Aurélien Bailly

Aurélien Bailly
University of Zurich | UZH · Institut für Pflanzenbiologie

Dr. Sc. Nat.

About

54
Publications
18,265
Reads
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3,281
Citations
Citations since 2016
22 Research Items
2094 Citations
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Introduction
...no matter how complex or affluent, human societies are nothing but subsystems of the biosphere, the Earth's thin veneer of life, which is ultimately run by bacteria, fungi and green plants. Vaclav Smil
Additional affiliations
September 2015 - present
University of Zurich
Position
  • Group Leader
March 2014 - September 2015
Agroscope
Position
  • PostDoc Position
April 2011 - July 2011
Université de Fribourg
Position
  • PostDoc Position

Publications

Publications (54)
Article
Full-text available
Rhizobia fix nitrogen within root nodules of host plants where nitrogenase expression is strictly controlled by its key regulator NifA. We recently discovered that in nodules infected by the beta-rhizobial strain Paraburkholderia phymatum STM815, NifA controls expression of two bacterial auxin synthesis genes. Both the iaaM and iaaH transcripts, as...
Article
Full-text available
Many bacteria utilize contact-dependent killing machineries to eliminate rivals in their environmental niches. Here we show that the plant root colonizer Pseudomonas putida strain IsoF is able to kill a wide range of soil and plant-associated Gram-negative bacteria with the aid of a type IVB secretion system (T4BSS) that delivers a toxic effector i...
Preprint
Full-text available
ABCG46 of the legume Medicago truncatula is an ABC-type plasma membrane transporter that selectively translocates endogenous phenylpropanoids from the biosynthetic pathway of the phytoalexin, medicarpin, namely 4-coumarate and liquiritigenin. To investigate molecular determinants of the observed substrate selectivity, we applied a combination of ph...
Preprint
Full-text available
ABCG46 of the legume Medicago truncatula is an ABC-type plasma membrane transporter that selectively translocates endogenous phenylpropanoids from the biosynthetic pathway of the phytoalexin, medicarpin, namely 4-coumarate and liquiritigenin. To investigate molecular determinants of the observed substrate selectivity, we applied a combination of ph...
Article
Full-text available
After a century of investigations, the function of the obligate betaproteobacterial endosymbionts accommodated in leaf nodules of tropical Rubiaceae remained enigmatic. We report that the α-d-glucose analogue (+)-streptol, systemically supplied by mature Ca.Burkholderia kirkii nodules to their Psychotria hosts, exhibits potent and selective root gr...
Preprint
Full-text available
Many bacteria utilize contact-dependent killing machineries to eliminate rivals in their environmental niches. Here, we show that Pseudomonas putida IsoF is able to outcompete a wide range of bacteria with the aid of a novel type IVB secretion system (T4BSS) that can deliver toxic effectors into bacterial competitors. This extends the host range of...
Article
Full-text available
Paraburkholderia phymatum STM815, a rhizobial strain of the Burkholderiaceae family, is able to nodulate a broad range of legumes including the agriculturally important Phaseolus vulgaris (common bean). P. phymatum harbors two type VI Secretion Systems (T6SS-b and T6SS-3) in its genome that contribute to its high interbacterial competitiveness in v...
Article
Full-text available
Paraburkholderia phymatum STM815 is a nitrogen-fixing endosymbiont that nodulate the agriculturally important Phaseolus vulgaris and several other host plants. We previously showed that the nodules induced by a STM815 mutant of the gene encoding the master regulator of nitrogen fixation NifA showed no nitrogenase activity (Fix−) and increased in nu...
Article
Full-text available
The widely used non-steroidal anti-inflammatory drugs (NSAIDs) are derivatives of the phytohormone salicylic acid (SA). SA is well known to regulate plant immunity and development, whereas there have been few reports focusing on the effects of NSAIDs in plants. Our studies here reveal that NSAIDs exhibit largely overlapping physiological activities...
Chapter
In contrast to animals, plants possess neither olfactory organs nor a central nervous system. However, they do perceive and systemically react to volatile stimuli. Such function serves in monitoring the immediate and remote environments and translates into optimized responses to biotic and abiotic stresses. While the ecological relevance of volatil...
Article
Full-text available
The plant hormone auxin must be transported throughout plants in a cell-to-cell manner to affect its various physiological functions. ABCB transporters are critical for this polar auxin distribution, but the regulatory mechanisms controlling their function is not fully understood. The auxin transport activity of ABCB1 was suggested to be regulated...
Preprint
Auxin transport activity of ABCB1 was suggested to be regulated by physical interaction with the FKBP42/Twisted Dwarf1 (TWD1), a bona fide peptidylprolyl cis-trans isomerase (PPIase), but all attempts to demonstrate such a PPIase activity on TWD1 have failed so far. By using a structure-based approach we have identified a series of surface-exposed...
Article
Full-text available
For plants, the advantages of associating with beneficial bacteria include plant growth promotion, reduction of abiotic and biotic stresses and enhanced protection against various pests and diseases. Beneficial bacteria rightly equipped for successful plant colonization and showing antagonistic activity toward plant pathogens seem to be actively re...
Article
Late blight caused by the oomycete Phytophthora infestans constitutes the greatest threat to potato production worldwide. Considering the increasing concerns regarding the emergence of novel fungicide-resistant genotypes and the general demand for reducing inputs of synthetic and copper-based fungicides, the need for alternative control methods is...
Preprint
Full-text available
Late blight caused by the oomycete Phytophthora infestans constitutes the greatest threat to potato production worldwide. Considering the increasing concerns regarding the emergence of novel fungicide-resistant genotypes and the general demand for reducing inputs of synthetic and copper-based fungicides, the need for alternative control methods is...
Article
The plant Psychotria kirkii hosts an obligatory bacterial symbiont, Candidatus Burkholderia kirkii, in nodules on their leaves. Recently, a glucosylated derivative of (+)‐streptol, (+)‐streptol glucoside, was isolated from the nodulated leaves and was found to possess a plant growth inhibitory activity. To establish a structure activity relationshi...
Article
Full-text available
Microbial lifeforms associated with land plants represent a rich source for crop growth- and health-promoting microorganisms and biocontrol agents. Volatile organic compounds (VOCs) produced by the plant microbiota have been demonstrated to elicit plant defenses and inhibit the growth and development of numerous plant pathogens. Therefore, these mo...
Article
Full-text available
Plant growth and architecture is regulated by the polar distribution of the hormone auxin. Polarity and flexibility of this process is provided by constant cycling of auxin transporter vesicles along actin filaments, coordinated by a positive auxin-actin feedback loop. Both polar auxin transport and vesicle cycling are inhibited by synthetic auxin...
Article
Plant development and architecture are greatly influenced by the polar distribution of the essential hormone auxin. The directional influx and efflux of auxin from plant cells depends primarily on AUX1/LAX, PIN, and ABCB/PGP/MDR families of auxin transport proteins. The functional analysis of these proteins has progressed rapidly within the last de...
Article
Full-text available
Late blight, caused by the oomycete Phytophthora infestans, is the most devastating disease of potato. In organic farming, late blight is controlled by repeated applications of copper-based products, which negatively impact the environment. To find alternative solutions for late blight management, we have previously isolated a large collection of b...
Article
Full-text available
The plant kingdom represents a prominent biodiversity island for microbes that associate with the below- or aboveground organs of vegetal species. Both the root and the leaf represent interfaces where dynamic biological interactions influence plant life. Beside well-studied communication strategies based on soluble compounds and protein effectors,...
Article
Full-text available
Bacteria emit volatile organic compounds with a wide range of effects on bacteria, fungi, plants, and animals. The antifungal potential of bacterial volatiles has been investigated with a broad span of phytopathogenic organisms, yet the reaction of oomycetes to these volatile signals is largely unknown. For instance, the response of the late blight...
Article
Recently, emission of volatile organic compounds (VOCs) has emerged as a mode of communication between bacteria and plants. Although some bacterial VOCs that promote plant growth have been identified, their underlying mechanism of action is unknown. Here we demonstrate that indole, which was identified using a screen for Arabidopsis growth promotio...
Chapter
The ABC-transporter protein superfamily assures the crossmembrane transport of a broad variety of substrates in all living forms. In plants, they contribute greatly to most of the cellular functions, ranging from nutrient exchange to secondary metabolites or hormonal control. This transport mechanism is solely energized by the consumption of two AT...
Article
ATP-binding cassette (ABC) transporters and P4-ATPases are two large and seemingly unrelated families of primary active pumps involved in moving phospholipids from one leaflet of a biological membrane to the other. This review aims to identify common mechanistic features in the way phospholipid flipping is carried out by two evolutionarily unrelate...
Article
Plant growth is achieved predominantly by cellular elongation, which is thought to be controlled on several levels by apoplastic auxin. Auxin export into the apoplast is achieved by plasma membrane efflux catalysts of the PIN-FORMED (PIN) and ATP-binding cassette protein subfamily B/phosphor-glycoprotein (ABCB/PGP) classes; the latter were shown to...
Article
Full-text available
Increasing evidence indicates that volatile compounds emitted by bacteria can influence the growth of other organisms. In this study, the volatiles produced by three different strains of Burkholderia ambifaria were analysed and their effects on the growth of plants and fungi, as well as on the antibiotic resistance of target bacteria, were assessed...
Chapter
Mounting evidence suggests that the emission of volatile organic compounds by bacteria plays a major role in plant–bacteria interactions. In this chapter, we describe a study by Blom and coworkers, in which a large array of soil and rhizosphere strains was analyzed for volatile-mediated effects on Arabidopsis thaliana (Blom et al. 2011a). This stud...
Article
Full-text available
Plant architecture is influenced by the polar, cell-to-cell transport of auxin that is primarily provided and regulated by plasma membrane efflux catalysts of the PIN-FORMED and B family of ABC transporter (ABCB) classes. The latter were shown to require the functionality of the FK506 binding protein42 TWISTED DWARF1 (TWD1), although underlying mec...
Article
Full-text available
Polar transport of the plant hormone auxin is controlled by PIN- and ABCB/PGP-efflux catalysts. PIN polarity is regulated by the AGC protein kinase, PINOID (PID), while ABCB activity was shown to be dependent on interaction with the FKBP42, TWISTED DWARF1 (TWD1). Using co-immunoprecipitation (co-IP) and shotgun LC-MS/MS analysis, we identified PID...
Data
Full-text available
ABCB1/PGP1 orthologs used in this study. All protein sequences used in the present work have been obtained from BLAST analyzes (blastp, psi-blast, phi-blast, and tblastn) using HsABCB1 and AtABCB1 translated cDNAs and a scoring threshold of 1000 points, 90% coverage, and e-value <0.01.
Data
Full-text available
Alignments of AtABCBs and MmABCB1 sequences that were used to build homology models for this study. For details, see Section “Material and Methods.”
Data
Full-text available
Complete template alignments for HsABCB1 are shown in two runs of HsABCB1 modeling based on Sav1866. For details, see Section “Material and Methods.”
Article
Full-text available
Bacteria interact with plants in many different ways. In recent years, bacterial production of volatiles has emerged as a novel process by which bacteria modulate plant growth. Exposure to the volatiles produced by certain bacterial strains has been shown to lead to up to 5-fold increased plant biomass or to plant death. Despite these drastic growt...
Article
Full-text available
In contrast to mammalian ABCB1 proteins, narrow substrate specificity has been extensively documented for plant orthologs shown to catalyze the transport of the plant hormone, auxin. Using the crystal structures of the multidrug exporters Sav1866 and MmABCB1 as templates, we have developed structural models of plant ABCB proteins with a common arch...
Article
Full-text available
Plant development and physiology are widely determined by the polar transport of the signaling molecule auxin. This process is controlled on the cellular efflux level catalyzed by members of the PIN (pin-formed) and ABCB (ATP-binding cassette protein subfamily B)/P-glycoprotein family that can function independently and coordinately. In this study,...
Article
Full-text available
Differential distribution of the plant hormone auxin within tissues mediates a variety of developmental processes. Cellular auxin levels are determined by metabolic processes including synthesis, degradation, and (de)conjugation, as well as by auxin transport across the plasma membrane. Whereas transport of free auxins such as naturally occurring i...
Article
The plant signalling molecule auxin provides positional information in a variety of developmental processes by means of its differential distribution (gradients) within plant tissues. Thus, cellular auxin levels often determine the developmental output of auxin signalling. Conceptually, transmembrane transport and metabolic processes regulate the s...
Article
Full-text available
The rate, polarity, and symmetry of the flow of the plant hormone auxin are determined by the polar cellular localization of PIN-FORMED (PIN) auxin efflux carriers. Flavonoids, a class of secondary plant metabolites, have been suspected to modulate auxin transport and tropic responses. Nevertheless, the identity of specific flavonoid compounds invo...
Article
Full-text available
The immunophilin-like FKBP42 TWISTED DWARF1 (TWD1) has been shown to control plant development via the positive modulation of ABCB/P-glycoprotein (PGP)-mediated transport of the plant hormone auxin. TWD1 functionally interacts with two closely related proteins, ABCB1/PGP1 and ABCB19/PGP19/MDR1, both of which exhibit the ability to bind to and be in...
Article
Compared with that of other eukaryotes, the nuclear genome of the model plant Arabidopsis thaliana encodes an expanded family of FK506-binding proteins (FKBPs). Whereas approximately half of the FKBPs are implicated in the regulation of photosynthetic processes, a subcluster appears to be stress responsive. Recent reports indicate that a discrete g...
Article
Full-text available
There is increasing evidence that immunophilins function as key regulators of plant development. One of the best investigated members, the multi-domain FKBP TWISTED DWARF1 (TWD1)/FKBP42, has been shown to reside on both the vacuolar and plasma membranes where it interacts in mirror image with two pairs of ABC transporters, MRP1/ MRP2 and PGP1/PGP19...
Article
Full-text available
The immunophilin-like protein TWISTED DWARF1 (TWD1/FKBP42) has been shown to physically interact with the multidrug resistance/P-glycoprotein (PGP) ATP-binding cassette transporters PGP1 and PGP19 (MDR1). Overlapping phenotypes of pgp1/pgp19 and twd1 mutant plants suggested a positive regulatory role of TWD1 in PGP-mediated export of the plant horm...
Article
Directional transport of the phytohormone auxin is required for the establishment and maintenance of plant polarity, but the underlying molecular mechanisms have not been fully elucidated. Plant homologs of human multiple drug resistance/P-glycoproteins (MDR/PGPs) have been implicated in auxin transport, as defects in MDR1 (AtPGP19) and AtPGP1 resu...

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Project (1)
Project
role of membrane transporters in phytohormones distribution