Faculty of Veterinary Medicine), Ankara University. Ayhan does research in Aquaculture, Environmental Science and Animal Science. His areas of expertise are veterinary pharmacology and toxicology include analytic toxicology, residues in food, feed, envrionmental, pharmacokinetic/toxicokinetic, pesticides, antibacterial treatment. His current projects are the studies on the environmental toxicity and determination of persistent organic pollutants in food and environmental samples.'
Additional affiliations
September 1989 - present
Ankara University
Position
  • Lecturer

Publications

Publications (169)
Article
Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons (PAHs) are endocrine-disrupting chemicals (EDCs). Their presence in the environment is particularly concerning in cases of fetal exposure, which is the most vulnerable period of life for both human and ani...
Article
Full-text available
Sublethal effects of low and high molecular weight phthalates were assessed in Unio with a biomarker approach using gills and digestive gland as the main targets of xenobiotic uptake. Diisononyl phthalate, diisodecyl phthalate and dimethyl phthalate were studied for aquatic toxicity to nontarget freshwater mussels. Adult Unio sp. were exposed to su...
Chapter
Boron is a naturally occurring element present in the form of borates in oceans, sedimentary rocks, coals, shale, and some soils. Inorganic borate compounds are used in industrial and medical applications. Boron can be released into air, water, or soil after natural weathering of soils and rocks. The major sources of boron exposure are food, and to...
Chapter
Vitamin A, a fat-soluble vitamin, is necessary for the development and maintenance of the organism for differentiation, growth, embryonic development, and homeostasis. Many natural and synthetic compounds are developed as potential pharmacologic agents for use in treating ailments ranging from cancer to acne. The physiological role of vitamin A and...
Chapter
Perfluoroalkyl and polyfluoroalkyl substances are synthetic chemicals used in many industrial and chemical products that are persistent in the environment. Exposure to general population to PFASs is inevitable mainly through oral routes but also inhalation and dermal routes as traces are found in drinking water, food packaging materials, foods, con...
Article
Full-text available
This study aims to develop a reliable and valid awareness scale that assesses levels of Endocrine Disruptor Chemicals (EDCs) engagement among allied health professionals for risk management. Preliminary item pool was created in collaboration with the expert research team and classification of the items to the sub-domains of awareness was done by th...
Article
Curcumin; the major polyphenolic compound, isolated from Curcuma longa L.; loaded polyvinylpyrrolidone K90 fibers were prepared using electrospinning method. Effectiveness was tested on human colorectal adenocarcinoma cells with the presence of the endocrine disrupter Bisphenol A. Curcumin-loaded fibers were shown to have good physicochemical prope...
Article
Full-text available
The ubiquitous use of antibiotics leads exposure of these chemicals on non-target aquatic species, while the toxicity assays for these chemicals are time/labor consuming and expensive. Alternative approaches using primary cell cultures which retain the tissue functionality at its highest form have received global attention compared to cell lines. I...
Article
Honeybees are exposed to several antropogenic environmental pollutants and able to transfer these compounds to their products. There are limited research on detection of several pollutants at the same time in bee products. This study aimed to investigate the residues of organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybromina...
Article
Bat populations have been steadily declining, most likely due to anthropogenic factors. Identification and classification of these risks have crucial importance to ensure the survival of this species. Bats often coexist with humans in urban, industrial, and agricultural areas and are potentially exposed to a range of environmental pollutants. We se...
Article
Synthetic pyrethroids and neonicotinoids are the most common pesticides used globally due to their low toxicity in mammals. Residues at very low concentrations and in mixtures are of concern to benthic species as these organisms are commonly exposed through water, particulate material, or sediments. In the current study, the cytotoxic effects of fl...
Article
Scorpions are arthropods covered with a thick layer of chitin, whose adult individuals have a length of 11,5-220 mm. Due to their venomous sting and predation nature, humans usually fear them. In scorpion envenomation, it is necessary to apply antivenom especially for patients with severe symptoms. Turkey is a suitable country for scorpion life in...
Chapter
Although endocrine system in cage birds is similar to the basic system in mammals, anatomical, physiological and biochemical differences are differentiated from mammals with their prognostic characteristics and require special treatment approaches. Due to the restricted number of studies in the field, the non-specificity of the diagnostic kits and...
Chapter
Recognition of potential toxins in birds may contribute to the prevention of poisoning in mammals living in the same environment. Birds are more sensitive to some substances than mammals. It is important for human health and the environment to learn the effects of potential poisons on the health and reproduction of birds. This review focused on the...
Article
Full-text available
It is important to investigate the monthly level of trace metals in freshwater systems to assess environmental health. This information can be used to support effective management and control of natural areas in regard to the introduction and bioavailability of chemicals in the aquatic environment. We aimed to determine monthly changes in the level...
Article
Full-text available
Environmental pollutants with endocrine-disrupting effect are of global importance due to their contribution to the aethiologies of variety of complex diseases. These lipophilic pollutants are persistent in the environment and able to bioaccummulate in nontarget organisms. BPA, DEHP and PCB118 (dioxin-like PCB) are associated with endocrine disrupt...
Article
Full-text available
Phthalates, which are among the most abundant plasticizers, have detrimental effects on the reproductive system. Similar to human, dogs are prominently exposed to phthalates in daily routines at low concentrations; while toys, training devices and commercial dog foods are considered as the primary sources of exposure. This study aimed to reveal and...
Article
Bee products produced in environments with persistent organic pollutants (POPs) may be contaminated by these compounds. Propolis usually consists of beeswax, resins, water, inorganic and phenolic substances, and essential oils. Although there are some studies on the detection of POPs in honey and some bee products, these are quite limited. Because...
Article
Full-text available
The novel coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has been described as a global pandemic. Regardless the efforts all over the world, there is still no effective treatment or vaccine. Therefore, prevention, early virus detection and identification methods are crutially important for dise...
Article
The most common persistent organic compounds are organic chlorinated pesticides, polybrominated diphenyl ethers and polychlorinated biphenyls, which have adverse effects on human, animal and environmental health. Eğirdir lake is fourth-largest lake of Turkey that is located in the Mediterranean area between Sultan and Karakus mountains in the provi...
Chapter
Bor periyodik tablonun IIIA kısmında yer alan atom numarası 5 ve molekül ağırlığı 10.81 olan metalloid (yarı metal) bir elementtir. Amerika Birleşik Devletleri (ABD), Türkiye ve Rusya bor bileşiklerinin üretimi bakımından lider konumda olan ülkeler olup, bunları Arjantin, Şili ve Çin takip etmektedir. Doğada serbest halde bulunmayan bor inorganik v...
Chapter
Boron is a metalloid element, in which USA, Turkey, and Russia are the leading countries in the production of boron compounds, followed by Argentina, Chile, and China. Boron is not found as free in nature; while it is present as inorganic and organic compounds. Under normal physiological conditions, only organoboron compounds are important for biol...
Article
We aimed to develop a rapid, simple, and reproducible method based on liquid chromatography/tandem mass spectrometry (LC‐MS/MS) to analyze β‐agonist residues (clenbuterol, zilpaterol, ractopamine, and isoxsuprine) in bovine tissues. The method was validated in accordance with the European Council Decision 2002/657/EC. The samples were homogenized,...
Article
Full-text available
Although the studies on ear, nose and throat (ENT) diseases and treatment methods are high in human medicine, they are rarely performed and neglected in veterinary medicine. Antibiotics are generally preferred for ENT diseases in animals. However, there is an increase in infections from microorganisms that develop multiple antibiotic resistance due...
Article
The study aimed to evaluate the effects of heat on macrocyclic lactone residues in cows’ milk. Ivermectin, abamectin, doramectin, eprinomectin and moxidectin were added to raw milk in three concentrations. The milk was then pasteurised (40 seconds at 74°C or 1 minute at 80°C) and boiled (10 minutes at 100°C). The analyses were performed with a vali...
Article
Full-text available
Polychlorinated biphenyls (PCBs), which cause environmental pollution, are found in animal-based fatty foods. Due to their long half-life and lipophilic properties, they can accumulate in the fat tissues of cattle. The study was conducted to compare the PCB levels (PCB28, 52, 101, 118, 138, 153, and 180) in the different fat tissues (muscle, liver,...
Article
Full-text available
This study aimed to measure zinc (Zn), selenium (Se), copper (Cu), iron (Fe), chromium (Cr), nickel (Ni), lead (Pb), cadmium (Cd), arsenic (As), and aluminum (Al) in whole, semi-skimmed, skimmed, organic, fruit-flavored (strawberry, banana, and cocoa), pasteurized, and raw cows’ milk. The samples were collected from sterilized and pasteurized milk...
Chapter
Tek sağlık, insan, hayvan ve çevrede en uygun sağlığı elde etmek için farklı disiplinlerin yerel, ulusal ve küresel düzeyde işbirliği içinde çalışmasını sağlayan bir yaklaşımdır. Tek sağlık üçlüsünü oluşturan disiplinler birbirlerine ayrılmaz bağlarla bağlıdır. Veteriner Hekimler hayvan refahı ve sağlığına yapmış oldukları katkılarla bu üçlünün en...
Article
Full-text available
Yasaklanmalarının üzerinden onlarca yıl geçmesine rağmen kalıcılıkları nedeniyle hala doğada bulunabilen Kalıcı organik kirleticiler (KOK)’den organik klorlu pestisit (OCP), polibromlu difenileter (PBDE) ve poliklorlu bifenil (PCB)’ler sedimentte birikerek çevre ve iklim koşullarına bağlı olarak suya geri salınmaktadırlar. Kızılırmak Nehri ise İç A...
Article
Full-text available
The history of endocrine disrupting chemicals that alter the synthesis/degradation of natural hormones by binding or activating endocrine receptors in the body goes back to the 1950s. Organochlorine pesticides (OCP), Polichlorinated biphenyls (PCBs) and Polybrominated diphenyl ethers (PBDEs), which are currently banned but are used extensively for...
Conference Paper
Full-text available
Due to the rapidly growing world population and changing demographic structure, the amount of global animal protein need is also rapidly increasing. Reasons such as limited agricultural areas, high amount of water need for agricultural activities, reduced availability of usable water and effects on global warming of greenhouse gases emitted to the...
Article
Full-text available
Among environmental endocrine-active chemicals, phthalates, commonly known as plasticizers, disrupt the development of the male reproductive tract. In this study, the effects of phthalates (DIBP, BBP, DINP, DBP, DEP, DEHP and DMP) were evaluated on cultures of bovine primary male reproductive cells (n = 3) and spermatozoa (n = 4). Epididymal (caput...
Poster
Purpose: Curcumin is the major polyphenolic compound of curcuminoids, extracted from Curcuma longa L. (turmeric). Curcumin gained increasing interest for its anti-inflammatory, anti-diabetic, anti-carcinogenic and anti-rheumatic properties with good tolerability and safety. However, several problems prevent marketing of curcumin as a drug such as t...
Conference Paper
Full-text available
Aim: Among phthalates DEHP (Bis(2-ethylhexyl) phthalate) and Bisphenol A (BPA) are estrogen active compounds. Eventhough its ban in toys and catheters, there are still various possible exposure scenarios. In estrogen receptor (ER)-positive breast cancers, environmental estrogen active compounds pose a risk for prominent treatment. In this study, we...
Conference Paper
Full-text available
Content Purpose: Curcumin is the major polyphenolic compound of curcuminoids, extracted from Curcuma longa L. (turmeric). Curcumin gained increasing interest for its anti-inflammatory, anti-diabetic, anti-carcinogenic and anti-rheumatic properties with good tolerability and safety. However, several problems prevent marketing of curcumin as a drug...
Poster
Transport proteins in the trophoblast cells in the placenta are responsible for the transplacental displacment of the xenobiotics (taking them in and out of cells) and protecting the fetus from maternal toxins. Environmental pollutants; they interacts with these transport proteins, increases and decreases their expression, and causes toxicokinetic...
Article
Full-text available
Veterinary vaccines have an important role in protecting both animal and public health, ensuring animal welfare, in reducing and preventing the loss of performance and economic loss due to animal diseases, in reducing the suffering of animals due to diseases, in ensuring the efficient production of animal originated foods necessary for the feeding...
Article
Full-text available
The use of pesticides is important in order to maintain the productivity in animal production and protect the crops in agriculture and to increase productivity, while veterinary medicines are sometimes used as preservatives and sometimes as medicines. Due to the substances and their degradation and metabolism products, they continue to exist in the...
Chapter
Due to global trend in healthy food from farm to fork which compromises human health, food safety, and environmental protection, consumers today are more sensitive to contaminant-free foods of animal origin. These contaminants are mainly fertilizers, biotechnological additives, agricultural products, pesticide residues, veterinary medicines, chemic...
Chapter
As a result of growing consumer demand for “clean, green, and ethical” products related to public awareness of environmental and health risks of veterinary medicinal products—and the increase in antimicrobial resistance, leading to loss of effectiveness—beef and dairy producers are striving to find effective alternatives. Nutraceuticals provide a v...
Chapter
The use of antibiotics at subtherapeutic doses with the aim of accelerating growth in poultry animals has either been prohibited or restricted in many countries, as it causes antibiotic-resistant microorganisms to develop and is a danger to consumers’ health. Excluding antibiotics from the diets of poultry animals has caused various performance and...
Article
Full-text available
Mycotoxins which are secondary metabolites of fungi have been reported to be carcinogenic, genotoxic, teratogenic, nephrotoxic and hepatotoxic. Mycotoxins, which are found in all stages of food and feed industry, also cause economic losses. Therefore, research and development studies for the control of mycotoxins are being carried out quite widely....
Chapter
Fast, sensitive, economic and 3R compatible new alternative methods are seeked in order to investigate the effects of the increasing diversity and quantity of pollutants on the ecosystem. Among these methods, invertebrates as biomonitors have an important role due to their bioaccumulation, widespread distribution and their abundance in the environm...
Chapter
Endokrin bozucu kimyasalların sucul sistemde yoğun olarak biriktiğinin tespit edildiği 1990'lardan itibaren, su ve sedimentlerdeki endokrin bozucuların etkinliğinin belirlenmesi oldukça önem kazanmıştır. Bu makalede amaç, su ve sedimentlerde endokrin sisteme etkili bileşiklerin östrojenik, androjenik ve progestojenik aktivitelerinin belirlenmesinde...
Chapter
Arılar hayatın devamı için vazgeçilmez canlılar olduklarından, zehirlenmelerine neden olan kimyasal maddeler hakkında bilgi vermek ve konuya dikkat çekmek amaçlanmıştır. Bal arıları, gerek doğal ve gerekse sentetik kaynaklı birçok maddeye maruz kalabilirler. Bazı doğal toksinler, arılar tarafından iyi tolere edilir ve hatta yararlı olurken, bazılar...
Technical Report
Full-text available
Androctonus crassicauda'dan elde edilen ve Türk Farmakopesine eklenen Türkiye'ye özgü akrep serum monografı
Article
Full-text available
An increasing amount of evidence suggests that phthalic acid esters (PAE), polychlorinated biphenyls (PCB), polybrominated diphenyl ethers (PBDE), and organochlorine pesticides (OCP) are related to mutagenic, carcinogenic, and endocrine disruptor effects (EDCs). These lipophilic compounds are highly resistant to breakdown processes, and consequentl...
Article
We aimed to determine and compare the nutrient and total aflatoxin (AF) content of ground red chili peppers from three different highest production regions of Turkey. Of the collected samples, 51.12% were found to be contaminated with AFs, while only 28.89% contained AF over maximum residue limits. AFB1 contamination in peppers was directly correla...
Article
Full-text available
Persistent organic pollutants (POPs) are banned in almost all countries due to their adverse health effects while they are still present in the environment due to their persistence. As the dissipation and the emission factors of POPs change by temperature and other environmental factors current study aimed to determine selected POPs, including poly...
Conference Paper
Full-text available
Among environmental contaminants polychlorinated biphenyls (PCBs) are still a concern due to their persistence in environment. As an emerging contaminant, they are directly linked to climate change and few studies are available for their relation between microbiota including bacteria. Antibiotic resistance (AMR) as an increasing global issue, is st...
Article
Full-text available
Herbal bioenhancers are active phytomolecules that increase the bioavailability, bioefficacy and biological activity of various drugs when coadministered at low concentrations. These valuable compounds reduce the dose, increase the treatment rate, decrease the treatment duration, drug resistance or related adverse reactions which have economical im...
Chapter
Amitraz is a formamidine derivative pesticide that is widely used in the preservation of agricultural products and the control of ectoparasites in animals. Due to its lipophilic property, amitraz is rapidly absorbed from the applied area, and may cause poisonings in horses and humans, and especially in cats and dogs. Therefore, its use is not recom...
Chapter
Boron is a naturally occurring element present in the form of borates in oceans, sedimentary rocks, coals, shale, and some soils. Inorganic borate compounds are used in industrial and medical applications. Boron can be released into air, water, or soil after natural weathering of soils and rocks. The major sources of boron exposure are food, and to...
Article
Full-text available
In order to preserve the global food safety; stakeholders from industry, government and academia related to poultry sector are required to renew and improve methods to encounter climate change, reemerging infectious diseases, environmental pollutants, antimicrobial/antiparasitic resistance and high production standards. Parasitic diseases in poultr...
Article
Full-text available
Antibacterial agents are the most important tools in the treatment and control of bacterial infections of poultry. The choice of the correct drug to prevent antibiotic resistance and to reduce overuse of medication should be well-characterized by dose and duration of treatment. This responsibility belongs mainly to veterinarians. For this reason, t...
Article
Full-text available
Phthalates are potential endocrine-disrupting chemicals, found widely in the environment, and commonly used to make plastics softer and more flexible. Little information is available about the presence of phthalates in yogurt products sold on the world market. This study aimed to develop a sensitive GC-MS method for the determination of selected ph...
Article
The cellular and subcellular effects of some synthetic pyrethroids (permethrin, cypermethrin, tetramethrin, and deltamethrin) on RTG-2 trout cell line were assessed. Mitochondrial function/cell viability and membrane integrity were measured by MTT and LDH release assays. Major morphological changes as evaluated by light and confocal microscopy were...
Article
Full-text available
Primary tissue cultures from Unio pictorum were developed for utilization in ecotoxicology studies. Cytotoxic effects of selected plasticizers (BPA, DiNP, DiDP, DMP) were tested on digestive gland, gonad, gill and mantle cells. DiNP on gill and BPA on digestive gland were the highest and lowest cytotoxic compounds (IC50 0.111, 170.718 ppt). Mantle...
Article
Full-text available
ABSTRACT: Genetic engineering involves a large spectrum of genomic modifications. Genetically modified animals (GMAs) that either over-express a foreign gene or in which the activity of a certain gene has been removed or replaced will be used incrementally to search molecular mechanisms of disease, to estimate innovative therapeutic targets, and to...
Chapter
Vitamin A, a fat-soluble vitamin, is necessary for the development and maintenance of the organism for differentiation, growth, embryonic development, and homeostasis. Many natural and synthetic compounds are developed as potential pharmacologic agents for use in treating ailments ranging from cancer to acne. The physiological role of vitamin A and...
Article
Residues of acaricide coumaphos were assessed in honey, bee brood, and beeswax during a 2-year field experiment. Honey, bee brood, and beeswax samples were collected before and after routine use of coumaphos in the treatment of bee colonies against varroosis in two consecutive years. Determination of coumaphos in honey and bee brood was based on RP...
Chapter
Full-text available
Mycotoxins, the toxic secondary metabolites of fungi, particularly produced by many species of Aspergillus, Fusarium and Penicillium, have affected animal and human health for over thousand years, whereas little has been discovered so far about these complex substances in poultry, which are generally very sensitive. Even though it varies by species...
Chapter
Full-text available
Consumption of poultry meat and products has increased as a consequence of economic crisis, driven by several factors, while people keep away from high priced beef/lamb meat or meat products. Meanwhile, due to this increasing demand in industry resulting strict measures in disease control and environmental factors, these products may involve some c...
Article
Full-text available
Objective: The effects of dimethyl phthalate, diethyl phthalate, diisobutyl phthalate, di-n-butyl phthalate, benzylbutyl phthalate, di-2-ethylhexyl phthalate were investigated on human prostate cancer cell lines DU145 and PC3 in vitro. Materials and methods: Standards of dimethyl phthalate, diethyl phthalate, di-isobutyl phthalate, dibutyl phtha...
Chapter
The importance of nutraceuticals is expanding globally in terms of scientific services, legal aspects, and marketing strategies for health promotion, reduction of disease, and health care costs. Due to its geographical position and cultural heritage, the Turkish perspective on nutraceuticals has been influenced by Europe (especially for regulations...
Article
Full-text available
ÖZET. Akuakültür, hayvansal ve bitkisel su canlılarının tüm sucul ortamlarda (nehir, göl, deniz, okyanus) başlıca gıda olmak üzere bilimsel ve diğer amaçlar için bakımı, beslenmesi ve yetiştiril-mesi olarak tanımlanır. Suda yaşayan canlılar suda oluşan fiziksel ve kimyasal değişikliklerden olum-suz etkilenmekte ve bu durum hem çevre sağlığına hem d...
Article
Full-text available
ÖZET: Sıtma ve Dang gibi vektörlerin aracılık ettiği hastalıklar, yüzyıllardır kontrol edilme çaba-larına rağmen halen birçok ülkede başlıca halk sağlığı problemi olarak kabul edilirler. Son yüzyıla kadar vektör kontrol programı hemen hemen tamamen kimyasal maddelerin kullanılmasına da-yanmaktaydı. Kimyasal maddeler vektörlerin kontrol edilmesinde...
Article
Phthalates are potential endocrine-disrupting chemicals, found widely in the environment, and commonly used to make plastics softer and more flexible. Little information is available about the presence of phthalates in yogurt products sold on the world market. This study aimed to develop a sensitive GC-MS method for the determination of selected ph...
Article
OBJECTIVE: The effects of dimethyl phthalate, diethyl phthalate, diisobutyl phthalate, di-n-butyl phthalate, benzylbutyl phthalate, di-2-ethylhexyl phthalate were investigated on human prostate cancer cell lines DU145 and PC3 in vitro. MATERIALS AND METHODS: Standards of dimethyl phthalate, diethyl phthalate, di-isobutyl phthalate, dibutyl phthalat...
Poster
Full-text available
TÜRKİYE’DE KANATLI YETİŞTİRİCİLİĞİNDE ANTİMİKROBİYALLERİN KULLANIMI, DİRENÇ, KALINTI RİSKLERİ VE DEZENFEKSİYON