Atul Kabra

Atul Kabra
Chandigarh University · University Institue of Pharma Sciences

Ph.D.

About

84
Publications
117,364
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496
Citations
Additional affiliations
July 2013 - December 2016
Punjab Technical University
Position
  • Ph.D. Scholar (PTU, Jalandhar)

Publications

Publications (84)
Article
Maintaining healthy skin is important for a healthy body. At present, skin diseases are numerous, representing a major health problem affecting all ages from neonates to the elderly worldwide. Many people may develop diseases that affect the skin, including cancer, herpes, and cellulitis. Long-term conventional treatment creates complicated disorde...
Chapter
Carbohydrate metabolic dysfunction leads to two sets of chronic states of illness namely hyperglycemia and hypoglycemia due to varied etiological interventions. Hyperglycemia is the medical term describing an abnormally high blood glucose (blood sugar) level. The state of hyperglycemia is known as diabetes (both type 1 diabetes and type 2 diabetes)...
Chapter
Hypopituitarism (failure to produce or underproduction of hormones released by the pituitary) and hyperpituitarism (excess production of hormones by the pituitary gland) are chronic endocrine disorders that arise as an outcome of diseases that affect brain tissue, namely metastatic deposits, primary tumors, trauma, surgery, radiotherapy, and vascul...
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Cassia fistula Linn, generally recognized as Indian laburnum, is one of the ancient trees in the Indian subcontinent used for its ornamental and diverse medicinal properties. It is known for its ethnic medicinal uses in inflammatory and infectious pathologies such as antihelmintic, purgative, carminative, antipyretic, expectorant, analgesic, laxati...
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Phytochemicals have been shown to possess multiple bioactives and have been reported to showcase many medicinal effects. A similar kind of evaluation of phytoconstituents for their antimicrobial action has been reported, based on in vitro and in silico data. The goal of the research was to explore bioactive phytoconstituents of Eclipta alba leaf fo...
Article
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Phytopathogenic fungi are serious threats in the agriculture sector especially in fruit and vegetable production. The use of plant essential oil as antifungal agents has been in practice from many years. Plant essential oils (PEOs) of Cuminum cyminum, Trachyspermum ammi, Azadirachta indica, Syzygium aromaticum, Moringa oleifera, Mentha spicata, Euc...
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Fresh fruit and vegetables are highly utilized commodities by health-conscious consumers and represent a prominent segment in the functional and nutritional food sector. However, food processing is causing significant loss of nutritional components, and the generation of waste is creating serious economic and environmental problems. Fruit and veget...
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Rivea hypocrateriformis (Desr.) Choisy is a robust woody climbing shrub of the genus Rivea which is widely distributed in India, Nepal, Sri Lanka, Pakistan, Bangladesh, Myanmar, and Thailand. R. hypocrateriformis is a promising medicinal herb with a wide range of beneficial and health-promoting properties. Since the ancient times, it has been used...
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Diabetic cardiomyopathy (DCM) pathogenesis is multifarious, and there are insufficient therapeutic options to treat DCM. The present research explored the effects of Citrus grandis peel ethanolic extract (CGPE) in alloxan-induced DCM in rats. Diabetes was triggered by intraperitoneal (i.p.) injection of alloxan (150 mg/kg) in Wistar rats (200-250 g...
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Cancer therapies are associated with various challenges including the emergence of multidrug resistant tumors, toxicological issues, severe side effects, and economic burden. To counteract these effects, natural products as substitutes and adjuvant therapies have received considerable attention owing to their safety, efficacy, and economic aspects....
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Diabetes mellitus (DM) is a very common metabolic disorder/disease. e deterioration of β-cells by autoimmune system is the hallmark of this disease. ioredoxin-Interacting Protein (TXNIP) is responsible for β-cells degradation by T-cells in the pancreas. is protein had been declared a good drug target for controlling DM. Lots of side e ects have bee...
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Chyawanprash (CP) is one of the most revered, effective, and best-selling health supplements of Indian Ayurvedic system of medicine, which is high on the trust and health quotient among Indian consumers. CP is an ancient synergistic blend of around fifty (50) medicinal herbs, herbal extracts with jam-like consistency, traditionally used to improve...
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The last two decades of developments in drug formulations and novel drug delivery systems have been seen as the beginning of a new era leading to increased patient adherence and pharmacological response to the therapeutic regimen. One of the most difficult tasks is efficiency and target-specific drug delivery or the extent of delivery at any given...
Article
The last two decades of developments in drug formulations and novel drug delivery systems have been seen as the beginning of a new era leading to increased patient adherence and pharmacological response to the therapeutic regimen. One of the most difficult tasks is efficiency and target-specific drug delivery or the extent of delivery at any given...
Article
Full-text available
Terpenoids and phenols from Trachyspermum ammi (T. ammi) have reported some pharmacological actions. The objective of the work was to isolate the active constituent, its identification by spectroscopic techniques, and evaluation of the antidiabetic and neuroprotective activity from T. ammi on STZ Wistar rats. The dried fruits of T ammi were kept in...
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Introduction: Natural products are among the most useful sources for the discovery of new drugs against various diseases. Keeping in view the ethnobotanical relevance ethnopharmacological significance of Polygonaceae family in diabetes, the current study was designed to isolate pure compounds from Persicaria hydropiper L. leaves and evaluate their...
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Background: Alzheimer's disease (AD) type dementia encompasses diverse cognitive deficits marked by free radicals and pro-inflammatory cytokines mediated progressive neurodegeneration and vascular damage including the blood-brain barrier. Subsequently, an imbalance in neurotransmitters, excitotoxicity, and synaptic loss provide impetus to AD patho...
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Polyalthia suberosa (Roxb.) is a plant used to cure coughs, dysentery, fevers, joint aches, rheumatic pain, inflammation, and a variety of skin diseases. The aim of the study was to evaluate the ethyl acetate extract of Polyalthia suberosa (P. suberosa) leaves and their effects on mice for neuropharmacological, analgesic, and antidiarrheal activiti...
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Diet and lifestyle play a crucial role in the progress of some cardiovascular disorders (CVDs). Rising interest in natural products and their pharmacological investigations witnessed therapeutic potential against CVDs. Caffeic acid (CA) is an organic composite hydroxycinnamic acid derivative classified among phenolics. It is a secondary metabolite...
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Impaired cerebral hemodynamic autoregulation, vasoconstriction, and cardiovascular and metabolic dysfunctions cause cerebral hypoperfusion (CH) that triggers pro-oxidative and inflammatory events. The sequences linked to ion-channelopathies and calcium and glutamatergic excitotoxicity mechanisms resulting in widespread brain damage and neurobehavio...
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Polyphenols are a family of naturally occurring organic compounds, majorly present in fruits, vegetables, and cereals, characterised by multiple phenol units, including flavonoids, tannic acid, and ellagitannin. Some well-known polyphenols include resveratrol, quercetin, curcumin, epigallocatechin gallate, catechin, hesperetin, cyanidin, procyanidi...
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Key words: Controlled drug delivery system Floating microspheres, Gastric emptying Gastric emptying might be a complex process, one that's highly variable which makes in vivo performance of drug delivery systems uncertain. This system is mainly purposed for drugs of anti-diabetic (like metformin hydrochloride), anti-ulcer, anti-emetic (like meclizi...
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Drug-related problems (DRPs) had often been a concern in the system that needed to be detected, avoided, and addressed as soon as possible. The need for a clinical pharmacist becomes even more important. He is the one who can not only share the load but also be an important part of the system by providing required advice. They fill out the patient'...
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Pollution and pollution-related consequences have a historic reputation, being even considered as chief causative agents behind several tragedies linked to a huge impact on health and environment. Nonetheless, the unforeseen viral outburst has surprisingly led to the recovery of the atmospheric immaculacy, besides to the serious destruction. Thus,...
Preprint
Full-text available
Rivea hypocrateriformis (Desr.) Choisy is a robust woody climbing shrub of the genus Rivea which is found in India, Nepal, Sri Lanka, Pakistan, Bangladesh, Myanmar and Thailand. R. hypoc-rateriformis is a promising medicinal herb with enormous helpful and wellbeing advancing impacts. R. hypocrateriformis has been utilized as a customary medication...
Article
Glitazones are synthetic derivatives of thiazolidinedione, and are designated as oral anti-diabetic agents, primarily acting on peroxisome proliferator-activated receptor-gamma (PPAR-γ) receptors and driving some crucial metabolic pathways linked to glucose and lipid metabolism at transcriptional level. Despite presenting adverse effects, including...
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Envenomation coming about because of snake bite is a significant general wellbeing peril in numerous areas of the world, especially revealed in tropical and subtropical nations. Snake bite has been remembered for the World Health Organization (WHO) rundown of dismissed tropical maladies. Snake bite is a typical word related peril among the ranch la...
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Alzheimer diseases were first described by German physician Dr. Alois Alzheimer in 1906, an Alzheimer disease is also known as neurodegenerative or aging disorder. Presently AD is categorized by psychopharmacological drugs. Alzheimer disease is a type of disorder where neurons are continuously degrade timely and said to be neuronal degenerative dis...
Chapter
Podophyllotoxin (PPT) is the unique natural precursor of Etoposide, a topoisomerase II inhibitor drug, used in more than a dozen anticancer chemotherapy treatments. Etoposide is appearing on the list of essential medicines of the World Health Organization. PPT is still exclusively extracted from the rhizome of Podophyllum species, its main natural...
Article
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Plants comprise a significant part of Pharmacotherapy in traditional medicine, folk medicine as well as Ayurveda. Plants are a vital source of medicinal agents both in developed as well as developing countries, but a large percentage of the population depends upon the use of medicinal plants because these are considered safer and economical as comp...
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Background: Myrica esculenta is a notable therapeutic plant widely utilized in Indian system of medicine. Ayurvedic literature reported fruit and bark of this plant is used in gulma, jvara, arsa, grahani, pandu roga, hrillasa, mukha roga, kasa, svasa, agnimandhya, aruchi, meha, and kantharoga. Objective: The present study aimed to investigate th...
Article
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Nymphaea lotus L. is the medicinal plant that has long been used as food, cosmetic and traditional medicines in Africa and Asia since the ancient time. Its flavonoids and other interesting phytochemical compounds from rhizome, leaf, and the whole flowers have been reported in the previous published researches. However, stamens, which are essential...
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At the end of December 2019, a novel coronavirus was identified which caused severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with a disease known as coronavirus disease 2019 (COVID-19). The virus first originated in the city of Wuhan in China, causing symptoms such as pneumonic plague, which began in the Wuhan region and then spread th...
Preprint
Full-text available
Nymphaea lotus L. is the medicinal plant that has long been used as food, cosmetic and traditional medicines in Africa and Asia since the ancient time. Its flavonoids and other interesting phytochemical compounds from rhizome, leaf, and the whole flowers have been reported in the previous published researches. However, stamens, which are essential...
Article
Full-text available
African Swine Fever Virus (ASFV) is highly contagious and often lethal to domestic and wild pigs, has been around for decades. African Swine Fever Virus (ASFV) causes a serious swine disease that is endemic in Africa and Sardinia and spreading in Russia and neighboring countries, including Poland, Czech Republic. ASF was introduced into East Asian...
Article
Full-text available
African Swine Fever Virus (ASFV) is highly contagious and often lethal to domestic and wild pigs, has been around for decades. African Swine Fever Virus (ASFV) causes a serious swine disease that is endemic in Africa and Sardinia and spreading in Russia and neighboring countries, including Poland, Czech Republic. ASF was introduced into East Asian...
Article
Full-text available
To examine the secondary metabolite present in the pine needle extract of Pinus gerardiana. Phytochemical screening of the needle extract was done to determine the phytochemical constituents in the various solvents studied. The phytochemical study carried out on the needle extracts of Pinus gerardiana confirms the existence of secondary metabolites...
Article
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Almond (Prunus dulcis (Mill.) D.A.Webb) is one of the most important nut crops both in terms of area and production. Over the last decades, an important part of the beneficial actions for health associated with their consumption was attributed to the phenolic compounds, mainly accumulated in almond skin. Interestingly, after cold-pressed oil extrac...
Preprint
Full-text available
Almond (Prunus dulcis (Mill.) D.A.Webb) is one of the most important nut crops both in terms of area and production. Over the last decades, an important part of the beneficial actions for health associated with their consumption was attributed to the phenolic compounds, mainly accumulated in almond skin. Interestingly, after cold-pressed oil extrac...
Chapter
Podophyllotoxin (PPT) is the unique natural precursor of Etoposide, a topoisomerase II inhibitor drug, used in more than a dozen anticancer chemotherapy treatments. Etoposide is appearing on the list of essential medicines of the World Health Organization. PPT is still exclusively extracted from the rhizome of Podophyllum species, its main natural...
Article
Full-text available
Silybum marianum (L.) Gaertn. (aka milk thistle) constitutes the source of silymarin (SILM), a mixture of different flavonolignans and represents a unique model for their extraction. Here we report on the development and validation of an ultrasound-assisted extraction (UAE) method of S. marianum flavonolignans follow by their quantification using L...
Article
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Background: Plant diversity is a basic source of food and medicine for local Himalayan communities. The current study was designed to assess the effect of different solvents (methanol, ethyl acetate, and water) on the phenolic profile, and the corresponding biological activity was studied. Methods: Antioxidant activity was investigated using 2,2-di...
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Preprint
Silybum marianum (L.) Gaertn. (aka milk thistle) constitute the almost exclusive source of silymarin, a mixture of different flavonolignans, and is thus considered as a unique model for their extraction. The present research deals with ultrasound-assisted extraction (UAE) of S. marianum flavonolignans and their quantification using LC system. The o...
Article
Full-text available
Myrica esculenta (Myricaceae) is a popular medicinal plant most commonly found in the subtropical Himalayas. It is widely used in folk medicine to treat several ailments such as asthma, cough, chronic bronchitis, ulcers, inflammation, anemia, fever, diarrhea, and ear, nose, and throat disorders. Due to its multidimensional pharmacological and thera...
Article
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Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs a...
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The present study was to evaluate antioxidant activity of ethanolic and aqueous extract of Benincasa hispida (Thunb.) Cogn. fruit for their therapeutic potential. In vitro antioxidant activity was performed by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and Hydrogen peroxide (H 2 O 2). For aqueous extract the scavenging activity of DPPH is 59.7% at the c...
Article
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Pharmacoepidemiology is the study of the use of drugs in a large number of people.It is a growing discipline that applies epidemiological techniques to study drugs used in a large population. Just as the term implies, pharmacoepidemiology combines clinical pharmacology with epidemiology. Pharmacology is the study of the effects of medications on hu...
Article
Full-text available
Introduction: Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder prevalent worldwide among elderly populations. Owing to limited efficacy, side effects and poor patient compliance for current rationally designed therapies, options are being searched from alternate therapies such as Indian (Ayurvedic), Chinese or other traditional...