Austin B. Lawrence

Western University of Health Sciences · College of Osteopathic Medicine of the Pacific

Phenotypic heterogeneity in monogenic neurodevelopmental disorders can arise from differential severity of variants underlying disease, but how distinct alleles drive variable disease presentation is not well understood. Here, we investigate missense mutations in DNA methyltransferase 3A (DNMT3A), a DNA methyltransferase associated with overgrowth,...

Bipedal locomotion is a defining feature of the human lineage. However, the form of bipedality in different hominin taxa and the timing of emergence of a human-like striding bipedal gait have long been a subject of debate. Morphological features of the hip and pelvis, among other lines of evidence, have been used to argue for kinematically differen...

Phenotypic heterogeneity is a common feature of monogenic neurodevelopmental disorders that can arise from differential severity of missense variants underlying disease, but how distinct alleles impact molecular mechanisms to drive variable disease presentation is not well understood. Here, we investigate missense mutations in the DNA methyltransfe...

Accurate and repeatable assessments of three-dimensional (3D) skeletal morphology are critical to interpretations of vertebrate functional anatomy. In skeletal specimens, these goals can be accomplished using in-silico models derived from 3D laser scan, photogrammetry, or computed tomography (CT) data. Assessments of skeletal morphology in living s...

Original article: https://doi.org/10.17159/sajs.2019/5911 Due to an error in the reference plane, the elevation range shown for the digital elevation model (DEM) in Figure 5a is incorrect. The correct elevation range is 1629.41–1679.64 m. The DEM and orthomosaic map data were reprocessed using Agisoft Metashape 1.7.4. Processing parameters for the...

Hominin pelvic form differs dramatically from that of other primates by having more laterally facing iliac blades, a wider sacrum and a larger, transversely broad pelvic inlet. Acetabular orientation may differ as well, plausibly related to differences in load transmission during habitual bipedal posture and locomotion. Here, we test the hypothesis...

Isimila is a Middle Pleistocene archaeological site located in southern Tanzania. The site is known for large surface assemblages of later Acheulean lithics such as hand axes, cleavers, scrapers and cores. While hominin remains have yet to be discovered at the site, Isimila offers a unique window into Middle Pleistocene Homo behaviour. Although Isi...

The taxonomic identification of mammalian fauna within fossil assemblages is a well-established component of paleoenvironmental reconstructions. However, many fragmentary specimens recovered from fossil sites are often disregarded as they can be difficult to identify with the precision required for taxonomic methods. For this reason, the large numb...

Classification of validation specimens using our QDA model. Misclassifications are in bold. See text for explanation of dietary categories. (DOCX)

Blomberg’s K for all measures. Values > 1 suggest that phylogeny is driving the similarities between closely related species. Only values < 1 were used in our analysis. (DOCX)

Dietary categorizations and incisor measurements (mm) of rodent species sampled (OA measured in degrees). See text for explanation of dietary categories. (DOCX)

Isimila is a Middle Pleistocene archaeological site located in southern Tanzania. The site is known for large surface assemblages of later Acheulean lithics such as hand axes, cleavers, scrapers, and cores. While hominin remains have yet to be discovered at the site, Isimila offers a unique window into Middle Pleistocene Homo behavior. Although Isi...

The taxonomic identification of mammalian fauna within fossil assemblages is a well-established component of paleoenvironmental reconstructions. However, many fragmentary specimens recovered from fossil sites are often disregarded as they can be difficult to identify with the precision required for taxonomic methods. For this reason, the large numb...

Past bioarchaeological analyses of human remains from the Early Christian Period site of Kulubnarti, Nubia (550‐800 CE), have revealed differences in patterns of stress between two contemporaneous cemeteries (mainland [21‐R‐2] and island [21‐S‐46]) that are thought to represent separate socioeconomic groups. However, to this point, differences in a...

Abstract: Femoroacetabular impingement (FAI) is a clinical pathology of the hip resulting from repeated abutment of an abnormally shaped femoral head-neck junction with the acetabular rim. One form of FAI, the cam-type deformity, is thought to result from mechanical stress on the femoral head-neck junction during epiphyseal fusion and from intense,...

Located in the southern highlands of Tanzania, the Middle Pleistocene site of Isimila contains one of the most abundant Acheulean stone assemblages in Africa, if not the world. Although the extensive riverine erosional beds are littered with innumerable artifacts which include hand-axes, hammerstones, and flaked tools, few faunal remains have been...

For more than a century, the morphology of the femoral head-neck junction has been used as a tool to reconstruct activity in the archaeological record. More recently, the head-neck junction has become the focus of intense study in the clinical literature following the description of femoroacetabular impingement (FAI), an injury common in athletes t...

Femoroacetabular impingement (FAI) is a clinical pathology of the hip resulting from repeated abutment of an abnormally shaped femoral head-neck junction with the acetabular rim. One form of FAI, the cam-type deformity, is thought to result from mechanical stress on the femoral head-neck junction during epiphyseal fusion and from intense, repeated...