Augustine Arukwe

Augustine Arukwe
Norwegian University of Science and Technology | NTNU · Department of Biology

Dr. scient

About

223
Publications
37,520
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7,404
Citations
Citations since 2017
53 Research Items
2821 Citations
20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500

Publications

Publications (223)
Article
Landfills and dumpsites are the final point of solid waste deposition and management in developing countries due to lack of recycling methods. Herein, we have investigated the occurrence, polymer composition and characterization of plastic pollution at the Lemna solid waste dumpsite, Calabar Nigeria. A total of 21 plastics were sampled and categori...
Article
Full-text available
This state-of-the-science review is aimed at identifying the sources, occurrence, and concentrations of EDCs, including potential public health risks associated with drinking water and aquatic food resources from Nigerian inland waters. A total of 6024 articles from scientific databases (PubMed, Scopus, Web of science, ScienceDirect, Google Scholar...
Article
Full-text available
We studied molecular effects (RNAseq and qPCR) of first feeding prey types (copepods or rotifers/ Artemia ) on skeletal muscle myogenesis and growth dynamics (proliferation, differentiation), metabolism (glycolysis, gluconeogenesis, oxidative phosphorylation), and antioxidant defense system (production/regulation of reactive oxygen species (ROS) in...
Article
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The increasing exploratory efforts in the Greenland mineral industry, and in particular, the proposed rare earth element (REE) mining projects, requires an urgent need to generate data on baseline REE concentrations and their potential environmental impacts. Herein, we have investigated REE concentrations in anadromous Arctic char (Salvelinus alpin...
Article
The Norwegian Scientific Committee for Food Safety performed the present assessment of the differences between organic and conventional foods and food production on plant health, animal health and welfare and human health at the request of the Norwegian Food Safety Authority. The work was divided into five parts: (I) Plant health and plant producti...
Article
Full-text available
In the present study, we investigated the dopaminergic and steroid hormone systems of A/J mice fed environmentally relevant concentrations of a perfluoroalkyl substance (PFAS) mixture over a period of 10 weeks. The PFAS mixture was chosen based on measured PFAS concentrations in earthworms at a Norwegian skiing area (Trondheim) and consisted of eig...
Article
Due to the heavy fuel oil (HFO) ban in Arctic maritime transport and new legislations restricting the sulphur content of fuel oils, new fuel oil types are continuously developed. However, the potential impacts of these new fuel oil types on marine ecosystems during accidental spills are largely unknown. In this study, we studied the toxicity of thr...
Article
Full-text available
Estrogenic compounds are widely released to surface waters and may cause adverse effects to sensitive aquatic species. Three hormones, estrone, 17β-estradiol and 17α-ethinylestradiol, are of particular concern as they are bioactive at very low concentrations. Current analytical methods are not all sensitive enough for monitoring these substances in...
Article
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In the present study, we have investigated the effects of three (elutriate, polar and non-polar) different soil extraction methods from the Lemna solid waste dumpsite (Calabar, Nigeria) on the biotransformation, antioxidant and cellular defense responses of PLHC-1 cell line. Following a 48 h exposure period to different concentrations of each extra...
Article
Perfluoroalkyl substances (PFAS) are contaminants that are applied in a wide range of consumer products, including ski products. The present study investigated the neuro-dopamine (DA) and cellular steroid hormone homeostasis of wild Bank voles (Myodes glareolus) from a skiing area in Norway (Trondheim), in relation to tissue concentrations of PFAS....
Article
Full-text available
Racemic ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP) are widely used non-steroidal anti-inflammatory drugs (NSAIDs), and commonly detected in the aquatic environment. The present study has evaluated the toxicological effects of RS-KP and S(+)-KP on biotransformation and oxidative stress responses in gills and liver of Atlantic sal...
Article
Full-text available
Because of their global consumption and persistence, per- and polyfluoroalkyl substances (PFASs), are ubiquitously distributed in the environment, as well as in wildlife and humans. In the present study, we have employed an ex vivo organ culture technique, based on the floating agarose method, of Atlantic cod ovarian tissue to investigate the effec...
Article
Full-text available
Microplastics (MPs) are physical anthropogenic pollutants and their ability to act as contaminant vectors in biological matrices is of serious ecosystem and human health concern. In the present study, we have, for the first time, screened and detected MPs in the stomach of a select group of commonly consumed fish species from a municipal water supp...
Article
Full-text available
In the present study, a previously capped waste disposal site at Kollevåg (Norway) was selected to study the effects of contaminant leakage on biomarkers associated with Atlantic cod (Gadus morhua) reproductive endocrinology and development. Immature cod were caged for 6 weeks at 3 locations, selected to achieve a spatial gradient of contamination,...
Article
In this experiment, golden rabbitfish (Siganus guttatus) were allocated between three treatment groups. The fish were injected with saline, human chorionic gonadotropin (hCG) and D‐Ala6, Pro9‐Net‐mGnRH. After injection, in 6 hr intervals, blood plasma samples were collected for steroid hormone (testosterone [T] in males and estradiol‐17β [E2] in fe...
Article
Full-text available
The Norwegian Scientific Committee for Food Safety (Vitenskapskomiteen for mattrygghet, VKM) has on request of The Norwegian Food Safety Authority performed a risk assessment of furan intake in the Norwegian population based on the most recent national food consumption surveys. National occurrence data of furan concentrations in food were preferent...
Article
Full-text available
Perfluoroalkyl substances (PFASs) are used in a wide range of consumer products, including ski products, such as ski waxes. However, there is limited knowledge on the release of PFASs from such products into the environment and the resultant uptake in biota and transport in food webs. We investigated levels, patterns, and biomagnification of PFASs...
Article
Black jaw tilapia (S. melanotheron) collected from Awba Dam (a watershed recipient of effluents from anthropogenic sources) was analysed for biological responses and trace metal burden with the aim of evaluating sex differences in these responses as a measure of environmental and biota health status. Concentration of heavy metals in fish muscle wer...
Article
Solid waste dumpsites (SWDs) and landfills are significant sources of emerging contaminants to terrestrial and aquatic ecosystems. We have studied the endocrine disruptive effects of simulated leachate from a solid waste dumpsite in Calabar, Nigeria. Juvenile C. gariepinus were exposed to simulated leachate, diluted to 0:0 (control), 1:10, 1:50, 1:...
Article
In this study, sediment samples from Makoko and Ikorodu sites of the Lagos lagoon (Nigeria) were screened for toxicological responses on mammalian and fish cell lines using different extraction methods. Rat hepatoma H4IIE and fish PLHC-1 cell-lines were exposed to serial dilutions of the elutriate, polar and non-polar extracts. We evaluated exposed...
Article
Full-text available
We examined the potential for ultrasound as a noninvasive tool for maturation monitoring in Atlantic salmon (Salmo salar) males. Ultrasound examination and measurements were compared to common practices for maturation monitoring such as gonadosomatic index (GSI), sex hormone analysis, and histological analysis of spermatogenesis. There were signifi...
Article
Due to a northward shift in off-shore activities, including increased shipping traffic and oil and gas exploration there is a growing focus on the potential effects of oil pollution on Arctic marine ecosystems. Capelin (Mallotus villosus) is a small fish and a member of the smelt family, and is a key species in the marine food chain. Capelin are se...
Article
The dopaminergic effect of PAH and PFAS mixtures, prepared according to environmentally-relevant concentrations, has been studied in juvenile female Atlantic cod (Gadus morhua). Benzo[a]pyrene, dibenzothiophene, fluorene, naphthalene, phenanthrene and pyrene were used to prepare a PAH mixture, while PFNA, PFOA, PFOS, and PFTrA were used to prepare...
Article
Organophosphate esters (OPEs) are frequently used as replacements for the banned polybrominated diphenyl ether (PBDEs). Since OPEs are structurally similar to organophosphate pesticides, exposure and toxicity of these compounds is of significant societal and scientific interest. Cytotoxicity (MTT), biotransformation (cyp1a1) and oxidative stress re...
Article
Despite the important ecosystem and hydrological roles of coastal and inland waters, there are no established biomonitoring protocols for evaluating environmental, wildlife and human health for these coastlines in Nigeria. In the present study, contaminants tissue burden and effects at molecular and physiological levels, were investigated in Tilapi...
Article
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The present report is based on data from the 2010 EFSA Report on pesticide residues in food, the Norwegian monitoring programmes 2007-2012 and data from peer reviewed literature and governmental agencies. It is a challenge to perform quantitative estimates and comparative studies of residue levels due to large variation in the measured levels, and...
Article
Full-text available
The Norwegian Food Safety Authority requested the Norwegian Scientific Committee for Food Safety (VKM) to assess the risk of lead exposure to the Norwegian population by consumption of cervid meat, including any subpopulations with an increased risk. Further, VKM was asked to describe the distribution of lead from ammunition in the carcass and to e...
Article
The aim of this study was to assess whether fish in Kollevåg, a sheltered bay on the western coast of Norway, previously utilized as a waste disposal site, could be affected by environmental contaminants leaking from the waste. Farmed, juvenile Atlantic cod (Gadus morhua) were caged for six weeks at three different locations in Kollevåg bay and at...
Conference Paper
Abstract Purpose Probiotics may have immunomodulatory role with potential anti-inflammatory effects on muscle, however the mechanism of action is unclear. Our article aim was to investigate on the effects of Pediococcus acidilactici on peroxisome proliferative activated receptor gamma (PPARγ) and underlying molecular mechanism in muscle tissue of...
Article
Full-text available
The mercury (Hg) poisoning of Minamata Bay of Japan widely activated a global attention to Hg toxicity and its potential consequences to the aquatic ecosystem and human health. This has resulted to an increased need for a dynamic assembly, contextualization, and quantification of both the current state-of-the-art and approaches for understanding th...
Article
In the present study, H295R human cells were used to investigate the endocrine disruptor potential of three different sediments extracts taken from a Nigerian tropical freshwater dam (Awba Dam), using three extraction methods that allowed a selective consideration of contaminants based on their binding affinity, which is mainly driven by polarity,...
Data
Figure S1. Rearing conditions. Temperature (blue), and natural (black) and artificial (dashed line) light profiles during seawater and freshwater phases. Horizontal boxes represent seawater and freshwater phases.
Data
Table S2. Histological classification of oocytes in sections from Atlantic salmon ovaries (Taranger et al. 1999; Andersson et al. 2009).
Data
Figure S2. Gonado‐somatic index (GSI) in female Atlantic salmon during the last year before ovulation. Samplings from September 2014 through July 2015 are monthly, while August and September 2015 samplings are weekly. Horizontal bars at the top represents changes in environment conditions. Data are mean ± SEM. Letters indicate significant differenc...
Data
Table S1. Mean fish weight (±SEM) and K factor (±SEM) for all samplings. Number of samples analyzed for sex hormone concentration and histology for each sampling. 11‐KT, 11‐keto testosterone; E2, oestradiol; FSH, follicle‐stimulating hormone; LH, luteinizing hormone; MIH, maturation inducing hormone, T, testosterone.
Data
Figure S3. Profiles of plasma sex steroids in female Atlantic salmon during the last year before ovulation. Samplings are monthly from September 2014 through July 2015, and then weekly from there. (A) oestradiol, (B) testosterone, (C) luteinizing hormone, (D) follicle stimulating hormone, (E) 11‐keto testosterone hormone, (F) maturation inducing ho...
Article
Full-text available
Aiming to explore ultrasound technology as a noninvasive method for maturation monitoring, we compared ultrasound observations and measurements in female Atlantic salmon (Salmo salar) during the last year before ovulation with standard, invasive methods such as gonadosomatic index (GSI), gonad histology and sex hormone analysis. Ultrasound measurem...
Article
Pharmaceuticals such as racemate ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP) are highly detectable non-steroidal anti-inflammatory drugs (NSAIDs) in the aquatic environment and therefore are designated as one of the most emerging groups of pollutants that can affect environmental and human health. The potential impact of these ph...
Article
Polychlorinated biphenyls (PCBs), and similar environmental contaminants, have been linked to virus outbreaks and increased viral induced mortality since the 1970s. Yet the mechanisms behind this increased susceptibility remain elusive. It has recently been illustrated that the innate immune viral detection system is tightly regulated by small non-...
Article
Given the compound differences between tris(2-butoxyethyl)- and tris(2-cloroethyl) phosphate (TBOEP and TCEP, respectively), we hypothesized that exposure of juvenile salmon to TBOEP and TCEP will produce compound-specific differences in uptake and bioaccumulation patterns, resulting in potential formation of OH-metabolites. Juvenile salmon were ex...
Article
Faroe Island pilot whales have been documented to have high body burdens of organohalogen contaminants (OHCs), including polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), but low burdens of their respective hydroxylated metabolites (OH-PCBs and OH-PBDEs). The present study investigated the hepatic expression and/or cataly...
Article
Understanding the effects of environmental factors in sperm qualities will be helpful in the development of optimal artificial reproduction methods and contributes towards the knowledge base of better short- and long-term fish semen preservation conditions The objectives of this study were to determine properties and activities of wild-caught strip...
Article
Receptor (i.e. genomic) and non-receptor (or non-genomic) effects of endocrine toxicology have received limited or almost non-existent attention for tropical species and regions. In the present study, we have evaluated the effects of di-(2-ethylhexyl) phthalate (DEHP) on neuro- and interrenal steroidogenesis of the African catfish (Clarias gariepin...
Article
The increased use of non-steroidal anti-inflammatory drugs (NSAIDs) has resulted in their ubiquitous presence in the environment. The toxicological properties of these two widely prescribed NSAIDs, namely - racemic ketoprofen (rac-KP) and its enantiomer S(+)-ketoprofen (dexketoprofen, DKP) were evaluated. Firstly, by acute and chronic toxicity test...
Article
We have investigated gross pathology, physiological (steroid precursors) and toxicological responses (oxidative stress and phase II biotransformation) in relation to tissue contaminant burden in Tilapia species along the entire length (320 km) of Ogun River, Nigeria. The Ogun River is the longest and largest river in Southwestern Nigeria located al...
Poster
We conclude that aro-1260 contributes to decreased host resistance to viral infections by modulation of the NF-kb1/miRNA pathway. We present the first data that environmental pollutants modulate mi-RNA induced viral signalling
Article
To date, knowledge of persistent organic pollutant (POP) mediated oxidative stress responses in avian species is rather limited. We therefore investigated whether exposure to polybrominated diphenyl ethers (PBDEs) and organochlorine pesticides (OCPs) in two predatory bird species, namely black kite (Milvus migrans) and spotted owlet (Athene brama),...
Article
In the present study, we investigated the occurrence of intersex condition, histopathological changes in the gonad and endocrine disruptor biomarker responses in Tilapia species (Tilaipia guineensis, Sarotherodon galileaus and Oreochromis niloticus) along the Ogun River, Nigeria. The study sites covered a length of 320 km and a total of 1074 tilapi...
Article
The distributions of polychlorinated biphenyl (PCB) congeners were determined in sediment and muscle of the African sharptooth catfish (Clarias gariepinus) from the Ogun and Ona rivers, southwest Nigeria. In addition, the effect of PCB congeners on condition factor (CF) and associated human health risk was assessed using muscle levels for a noncarc...
Article
There is limited knowledge on the toxicological, physiological, and molecular effects attributed to organophosphate (OP) compounds currently used as flame retardants or additives in consumer products. This study investigated the effects on oxidative stress and lipid peroxidation in juvenile Atlantic salmon liver and brain samples after exposure to...
Article
Full-text available
The relationship between condition factor (CF), peroxisome proliferator-activated receptors (PPARs), phase 1 biotransformation (CYP1A isoforms) and contaminant burden has been studied in S. melanotheron from a contaminated tropical freshwater dam (Awba Dam) and compared to a reference site (Modete Dam) in Southwest, Nigeria. A total of 89 fish (57...
Article
In the present study, the developmental (including fertility) and endocrine-disruptive effects in relation to chemical burden in male and female Nile crocodiles (Crocodylus niloticus), from a commercial crocodile farm in the Brits district, South Africa, exposed to various anthropogenic aquatic contaminants from the natural environment was investig...
Article
Full-text available
The interactions between tri-m-cresyl phosphate (TMCP; an organophosphate flame retardant) and peroxisome proliferator activated receptors (PPARs) or liver X receptor α (LXRα) were investigated in seabream hepatocytes. The study was designed to characterize the binding of TMCP to PPARα, PPARγ and LXRα by computational modeling (docking) and transcr...
Article
Full-text available
In the present study, the biotransformation and oxidative stress responses in relation to chemical burden in the liver of male and female Nile crocodiles-Crocodylus niloticus-from a commercial crocodile farm passively exposed to various anthropogenic aquatic pollutants was investigated. In general, the data showed that male crocodiles consistently...
Conference Paper
Biochemical parameters and metallothionein gene expressions are sensitive biomarkers for assessing the health of aquatic biota exposed to environmental contaminants. Tilapia species collected between June to September, 2014 from Awba dam (a recipient of effluents from anthropogenic sources) were analysed for biochemical parameters such as AST, ALT,...
Conference Paper
Environmental contaminants discharged into the aquatic environment may disrupt normal endocrine physiology in fish. Herein, the occurrence of endocrine disruptive responses in Tilapia species from Awba Lake has been investigated. The Awba Lake is a recipient of effluents from several anthropogenic sources. A total of 89 Tilapia species (Tilapia gui...
Conference Paper
The effects of increasing exposure to endocrine disrupting chemicals on weight homeostasis is currently receiving great attention due to the assumption that long term exposure to environmental pollutants can influence the development of metabolic diseases such as diabetes and obesity by activating the PPAR receptors regulating adipogenesis. A total...
Article
Evidence that endocrine-disrupting chemicals (EDCs) may target metabolic disturbances, beyond interference with the functions of the endocrine systems has recently accumulated. Among EDCs, phthalate plasticizers like the di-isodecyl phthalate (DiDP) are commonly found contaminants of aquatic environments, and have been suggested to function as obes...
Conference Paper
The alarming number of legacy and emerging contaminants that have been released and are currently released through a variety of human activities into the aquatic environment has made them become increasingly threatening for the health of the aquatic environment and humans. For developing countries such as Nigeria and in spite of the increasing use/...
Conference Paper
The environmental obesogen hypothesis has proposed the role of EDCs in the development of obesity through the activation of PPARγ, a key regulator of adipogenesis and medically implicated in obesity. In addition, the induction of cytochrome P450 by environmental pollutants (PAHs, PCBs, dioxin and furans) in organisms through the AhR is generally us...
Conference Paper
Full-text available
Fisk som vokser raskt har god appetitt med et høyt fôropptak og får dermed rask og effektiv tilførsel av energi og næringsstoffer. Fiskens appetitt er en rask og god indikator på fiskens ve og vel. Høyt fôrinntak er ønskelig allerede fra startfôring, samtidig som lite er kjent om de indre faktorer som påvirker og styrer fiskens appetitt, spesielt p...
Article
Full-text available
The effects of hypoxia and perfluorooctane sulfonamide (PFOSA), given singly and also in combination on endocrine, biotransformation, and oxidative stress responses were investigated in primary culture of salmon hepatocytes. Hypoxia was induced chemically using cobalt chloride (CoCl2) or deferroxamine (DFO). Primary culture of salmon hepatocytes we...
Conference Paper
Vitellogenin (Vtg: egg yolk precursor) and zona radiata (Zrp: eggshell) proteins are phenotypic female-specific responses that are under estrogenic control in oviparous species. The expression of these genes in male and juvenile fish is widely used as biomarkers of exposure and effect for endocrine disrupting chemicals (EDCs). Despite the universal...
Article
In the present study, we have investigated the effects of 30-day dietary (pre-pubertal) exposure to different doses (0 (control), 1, 10, 50,200 and 400 mg/kg bodyweight/day) of di(n-butyl) phthalate (DBP) on Leydig cells of adult male Japanese quails by quantifying the transcript levels for P450 side-chain cleavage (p450scc), P450c17 (CYP17), and 3...