Atef Badji

Atef Badji
Karolinska Institutet | KI · Clinical Geriatrics Division

MD, PhD

About

26
Publications
3,367
Reads
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353
Citations
Citations since 2016
25 Research Items
351 Citations
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2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Introduction
I am Neuropoly alumni (Polytechnique, Montreal, Canada) and a resident in Geriatrics at Karolinska University Hospital, working towards a double specialization in Geriatric and Neurology. I have a deep interest in neurodegenerative disease and neurocognitive disorders to which I was drawn through a series of personal and professionals experiences.

Publications

Publications (26)
Article
Full-text available
Background Subjective cognitive decline (SCD) has been postulated as an early marker of Alzheimer’s Disease (AD) but it can also be associated to other non-AD pathologies such as Vascular Dementia (VaD). Nevertheless, there is scarce data about SCD as a potential harbinger of cerebrovascular pathology. Thus, we conducted a systematic review and met...
Article
Full-text available
Background Alzheimer’s disease and dementia in general constitute one of the major public health problems of the 21st century. Research in arterial stiffness and pulse pressure (PP) play an important role in the quest to reduce the risk of developing dementia through controlling modifiable risk factors.Objective The aim of the study is to investiga...
Article
Full-text available
Background: Hypertension is an important risk factor for Alzheimer’s disease (AD). The pathophysiological mechanisms underlying the relationship between AD and hypertension are not fully understood, but they most likely involve microvascular dysfunction and cerebrovascular pathology. Although previous studies have assessed the impact of hypertensio...
Article
Full-text available
Background Evidence supports that time spent on physical activity has beneficial effects on cognition in older adults. Nevertheless, this beneficial effect is likely to change in function of individual modifying factors like age and level of arterial stiffness. This study aims to reveal whether arterial stiffness and age modulate the positive impac...
Article
Full-text available
Introduction: While alcohol overconsumption is regarded as a risk factor for Alzheimer's disease, the specific relationship between alcohol consumption and cognitive impairment remains unclear and poorly understood. Our primary objective is to investigate whether alcohol consumption is associated with lower cognitive performance at an early phase...
Article
Background: Evidence supports that time spent on physical activity has beneficial effects on cognition in older adults. Nevertheless, whether these beneficial effects are still present at the intersection of different levels of arterial stiffness and age is uncertain. Methods: One hundred and ten healthy older adults aged 60-75 years were examin...
Article
Full-text available
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Merck Sharp & Dohme Corp Program of the Faculty of Medicine of the Université de Montréal The Canadian Institutes of Health Research (CIHR) Background The growing concern on the impact of higher arterial stiffness on cognitive decl...
Article
Hypertension, elevated morning blood pressure (BP) surges, and circadian BP variability constitute risk factors for cerebrovascular events. Nevertheless, while evidence indicates that hypertension is associated with cognitive dysfunctions, the link between BP variability and cognitive performance during aging is not clear. The purpose of this study...
Article
Background: Evidence supports that time spent on physical activity has beneficial effects on cognition in older adults. Nevertheless, this beneficial effect is likely to change in function of individual modifying factors like age and level of arterial stiffness. This study aims to reveal whether arterial stiffness and age modulate the positive impa...
Article
Alzheimer's disease (AD) is recognized as multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. Given that a revision of the AT(N) classification is expected in the near future, the present work supports the importance to add an additional vascular (V) category to the framework....
Article
Background: Vascular risk factors such as arterial stiffness play an important role in the etiology of Alzheimer's disease (AD), presumably due to the emergence of white matter lesions. However, the impact of arterial stiffness to white matter structure involved in the etiology of AD, including the corpus callosum remains poorly understood. Objec...
Article
Despite important efforts to solve the clinico-radiological paradox, correlation between lesion load and physical disability in patients with multiple sclerosis remains modest. One hypothesis could be that lesion location in corticospinal tracts plays a key role in explaining motor impairment. In this study, we describe the distribution of lesions...
Article
Full-text available
Arterial stiffness and blood pressure (BP) are contributors to cognitive decline and dementia. Lower global cerebral blood flow (CBF) is one of the earliest manifestations of biological alterations linked to cognitive decline, nevertheless the best cardiovascular predictor of CBF in gray-matter (CBF-GM) remains to be identified. Our objective is to...
Article
Full-text available
Objective: Central artery stiffness is a confirmed predictor of cardiovascular health status that has been consistently associated with cognitive dysfunction and dementia. The European Society of Hypertension has established a threshold of arterial stiffness above which a cardiovascular event is likely to occur. However, the threshold at which art...
Article
Full-text available
Background: Given the increasing incidence of vascular diseases and dementia, a better understanding of the cerebrovascular changes induced by arterial stiffness is important for early identification of white and grey matter abnormalities that might antedate the appearance of clinical cognitive symptoms. Here, we review the evidence from neuroimagi...
Article
Introduction: Hypertension in midlife adults is associated with cognitive decline later in life. In individuals treated for hypertension, blood pressure (BP) loads have been associated with end organ damages. This study examines whether BP load inversely correlates with performance in cognitive tasks in normotensive or controlled hypertensive (CHT...
Article
Full-text available
Introduction: Hypertension in midlife adults is associated with cognitive decline later in life. In subjects treated for hypertension, blood pressure (BP) loads have been associated to end organ damages. This study examines whether BP load inversely correlates with performance in cognitive tasks in normotensive or controlled hypertensive (CHT) subj...
Article
Spinal cord lesions detected on MRI hold important diagnostic and prognostic value for multiple sclerosis. Previous attempts to correlate lesion burden with clinical status have had limited success, however, suggesting that lesion location may be a contributor. Our aim was to explore the spatial distribution of multiple sclerosis lesions in the cer...
Article
Full-text available
Background and purpose: The stiffness of large arteries and increased pulsatility can have an impact on the brain white matter (WM) microstructure, however, those mechanisms are still poorly understood. The aim of this study was to investigate the association between central artery stiffness, axonal and myelin integrity in 54 cognitively unimpaired...
Poster
Full-text available
While higher morning systolic blood pressure surges (MBPS) have been associated to increased stroke risk, the association with cognitive performances remains unknown. The aim of this study is to determine which method for calculating MBPS is the best predictor of performance in task-switching and processing speed in both elderly normotensive and hy...
Article
Full-text available
Background: Studies including patients with well-established multiple sclerosis (MS) have shown a significant and disability-related reduction in the cervical spinal cord (SC) magnetisation transfer ratio (MTR). Objectives: The objectives are to (1) assess whether MTR reduction is already measurable in the SC of patients with early relapsing–remitt...
Preprint
The spinal cord is frequently affected by atrophy and/or lesions in multiple sclerosis (MS) patients. Segmentation of the spinal cord and lesions from MRI data provides measures of atrophy and lesion burden, which are key criteria for the diagnosis, prognosis and longitudinal monitoring in MS. Achieving robust and reliable segmentation across multi...
Article
Full-text available
The aim of this study was to investigate the interplay between structural connectivity and cortical demyelination in early multiple sclerosis. About 27 multiple sclerosis patients and 18 age-matched controls underwent two MRI scanning sessions. The first was done at 7T and involved acquiring quantitative T1 and T2* high-resolution maps to estimate...

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Projects

Projects (4)
Project
Toward a better understanding of Multiple Sclerosis
Project
Better understand the impact of hypertension on brain integrity and cognition.