Aurora Almadori

University College London | UCL · Academic Department of Surgery

Multiple handheld 3-dimentional systems are available on the market but data regarding their use in detecting small volumes are limited. The aim of this study was to compare different portable 3D technologies in detecting small volumetric enhancement on a mannequin model and a series of patients. Five portable 3D systems (Artec Eva, Crisalix, Go!Sc...

Scleroderma is a rare chronic connective tissue disease affecting 1 in 4000 adults. It is characterized by immunological changes, vascular damage in the small- and medium-sized arteries, and excessive collagen deposition, with reduced tissues elasticity and skin fibrosis. It is classified into localized scleroderma and systemic sclerosis on the bas...

Lichen Sclerosus (LS) is an autoimmune disease characterized by chronic inflammation and skin atrophy that over time tends to evolve towards fibrosis and scarring. Lacerations and fissures can also be present. Typical symptoms include itching, soreness, and pain with dyspareunia and difficult sexual intercourse. If untreated, the cicatricial sequel...

The term Female Genital Mutilation (FGM) defines all the procedures where the female external genitalia are partially or totally removed on the basis of cultural reasons without any medical indication. Because of the migration flows, FGM is an issue of increasing concern also in countries where FGM is not traditionally practiced. It is frequently a...

The number of cancer survivors treated with radiotherapy is increasing each year. The long-term side effects of radiotherapy may persist for decades after treatment and one of the major causes of long-term disability is the radiation-induced fibrosis (RIF). It has a major impact on head and neck cancer survivor, with impaired physiologic functions...

Autologous tissue-assisted regenerative procedures have been considered effective to close different types of fistula, including the leakage around tracheoesophageal puncture. The aim of this study was to retrospectively review 10 years of lipotransfer for persistent periprosthetic leakage in laryngectomized patients with voice prosthesis. Clinical...

PurposeParastomal recurrence of squamous cell carcinoma (SCC) with tracheal involvement following salvage total laryngectomy after prior concurrent chemoradiotherapy is one of the most insidious challenges in head and neck surgery because a complex reconstruction is often required for covering a large area of skin loss, filling the dead space benea...

Background Autologous fat grafting has become an established therapeutic entity in several regions of the body. Especially in the facial region, AFG has been widely applied in the field of plastic and reconstructive surgery. Indications include reconstructive purposes such as primary genetic disorders in maxillofacial development, or secondary asy...

Background. Three-dimensional (3D) photography provides a promising means of breast volumetry. Sources of error using a single-captured surface to calculate breast volume include inaccurate designation of breast boundaries and prediction of the invisible chest wall generated by computer software. An alternative approach is to measure differential v...

Background The vulva is composed of aesthetic units that can be affected differently by vulvar conditions. A reliable, comprehensive, and quick-to-use clinical scoring system is required to assess the disease extent in the vulvar area. Objectives The aim of this study was to develop and validate a grading scale based on the aesthetic unit principl...

Objective: The aim of the study was to evaluate the effect of lipotransfer in women presenting with fibrosis and scarring due to lichen sclerosus. Materials and methods: This prospective cohort study included 33 women attending the vulvar clinic of a public hospital. Patients received one lipotransfer treatment. Validated measures were used pros...

Background: Salvage total laryngectomy (TL) and laryngopharyngectomy (LP) after chemoradiotherapy may produce disfiguring defects with severe complications that require complex reconstructions. Methods: Between January 2012 and December 2018, we enrolled 25 patients who underwent internal mammary artery perforator (IMAP) flap reconstruction afte...

Background: Multimodality treatment for head and neck cancer leads to substantial functional and esthetic impairment mainly manifested as radiation-induced skin fibrosis (RIF) in combination with volumetric defects and reduction in neck mobility. This study assessed the impact of lipotransfer as part of secondary surgical procedure(s) in patients...

Oro-facial fibrosis in systemic sclerosis (Scleroderma;SSc) has a major impact on mouth function, facial appearance, and patient quality of life. Lipotransfer is a method of reconstruction that can be used in the treatment of oro-facial fibrosis. The effect of this treatment not only restores oro-facial volume but has also been found to reverse the...

Background Adipose-derived stem cells (ASCs) are capable of secreting regenerative growth factors and replacing multiple tissue types. Although current literature suggests that ASCs accelerate wound healing and reduce scarring, the dose-response relationship has not been adequately investigated in large animals. We sought to establish a porcine mod...

Background Vascularized composite allotransplantation opens new possibilities in reconstructive transplantation such as hand or face transplants. Lifelong immunosuppression and its side-effects are the main drawbacks of this procedure. Mesenchymal stem cells (MSCs) have clinically useful immunomodulatory effects and may be able to reduce the burden...

Systemic sclerosis (SSc) is characterised by fibrosis of the skin and underlying connective tissue structures, together with localised loss of subcutaneous fat. Oro-facial fibrosis in systemic sclerosis (SSc) is almost always present in established cases and has major impact on oro-facial function, facial appearance, and quality of life. Based upon...

Lipotransfer for soft tissue filling is a well-established plastic and aesthetic surgical technique. Elective fat grafting is considered a safe and well-tolerated procedure. Coleman and others have reported that fat grafting may have tissue regenerative properties and not only serve as a soft tissue filler. There have been reports from our group an...

The World Health Organization estimates that by 2050 nearly 25% of the world's population will be over 60 years of age. However, increasing lifespan doesn’t necessary increase health quality. Ageing is considered as the biggest risk factor for a range of diseases, including cancer, Alzheimer, cardiovascular and atherosclerosis. For this reasons it...

Several alloplastic biomaterials are available for injection to the breast, nevertheless not all of them are approved for biomedical use. Although in North America and Western Europe experience with synthetic biomaterials for breast augmentation is very limited, migratory streams might expose physicians worldwide to manage the related complications...

Background: One of the most interesting developments in practical applications of fat grafting in recent years is the use of prosurvival strategies to improve maintenance of volume. Platelet-rich plasma (PRP) plays a decisive role in the repair and regeneration of different tissues via the activation and secretion of a great variety of growth fact...

Background: Because of immigration, female genital mutilation (FGM) is an issue of increasing concern in western countries. Nevertheless operators without a specific training may ignore the health condition of women subjected to this practice and fail to provide them adequate assistance. The purpose of the study was to estimate the current knowled...