Atul Phatak

• M. PHARM. Ph. D.
• Head of Department at P. E. S. Modern College of Pharmacy, Nigdi, Pune-411044

Cosmetic creams for the antioxidant activity of Punica granutum L seed oil (PSO) were formulated in different concentrations of oil in F1 to F6 formulations of cosmetic creams and their physicochemical properties were evaluated. There are several different pharmacological actions attributed to P. granutum L seed oil. The prepared cream was evaluate...

Objective: Development of robust and effective oral solid immediate release film coated tablet of empagliflozin using Quality-by-Design (QbD) approach was the objective of present research work. This belongs to Sodium Glucose Co-Transporter-2 inhibitors-oral hypoglycemic class to treat Type-2 diabetes mellitus and associated cardiovascular comorbid...

Psychiatric illness typically necessitates long-term therapy, and like with most chronic illnesses, Antipsychotics are neuroleptic drugs that belong to the class of psychotropic medications which are used majorly to manage a condition like paranoia. D2-like receptors are majorly involved in the antipsychotic action of the drug. Antipsychotics were...

Activated carbon black also known as Activated charcoal is a fine black powder that is made by burning biomass in a low oxygen environment which develops pores and increases its surface area. Activated carbon black is used in the food and pharmaceutical industry as a pH regulator, chelating agent and antioxidant synergist. Activated carbon black is...

The aim of the present study was to formulate and evaluate Posaconazole loaded NLCs gel using solid lipid as GMS, liquid lipid as oleic acid and surfactants as tween 80 and span 80, with the help of high-speed homogenization followed by sonication technique to improve the bioavailability, to avoid the oral side effects, to achieve the site-specific...

A new, simple, selective, precise and economical UV spectroscopic method was developed for the estimation of Rilpivirine in bulk forms and tablet formulation. The spectrophotometric detection was passed out at an absorption maximum of 304 nm using acetonitrile (50%) and water (50%) as solvent. The method was validated for specificity, linearity, ac...

Fast dissolving tablet of Oseltamivir is formulated by using solid dispersion technique and evaluated for in vitro dissolution syudies.

The present investigation was started with aim to formulate and assess the antimicrobial potential of Punica granatum seed oil cream. The P. granatum seed oil cream was formulated using glyceryl monostearate and other lipids like stearic acid as well as cetyl alcohol. The formulated cream was then evaluated with respect to physicochemical propertie...

Colesevelam HCL is non-absorbable lipid lowering substance that binds to bile acids in the intestine, impending their reabsorption. It is commonly used bile acid sequestrant in high doses. Cholesterol is the sole precursor of bile acids. Epidemiological investigations have established that cardiovascular morbidity and mortality vary directly with t...

Itraconazole (ICZ), an antifungal drug, which is poorly water soluble which makes it difficult to form a stable formulation with enhanced safety and therapeutically effective formulation. Nano minerals help by modulating drug delivery. The study deals with the investigation of itraconazole (ICZ) intercalated into montmorillonite (MMT) by ion exchan...

Nitrofurantoin (NFT) is an antibacterial drug. Nitrofurantoin is slightly soluble in water. Nitrofurantoin shows both bacteriostatic and bactericidal effects. Bacteriostatic or bactericidal effect inhibits the synthesis of DNA, RNA, protein and cell wall synthesis. The sustained release tablet will optimize safety of a drug and therapeutic effect....

Nanocomposites have become a promising area of research and development. Polymer nanocomposites can be divided into two classes, the polymer nanocomposites which gives improvement in mechanical properties and the clay-polymer nanocomposites which gives additional property enhancements. The nanocomposites can be used as drug carriers due to their su...

Transdermal route of drug administration is an important way of drug application for both local and systemic effects. However in this route the primary barrier is the skin, in particular the stratum corneum is the main barrier for drug penetration. Penetration enhancement technology is a challenging task and that would increase the number of drug a...

Aims The work is aimed to formulate aqueous nanodispersion of aceclofenac Nanostructured Lipid Carriers (NLC) by using modified hot sonication method and to prepare NLC based gel for topical delivery of aceclofenac. Methods The lipids incorporated in the study were Compritol 888 ATO and Miglyol and the emulsifier/stabilizer used was Polysorbate 80...

The study was aimed at developing and optimizing a stable nonionic surfactant vesicular system known as niosomes for Tramadol HCl in order to improve its release properties and bioavailability. In the study different composition of non ionic surfactants and lipids were used to prepare nonionic surfactant vesicles formulation. The formulations were...

Pharmaceutical waste is a form of medical waste that includes unused medications, over-the-counter personal care products, and sometimes accessories such as sharps, used test strips, and other supplies. It is a cause for concern because it poses a threat to human and environmental health. Because of the dangers, pharmaceutical waste cannot be dispo...

The incidence of multidrug resistance in bacterial population has increased the importance of conventional ayurvedic and herbal medicines. In this study we have evaluated the effect of Azadirachta indica, Mangifera indica, Hemidesmus indicus, Caryophyllus aromaticus, Cinnamomum zeylanicum, Quercus infectoria, Rubia cordifolia, Embilica officinalis,...

In the present study, aceclofenac loaded polymeric nanosuspension were formulated and evaluated. Aceclofenac is a potent analgesic under BCS Class II. Due to the need for its frequent dosing, aceclofenac is an ideal candidate for sustained or controlled drug delivery. For optimization of prepared formulation, the three square (3 2) factorial design...

The aim of the present study is to formulate nanosized dispersion of aceclofenac by emulsion-solvent diffusion method and then incorporate it into a gelling agent to produce nanogel. The formulations are characterized for the particle size and found to be below 400 nm. The drug content in the formulations was found satisfactory. DSC and FTIR analys...

Spherical crystallization is the novel agglomeration technique that can transform directly the fine crystals produced in crystallization process into a spherical shape. Methods for the preparation of spherical crystallization are spherical agglomeration, quasi emulsion solvent diffusion, ammonia diffusion method, neutralization method. In spherical...

Fungal keratitis is a sight threating ocular infection that most frequently occur as a infection of candida species. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antifungal agent, fluconazole, based on the concept of ion-activated in situ gelation. ocular in situ gels can increase the drug residen...

Modified-release multiple unit dosage form (MRMUD) of desloratadine and pseudoephedrine hydrochloride with different release profiles were prepared. The MRMUD system consists of the immediate-release pellets containing desloratadine and sustained release pellets containing pseudoephedrine hydrochloride. The immediate and sustained release pellets w...

The simple, selective, rapid, precise and economical spectrophotometric method has been developed for simultaneous estimation of Desloratadine and Pseudoephedrine Hydrochloride, from two components solid dosage forms and dissolution media. Dissolution media 0.1N Hydrochloride acid and 0.1M Potassium Phosphate Buffer P H 7.5 was used. The simultaneo...

The extracts of six herbs (cf. medicinal plants) namely Azadirachta indica A.Juss., Emblica officinales Gaertn., Terminalia belerica Linn., Terminalia chebula Retz., Terminalia arjuna (Roxb.ex DC) Wight and Arn., and Mangifera indica L, as individual and as combination were tested for animal toxicity, anti-microbial activity in vitro and for Total...

Dental diseases are presently seemed to be very painful and critical to diagnose. The microbial flora of oral cavity is characteristic and changes in its composition may result in to development of dental diseases. An important microbial species found in oral cavity is Actinomycetes. Actinomycetes are not only responsible for causing actinomycosis...

Dental diseases are presently seemed to be very painful and critical to diagnose. The microbial flora of oral cavity is characteristic and changes in its composition may result in to development of dental diseases. An important microbial species found in oral cavity is Actinomycetes. Actinomycetes are not only responsible for causing actinomycosis...