Axel Boese

Axel Boese
Otto-von-Guericke-Universität Magdeburg | OvGU · Medical Faculty - INKA Application Driven Research

Dr.-Ing.

About

215
Publications
18,481
Reads
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476
Citations
Introduction
Dr. Ing. Axel Boese is expert in medical device development and clinical application with years of experience. Beside several developments, publications and patents in the field of image guided therapies and instruments, he is certified Quality Manager for ISO 13485 medical devices, investigator for clinical studies and medical device testing, evaluation and GCP, Member of VDE and DGBMT and of the DIN Standardisation committee 063-01-02 AA, Co-founder of the company M3DP and CEO of MEDICS GmbH.
Additional affiliations
May 2020 - present
INKA Research Group @ Medical Faculty Magdeburg
Position
  • Project Manager
March 2020 - April 2021
MEDICS GmbH
Position
  • CEO
Description
  • Consultant for medical innovation, device development, regulatory and testing
April 2015 - August 2019
M3DP Medical Devices and Prototypes UG
Position
  • Shareholder
Description
  • Co-Founder of the start up M3DP Medical Devices and Prototypes UG
Education
September 2019 - September 2019
TÜV Süd Group
Field of study
  • Clinical Evaluation Medical Devices
July 2019 - July 2019
TÜV Süd Group
Field of study
  • Expert on Quality Management for Medical Devices
May 2019 - May 2019
TÜV Nord Group
Field of study
  • Radiation Safety

Publications

Publications (215)
Article
Full-text available
Creating surgical access is a critical step in laparoscopic surgery. Surgeons have to insert a sharp instrument such as the Veress needle or a trocar into the patient’s abdomen until the peritoneal cavity is reached. They solely rely on their experience and distorted tactile feedback in that process, leading to a complication rate as high as 14% of...
Article
Minimal-invasive procedures come with significant advantages for the patient. They also come with problems as the navigation/guidance of the devices to a target location is either based on pre-operatively acquired images and then performed free-hand or is accompanied by intraoperative imaging such as MRI or CT that is expensive, complicated and pro...
Article
Full-text available
One of the most applied imaging methods in medicine is endoscopy. A highly specialized image modality has been developed since the first modern endoscope, the “Lichtleiter” of Bozzini was introduced in the early 19th century. Multiple medical disciplines use endoscopy for diagnostics or to visualize and support therapeutic procedures. Therefore, th...
Article
Full-text available
(1) Background: Contact Endoscopy (CE) and Narrow Band Imaging (NBI) are optical imaging modalities that can provide enhanced and magnified visualization of the superficial vascular networks in the laryngeal mucosa. The similarity of vascular structures between benign and malignant lesions causes a challenge in the visual assessment of CE-NBI image...
Article
Full-text available
Background: Biometric sensing is a security method for protecting information and property. State-of-the-art biometric traits are behavioral and physiological in nature. However, they are vulnerable to tampering and forgery. Methods: The proposed approach uses blood flow sounds in the carotid artery as a source of biometric information. A handhe...
Article
Full-text available
Purpose Percutaneous needle insertion is one of the most common minimally invasive procedures. The clinician’s experience and medical imaging support are essential to the procedure’s safety. However, imaging comes with inaccuracies due to artifacts, and therefore sensor-based solutions were proposed to improve accuracy. However, sensors are usually...
Article
Full-text available
Auscultation methods allow the non-invasive diagnosis of pathological conditions (e.g., of the lung, heart or blood vessels) based on sounds that the body produces (e.g., breathing, heartbeat, swallowing or the blood flow). Through regular homebased examinations and Big Data combined with Machine learning techniques like Deep Learning, these could...
Article
Full-text available
About 50 % of complications during laparoscopy occur when surgical access is created. The Veress needle and proposed technical alternatives do not provide reliable information to support the surgeons in guiding the needle, or the feedback is not clearly perceivable. Based on acoustic emissions, Surgical Audio Guidance (SURAG) proposes a non-invasiv...
Article
Full-text available
Ultrasound (US) imaging is used as a preliminary diagnostic tool for the detection, risk-stratification and classification of thyroid nodules. In order to perform the risk stratification of nodules in US images physicians first need to effectively detect the nodules. This process is affected due to the presence of inter-observer and intra-observer...
Article
Full-text available
Polyethylene (PE) inlays of knee endoprostheses are exposed to constant mechanical stress causing particle abrasion and volumetric wear. With the current inlay surveillance strategy, significant change often can be only detected when the implant has already failed. To reduce medical complications arising from implant malposition or failure, early a...
Article
Full-text available
Introduction : The grade of reperfusion after endovascular treatment of ischemic stroke e.g. mechanical thrombectomy is determined based on the mTICI score. The mTICI score shows significant interrater variability; it is usually biased towards better reperfusion results if selfassessed by the operator. We therefore developed a semiautomated image p...
Article
Full-text available
The use of catheters and guide-wires in minimally invasive therapeutic approaches is an important part of clinical practice. In the neurovascular field, the unique nature of cerebral blood vessels necessitates very thin-walled and flexible catheters. The blood vessels in question are highly branched and at the same time can be less than one millime...
Article
Full-text available
Irreversible Electroporation (IRE) is a non-thermal tumor ablation treatment applicable for prostate cancer. IRE uses ultra-short but strong electrical pulses to destroy cancer cells nonthermally [1]. Clinically available IRE therapy requires two or more needle electrodes placed around the target tissue to apply the electric fields. A pre-requireme...
Article
Full-text available
Today's healthcare challenges with unmet clinical needs, high regulation and certification standards, and increasing costs demand faster innovation and technical translation. To address this challenge, Stanford released a fellowship called Biodesign, where need-based healthcare innovation is taught with the approach identify, invent and implement....
Article
Full-text available
We have witnessed impressive advances in preoperative imaging of cancer and the development of dualmodality scanners. However, there is a need for a scanner with functional and anatomical imaging capability suitable for surgical settings and radioguided surgery. The current paper introduces a handheld gamma-ultrasound scanner prototype and illustra...
Article
Full-text available
Auscultation methods allow a non-invasive diagnosis of cardiovascular diseases like atherosclerosis based on blood flow sounds of the carotid arteries. Since this process is highly dependent on the clinician’s experience, it is of great interest to develop automated data processing techniques for objective assessment. We have recently proposed a co...
Conference Paper
Full-text available
Background The mTICI score used to assess the degree of reperfusion after mechanical thrombectomy is an independent predictor of patient outcome after acute ischemic stroke. Its inter-rater reliability, however, is low and interventionalists often overrate their own performance.¹ Objectives We devised an image-processing based semi-automated gradi...
Article
Full-text available
Under-staffing of nurses is a significant problem in most countries. It is expected to rise in the coming years, making it challenging to perform crucial tasks like assessing a patient's condition, assisting the surgeon in medical procedures, catheterization and Blood Transfusion etc., Automation of some essential tasks would be a viable idea to ov...
Article
Full-text available
This paper presents the setup, network environment, and some of the initial results and learn ings from developing Innolab IGT, a medical, technology and innovation laboratory at a university clinic in Germany over four years. We created a learning environment that had short distances between operating rooms and labs, quick, responsive communicatio...
Article
Full-text available
Background: Feature extraction is an essential part of a Computer-Aided Diagnosis (CAD) system. It is usually preceded by a pre-processing step and followed by image classification. Usually, a large number of features is needed to end up with the desired classification results. In this work, we propose a novel approach for texture feature extracti...
Article
Full-text available
Longitudinal and perpendicular changes in the blood vessels of the vocal fold have been related to the advancement from benign to malignant laryngeal cancer stages. The combination of Contact Endoscopy (CE) and Narrow Band Imaging (NBI) provides intraoperative realtime visualization of vascular pattern in Larynx. The evaluation of these vascular pa...
Article
Full-text available
Introduction Endoscopy is an important modality in medical imaging. Thin flexible endoscopes are for example used to exam-ine the upper airways, for gastroscopy procedures or lung inspection. With standard flexible endoscopes one can change the direction of view by bending the tip with the disadvantage of large space required due to the bending ra...
Article
Full-text available
Arthroscopic surgery is a technically challenging but common minimally invasive procedure with a long learning curve and a high incidence of iatrogenic damage. These damages can occur due to the lack of feedback and supplementary information regarding tissue-instrument-contact during surgery. Deliberately performed interactions can be used however...
Article
Full-text available
For assessing clinically relevant structures in the neck area, especially the thyroid, it has been shown that 3D or tomographic ultrasound (3D US or tUS) is able to outperform standard 2D ultrasound [1] and computed tomography [2] for certain diagnostic procedures. However, when using a freehand and unassisted scanning method to acquire a 3D US vol...
Article
Full-text available
Vascular endoscopic imaging is known for a long time but has never made its way into clinical routine. Reasons for that are the complexity, lack of low-cost portable systems, and the lack of suitable endoscopes providing high image quality with small dimensions. In addition, an interruption of the blood flow caused by the device and the opacity of...
Article
Full-text available
Photodynamic diagnostic (PDD) is an optical enhancement option for the endoscope to support the detection of cancer, for example in the bladder. In real application PDD efficiency suffers due to the complex accumulation of the photosensitizing drug inside the tumor and the associated processes of heme syntheses to create the fluorescent components...
Article
Full-text available
Novel challenges and developments require adaptations on skill set, content, and associated education. A biomedical engineer will require a broad range of skills - which to a large extent are currently not taught - in the coming years to meet the development needs of future healthcare: intensive interdisciplinary team work, advanced communication s...
Article
Full-text available
In robot-assisted procedures, the surgeon controls the surgical instruments from a remote console, while visually monitoring the procedure through the endoscope. There is no haptic feedback available to the surgeon, which impedes the assessment of diseased tissue and the detection of hidden structures beneath the tissue, such as vessels. Only visua...
Article
Full-text available
Introduction: Atherosclerotic diseases of the carotid are a primary cause of cerebrovascular events such as stroke. For the diagnosis and monitoring angiography, ultrasound- or magnetic resonance-based imaging is used which requires costly hardware. In contrast, the auscultation of carotid sounds and screening for bruits - audible patterns related...
Poster
Full-text available
PRELIMINARY DATA Ex-vivo Lungenperfusions-Systeme (EVLP) erhalten das Organgewebe strukturell und funktionell außerhalb des Körpers. Neben der klinischen Anwendung in der Transplantationsmedizin werden EVLP-Systeme für translationale Forschungsansätze in der Lungenmedizin benötigt. Kommerziell erhältliche Système sind bei vielen experimentellen Ans...
Conference Paper
Full-text available
Accurate needle placement is highly relevant for puncture of anatomical structures. The clinician’s experience and medical imaging are essential to complete these procedures safely. However, imaging may come with inaccuracies due to image artifacts. Sensor-based solutions have been proposed for acquiring additional guidance information. These senso...
Article
Full-text available
Photodynamic diagnostic (PDD) is an optical enhancement option for the endoscope to support the detection of cancer, for example in the bladder. In real application PDD efficiency suffers due to the complex accumulation of the photosensitizing drug inside the tumor and the associated processes of heme syntheses to create the fluorescent components...
Article
Full-text available
During thermal ablation in a target tissue the information about temperature is crucial for decision making of successful therapy. An observable temporal and spatial temperature propagation would give a visual feedback of irreversible cell damage of the target tissue. Potential temperature features in ultrasound (US) B-Mode image sequences during r...
Article
Full-text available
This work aims to demonstrate the feasibility that haptic information can be acquired from a da Vinci robotic tool using audio sensing according to sensor placement requirements in a real clinical scenario. For that, two potential audio sensor locations were studied using an experimental setup for performing, in a repeatable way, interactions of a...
Article
Full-text available
Longitudinal and perpendicular changes in the vocal fold’s blood vessels are associated with the development of benign and malignant laryngeal lesions. The combination of Contact Endoscopy (CE) and Narrow Band Imaging (NBI) can provide intraoperative real-time visualization of the vascular changes in the laryngeal mucosa. However, the visual evalua...
Article
Full-text available
TURBT (transurethral resection of bladder tumor) is a standard treatment for bladder cancer. Gas bubble formation is caused by the heating of the RF-electrode from the resectoscope, which causes visual impairments and can also lead to explosive gas formation. The purpose of this work is to find a proper technical solution for removing the air bubbl...
Article
Full-text available
Epilepsy is a neurological disorder that happens because of the propagation of abnormal signals produced by clusters of neurons in the brain. The majority of those with epileptic seizures can be treated by drug therapies and surgery. However, 25% of the patients with diagnosed epilepsy continue to have seizures. Seizures can cause serious injuries...
Patent
The patent illustrates a concept that is a basis for developing a hybrid gamma-ultrasound scanner. This scanner, which is capable of acquiring both physiological and anatomical information, can be held with one hand. This feature of the scanner makes it a suitable device for use in image-guided surgery as well as small-field-of view imaging.
Patent
The patent describes a method for superficial skin cancer radiation therapy using beta-emitting isotopes, with 3D printing technology in its foundation. The therapeutic models/patches are printed based on tumor imaging information. Therefore, the offered treatment will be patient-specific with a dose profile matching the tumor shape.
Article
Full-text available
The endoscopic detection of perpendicular vascular changes (PVC) of the vocal folds has been associated with vocal fold cancer, dysplastic lesions, and papillomatosis, according to a classification proposed by the European Laryngological Society (ELS). The combination of contact endoscopy with narrow-band imaging (NBI-CE) allows intraoperatively a...
Article
Full-text available
The healthcare industry is consistently developing a constant supply of medical equipment, e.g. radiation protection wear. These must be inspected regularly to ensure safety and quality. As this equipment keeps on moving from department to department, it has to be located in one place for annual inspection and must be properly documented after qual...
Conference Paper
Full-text available
This study describes a concept for MRI-compatible core needles based on a plastic sheet filled with a fiber-bundle core. Standard MRI needles still show huge artifacts in imaging due to the material's interactions with the magnetic field. Different prototypes were built up and compared to a standard MRI core needle.
Conference Paper
Full-text available
The proposed work involves the use of Nitinol as a bended tip biopsy needle. Nitinol performs as the hollow core for tissue sampling. The goal is to show the visibility of the superelastic property of the Nitinol bended needle tip under ultrasound image guidance.
Article
Full-text available
Introduction: Contrast media injections, infusions, or experiments that require a constant volume flow close to or within a very high magnetic field like in magnetic resonance imaging (MRI) require a liquid reservoir and a power unit to deliver the fluid. However, most power units are driven by motors that are either not MRI-compatible or require...
Conference Paper
Full-text available
In this work we summarize applications of a novel approach for providing complementary information for guiding medical interventional devices (MID) and that have been recently published by our research team. This approach consist of using an audio sensor located in the proximal end of the MID in order to extract meaningful information concerning th...
Conference Paper
Core needle biopsy is an established method for diagnosis of cancerous tissue. To achieve high sensitivity of the diag-nosis multiple samples are collected from and around the suspected tumour zone. This is connected to multiple punc-tures and removal of the biopsy gun. Another possibility is the use of biopsy guns with large diameters. Both lead t...
Conference Paper
Sentinel lymph node (SLN) biopsy is an intraoperative technique to determine the status of a primary tumor. The procedure is based on the use of an external gamma probe, which generates an audio signal based on the direction and intensity of gamma radiation to guide the surgeon to the location of the SLNs. This method, however, does not provide any...