AUGUSTINE Oseloka Ibegbu

AUGUSTINE Oseloka Ibegbu
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Alex Ekwueme Federal University, Ndufu-Alike | FUNAI · Anatomy

PhD

About

101
Publications
45,154
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Introduction
AUGUSTINE OSELOKA Ibegbu worked in the Department of Human Anatomy, Ahmadu Bello University. AUGUSTINE does research in Anatomy, Neuroscience, and Human Biology. He is 'Presently working in the Department of Anatomy, Faculty of Basic Medical Sciences, Federal University Ndufu Alike Ebonyi State. His research is centered on the use of some local herbs with antioxidant properties in protecting and treating neurodegeneration disorders caused by oxidative stress induced by some heavy metals and some environmental toxicants.'
Additional affiliations
Alex Ekwueme Federal University Ndufu Alike Ikwo (AEFUNAI)
Position
  • Professor
August 2016 - present
Alex Ekwueme Federal University Ndufu Alike
Position
  • Professor
Description
  • Teaching, Research, and Community Service
August 2015 - August 2016
Federal University Dutse
Position
  • Professor (Full)
Description
  • Teaching and Research
Education
September 2004 - July 2009
Queen Margaret University
Field of study
  • Neuroscience

Publications

Publications (101)
Article
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Background The Microtubules-associated protein tau (MAPT), alpha-synuclein (SNCA), and leucine zipper tumor suppressor 3 (LZTS3) genes are implicated in neurodegeneration and tumor suppression, respectively. This study investigated the regulatory roles of eugenol on paraquat-altered genes. Results Forty male Wistar rats divided into five groups of...
Article
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INTRODUCTION: Accurate body weight and height estimation is crucial for pediatric healthcare, nutrition assessment, and forensic investigations. Traditional methods often rely on direct measurements, which may not always be feasible, especially in emergency or resource-limited settings. The present study aimed to develop regression equations for pr...
Article
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BACKGROUND AND AIM: Nicotine is an additive abused among youths, which gradually becomes behavioral. The aim of this study was to investigate the ameliorative roles of aqueous garlic cloves and honey extract on nicotine-induced cognitive, spatial memory, and psychosocial behavior impairments. METHODOLOGY: Forty rats were divided into 5 groups of ei...
Article
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Objectives: We considered maternal and birth anthropometric features and fetal sex in developing a labor protocol. Materials and Method: A prospective study of 400 mothers, having healthy pregnancies and their newborn singletons in gynecology ward of Alex Ekwueme Federal University Teaching Hospital, Abakaliki. The study adopted a convenient sampli...
Article
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ABSTRACT Cloves possess antimicrobial and antioxidant activities, among other roles, they can play. This study investigated the effect of clove oil (CLO) on testicular and epididymal changes induced by cadmium chloride (CdCl). A total of 25 rats were randomly assigned to five groups of five rats. Group A was allowed feed and water ad libitum....
Article
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The longstanding use of artemisinin and its derivatives, mainly artesunate among pregnant women is recommended as first line treatment for malaria especially in endemic area like Nigeria. The present study investigated the morphological and histological effects of artesunate on the developing cerebral cortex of Wistar rat foetuses. Twenty healthy f...
Article
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Mercury is a hazardous heavy metal and the nervous system has been shown to be the main target. The present work was aimed at evaluating the effects of ascorbic acid on mercury exposure on spatial learning and memory of adult Wistar rats. Twenty five adult Wistar rats (average weight 185 g) were randomly divided into five groups of five rats per gr...
Article
Full-text available
Artesunate an antimalarial drug has been reported to cause irreversible brain damage in experimental rats, and to cause other toxic effects like haemolysis and neutropenia. This study was conducted to investigate the morphometric teratogenic effect of the antimalarial agent artesunate (ARTS) on the developing olfactory bulb of Wistar rats following...
Article
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Mercury is a highly toxic metal that exerts its adverse effects on the health of humans and animals worldwide. The present study was aimed at the histological studies of the hepatoprotective effects of aqueous and ethanolic fruit extracts of Phoenix dactylifera L. on mercury induced liver damage in Wistar rats. A total of forty five (45) adult Wist...
Article
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Cadmium toxicity affected muscle tone and grip strength and also increased the anxiety level of Wistar rats, which was backed by the alterations recorded in various parts of the brain as seen in the untreated group. The treated groups showed an improvement that may have been enhanced by the antioxidant and anti-inflammatory properties of the clove...
Article
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This study analyzed the differences in the decomposition patterns and post mortem intervals of hanged and surface carcasses using domestic pigs as human analogues. Six domestic pigs weighing between 25kg–30 kg were separated into two groups comprising three pigs each. Three pigs were hanged on the branches of trees at the research facility; whereas...
Article
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Objective: To investigate the roles of Curcuma longa in ketamine-induced motor impairments, anxiety, and contextual fear caused by alterations in the hippocampus, prefrontal cortex, and cerebellum. Methods: The thirty-five female Wistar rats were assigned into five groups of seven rats. Group A served as a control; Group B received ketamine only. G...
Article
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The study evaluated the role of Irvingia gabonensis as an antidote for memory loss in streptozotocin (STZ) hyperglycemia. Forty-two rats were grouped into six groups of seven rats. A single dose of STZ (60mg/kg) given intraperitoneally was used to induce hyperglycemia and confirmed after 72 hours with over 200mg/dL of fasting blood glucose. Three...
Article
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Hyperglycemia as a life threatening disease causes motor impairments which has been ignored by researchers and clinicians. The study investigated the antidiabetic potential of Irvingia gabonensis (IG) on diabetic induced motor disorder in albino rats. Thirty rats were assigned into 6 groups of 5 rats each. Diabetes was induced by a single intra-per...
Article
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Background : Thymus and bone marrows are vital and primary organs of the lymphoid system and important targets for toxins and chemical agents. Objective : The aim was to study the role of clove oil on Cadmium-induced changes in TNFα and lymphatic tissues of adult Wistar rats. Methodology : Twenty-five rats were assigned into five groups of five r...
Article
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Background: Piper guineense and honey contain antioxidative, anti-inflammatory, and antimicrobial properties that can help restore neuronal and other cell damage. To investigate the neuromodulatory roles of p. guineense and honey against lead toxicity on the hippocampus and cerebellum, impairing social behaviors and motor activities. Methodology:...
Article
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Abstract Aim: This study aims to characterize the body stature and age, handgrip, and endurance strength of elite male weightlifters, and ascertain the anthropometric features that can boost IRM bench press. Methods: Forty-four elite male weightlifters of different weight categories participated in this study. All participants were members of the E...
Article
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Context: Mercury is a widespread environmental and industrial pollutant that exerts toxic effects on vital organs. The cerebrum, composed of cortical areas such as the primary motor cortex (M1), is a vulnerable target of mercury toxicity within the central nervous system. Phoenix dactylifera is used in folk medicine to treat diverse disorders, such...
Preprint
Full-text available
Objectives: We aim to develop a labor protocol for male or female birth, base on maternal and neonatal stature. Materials and method: A prospective study of a cross section of pregnant mothers and their newborn babies, based on convenient sampling technique. A total of 480 mothers that were identified by a gynecologist as having healthy pregnancies...
Article
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Build-up of Aluminium within the brain can occur via different routes. Accumulation of aluminium in different forms have been known to trigger neuronal excitotoxicity and hence triggering apoptosis among neuronal cells. The aim of this study was to study the protective effects of eugenol on aluminium induced neurotoxicity on the cerebellum of adult...
Article
Full-text available
The metal aluminium (Al) is a well-documented neurotoxin and has been known to exacerbate excitotoxicity within the human nervous system. This present research is aimed and intended at assessing the neuroprotective effect of eugenol (EG) against the toxic effects of aluminium chloride (AlCl3) in vivo using Wistar rats as a study model. 20 adult Wis...
Article
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Mercury toxicity has been reported to cause distortion of gait and motor coordination due to deficit in the activity of cerebellum. Chelation therapy used in heavy metal toxicity is expensive and has been associated with adverse side effects. Therefore, the present study was aimed at evaluating the effect of ethanolic extract of Psidium guajava lea...
Article
Full-text available
Nicotine is an additive drug and one of the most abused drugs especially by the youths. Thestudy was aimed at elucidating the effects of garlic and honey on nicotine induced toxicity onspatial learning and memory, and hippocampus of Wistar rats. Forty male Wistar rats weredivided into eight groups of five rats each. Group A received food and water...
Article
Full-text available
ABSTRACTBuild-up of Aluminium within the brain can occur via different routes. Accumulation of aluminium in different forms have been known to trigger neuronal excitotoxicity and hence triggering apoptosis among neuronal cells. The aim of this study was to study the protective effects of eugenol on aluminium induced neurotoxicity on the cerebellum...
Article
Full-text available
Context: Mercury is a widespread environmental and industrial pollutant that exerts toxic effects on vital organs. The cerebrum, composed of cortical areas such as the primary motor cortex (M1), is a vulnerable target of mercury toxicity within the central nervous system. Phoenix dactylifera is used in folk medicine to treat diverse disorders, such...
Article
Full-text available
Introduction: World scientists are using facial morphometry as a reconstructive option in the treatment of patients and ethnic differentiations. Hence, the authors aimed to study the naso-facial dimensions of northern population in Nigeria. Materials and methods: About 500 subjects (Igede, n = 260 and Idoma, n = 240) were recruited from schools...
Preprint
Background Nicotine form the major constituent of consumed tobacco and cigarettes throughout the World resulting in oxidative stress while garlic and honey have been shown to contain numerous natural antioxidants. We investigated the role of combined effects of garlic and honey on nicotine induced Cerebellar and behavioral toxicity in Wistar rats....
Article
Full-text available
Aim: The study aimed at comparing the effects of ethanolic extract of Sesamum indicum seeds with mesterolone on some testicular morphometry following ketoconazole induced damage in Wistar rats. . Methods: Thirty-six (36) adult male Wistar rats were divided into six (6) groups of six rats each. Groups 1,2,3,4,5 and 6 were administered 1 ml of normal...
Article
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Title: "Histological and Histochemical Studies on the Neuroprotective Effect of Aqueous Fruit Extract of Phoenix dactylifera l. (date palm) on Mercury–induced Cerebellar Damage in Wistar Rats" ABSTRACT The cerebellum is vulnerable to damage from a variety of sources such as degenerative diseases, infectious processes and toxins, like, mercury. In...
Article
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The study of the behaviour, the hippocampus and cerebellar cortex of adult Wistar rats exposed to lead and treatment with Psidium guajava leaf extract. Iliyasu Musa Omoyine1,∗, O. Ibegbu Augustine2, S. Sambo James3, A. Musa Sunday4, S. Akpulu Peter 4, A. Animoku Abdulrazaq1, Musa Mustapha4 1 Department of Anatomy, Faculty of Basic Medical Science...
Article
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Beta-carotene (βC), a lipid-lowering agent, has been proposed to be a lipid-soluble antioxidant that functions as a precursor of vitamin A. The aim of this study is to evaluate β-carotene-induced effects on hepato-biochemical parameters of Wistar rats exposed to dietary fats. Thirty Wistar rats were divided into six groups. Group A received rat cho...
Article
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Lead is a heavy metal found in earth’s crust. It is a widespread and insidious environmental toxin known as a severe and aggressive contaminant to human and animal organisms’ health status. This work is aimed at evaluating the effect of aqueous extract of Ocimum gratissimum (OG) on lead induced changes in the thymus of adult albino wistar rats. Thi...
Article
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The Grasscutter ( Thryonomys swinderianus ), is a wild herbivorous rodent peculiar to Africa. It is widely eaten in Nigerian rural communities as a protein source hence its domestication as microlivestock. There is paucity of data on the histochemical studies. This study was aimed at histochemically analyzing the stomach in order to determine if it...
Article
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BACKGROUND: Stature reconstruction from skeletal remains forms part of forensic investigations in anthropology for the purpose of individual identifications. Despite a growing number of forensic cases in Idomaland, a very little work has been done to document stature estimation among modern Idoma people. AIM: This study aimed to determine stature f...
Article
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Introduction: Ethanol consumption during pregnancy has been shown to jeopardize the health of the mother and the embryo. Aim: The aim of the present study was to evaluate the histological and biochemical changes associated with the administration of Tamarindus indica pulp extract (TIPE) on the cerebral cortex in prenatal ethanol exposed Wistar rats...
Article
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Assessment of nutritional status in pediatric populations is useful to estimate growth patterns and identify signs and symptoms associated with malnutrition or excessive nutritional intake. The present study was aimed at assessing the nutritional status of Hausa infants between 2 to 5 years of age attending Nursery Schools in Zaria Local Government...
Thesis
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Nicotiana tabacum is the scientific name of the tobacco plant grown in several countries of the world. It has been used in variables ways such as smoking, snuffing, even chewing. The present study was to investigate the possible effects of aqueous and ethanolic leaf extracts of Nicotiana tabacum on the hippocampus, cerebral and cerebellar cortices...
Article
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Aim: Using an animal model the direct effect of aqueous extract of Nicotiana tabacum (ANT) administration on the biochemical parameters and cerebellum in Wistar rats was investigated. Methods: Twenty four (24) rats were divided into four groups with six rats per group with an average weight of 150 g. Group 1 served as the Control and was administer...
Conference Paper
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Introduction: Heavy metals such as lead has been found to cause adverse effects on the body’s organs and systems which ultimately affect their functionality. Aim: effects of the aqueous allium sativum (garlic) extracts on lead-induced changes on histological and biochemical changes on the hippocampus of Wistar rats was investigated. Materials:...
Article
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The cerebellum is vulnerable to damage from a variety of sources such as degenerative diseases, infectious processes and toxins, like, mercury. In traditional medicine, various parts of Phoenix dactylifera (date palm) are used to treat disorders, such as, loss of consciousness, nervous disorders, memory disturbances, etc, in different parts of the...
Article
Full-text available
Background: Academic performance is a term used for students based on how well they are doing in their studies. It is the outcome of education; the extent to which a student, teacher or institution has achieved their educational goals, while 2D:4D is the ratio of second (Index) to fourth (Ring) digit length. Aim: The study aimed to determine the re...
Article
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Aim: The present study was carried out to assess the relationship between nutritional status and academic performance of primary school children in Zaria, Kaduna State, Nigeria. Materials and Methods: School children from primary 3 to 6 were enrolled for the study and they were selected from three randomly selected primary schools within Zaria in K...
Article
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Aim: The aim of the study was to evaluate the effect of ethanolic pulp extract of Tamarindus indica (EPTI) on the cerebral cortex in prenatal ethanol exposure in Wistar rats. Method: Twenty four pregnant rats were divided into 7 groups. The Control received 1ml of water, Groups 2 and 3 received 200mg/kg and 300mg/kg body weight (bw) of EPTI and Vit...
Article
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Aim: The effect of ethanolic leaf extract of Ocimum gratissimum on sodium nitrite-induced cerebral oxidative stress in adult Wistar rats was evaluated. Methods: Twenty four adult Wistar rats of weight between 150g to 250g were divided into six groups of four rats each. Group I was the Control and received 2ml/kg bwt of distilled water, Group II rec...
Article
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Background: Anthropometric variables are important biometric characteristics that varies with age, sex, and tribe. Aim: Following the paucity of research in cephalometry as subdivisions of biological and forensic anthropology, this study was undertaken due to lack of adequate cephalometry among Nigerians. Methods: Four hundred and twenty five subje...
Article
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The comparative study of cephalometric indices among the Igede and Idoma ethnic groups of Benue State was undertaken due to lack of adequate cephalometry among Nigerians. The anthropometric characteristics of 425 apparently normal adults of ages 17-40 years of Igede and Idoma ethnic extractions of Benue State, Nigeria with no physical deformities o...
Article
Full-text available
Introduction: Intoxication of nitrites mainly from food and water constitute a potential hazard with a resultant hypoxia. Aim: The aim was to study the effects of ethanolic leaves extract of Ocimum gratissimum on sodium nitrite (NaNO 2 )-induced cerebellar toxicity in adult Wistar rats. Materials and Methods: Twenty-four adult Wistar rats weighing...
Article
Full-text available
Aim: The present study was aimed at evaluating the effects of aqueous leaves extract of Psidium guajava on histopathological changes observed in hippocampus of adult Wistar rats exposed to lead acetate. Methods: Thirty-five adult Wistar rats were grouped into 7 Groups of 5 rats per Group. The rats were exposed to lead acetate at a concentration of...
Article
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Von Economo neurons (VENs) are large bipolar neurons found in the anterior cingulate, frontoinsular and dorso-lateral prefrontal cortices of great apes and the humans. VENs are defined by their thin, elongated cell body and long dendrites projecting from the apical and basal ends. These neurons are mostly present in particularly high densities in c...
Article
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Introduction. The anthropometric characteristics of 600 normal Nigeria School Children of ages between 5-10 years of Gbagyi tribe of Abuja, with no obvious deformities or previous history of trauma to the hand were selected for this study. Materials and methods. Of these children, males (n=300) with mean age of 7.10 ± 1.98, and females (n=300) with...
Article
Full-text available
Introduction. Mercury is one of the most hazardous environmental contaminants to living organisms and the central nervous system has been shown to be the main target. Objective. The present work was aimed at evaluating the effect of ascorbic acid on mercury chloride-induced changes on the cerebellar cortex of adult Wistar rats. Material and method....
Article
Full-text available
Aim: The present study was aimed at evaluating the effect of ascorbic acid on mercury-induced changes on the cerebellar cortex of adult Wistar rats. Methods: Thirty adult Wistar rats of average weight of 200g were randomly divided into 6 groups of 5 rats each. The animals in Group 1 (control) were administered with distilled water, Groups 2 and 3 w...
Article
Full-text available
S The study was aimed at evaluating the hypoglycaemic effects of melatonin and Azadirachta indica administration on blood glucose levels in streptozotocin (STZ) induced diabetic Wistar rats. To achieve this, thirty Wistar rats were used in the study. The animals were assigned into the following groups: Group 1: Normal control + normal saline orally...
Article
Full-text available
This study was aimed at evaluating the histological effects of melatonin and Azadirachta indica leaves ethanolic extract administration on the pancreatic tissue in streptozotocin-induced diabetic Wistar rats. Forty five male Wistar rats were used in the study. The animals were divided into two main groups control group A and diabetic group B. The a...
Article
Full-text available
This study was aimed at evaluating the histological and biochemical effects of ethanol leave extract of Azadirachta indica and melatonin in streptozotocin-induced diabetic Wistar rats. To achieve this, forty five Wistar rats were used in the study. The animals were assigned into the following groups: Group 1: Normal control + normal saline orally;...
Article
Full-text available
The aim of the present study was to evaluate the relationship between handgrip strength and some anthropometric variables in 400 randomly selected Secondary School Students in Kano, Nigeria. The students were from two secondary schools and were aged 14-18 years with mean age of 16.00±1.35. The anthropometric variables namely, the height, weight, BM...