Ashwin Mohan

Washington University in St. Louis | WUSTL , Wash U · Department of Biomedical Engineering

Extracellular neurotransmitter concentrations vary over a wide range depending on the type of neurotransmitter and location in the brain. Neurotransmitter homeostasis near a synapse is achieved by a balance of several mechanisms including vesicular release from the presynapse, diffusion, uptake by transporters, nonsynaptic production, and regulatio...

College graduates are increasingly expected to collaborate across disciplines in the modern workplace. In addition to possessing content knowledge, this requires them to be adept in professional skills, including written and verbal communication skills, team building and leadership, and to have an understanding of relevant global issues. A growing...

Neurotransmitter homeostasis in and around a synapse involves complex random processes such as diffusion, molecular binding, and uptake by glial transporters. A three-dimensional stochastic diffusion model of a synapse was developed to provide molecular-level details of neurotransmitter homeostasis not predicted by alternative models based on conti...

Faculty from the Department of Electrical and Computer Engineering and the College of Education at the University of Missouri (MU), Columbia, developed a novel course for engineering graduate students emphasizing pedagogy and professional skills. The two-semester course sequence, titled “Preparing Engineering Faculty and Professionals,” includes re...

Neurotransmitter homeostasis in and around synapses involves random processes such as diffusion, molecular binding and unbinding. A three-dimensional stochastic diffusion model of a synapse was developed to provide molecular level details of neurotransmitter homeostasis not predicted by alternative models based on continuum approaches. This framewo...

Chronic cocaine administration causes instability in extracellular glutamate in the nucleus accumbens that is thought to contribute to the vulnerability to relapse. A computational framework was developed to model glutamate in the extracellular space, including synaptic and nonsynaptic glutamate release, glutamate elimination by glutamate transport...

The study of group behavior in animals emerging from social interactions among individuals using agent based models has gained momentum in recent years. Although most of the individuals in a group of the treehopper Umbonia crassicornis do not have information about where the predator is, the signaling behavior of the group yields an emergent patter...

A computational model of glutamate dynamics in the PFC-NAc syapse is developed. The mechanisms considered are release of glutamate into the synapse, diffusion of synaptic glutamate into the extracellular space, Glu added by cystine-glutamate exchanger, Glu removal via transporters, and binding to mGluR's. The model will be used to determine the rel...

Typescript. Thesis (M.S.)--University of Missouri-Columbia, 2004. Includes bibliographical references (leaf 54).