Ayesha Noor

Ayesha Noor
VIT University | VIT · Centre for Bioseparation Technology

PhD
Natural Products Research, Metabolic Disorders (Diabetes, Obesity), Encapsulation of bioactive compounds & Nutraceutical

About

41
Publications
10,065
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Citations
Introduction
Our research group is actively conducting extensive research on the potentials of Aloe vera extract and other medicinal plants and their bioactive constituents in the alleviation of diabetes. Further profiling and identification of bioactive fractions responsible for the antidiabetic potentialare being carried out in animal models as well as in different cell lines. These studies will further add value to the product which could be used in developing an Ayurvedic nutraceutical product/supplement
Additional affiliations
November 2019 - September 2020
Vellore Institute of Technology
Position
  • Professor (Associate)
September 2014 - October 2019
Vellore Institute of Technology (VIT), Vellore
Position
  • Professor (Assistant)
June 2009 - August 2014
VIT University
Position
  • Professor (Assistant)

Publications

Publications (41)
Article
Full-text available
An attempt was made to study the beneficial effects of Aloe vera (L.) Burm. fil. in streptozotocin-induced diabetic rats. In diabetic induced rats fed with A. vera (300 mg/kg body wt), the fasting plasma glucose levels were reduced to normal and body weight was found to be increased. In the pancreatic sections of diabetic rats fed with A. vera, the...
Article
Full-text available
Objective: To evaluate the anti-inflammatory potential of peptide/polypeptide fraction of Aloe vera through in vitro and in vivo studies. Methods: The peptide/polypeptide fraction from Aloe vera was obtained through trichloroacetic acid precipitation. The anti-inflammatory property of the peptide/polypeptide fraction was tested by protein denaturat...
Article
Ethno-pharmacological relevance The genus Aloe has a long history of usage in medicine. Aloe barbadensis Miller, commonly known as Aloe vera, is said to possess anti-diabetic, anti-inflammatory, anti-cancer, anti-microbial, immunomodulation, wound healing properties. Aim of the study In diabetes mellitus, loss in intestinal permeability is observe...
Article
Ethnopharmacological relevance Aloe vera (L.) Burm.f. is an ancient medicinal plant that belongs to the family Asphodelaceae. It has a rich source of bioactive constituents such as carbohydrates, polyphenols, peptides, sterols and tannins, etc. Aloe vera has multiple biological activities such as anti-inflammatory, antioxidant and antidiabetic acti...
Article
Full-text available
Background: Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. Plant extracts and their products are being used as an alternative system of medicine for the treatment of diabetes. Aloe vera has been traditionally used to treat several diseases and it exhibits antioxidant, anti-inflammatory, and wound-healing effects....
Article
Plant polyphenols have recently gained attention in nutraceutical and pharmaceutical industries due to their various therapeutic potentials. However, the polyphenols are prone to oxidation, unstable towards heat, light, pH and their unpleasant taste also limits their application. The usage of encapsulated polyphenols can alleviate these drawbacks a...
Article
Bioactive constituents of plants have received great attention in recent times due to their many pharmacological and therapeutic properties. Plant polysaccharides are one of the constituents which are found abundantly in nature and are involved in cell-cell communication, immune recognition and eliciting defense mechanisms against infection of path...
Article
Ethnopharmacological relevance Aloe barbadensis Miller, commonly known as Aloe vera has been used since time immemorial for treatment of various diseases such as cancer, inflammatory disorders, diabetes, wound healing etc. Aim Diabetes mellitus is a complex disorder and understanding the molecular mechanisms involved is a key to identify different...
Article
Aloe vera (L.) Burm. F (Asphodelaceae) is a traditional medicinal plant having multiple biological activities such as wound healing, anticancer and antidiabetic activity, etc. These properties have been attributed to the constituents present in Aloe vera. One of the major constituents is carbohydrate, which has not been explored much for its antiox...
Article
Full-text available
The therapeutic and pharmacological properties of plant bioactive constituents still continue to be the subject of many researches. Species of the Aloe genus have a history in folklore medicine and they have gained more attention over the years due to their various medicinal properties. Phytochemical studies have revealed that the Aloe species cont...
Book
Objective: To evaluate Aloe vera (Aloe barbadensis Miller) gel extract for in vitro antioxidant activity and in vivo antioxidant & anti-inflammatory activities. Methodology: In vitro antioxidant activity of Aloe vera gel extract was evaluated by ABTS, DPPH, hydrogen peroxide and metal chelating activity and anti-inflammatory activity by inhibitio...
Chapter
Full-text available
Objective: To evaluate Aloe vera (Aloe barbadensis Miller) gel extract for in vitro antioxidant activity and in vivo antioxidant & anti-inflammatory activities. Methodology: In vitro antioxidant activity of Aloe vera gel extract was evaluated by ABTS, DPPH, hydrogen peroxide and metal chelating activity and anti-inflammatory activity by inhibitio...
Article
Full-text available
A series of spiro-[indoline-3,3′-pyrrolizin/pyrrolidin]-2-ones, 4, 5 and 6 were synthesized in a sequential manner from Cu–TEMPO catalyzed dehydrogenation of alkylated ketones, 1 followed by 1,3-dipolar cycloaddition of azomethine ylides via decarboxylative condensation of isatin, 2 and L-proline/sarcosine, 3 in high regioselectivities and yields....
Chapter
Vegetables are known to possess various health benefits besides being beneficial to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. Most of common vegetables are consumed after being cooked. Zingiberofficinale (Ginger) and Colocasiaesculenta (Taro) are edible tubers which are predomin...
Book
Murraya koenigii (Curry leaves), Moringa oleifera (Drumstick leaves) and Allium fistulosum (Spring Onion) are leafy vegetables which are used for their nutritional properties. These are used as dietary source and for its iron bioavailability. These are culinary vegetables which are available throughout the year and are cost-effective. An attempt wa...
Book
Vegetables are known to possess various health benefits besides being beneficial to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. Most of common vegetables are consumed after being cooked. Zingiberofficinale (Ginger) and Colocasiaesculenta (Taro) are edible tubers which are predomin...
Book
Vegetables are known to possess various health benefits besides being beneficial to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. Most of common vegetables are consumed after being cooked. Zingiberofficinale (Ginger) and Colocasiaesculenta (Taro) are edible tubers which are predomin...
Article
Full-text available
Aloe vera (Aloe barbadensis Miller) is a perennial succulent plant belonging to the Aloeaceae family and has been used for many centuries for its medicinal properties. Among the Aloe vera plant parts, gel is being widely studied for their biological properties. However, epidermis and flowers are neglected and are not probed for their importance. In...
Presentation
Effect of phytoconstituents/phytochemicals in different cooking methods on the oxidative stability in murraya koengii, moringa oleifera and allium fistulosum
Article
Streptozocin (STZ) is a broad range antibiotic, highly genotoxic, antineoplastic and hyperglycemic. HSA is the most abundant protein in physiology and it binds to almost all exogenic and endogenic ligands, including drugs. STZ-induced fluorescence quenching of HSA has been done at pH 7.4, pH 3.5 and at pH 7.4 with 4.5M urea at temperatures 286K, 29...
Article
Full-text available
Streptozocin (STZ) is a broad range antibiotic, highly genotoxic, antineoplastic and hyperglycemic. HSA is the most abundant protein in physiology and it binds to almost all exogenic and endogenic ligands, including drugs. STZ-induced fluorescence quenching of HSA has been done at pH 7.4, pH 3.5 and at pH 7.4 with 4.5 M urea at temperatures 286 K,...
Article
Full-text available
Although extensive literature exists on antioxidant properties of medicinal plants, very few studies have focused on their polyphenolic composition. Here, preliminary phytochemical screening and total flavonoid content in extracts of seeds of Myristica fragrans and leaves of Cordyline terminalis have been investigated. Screening of potential flavon...
Conference Paper
ABSTRACT Introduction: Although a lot of research has been conducted on the antioxidant properties of medicinal plants, very few studies have focused on their phenolic composition. Flavonoids are the most common group of polyphenolic compounds in the human diet and are found ubiquitously in plants. Flavonoids have been shown to have a wide range o...
Poster
The extracts were investigated by liquid chromatography (reverse phase) coupled to electrospray ionization mass spectrometry (LC-ESI-MS). Interpretation of LC-ESI-MS data was done by using the database of Lipid Metabolites and Pathways Strategy Consortium (LIPID MAPS). Such a profiling can help in designing interesting formulations, wherein, differ...
Article
Full-text available
Diabetes is a growing health concern worldwide and now emerging as an epidemic world over. The management of diabetes is still a major challenge. Thus there is great demand for research on natural products with anti-diabetic properties. Numerous studies have confirmed the benefits of medicinal plants with anti-hyperglycemic effects in the managemen...
Article
Full-text available
The context and purpose of the study: Plants that have been used for traditional medicines are very good sources of phyotochemicals. There are many plants like Casuarina equisetifolia, which are still unexplored for their medicinal properties. In the present study, we have elucidated the in vitro antioxidant and antiproliferative activity of differ...
Article
Black gram (Vigna mungo) is a legume which belongs to Fabaceae family. It is a rich source of protein. It has been known to have interesting small molecule antioxidant activity. However, its enzymatic antioxidant properties have not been explored much. In the present work we studied catalase, a principal antioxidant enzyme from black gram seeds. Da...
Article
Full-text available
In the present study, we have developed an encapsulation procedure which retains the antioxidant properties and polyphenol contents from two novel plants stable over a period of one year at room temperature at non-toxic level. Methanolic extracts containing polyphenols were prepared from Cordyline terminalis and Myristica fragrans under optimized c...

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Project (1)
Project
My research group revolves around the efficacy and safety evaluation, phytochemical characterization of indigenous Indian medicinal plants for practical applications towards alleviation of diabetes for the growing diabetic population in India. The increasing challenges associated with the medicinal plants geared me towards exploring the application of the AYUSH guidelines approach for screening of medicinal plants and isolating biomarkers/lead molecules for metabolic diseases for promoting Indian traditional medicine.