Asmita Wele

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• M.D. {ayurveda pharmacology}
• Director Research and Professor at Dr. D.Y. Patil Vidyapeeth, Pune

Bhasma is the most controversial, important, and foremost dosage form from Ayurvedic herbo-mineral pharmaceutics, and it has been discussed in journals like JAMA due to its metallic origin and purported toxicity concerns associated with heavy metals. However, in the current Ayurveda scenario, remarkable efforts are being carried out on production o...

Background: Manipur Chakra situated at naval region governs the digestive health and affects the functions of the abdominal organs. Intoning the Beeja mantra of Manipur Chakra may activate its vitality and dormant potential. The study aims to evaluate the effect of Beeja Mantra therapy on gut health using Gastrointestinal Quality of Life Index scal...

Introduction The Bhasmas, herbo-minerals, are reported to produce adverse effects when used clinically. Therefore, the present study aimed to assess the safety of Krishna Vajra Abhraka Bhasma (KVB), through acute and subacute toxicity testing. Materials and Methods After ethics committee approval, total 66 Wistar albino rats weighing 180–200 gms w...

Millets are smart foods that have noteworthy nutritional and therapeutic benefits. Regular consumption of millets is beneficial as it manages postprandial glucose levels, lowers insulin resistance, positively affects HbA1c, reduces the risk of atherosclerotic changes and cardiovascular disease, lowers LDL and improves hypertension. The Government o...

Globalization of Ayurveda is a continuous process. It happens due to committed collaboration of expert vaidyas from India and abroad, professionals from different countries, pharmaceutical suppliers, and patients. The obstacles to practise, regulate and educate Ayurveda, differ from country to country; however there are some common threads. The Int...

Effect of Dietary and Spice Bio-actives on Telomerase in Cancers: A Review from Ayurvedic perspective. Introduction: Ayurvedic diet concepts have very important therapeutic role in cancer. A variety of diets have been recommended by clinicians as a part of management of cancers. Though the exact effect of the specific ayurvedic diet on cancer is no...

Context:Siddha ghrita and taila(medicated lipids) are the most widely used Ayurvedic dosage forms that pose a great challenge of palatability owing to strong odor, greasiness, and higher dose in the present era. A major need for standardization of these dosage forms arises due to the crude methods of manufacture. Avartana, mentioned in context with...

Cerebral palsy (CP) is a neurodevelopmental condition that causes disorders of posture and movement, leading to activity limitation, sensory disturbances, intellectual disability, communication, and behavioural problems. To date, there is no proven oral medication for the brain insults which leads to motor dysfunction in cerebral palsy. Neurologica...

Background: Traditional knowledge and scientific shreds of evidence strongly support the repurpose of Kalmegh (Andrographis paniculata, CIM-MEG19) as an alternate therapy for prophylactic management and treatment of severe acute respiratory syndrome coronavirus (SARS-CoV) and associated health disorders. Purpose: The study aimed to assess the effic...

Ayurvedic Medicine, or Ayurveda, is a traditional Indian health care system. Research into the medicinal plants utilised in Ayurveda is becoming a global endeavour, and large pharmaceutical companies are investing in novel drug discovery from Ayurvedic sources as a number of clinical studies have demonstrated efficacy of natural products from Ayurv...

Ayurvedic nano-medicine preparations (ANMPs), Bhasma and Sindura, are considered as most effective dosage forms in Ayurveda. These are the preparations of metals and minerals used for therapeutic purposes in Ayurveda. Those are prepared by repeated trituration with liquid media from plant materials and incineration at high temperature above 650°C....

The scenario after the COVID-19 pandemic has brought the modern and traditional medicine systems on a level playing field. The situation demands assessment of the capacity of the Indian traditional medicine sector to take up the challenge of delivering healthcare products to the global population. A review of the status of AYUSH products across the...

Dandruff (Darunak)is the common skin disease affecting the scalp area with the presence of itching, hair fall, dryness of scalp and dander. It is affecting the half of the adult population of either gender worldwide. Even though the prevalence is so high, its etiology being varied the treatment modalities are also different. Although dandruff is no...

Background: Gold bhasma [Swarnabhasma] is a ancient Ayurvedic medicine used for rejuvenation and longevity. This is a preliminary attempt to study the bioavailability of this medicine. Objectives: It was aimed to estimate comparative bioavailability of gold bhasma up to five hours after oral dose with four different anupana. Materials and methods:...

The importance of nutrition in health and disease has always been discussed in Ayurveda. A Vaidya invariably adds a list of dietary substances to be consumed and avoided along with the patient’s prescription. It is a well-accepted norm that a patient cannot have the foods as he pleases or are available to him till his dosha imbalance normalizes. He...

Background Swarnabhasma (calcined gold) is a famous ancient Ayurvedic medicine. However, its detail characteristic investigations are very limited. Objective(s) Herein, investigation of swarnabhasma is demonstrated using ancient and ultramodern techniques to understand the physicochemical nature of this drug, and to understand whether the mercury...

The relationship of humans and foods is eternal so as the knowledge of its variety and tastes. The therapeutic effects of foods have been explored in Ayurveda, the traditional Medicine of Indian subcontinent. Its health pyramid starts with foods, medicated foods, and medicines. The principles of taste, amount, proportion, processing, compatible- in...

Rasoushadhies are herbo-mineral formulations that despite toxicity concerns in many countries are traditional treatments of choice by Ayurvedic Physicians in South Asia due to their tastelessness, smaller dosage, fast action and broader indications. Many compound formulations contain components like diamond, tourmaline, mica, arsenic, copper, gold...

Characterization of Krishna vajra Abhrak Bhasma [ nanoparticles of Biotitie] ,includes preparation details, morphological, structural, elemental and chemical composition

Mini-Review on Meat-Based Functional Food Dietary supplements, nutraceuticals, and functional foods are the terms, that are frequently used interchangeably. However functional food is food, which can be consumed as a part of a regular dietary regimen and not merely a capsule, tablet, or pill. The use of functional food has gained momentum in today’...

Background: Bio-inorganic nanoparticles or metal nanoparticles are used in medicine for diagnostic and treatment purposes. The nanomedicines from traditional Ayurvedic system are termed as bhasma. Rasashastra, the branch of inorganic medicines of Ayurveda, has documented monographs of metal-mineral bhasmas as potent drugs. However there is lack of...

Background: Bio-inorganic nanoparticles or metal nanoparticles are used in medicine for diagnostic and treatment purposes. The nanomedicines from traditional Ayurvedic system are termed as bhasma. Rasashastra, the branch of inorganic medicines of Ayurveda, has documented monographs of metal-mineral bhasmas as potent drugs. However there is lack of...

Introduction: The widely used rasaushadhi Kapardika bhasma (calcined Cowrie) may have a potential of an active drug molecule to treat GIT diseases with proven safety and efficacy. Objectives: Present study was aimed at process standardization of 15 samples of Kapardika bhasma made by various permutations and combinations of shodhan ingredients and...

Siddha sneha are largely preferred by Ayurved clinicians for their improved efficacy; but face the issues of patient compliance which needs to be addressed. Process of avartana (repetitions) potentiates the formulation and therefore can reduce the high dose needs. Repulsive odour and taste can be masked by encapsulation. This review presents the an...

Principles of Research Methods for Ayurveda addresses the specific challenges faced by Ayurveda scholars and clinicians without formal training in conventional science or medicine. The aim of the book is to introduce the reader to core literary, observational, experimental and clinical methods commonly used to answer questions in health research. I...

Pain is a serious problem globally due to its high prevalence and is regarded as the fifth vital sign. The standard methods comprising of NSAID and opioid group, interventional methods and implantable methods; although often very effective, have known adverse effects on gastrointestinal, renal and cardiovascular systems and surgical risks. Ayurvedi...

Schizophrenia is a chronic and complex mental disorder characterized by hallucinations and delusions that significantly affect emotions, behavior, and mental processes. Currently used antipsychotics are characterized by the multireceptor mode of action (antagonism of dopamine D 2 and serotonin receptors), there is no consensus regarding an "ideal"...

Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder characterized by insulin resistance which in turn leads to elevated levels of androgens, anovulation, amenorrhea or oligomenorrhea, obesity and polycystic ovaries. Objectives: To evaluate efficacy of herbal formulations-Nishamalaki and Kanchanar Guggulu in animal model of PCOS. Mate...

Bioavailability of the well-known Ayurvedic drug Swarnabhasma (gold bhasma or calcined gold) is unknown. It is orally administered either sublingually or directly with various Anupanas like black pepper powder (Piper nigrum Linn.) and cow ghee in the dose range of 15–240 mg by Ayurvedic physicians. Study of bioavailability of Swarnabhasma is necess...

Strengthening of the internal system by way of choice of area, courses, freedom of debate, availability of literature resources from paid databases, equipment and chemicals, trust factor, logical and systematic brainstorming brings a conducive atmosphere for research in a university setting. This is the common factor in statutory and private univer...

Gold is an important medicinal ingredient known to render rejuvenation and longevity as stated by ancient Ayurvedic literature. Research based on gold bhasma has led to evidence regarding physico chemical nature of the drug, revealing nano-size and unique nature of gold particles in it. A pubmed search was performed to identify all relevant researc...

Context: With a rising need for development of drugs that are effective with multifaceted therapeutics for the treatment of depression and the associated behavioral changes, brāhmī ghr̥ta offers a choice of treatment. The challenge of palatability of ghr̥ta in therapeutic dose of 20 to 40 g per day can be overcome by potentiation and the same was t...

Objective: Present exploratory clinical study dealt with comparative assessment of therapeutic effect of medicated ghee formulations i.e. Vachadi [VG] and Hingwadi Ghrita [HG] in patients of mild to moderate depression.Methods: Open label nonrandomized standard controlled clinical trial was carried out. Using Hamilton scale test total twelve patien...

The concept of bioinorganicals is not new to Ayurveda. Rasashastra the branch of metal-mineral medicine gives detail monographs of over 80 inorganic elements which are treated with organic substances to convert them into potent medicines. Unlike modern metal-ions these bioinorganicals are not in ionic form. Most widely known category of bioinorgani...

Context: Depression, a sustained mood disorder caused by selective diminution of specialized cells in brain is increasing at an alarming rate. It will be the second largest morbid illness by next decade and is the leading cause of suicidal deaths. The available antidepressant medications benefit only a third of its recipients and have many side ef...

Rasashastra -The science of Mercurial (Metal and Mineral) Medicine - is one of the oriental sciences, associated with the Shaivite school of philosophy. Rasa is the synonym of the metal Mercury which represents the inorganic group of drugs used as medicines with appropriate processing. Today Rasashatra is a branch of Ayurveda, which documents monog...

Introduction: Vasarishta built upon Mritasanjeevani Sura (MS) is a polyherbal hydro-alcoholic anti-asthmatic formulation which is administered in a dose of 1 ml instead of standard dose 40 ml, generally advocated for any "Asava-Arishta" in Ayurveda. Aim: The present study was aimed at finding out rationale for the peculiar distillation process t...

Background: Vachadi ghrita is medicated ghee ayurvedic formulation,recommended to improve cognition.Synergism of herbal drugs of preparation of VG and extraction of lipid soluble extractives of these drugs in Goghrita [Cow Ghee] may show cumulative positive effect on cognition. Thus the cognitive-enhancing activities of medicated ghee formulation V...

Talisadi choorna and Guti is routinely used in the treatment of Shwas. Vanshlochan is an important ingredient of Talisadi Choorna and Guti. But Vanshlochan has become extinct due to problems in procurement and availability. It is formed only after twelve years of flowering period in hollow internodes of Bamboo. Hence its synthetic substitute is rou...

Talisadi choorna and Guti is routinely used in the treatment of Shwas. Vanshlochan is an important ingredient of Talisadi Choorna and Guti. But Vanshlochan has become extinct due to problems in procurement and availability. It is formed only after twelve years of flowering period in hollow internodes of Bamboo. Hence its synthetic substitute is rou...

Epilepsy is the most common chronic neurological disorder characterized by episodes of recurrent unprovoked seizures Unmadgajakesari(UGK) is a herbomineral formulation claimed to be useful in epilepsy in traditional medicine. Lack of scientific evidence of UGK for its use in epilepsy lead to the objective of the present work. To evaluate the antie...

Background: Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder characterized by elevated levels of androgens, insulin resistance, anovulation, amenorrhoea or oligomenorrhoea, obesity and Polycystic ovaries. Objective: To evaluate efficacy of Ayurvedic formulations Nishamalaki and Gugul in PCOS induced in wistar rats. Material and Me...

Background: Schizophrenia is a complex neuropsychiatric disorder with abnormalities involving multiple neurotransmitters like dopamine, serotonin, glutamate and gamma-aminobutyric acid (GABA). Unmadgajakesari (UGK) is a herbomineral formulation claimed to possess antipsychotic activity. Hence, the present study was carried out to assess the antipsy...

Amalakyadi Ghrita (AG) a ghee based formulation is recommended for the treatment of Apasmar (Epilepsy) in Ayurved. Present study has been designed to prepare standard Amalakyadi Ghrita and evaluate it's antiepileptic activity using animal models namely Maximal Electricshock Seizures (MES) and Pentelenetetrazole (PTZ) induced seizure. It has been pr...

Materials and methods Qualitative interviewing methods were used. Key informant interviews were done on 33 faculty and students from five AYUSH institutions including: From Pune, Maharashtra -3 Ayurvedic, 1 Homeopathic and 1 Unani College/University; in Chennai, Tamil Nadu, 1 Siddha College. Respondents represented all levels of seniority and exper...

The Ayurvedic approach of treatment for voice disorders, as mentioned in classical texts of Ayurved, has been utilized effectively over the years. But limited research is available to validate it. Keeping all these facts in view, a clinical trial was planned to study the efficacy of an Ayurvedic formulation over hyperfunctional voice disorders. Eig...

Purpose: Triphala is a well-known Ayurvedic treatment for bowel problems. Current aim is to evaluate the effects of Triphala in 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced Inflammatory bowel disease (IBD), which is characterized by excessive oxidative stress and inflammation of intestinal tract. Methods: Aqueous Triphala extract was assessed...

Background and objective: There are over 500 colleges within the Indian System of Medicine and Homeopathy (ISM & H) that includes Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homeopathy (AYUSH). Therapies from AYUSH are widely utilized throughout India for both acute and chronic illnesses and may be an important source of care for HIV-infected...

‘Medical Pluralism’ is the key word of coming decade. In search of ‘feeling of well being’ more and more physicians and patients are considering and using alternative medical systems. It is important to understand the scientific approach of ‘Ayurveda – Indian System of Medicine’ regarding Tumours and Cancer’ to analyze probable co-relation with kno...

Objective: In Ayurvedic therapeutics, drugs in crude as well as processed forms are used. The ingredients are extracted from the plant and put to therapeutic use through various ways; the commonest are Kashaya and Ksheerapaka. Present study was designed to evaluate comparative free radical potential of these dosage forms. Methods: Kashaya are decoc...

Talisadi Choorna (TC) is one of the commonly used formulations. Lesser stability up to 2 months and poor palatability of TC; creates need to search for a better and equipotent dosage form. The effort was made to develop standardized Syrup and Suspension of TC and compare their activity against common respiratory and GIT pathogens in vitro as well a...

Sandhana kalpana (biomedical fermented formulations) are one of the best dosage forms of Ayurveda in practice since thousands of years. In order to prepare these medicaments, certain sets of conditions are prearranged, which lead to fermentation. Thus, products bequeath with self-generated ethyl alcohol, which potentiate these preparations (Asava-A...

Myrrh (guggulu) oleoresin from the Commiphora mukul tree is an important component of antiarthritic drugs in Ayurvedic medicine. Clinical data suggest that elevated levels of hyaluronidase and collagenase type 2 enzymes contribute significantly to cartilage degradation. Triphala guggulu (TG) is a guggulu-based formulation used for the treatment of...

The Chinese Hamster ovary (CHO) cell line is widely used for measuring drug cytotoxicity and resistance. Therefore, the effects of two major Ayurvedic drugs (W. somnifera root and E. officinalis fruits) on the short and long-term growth of these cells were investigated. A standard 96-well plate assay was used to measure short-term growth. For asses...

The dry fruit of Marich (Piper nigrum L.) is an ingredient of more than 3500 Ayurvedic formulations.Its bioavailability enhancing activity on accompanying ingredients and its imperative'pharmacological actions rationalize this. Piper nigrum has been proved to possess bioavailability-enhancing activity with various structurally and therapeutically d...

The article maybe cited as follows: Wele AA. Research Methodology and Statistics Evident in Ayurveda Treatises. In: AYUSOFT. First. C-DAC, MCIT, India; 2011.

A survey was conducted to assess the quality of education of Ayurveda in the State of Maharashtra, across state government, private, deemed institutes imparting undergraduate and post graduate curriculum. Status of theoretical and practical or clinical training and associated factors were evaluated using structured questionnaires from a sample of s...

Rasashastra – The science of metal and mineral medicine is one of the oriental sciences mainly of Hindu origin. It comes in the domain of God Shiva or ‘Rudra’ an important deity of Tantric cult. And it gets a mystical dimension, as it is associated with the Shaivite school of thought, which emphasizes a systematic practical teaching from creation t...