Austin Lim

Austin Lim
DePaul University · College of Science and Health

PhD

About

10
Publications
1,839
Reads
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560
Citations
Introduction
Austin Lim currently teaches Neuroscience at DePaul University. Previous research experience includes electrophysiology and optogenetics work with the Surmeier Lab at Northwestern University and the McGehee Lab / Kang Lab at University of Chicago. His main interest is the striatum in disease states.
Additional affiliations
September 2010 - December 2010
University of Chicago
Position
  • Research Assistant
August 2007 - August 2008
Rosalind Franklin University of Medicine and Science
Position
  • Technician
September 2009 - July 2014
University of Chicago
Position
  • Predoctoral Candidate
Education
September 2008 - July 2014
University of Chicago
Field of study
  • Neurobiology

Publications

Publications (10)
Article
The steadily-rising cost of higher education is a tremendous financial burden, and the purchasing of textbooks represents a significant cost of higher education. Financial hardship exaggerates wealth disparities, decreasing the diversity of learners. Additionally, a growing interest in the field of neuroscience among the population at large has inc...
Article
Full-text available
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that initially manifests itself in the striatum. How intrastriatal circuitry is altered by the disease is poorly understood. To help fill this gap, the circuitry linking spiny projection neurons (SPNs) to cholinergic interneurons (ChIs) was examined using electrophysiolog...
Article
Giant, aspiny cholinergic interneurons (ChIs) have long been known to be key nodes in the striatal circuitry controlling goal directed actions and habits. In recent years, new experimental approaches, like optogenetics and monosynaptic rabies virus mapping, have expanded our understanding of how ChIs contribute to the striatal activity underlying a...
Article
Full-text available
Huntington’s disease (HD) is a neurodegenerative disorder characterized by deficits in movement control that are widely viewed as stemming from pathophysiological changes in the striatum. Giant, aspiny cholinergic interneurons (ChIs) are key elements in the striatal circuitry controlling movement, but whether their physiological properties are inta...
Article
Full-text available
Levodopa is the most effective therapy for the motor deficits of Parkinson's disease (PD), but long term treatment leads to the development of L-DOPA-induced dyskinesia (LID). Our previous studies indicate enhanced excitability of striatal cholinergic interneurons (ChIs) in mice expressing LID and reduction of LID when ChIs are selectively ablated....
Article
Full-text available
The striatum plays a central role in motor control and motor learning. Appropriate responses to environmental stimuli, including pursuit of reward or avoidance of aversive experience all require functional striatal circuits. These pathways integrate synaptic inputs from limbic and cortical regions including sensory, motor and motivational informati...
Article
Full-text available
Treatment of Parkinson disease (PD) with L-3,4-dihydroxyphenylalanine (L-DOPA) dramatically relieves associated motor deficits, but L-DOPA-induced dyskinesias (LID) limit the therapeutic benefit over time. Previous investigations have noted changes in striatal medium spiny neurons, including abnormal activation of extracellular signal-regulated kin...
Article
The gaseous neurotransmitter nitric oxide plays an important role in the modulation of corticostriatal synaptic transmission. This study examined the impact of frontal cortex stimulation on striatal nitric oxide efflux and neuron activity in urethane-anesthetized rats using amperometric microsensor and single-unit extracellular recordings, respecti...

Questions

Questions (2)
Question
Has anyone been successful using the A-M Systems 3100 electrometer for field recordings from a hippocampal slice? (Link here: https://www.a-msystems.com/p-201-model-3100-intracellular-electrometer.aspx) If so, would you be willing to share your ephys rig set up with me?
Thanks in advance,
Question
Hi everyone,
I have a 700C vertical puller, but the moving part is stuck. The exposed metal is a bit rusted, and I suspect that the metal cylinder is rusted underneath the "sleeve" as well, maybe causing it to get stuck.
Would it be safe to spray some WD40 in the space between the sleeve and the metal rod? Alternatively, what about citric acid?
Thanks in advance, any advice would be appreciated!

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