Aude Allemang-Trivalle

• Doctor of Pharmacy
• PhD Student at University of Tours

In the individual stepped‐wedge randomized trial (ISW‐RT), subjects are allocated to sequences, each sequence being defined by a control period followed by an experimental period. The total follow‐up time is the same for all sequences, but the duration of the control and experimental periods varies among sequences. To our knowledge, there is no val...

Background: Vascular anomalies (VAs) are increasingly being treated with PI3K/AKT/mTOR pathway inhibitors. These drugs have immunosuppressive properties and thus theoretically overexpose patients to opportunistic infections, especially Pneumocystis jirovecii pneumonia (PJP). PJP prophylaxis use lacks consensus. We aimed to investigate the prevalen...

Background Rare superficial vascular anomalies represent a wide range of diseases. Their management is difficult given the broad spectrum and the lack of clinical trials assessing treatment efficacy. A randomized clinical trial of vascular anomalies is difficult because of the rarity of the diseases and is enhanced by the population of interest oft...

Background: Topical drugs are often used as first-line treatment for dermatological conditions. A within-person design may then be well adapted: it consists of randomizing lesions/body sites rather than patients, which are then concomitantly treated by the different drugs compared, reducing inter-group variability and therefore requiring fewer pat...

Background: Stressful events during a pandemic are a major cause of serious health problems, such as burnout, depression and posttraumatic stress disorder (PTSD) among health care workers (HCWs). During three years, HCWs, on the frontline to fight the COVID-19 pandemic, have been at an increased risk of high levels of stress, anxiety, depression, b...

Background COVID-19 has severely affected the elderly who are expected to display decreased immune responses due to immunosenescence. Methods This study retrospectively assesses neutralizing antibodies (NAb) productions up to 12 months(M) after infection in Long-term care patients. We used Roche diagnostics immunoassay to quantify anti-Spike(S) an...

Introduction Les anomalies vasculaires (AVs) superficielles rares représentent un large panel de maladies et sont classées par l'International Society for the Study of Vascular Anomalies dans le groupe des tumeurs vasculaires ou des malformations vasculaires. Leur prise en charge est difficile étant donné le large spectre de ces pathologies et le m...

Introduction La pandémie de COVID-19 a gravement affecté les personnes âgées. Rares études ont évalué la réponse anticorpale anti-SARS-CoV-2 dans cette population, qui a une diminution attendue des réponses immunitaires humorales et cellulaires due à l’immunosénescence. Matériels et méthodes Nous décrivons les caractéristiques cliniques et sérolog...

Résumé Les méthodes de stimulation multisensorielle principalement représentées par le concept de Snoezelen sont de plus en plus utilisées comme thérapeutique non médicamenteuse dans les troubles du comportement liés à la maladie d’Alzheimer et aux pathologies apparentées. À ce jour, les études sur leur efficacité restent contradictoires. Dans ce t...