Atte Eskelinen

Atte Eskelinen
University of Eastern Finland | UEF · Department of Applied Physics

PhD
Developing multi-scale, patient-specific, predictive Mathematical models of KneeOsteoArthritis (MathKOA)

About

17
Publications
1,201
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37
Citations
Introduction
I am currently a postdoctoral researcher in the fields of biomechanics, mechanobiology, computational modeling, musculoskeletal diseases, and osteoarthritis. My current research interests include experimental and computational modeling of cartilage degradation, and biomechanical and inflammatory mechanisms in osteoarthritis and joint pain. The aim of the current research project is to develop personalized predictive models of osteoarthritis progression and pain to optimize treatments.
Additional affiliations
August 2019 - December 2019
Massachusetts Institute of Technology
Position
  • Visiting doctoral researcher
Description
  • Development of experimental osteoarthritis models: Biomechanical overloading, pro-inflammatory cytokine challenge, and moderate cyclic loading
June 2018 - June 2022
University of Eastern Finland
Position
  • Doctoral researcher
Description
  • Development of experimental and computational osteoarthritis models: Biomechanical and inflammatory disease mechanisms
Education
August 2019 - December 2019
Massachusetts Institute of Technology
Field of study
  • Biomedical engineering; PhD-study exchange
June 2018 - June 2022
University of Eastern Finland
Field of study
  • Science, technology, and computing
February 2017 - July 2017
Eindhoven University of Technology
Field of study
  • Biomedical engineering; MSc-study exchange

Publications

Publications (17)
Conference Paper
Full-text available
Introduction: Traumatic knee cartilage injuries trigger chondrocyte death via the release of damage-associated molecular patterns (DAMPs) and reactive oxygen species (ROS) 1-3. Chondrocyte death disrupts cartilage metabolism, with decreased production of matrix constituents and subsequent post-traumatic osteoarthritis 1. A better understanding of b...
Preprint
Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint injury, it is designated as post-traumatic OA (PTOA). The etiology of PTOA remains poorly understood, but it is known that proteoglycan (PG) loss, cell dysfunction, and...
Article
Full-text available
Injurious overloading and inflammation perturbate homeostasis of articular cartilage, leading to abnormal tissue-level loading during post-traumatic osteoarthritis. Our objective was to gain time- and cartilage depth-dependent insights into the early-stage disease progression with an in vitro model incorporating for the first time the coaction of (...
Thesis
Full-text available
Osteoarthritis is a debilitating musculoskeletal whole-joint disease affecting the quality of life of over 340 million people globally. One of the most common disease sites is the knee joint. The disease is characterized by degradation of the articular cartilage covering the ends of bones. Degraded cartilage exhibits detrimental changes in its stru...
Article
Full-text available
Excessive tissue deformation near cartilage lesions and acute inflammation within the knee joint after anterior cruciate ligament (ACL) rupture and reconstruction surgery accelerate the loss of fixed charge density (FCD) and subsequent cartilage tissue degeneration. Here, we show how biomechanical and biochemical degradation pathways can predict FC...
Preprint
Full-text available
Post-traumatic osteoarthritis is a degenerative musculoskeletal condition where homeostasis of articular cartilage is perturbated by lesions and inflammation, leading to abnormal tissue-level loading. These mechanisms have rarely been included simultaneously in in vitro osteoarthritis models. We modeled the early disease progression in bovine carti...
Conference Paper
Full-text available
In efforts to predict post-traumatic osteoarthritis (PTOA) progression, contemporary mechanobiological models implement cytokine diffusion-mediated inflammation. However, they lack an important biomechanical factor, the advection of cytokines along with the flow of interstitial fluid during physiological loading. Here, we refine the models predicti...
Article
Full-text available
Post-traumatic osteoarthritis (PTOA) is associated with cartilage degradation, ultimately leading to disability and decrease of quality of life. Two key mechanisms have been suggested to occur in PTOA: tissue inflammation and abnormal biomechanical loading. Both mechanisms have been suggested to result in loss of cartilage proteoglycans, the source...
Article
Full-text available
Post-traumatic osteoarthritis (PTOA) is a common disease, where the mechanical integrity of articular cartilage is compromised. PTOA can be a result of chondral defects formed due to injurious loading. One of the first changes around defects is proteoglycan depletion. Since there are no methods to restore injured cartilage fully back to its healthy...

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