Aslı Suner Karakülah

Aslı Suner Karakülah
Ege University · Department of Biostatistics and Medical Informatics

22.35
 · 
PhD. Department of Biostatistics and Medical Informatics, Ege University

About

102
Publications
8,215
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124
Citations
Introduction
She currently works at Ege University as an Assoc. Prof. She obtained BSc (2005), MSc (2007) and PhD (2013) degrees from Dokuz Eylül Uni., Turkey. In 2011, she joined Prof. Klaus-Peter Adlassnig’s research group (MediUni of Vienna) as a visiting PhD student for a year. Her main research interests include: biostatistics, bioinformatics, medical informatics and applied statistics – particularly the analysis of problems in decision theory, multicriteria decision
Research Experience
October 2013 - present
Ege University
Position
  • Professor (Assistant)
March 2011 - March 2012
Medical University of Vienna,
Position
  • Visiting Researcher
February 2009 - October 2013
Dokuz Eylul University
Position
  • Research Assistant

Publications

Publications (102)
Article
Full-text available
The aim of the study is to determine the most appropriate method for construction of a sequential decision tree in the management of rectal cancer, using various patient-specific criteria and treatments such as surgery, chemotherapy, and radiotherapy. An analytic hierarchy process (AHP) was used to determine the priorities of variables. Relevant cr...
Article
Full-text available
Summary Background: The selection of appropriate rectal cancer treatment is a complex multi-criteria decision making process, in which clinical decision support systems might be used to assist and enrich physicians’ decision making. Objective: The objective of the study was to develop a web-based clinical decision support tool for physicians in the...
Article
Full-text available
The improper use of statistical methods is common in analyzing and interpreting research data in biological and medical sciences. The objective of this study was to develop a decision support tool encompassing the commonly used statistical tests in biomedical research by combining and updating the present decision trees for appropriate statistical...
Article
Full-text available
Background Hand hygiene is one of the most effective attempts to control nosocomial infections, and it is an important measure to avoid the transmission of pathogens. However, the compliance of healthcare workers (HCWs) with hand washing is still poor worldwide. Herein, we aimed to determine the best hand hygiene preference of the infectious diseas...
Article
A number of specialized clustering methods have been developed so far for the accurate analysis of single-cell RNA-sequencing (scRNA-seq) expression data, and several reports have been published documenting the performance measures of these clustering methods under different conditions. However, to date, there are no available studies regarding the...
Article
Full-text available
Introduction: Type 2 diabetes mellitus (T2DM) incidence is increasing all over the world due to obesity. Heart failure (HF) occurs when the functional impairment develops in the myocardium. T2DM may concur with HF and cause its development. The excellent pleiotropic effects of SGLT2 inhibitors within the cardiovascular system make these drugs attra...
Article
Full-text available
Background Inflammation is a recognized concomitant of hepatocellular carcinoma (HCC) and its indices are prognostically useful. Aims To evaluate two commonly used inflammatory indices, neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), to examine their relationship to maximum tumor diameter (MTD) and to survival. Me...
Article
Full-text available
Since its emergence in Wuhan, China in late 2019, the origin and evolution of SARS-CoV-2 have been among the most debated issues related to COVID-19. Throughout its spread around the world, the viral genome continued acquiring new mutations and some of them became widespread. Among them, 14408 C>T and 23403 A>G mutations in RdRp and S, respectively...
Preprint
Full-text available
SARS-CoV-2 is a betacoronavirus responsible for human cases of COVID-19, a pandemic with global impact that first emerged in late 2019. Since then, the viral genome has shown considerable variance as the disease spread across the world, in part due to the zoonotic origins of the virus and the human host adaptation process. As a virus with an RNA ge...
Article
Full-text available
COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of the viral genome over time as it spread across the world. An important question that still needs to be an...
Article
Objective We aimed to develop and evaluate a mobile learning (m-learning) design for large group application learning based on flipped classroom approach within an integrated curriculum of medical faculty. Materials and methods Totally 359 students enrolled in a two-credit course during the 2017–2018 academic year. An instructional design called 5...
Preprint
Full-text available
Since its emergence in Wuhan, China in late 2019, the origin and evolution of SARS-CoV-2 have been among the most debated issues related to COVID-19. Throughout its spread around the world, the viral genome continued acquiring new mutations and some of them became widespread. Among them, 14408 C>T and 23403 A>G mutations in RdRp and S, respectively...
Preprint
Full-text available
COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of viral genome over time as it spread across the world. An important question that still needs to be answer...
Article
Full-text available
Amaç: Günümüzde makine öğrenmesi yöntemleri hastalık tanısının konulmasında yaygın olarak kullanılmaktadır. Ancak sağlık verisinin büyük hacimli, çok boyutlu ve karmaşık olması nedeniyle dengesiz sınıf problemi ile karşılaşılması durumunda bu yöntemlerin doğrudan kulla-nımı performans düşüşüne neden olmaktadır. Bu çalışmada diyabet hastalarına iliş...
Article
Full-text available
Bu araştırmada, işitme kaybına bağlı olarak koklear implant kullanan ve normal işiten okul öncesi dönem çocukların matematiksel akıl yürütme becerilerinin karşılaştırılması amaçlanmıştır. Araştırmaya, okul öncesi dönemde (60-72 ay) anasınıfına ve özel eğitim merkezine devam eden 22 koklear implantlı çocuk ve bu çocuklarla yaş ve cinsiyete göre eşle...
Article
Objective: The aim of this study was to compare antioxidant vitamin C and vitamin E levels in the non-acromegaly control group and in patients with acromegaly with and without remission. Material and methods: In this study, 100 cases, acromegaly patients of 57% (n=57, 29F, 28M, mean ages of 49.5±12.1) and control subjects of 43% (n=43, 29F, 14M,...
Article
Full-text available
Introduction Recent studies highlight the crucial regulatory roles of transposable elements (TEs) on proximal gene expression in distinct biological contexts such as disease and development. However, computational tools extracting potential TE –proximal gene expression associations from RNA-sequencing data are still missing. Implementation Herein,...
Article
Full-text available
Although latent tuberculosis infection (LTBI) treatment is given before starting anti-TNF treatment, tuberculosis (TB) still develops in these patients. The incidence of hepatotoxicity associated with INH treatment is not known in this group of patients. The aim of this study was to determine the risk factors for the development of tuberculosis and...
Article
Full-text available
Introduction: The aim of this study was to evaluate usage habits, attitudes and perceptions towards mobile learning (m-learning), as well as to identify variables related to those attitudes amongst undergraduate dental students. Materials and methods: The study consists of 81 dental undergraduate students who who volunteered to participate. The...
Conference Paper
GİRİŞ VE AMAÇ:Granülom oluşumunda ve idamesinde önemli bir sitokin olan TNF- α (tümör nekroz faktörü) eksikliğinde ya da anti-TNF kullanımında granülomatöz enfeksiyonların gelişme riski artmaktadır. Bu enfeksiyonların prototipi sayılabilecek tüberküloz riski artması nedeniyle anti-TNF kullanması planlanan hastaların tedavi öncesinde latent tüberkül...
Article
Full-text available
Introduction: Prolactin plays a significant role in lactation and prolactin levels are increasing physiologically in pregnancy and breastfeeding period. There might be different mechanisms during breastfeeding between prolactin and insülin levels. In order to highlighten this mechanisms we compared the plasma levels of glucose, insülin, prolactin,...
Article
Full-text available
Background: Mosquitoes, being a nuisance species, are considered as one of the most important species in public health control programs due to their role as a vector in mosquito-borne diseases observed in humans and animals. We evaluated the susceptibility status of Culex pipiens collected from northern Izmir, Turkey in 2011-16. Methods: Mosquito...
Article
Full-text available
The hepatocellular carcinoma (HCC) tumor marker alpha-fetoprotein (AFP) is only elevated in about half of the HCC patients, limiting its usefulness in following the effects of therapy or screening. New markers are needed. It has been previously noted that the inflammation markers C-reactive protein (CRP) and platelet-lymphocyte ratio (PLR) are prog...
Article
Introduction and Objective Acute bronchiolitis might be associated with morbidity and mortality in infants. The aim of this study was to evaluate the role of mean platelet volume (MPV) in the prediction of acute bronchiolitis. Method One hundred and eighty four of these infants were diagnosed with acute bronchiolitis and 100 were healthy children....
Article
Full-text available
Objective: Bone morphogenic protein-4 (BMP-4) is a proinflammatory cytokine which is controlled by BMP-4 antagonists. Our aim was to investigate the levels of BMP-4 and its antagonists, noggin and matrix Gla protein (MGP), in prediabetes and diabetes. Design: One hundred and forty-two type 2 diabetic, 32 prediabetic, and 58 control subjects part...
Article
Full-text available
Introduction: Several markers of systemic inflammation, including blood C-reactive protein, platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) have been identified as independent prognosticators for hepatocellular carcinoma (HCC). Methods: To attempt to understand the significance of these markers, they were examined in relati...
Article
Full-text available
PurposeFibroblast growth factor-21 (FGF-21) is a member of fibroblast growth factor family. Both growth hormone (GH) and FGF-21 take place in the regulation of glucose and lipid metabolism. We aimed to investigate FGF-21 levels in acromegaly which is characterized by excess GH levels and is associated with comorbidities and altered body composition...
Conference Paper
Full-text available
Amaç: Bu çalışma entegre tıp fakültesi programlarında yer alan büyük grup eğitimlerinde kısıtlı ders süresini verimli kullanmak için bir mobil öğretim tasarımı modelinin geliştirilmesi amacıyla tasarlanmıştır. Bu modelle dersin içeriğinin etkili aktarımı, öğrenme düzeylerindeki artış, öğrencilerin aktif katılımı ve öğrenilen bilginin kalıcılığı sın...
Article
Full-text available
Aim: In this study, it was aimed to examine the readiness situations of the e-learning processes of the students who received internet assisted biostatistics education with Moodle, and to evaluate their thoughts and satisfaction. Materials and Methods: Nineteen students who took undergraduate and graduate courses in Moodle in the 2015-2016 and 2016...
Article
Full-text available
Background: The aim of this study was to evaluate the sensitivity and specificity of physical examination findings and functional tests in adult acute wrist trauma patients who presented to the emergency department (ED) and to create a reliable and practical clinical decision rule for determining the necessity of radiography in wrist trauma. Meth...
Article
Full-text available
Öz Çalışanların iş yerlerindeki refahı, iş yerinde özerklik sahibi olup olmadıklarına, öğrenme fırsatlarının ve iyi tanımlanmış iş hedeflerinin bulunup bulunmamasına, kişilerin yönetim ve meslektaşları tarafından desteklenmesine bağlıdır. İş kalitesi, çalışanların refahına katkıda bulunmanın yanı sıra; iş gücüne katılımın, verimliliğin ve toplam ek...
Presentation
Radyolojide Karar Destek Sistemleri
Article
Transposable elements (TEs) are mobile DNA sequences that play roles in gene regulation, and have a potential to influence the expression of nearby genes by functioning as cis-regulatory sequences. However, bioinformatics tools facilitating analysis of the associations between TEs and nearby genes in plants are still lacking. We therefore reanalyze...
Conference Paper
Giriş: Hayvan çalışmasında hiperkolesteroleminin HKH mobilizasyonuna neden olduğu gösterilmiştir. İnsanlarda kolesterol düzeylerinin kök hücre mobilizasyonuna katkısı üzerinde geriye dönük olarak gerçekleştirilen çalışmalarda farklı sonuçlar elde edilmiştir. Çalışmamızda hiperlipidemili olgularda çevresel kan CD34+ (ÇKCD34+) düzeylerini belirlemeye...
Poster
Transposable elements (TEs) are mobile DNA sequences that have the ability to insert themselves into new sites of genome and are found abundantly in most eukaryotes, particularly in plants. They dominate major proportions of several plant genomes. For example, >80% and >60% of maize and sorghum genomes comprise TEs, respectively. In addition to the...
Conference Paper
Amaç: Bu çalışmada hastanede yatan erişkin yaş grubundaki hastaların el hijyeni konusundaki farkındalıklarının saptanması amacıyla el hijyeni konusundaki düşüncelerini öğrenmek için hasta görüşleri toplanmıştır. Yöntem: Ege Üniversitesi Hastanesi ile İzmir Çiğli Eğitim ve Araştırma Hastanesi’nde yatan hastalara el hijyenine ilişkin on sekiz soruda...
Article
Full-text available
Amaç: Biyoistatistik, diş hekimliğinde araştırma tasarlanması ve uygulanması için verilerin analiz edilmesi, sonuçların yorumlanması ve yüksek kalitede yayın basılmasında büyük öneme sahiptir. Bu çalışma, diş hekimliği fakültesinde öğrenim görmekte olan lisans öğrencilerinin biyoistatistik dersine yönelik tutumlarını ve derse ilişkin başarılarını i...
Conference Paper
Full-text available
Amaç: Büyüme, farklılaşma ve gelişim gibi biyolojik süreçlerdeki dinamik gen ifadesi örüntüleri, çoğunlukla farklı zaman noktalarında toplanan gen düzeylerinin modellenmesi ile ortaya konulmaktadır. Gen ifadesi zaman serileri, incelenen biyolojik sürecin farklı koşullarda veya organizmalarda değişen hızlarda ilerlediği bazı durumlarda, özel yönteml...
Conference Paper
Full-text available
Amaç: Toplum kökenli pnömoni hastalarının ayaktan, yatarak ya da yoğun bakım ünitesinde tedavi kararının verilmesi sürecinde etkin olan kriterlerin uzman görüşleri ile değerlendirilerek, önceliklerinin belirlenmesi ve elde edilen bulgular yardımı ile aile hekimlerinin, asistanların ve uzman hekimlerin kararlarına destek verilmesi amaçlanmaktadır. Y...
Conference Paper
Full-text available
Özet: Günümüzde, çoğu insan yaşamının önemli bir parçasını çalışarak harcamakta ve zamanının büyük bir kısmını işyerinde geçirmektedir. İş kalitesi, çalışanların refahına katkıda bulunan çok boyutlu bir yapıyı temsil etmektedir. Gelişmekte olan ülke ekonomilerinde iş kalitesindeki düşüklük öne çıkan bir politika kaygısıdır. Ekonomik Kalkınma ve İşb...
Article
Background Leishmaniasis, visceral and cutaneous, is seen in Turkey and has both public and veterinary importance. So far, four Leishmania species and their vectors have been detected in Turkey. Vector control is essential in endemic areas and several personal protection methods are available including long-lasting insecticidal nets (LLINs). In thi...
Article
Species identification of sandflies is mainly performed according to morphological characters using classical written identification keys. This study introduces a new web-based decision support tool (sandflyDST) for guiding the morphological identification of sandfly species present in Anatolia and mainland Europe and classified in the Phlebotomus...
Conference Paper
Full-text available
1. Giriş Tiroid kanseri, en sık görülen endokrin bez kanseri olmakla beraber tüm kanserler içinde küçük bir bölümü oluşturmaktadır. Son 20 yılda dünyada pek çok ülkede insidansta dikkati çeken bir artış olduğu, ancak mortalitenin artış göstermediği ve sağkalımın da giderek artma eğiliminde olduğu bildirilmektedir. Bu çalışmada, Ege Üniversitesi Has...
Conference Paper
Full-text available
Abstract: Introduction Hashimoto’s thyroiditis (HT), also known as chronic lymphocytic thyroiditis, is an organ-specific autoimmune disease characterized by the presence of goitre, lymphocytic infiltration and serum thyroid autoantibodies. HT is a complex disease caused by overt autoimmune response, multiple gene susceptibility and environmental...
Article
Full-text available
Purpose: The growing prevalence of obesity has become a major concern. The efficacy of medical treatment, diet and behavior therapy in morbidly obese patients is limited. Obesity surgery is a treatment option for selected morbidly obese patients. Material and Method: Data of 47 patients (n=39 women, 8 men) who underwent bariatric surgery were inves...
Article
Full-text available
Statistical hypothesis testing is an essential component of biological and medical studies for making inferences and estimations from the collected data in the study; however, the misuse of statistical tests is widely common. In order to prevent possible errors in convenient statistical test selection, it is currently possible to consult available...
Article
Full-text available
The lack of laboratory tests for the diagnosis of most of the congenital anomalies renders the physical examination of the case crucial for the diagnosis of the anomaly; and the cases in the diagnostic phase are mostly being evaluated in the light of the literature knowledge. In this respect, for accurate diagnosis, ,it is of great importance to pr...
Conference Paper
Full-text available
The lack of laboratory tests for the diagnosis of most of the congenital anomalies renders the physical examination of the case crucial for the diagnosis of the anomaly; and the cases in the diagnostic phase are mostly being evaluated in the light of the literature knowledge. In this respect, for accurate diagnosis, ,it is of great importance to pr...
Conference Paper
Full-text available
Statistical hypothesis testing is an essential component of biological and medical studies for making inferences and estimations from the collected data in the study; however, the misuse of statistical tests is widely common. In order to prevent possible errors in convenient statistical test selection, it is currently possible to consult available...
Conference Paper
Full-text available
Abstract: Obezite prevalansı gittikçe artan önemli bir sağlık sorunu haline gelmiştir. Obezite için uygulanan tedavilerden; diyet, fiziksel aktivite, davranış terapisi ve kilo verdirici ilaçlar kilo verdirme açısından çok güçlü olmadığı gibi uzun dönem sürdürülebilir etkileri zayıf kalmaktadır. Obezite cerrahisi anlamlı ve kalıcı kilo verilme...
Conference Paper
In the treatment of the rectal cancer which is the second most common type of cancer in women and the third in men worldwide; there are various criteria and treatment options that effect the decision of which treatment should be applied. It was aimed to create a system to support the physician’s decisions in order to determine the most appropriate...
Conference Paper
The extensive profiles of all the Departments of Statistics in Turkey were compiled in this study. Data on the departments’ curriculum, academic staff, and undergraduate, graduate and postgraduate programs were collected via information forms. Statistics regarding the Departments of Statistics in Turkey were summarized. The past, present and future...