Astrid Chevance

French Institute of Health and Medical Research | Inserm · Epidemiology and Biostatistics Center

Objectives This descriptive study of registered trials aimed to identify large clinical trials on antidepressants for mental disorders: (1) to assess what proportion could be labelled as ‘seeding trials’ (trials for marketing purposes) and (2) to describe their methodological characteristics and outcomes. Design A search was conducted across all t...

Depression is one of the leading causes of morbidity worldwide and increases the risk of suicide. Students are known as a population at risk for depression. This study aimed to evaluate the prevalence of 12 months major depressive episode (MDE) and suicidal thoughts in French students and investigate associated factors. A questionnaire was sent by...

Objectives In modern professional life, mental health prevention and promotion have become a major challenge for decision-makers. Devising appropriate actions requires better understanding the role played by each work-related psychosocial factor (WPSF). The objective of this study was to present a relevant tool to hierarchise WPSFs that jointly tak...

Background There is a need to develop an awareness raising tool for GPs to reach out their patients in order to increase blood donation. The main objective was to create and validate a tool to raise awareness about blood donation that meets acceptability and preference criteria and is applicable in general practice. Material and Methods This cross...

Background Non-serious adverse events (NSAEs) should be captured and reported because they can have a significant negative impact on patients and treatment adherence. However, the reporting of NSAEs in randomised controlled trials (RCTs) is limited. Objective To identify the most important NSAEs of antidepressants for patients and clinicians, to b...

Question Although mental pain is present in many mental disorders and is a predictor of suicide, it is rarely investigated in research or treated in care. A valid tool to measure it is a necessary first step towards better understanding, predicting and ultimately relieving this pain. Study selection and analysis Following the Preferred Reporting I...

The clinical guidelines that underpin the use of drugs for mental disorders are informed by evidence from randomised controlled trials (RCTs). RCTs are performed to obtain marketing authorisation from regulators. The methods used in these RCTs could be appropriate for early phases of drug development because they identify drugs with important harms...

Background Digital pills are pills combined with a sensor, which sends a signal to a patch connected to a smartphone when the pills are ingested. Health care professionals can access patient data from digital pills online via their own interface, thus allowing them to check whether a patient took the drug. Digital pills were developed for the state...

Résumé La philosophie de l’esprit (Philosophy of Mind) représente aujourd’hui l’un des champs de recherche les plus prolifiques en philosophie et connaît une hybridation progressive avec les sciences cognitives. Elle étudie des questions fondamentales pour les neurosciences et la psychiatrie, comme la nature des états mentaux et des processus cogni...

Philosophy of Mind is currently one of the most prolific fields of research in philosophy and has witnessed a progressive hybridization with cognitive science. It focuses on fundamental questions to neuroscience and psychiatry, such as the nature of mental states and cognitive processes, or the relationships between mental states and the world. Ant...

BACKGROUND Digital pills are pills combined with a sensor, which sends a signal to a patch connected to a smartphone when the pills are ingested. Health care professionals can access patient data from digital pills online via their own interface, thus allowing them to check whether a patient took the drug. Digital pills were developed for the state...

Background Many clinical trials have assessed treatments for depressive disorders and bipolar depression. However, whether, and which, assessed outcome domains really matter to patients, informal caregivers, and health-care professionals remains unclear. Methods We did an international online survey in French, German, and English. Participants wer...

Purpose The study estimates the prevalence of probable psychiatric disorder in the working population, determines the proportion of people presenting a probable psychiatric disorder among people exposed to work-related psychosocial risk factors (PSRFs), and identifies which PSRF has the strongest association with having a probable psychiatric disor...

Résumé Les effets psychologiques de l’isolement ont déjà été décrits dans la littérature (expéditions polaires, sous-marins, prison). Néanmoins l’échelle du confinement mis en œuvre à l’occasion de la pandémie à COVID-19 est inédite. Il nous faut non seulement relire les études publiées, mais aussi anticiper les problèmes psychologiques qui pourrai...

Objective: The lack of resources and coordination to face the coronavirus epidemic raises concerns for the health of patients with mental disorders in a country where we still have memories of the dramatic experience of famine in psychiatric hospitals during the Second World War. This article aims to propose guidance to ensure mental health care du...

Objectif : L’absence de préparation du système de soins psychiatriques à l’épidémie de virus SARS-CoV-2 fait redouter un scénario pessimiste pour la santé physique et mentale des patients suivis en psychiatrie. L’objectif de cet article est de proposer des éléments de guidance pour réorganiser les soins psychiatriques dans le contexte de pandémie...

Clinical sciences do not only aim to describe psychological disorders, but also aim to explain them. And we are currently witnessing revisions of theoretical, methodological, and epistemological approaches. For instance, the ongoing debate about the use of psychiatric classifications, such as the DSM and possible alternatives (Rdoc, HiTOP), illustr...

Core outcome sets (COSs) are agreed-upon standardized sets of outcomes that should be minimally measured in all trials of a given disease. To enhance the uptake of COSs in trials, their generalizability should be increased by a change in the number and diversity of stakeholders involved in their development. Also, their credibility should be improv...

Editorial for the article Bortolon & Raffard, Network analysis: are we moving towards a new conceptualization and treatment of mental disorders? 10.1016/j.encep.2019.06.001

Introduction Au cours des dernières décennies, le monde du travail a connu de profond changement. La précarisation croissante des emplois ou encore l’augmentation actuelle des pressions au travail ne sont pas sans conséquences sur l’aggravation des problèmes de santé mentale au travail. Ces troubles mentaux peuvent être la source d’une productivité...

Introduction We have recently compared all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression. Here we present a protocol for a network meta-analysis aimed at extending these results, updating the evidence base and comparing all second-generation a...

Objective To evaluate the impact of controllable design factors on the power of antidepressants trials. Methods Using clinical trial simulation (CTS), we analyzed the combined impact on the power of trials of controllable design factors (sample size, outcome metrics, and disease severity at inclusion) and uncontrollable parameters (heterogeneity o...

Background: Few studies have examined the prevalence and correlates of subsyndromal and syndromal depressive symptoms (SSSD) among older adults with schizophrenia spectrum disorder. In this report, we examined the prevalence of SSSD and their associations with sociodemographic characteristics, clinical characteristics of schizophrenia, comorbidity,...

Loi jardé et thèses des internes de médecine générale, combien sont concernées ? - Revue Francophone de médecine générale- Exercer, numéro 150 février 2019 page 68 - 73 Auteurs : A.Jouannin , M.De Fallois , A.Chevance , J.Reymann , M.Mamzer-Bruneel

Background: Little is known about differences in mental health comorbidity and quality of life in individuals with social anxiety disorder (SAD) according to the number and the types of feared situations. Methods: Using a US nationally representative sample, the National Epidemiologic Survey on Alcohol and Related Conditions, we performed latent...