Aubrey de Grey

Aubrey de Grey
SENS Foundation · n/a

PhD

About

328
Publications
33,364
Reads
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5,293
Citations
Additional affiliations
April 2009 - November 2014
SENS Foundation
Position
  • Chief Science Officer

Publications

Publications (328)
Article
Theses reviewed in this issue include "Engineering Protein Disaggregases to Counter Alpha-Synuclein and Amyloid-Beta Neurotoxicity", "Hyperglycaemia induced immunomodulation of macrophages in diabetic vascular disease", "Microvasculature-on-a-Chip Systems for Human Disease Modeling", "Senescence surveillance : the interplay between the immune syste...
Article
Theses reviewed in this issue include "An Aging Tug of War: The Accumulation of the Spontaneous L-Isoaspartate Modification in Proteins vs. Canonical and Novel Maintenance Pathways", "Cellular and molecular mechanisms underpinning microglial activation during remyelination", "Early Detection of Cancer Metastasis at a Synthetic Pre-Metastatic Niche...
Chapter
SENS Research Foundation (SRF) is a 501(c)3 biomedical research charity founded in 2009, headquartered in Mountain View, California. Its mission is to catalyze the development of the Strategies for Engineered Negligible Senescence (SENS) platform of therapies to prevent and reverse biological aging and attendant age-related disease and disability (...
Article
Theses reviewed in this issue include "Developing the Next Generation of Universal Immune Receptors", "From Synthesis to Pathology: A Bottom-Up Approach to Studying the Role of Advanced Glycation End-Products in Diabetes and Aging", "Hybrid Bioactive Nanoparticles for Modulation of Tumor Microenvironment and Enhancing Radiation and Chemotherapy Eff...
Article
Full-text available
Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from...
Article
Theses reviewed in this issue include "Advances on Chip-In-Cell Wireless Platform for Continuous Monitoring of Physiological Parameters in Single Cells," "Design and Delivery of Synthetic mRNA by a Peptide Nanoparticle," "Inflammation Alters Endothelial Progenitor Cell-derived Exosome Contents and Therapeutic Effect on Myocardial Repair," "Partial...
Article
Theses reviewed in this issue include "Engineering efficient and safe in situ genome regulation via CRISPR-Cas9 for enabling gene therapies", "Investigating the Mechanism of LINE-1 Retrotransposition in Human Cells", "Machine Learning Approaches for Prediction of Kidney Transplant Survival", "Novel Obesity Suppressor Function of the Retinoblastoma...
Article
Theses reviewed in this issue include "Characterization and Purification of Putative Stem Cells from the Adult Murine Pancreas", "Inhibition of TLR4 Minimizes Islet Damage due to Sterile Inflammation and Improves Islet Transplant Outcomes", "Liquefaction of the Brain Following Stroke Shares Multiple Characteristics with Atherosclerosis and Mediates...
Article
Theses reviewed in this issue include "Clearance of Capillary Occlusions Improves Cortical Blood Flow and Cognitive Function in Alzheimer's Mouse Models", "Dermato-informatic approaches to understanding and improving lesional diagnostic expertise in cutaneous oncology", "Furthering the Scope, Understanding, and Application of Proteolysis Targeting...
Article
Theses reviewed in this issue include "Advanced Imaging Technologies for Combined Biomedical Ultrasound and Photoacoustic Imaging", "Engineering Bispecific Chimeric Antigen Receptors to Improve the Efficacy of Adoptive T-Cell Therapy", "Il-36 Gamma Promotes Anti-Tumor Immunity Through Therapeutic Induction of Tumor-Associated Tertiary Lymphoid Stru...
Article
Theses reviewed in this issue include "Automated Analysis of Quantitative Image Biomarkers from Low-Dose Chest CT Scans", "Design, Synthesis and Delivery of a Self-Cleaving Replicon System Yielding Biologically Active MicroRNAs in vivo", "Mechanisms of Physiological Amyloidogenesis", "Programming and reprogramming neural cell types using synthetic...
Conference Paper
Full-text available
An increasing aging population poses a significant challenge to societies worldwide. A better understanding of the molecular, cellular, organ, tissue, physiological, psychological, and even sociological changes that occur with aging is needed in order to treat age-associated diseases. The field of aging research is rapidly expanding with multiple a...
Article
Theses reviewed in this issue include "Atrophied Thymus, a Tumor Reservoir for Harboring Melanoma Cells", "Evolutionary Adaptations in Developmental Signaling Pathways Underlie Regenerative Scar-Free Wound Repair in African Spiny Mouse (Genus Acomys)", "Integrated Immunoassays on Paper/Polymer Hybrid Microfluidic Devices for Low-Cost Detection of D...
Article
Theses reviewed in this issue include "Cancer and Stem Cell Extravasation through Angiopellosis", "Human Chimeric Antigen Receptor Macrophages for Cancer Immunotherapy", "Insights on Alzheimer's Disease Etiology from Network Approaches in Healthy Aging", "Myelin and Glial Pathology in Aging and Cognitive Decline: Evidence for Faulty Myelin Clearanc...
Article
Full-text available
Growing evidence supports the antagonistic pleiotropy theory of mammalian aging. Accordingly, changes in gene expression following the pluripotency transition, and subsequent transitions such as the embryonic–fetal transition, while providing tumor suppressive and antiviral survival benefits also result in a loss of regenerative potential leading t...
Article
Theses reviewed in this issue include "Downregulation of the Apelinergic Axis Accelerates Aging, Whereas Its Systemic Restoration Improves the Mammalian Healthspan," "Intracellular Delivery of Exogenous Molecules Via an Ultrahigh Throughput Mechanoporation Microdevice," "Intrinsic and Extrinsic Drivers of Treg Fragility in the Tumor Microenvironmen...
Chapter
Full-text available
The cellular environment is an extremely dynamic one, and cells are continuously subject to a range of intrinsic and extrinsic stressors that threaten the integrity of their functional units, including organelles, proteins, DNA, and membranes and functional lipids. Accordingly, systems have evolved to reduce rate of generation of endogenous damage,...
Article
Theses reviewed in this issue include "Age-Associated Lamin-B1 Reduction in the Thymic Epithelial Cells and Its Role in Thymic Involution," "Brainstem Structural Integrity in the Progression of Alzheimer's Disease," "Challenging Current Paradigms: Increasing the Efficacy of Radiation Therapy with Novel Radiation Schemes," "Cross-Talk Between the Sk...
Article
Theses reviewed in this issue include "Alpha-Synuclein Oligomers: Cellular Mechanisms and Aspects of Antibody Treatment," "Cx3cr1/cx3cl1 Axis Drives the Migration and Maturation of Oligodendroglia in the Central Nervous System," "Genome-Wide Expression Profiling of Human Circulating Monocytes and Macrophages Identifies Diagnostic and Prognostic Sig...
Article
Theses reviewed in this issue include Characterization and Modeling of Metabolic Stress Responses in Cellular Aging; Engineering Immunity: Enhancing T Cell Vaccines and Combination Immunotherapies for the Treatment of Cancer; Extracellular Inflammatory Signaling from Dysfunctional Telomeres; High-Throughput Microfluidic Labyrinth for the Label-Free...
Article
Full-text available
Background The role of brown fat in non-shivering thermogenesis and the discovery of brown fat depots in adult humans has made it the subject of intense research interest. A renewable source of brown adipocyte (BA) progenitors would be highly valuable for research and therapy. Directed differentiation of human pluripotent stem (hPS) cells to white...
Article
Theses reviewed in this issue include "A Thromboresistant Cell-Derived Biomaterial Modification for Vascular Grafts," "Actomyosin Mediated Tension Orchestrates Thermogenic Programs in Adipocytes," "Age-Associated Changes in Intrathymic B Cell Population in Mice," "Endoplasmic Reticulum Stress Is Transmissible Among Cells of the Central Nervous Syst...
Article
Full-text available
Article
Theses reviewed in this issue include "Computational Pathology for Quantifying Spatial Heterogeneity in Digital Images of Tissue Sections from Solid Tumors", "Molecular Analysis of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Brain Tissue Identifies Disease Mechanisms Associated with Repetitive DNA Elements", "Neuroprotective Poten...
Article
Theses reviewed in this issue include "Bowties, Barcodes, and DNA Origami: A Novel Approach for Paired-Chain Immune Receptor Repertoire Analysis", "Development of Canine Chimeric Antigen Receptor T Cell Therapy for Treatment & Translation", "Endocytic Vesicle Rupture in the Pathogenesis and Propagation of Neurodegenerative Proteinopathies", "Explor...
Article
Full-text available
We present a family of finite unit-distance graphs in the plane that are not 4-colourable, thereby improving the lower bound of the Hadwiger-Nelson problem. The smallest such graph that we have so far discovered has 1567 vertices.
Article
Theses reviewed in this issue include "An Intranasal GDNF Gene Therapy Approach for Treating Parkinson's Disease", "Controlling Depth of Cellular Quiescence By an Rb-E2F Network Switch", "Immunoregulation of the Central Response to Peripheral Nerve Injury: Motoneuron Survival and Relevance to ALS", and "Single-Cell Whole-Genome Sequencing Reveals W...
Article
Theses reviewed in this issue include "Characterizing Senescence in Astrocytes and its Effect on Neurons", "Contribution of Adult Skeletal Muscle Stem Cells to the Regeneration and Lifelong Maintenance of Neuromuscular Junctions", "Investigation into Feasibility of Color and Texture Features for Automated Detection of Lymph Node Metastases in Histo...
Article
Theses reviewed in this issue include "Engineering Cellular Input-Output for the Robust Control of Mammalian Cell-Based Therapies"; "Enzyme-Instructed Self-Assembly (EISA) Selectively Targets Cancer Cells"; "Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft rejection and autoimmune disea...
Article
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