Ashraf Zaghloul

• Professor
• Professor at National Cancer Institute Egypt

Background: Laparoscopic Radical Nephrectomy (LRN) is the standard for treating patients with T1 Renal Cell Carcinoma (RCC) who are not candidates for nephron-sparing surgery. However, LRN is still considered controversial in patients with T2 tumors. The aim of the study was to compare the surgical and oncologic outcomes of LRN vs Open Radical Neph...

Background: Laparoscopic Radical Nephrectomy (LRN) is the standard for treating patients with T1 Renal Cell Carcinoma (RCC) who are not candidates for nephron-sparing surgery. However, LRN is still considered controversial in patients with T2 tumors. The aim of the study was to compare the surgical and oncologic outcomes of LRN vs Open Radical Neph...

Purpose The clinical effect of neoadjuvant intravesical instillation of chemotherapy immediately before transurethral resection of bladder tumors (TURBT) has been a subject of recent research. The aim of this study was to assess the effect of immediate neoadjuvant electromotive instillation of mitomycin C before transurethral resection for patients...

Background: The purpose of this article is to summarize the opinions of the surgical oncology leaders from the Global Forum of Cancer Surgeons (GFCS) about the global impact of COVID-19 pandemic on cancer surgery. Methods: A panel session (virtual) was held at the annual Society of Surgical Oncology 2021 International Conference on Surgical Canc...

BACKGROUND: Robotic prostatectomy is showing progressive worldwide spread owing to potential clinical benefits, but at a higher cost. AIM: This article describes the challenges and clinical outcomes of the first group of patients undergoing robotic prostatectomy in Egypt. DESIGN, SETTING, PARTICIPANTS: From 2017 to 2019, the data of all (55) patien...

A correction to this paper has been published: https://doi.org/10.1245/s10434-021-09970-4

Background Robotic prostatectomy is showing progressive worldwide spread owing to potential clinical benefits, but at a higher cost. Objective This article describes the challenges and clinical outcome of the first group of patients undergoing robotic prostatectomy in Egypt. Design, setting, participants From 2017 to 2019, the data of all (55) pa...

BACKGROUND: Minimally invasive nephrectomy is considered a technically challenging procedure requiring a long learning curve to reach acceptable warm ischemia time and perioperative complications. These minimally invasive techniques result in a shorter hospital stay and less post-operative pain. AIM: This study aims to demonstrate the National Canc...

Objective: To assist in the diagnosis, treatment, and prognostic prediction of bladder cancer, the molecular patterns associated with it should be elucidated. Competing endogenous RNA network: MicroRNA (miRNA), long noncoding RNA (lncRNA), and their target autophagy genes have been strongly implicated in tumor development and metastasis. Patients...

Background Undoubtedly, robotic systems have largely penetrated the surgical field. For any new operative approach to become an accepted alternative to conventional methods, it must be proved safe and result in comparable outcomes. The purpose of this study is to compare the short-term operative as well as oncologic outcomes of robotic-assisted and...

Aim of work: Robotics in surgery led to an improvement of visualization, a better handling of tissues and better suturing. This study aimed to document the first experience of the Egyptian National Cancer Institute (NCI) using the robot-assisted laparoscopic approach in radical hysterectomies for cervical cancer and to highlight observed advantage...

Multidrug resistance (MDR) is a critical factor, which results in suboptimal outcomes in cancer chemotherapy. One principal mechanism of MDR is the increased expression of ATP-binding cassette (ABC) transporters. Of these, multidrug resistance-associated protein 3 (MRP3) and breast cancer resistance protein (BCRP) confer MDR when overexpressed in c...

The available literature on minimally invasive colorectal cancer demonstrates that laparoscopic approach is feasible and associated with better short term outcomes than open surgery while maintaining equivalent oncologic safety. Reports have shown that robotic surgery may overcome some of the pitfalls of laparoscopic intervention. To evaluate earl...

Introduction: Abdomino-perineal resection has been the standard treatment for rectal tumors located ⩽5 cm from the anal verge. Recently, intersphincteric resection became a valid option which preserves the bowel continuity with better functional outcome. Aim: Is to evaluate the oncological and functional outcome alongside the associated surgical mo...

A new, sensitive, noninvasive method for the detection of urothelial carcinomas of the bladder would open new possibilities in both the diagnosis and follow up of patients. Voided urine specimens were collected from patients with histologically confirmed bladder urothelial carcinoma (Group 1: n = 60), urological patients without urothelial carcinom...

Objectives: Pancreatic cancer has an extremely dismal clinical course and high fatality rate. Knowing that, adipokines could regulate insulin resistance, inflammation, immunity and carcinogenesis. Accordingly, an understanding of adipokines in relation to pancreatic cancer could be useful to improve disease outcome. We aimed to determine serum ret...

Objectives: Early diagnosis of pancreatic cancer (PC) in diabetic patients is difficult owing to late presentation of symptoms. Hence, finding a marker to identify cancer stage early would be useful to improve survival. We aimed to determine levels of serum retinol binding protein 4 (RBP-4), neutrophil gelatinase-associated lipocalin (NGAL), insul...

After maxillectomy, prosthetic restoration of the resulting defect is an essential step because it signals the beginning of patient's rehabilitation. The obturator used to restore the defect should be comfortable, restore adequate speech, deglutition, mastication, and be cosmetically acceptable, success will depend on the size and location of the d...

Unlabelled: After maxillectomy, prosthetic restoration of the resulting defect is an essential step because it signals the beginning of patient's rehabilitation. An obturator used to restore the defect should be comfortable, restore adequate speech, deglutition, and mastication, and is acceptable cosmetically, Success will depend on the size and l...

Precise prognostication of breast cancer based on immunohistochemicalfeatures is a challenging assay. Thus, there is a need for more sophisticated prognostic determinants. This work aims to investigate the sensitivity of flow cytometry for the accurate evaluation of steroid receptor positive, tumor cells in formalin-fixed paraffin embedded tissue s...

The aim of this work was to assess the epidemiologic aspects, clinico-pathological features and the results of multidisciplinary treatment of Wilms' tumor (WT) in pediatric patients treated at the National Cancer Institute (NCI), Cairo University, between January 2002 and December 2004. This study included 53 patients, all under the age of 16 years...

Gastric GISTs account for more than half of all gastrointestinal stromal tumors and represent less than 5% of all gastric tumors. The peak age for harboring GIST of the stomach is around 60 years and a slight male preponderance is reported. These tumors are identified by expression of CD117 or CD34 antigen. Symptoms at presentation usually include...

To evaluate the clinical presentation and treatment end results of primary adenocarcinoma of the urinary bladder, and to determine the significant independent prognostic factors that determine this outcome. Of 3659 patients who underwent cystectomy, 192 had adenocarcinoma of the urinary bladder, with a relative frequency of 5.2%. Most of these pati...

The aim of this work is to study the use of this technique in extirpation of malignant tumors of the maxillary sinus. This includes the exposure for adequate tumor resection and the preservation of as much as possible functional tissue integrity. This approach will be evaluated including the advantages and disadvantages as regards the physiological...

To compare the urodynamic parameters, continence rates, and complications between two different continent urinary reservoirs-the sigmoid neobladder (SN) and W-shaped ileal neobladder (IN). Sixty patients with bladder cancer underwent radical cystectomy and were divided into two groups. The first group comprised 33 patients who underwent detubulariz...

Egypt has one of the highest prevalence rates of hepatitis C virus (HCV) infection in the world; however, the risk and attribution related to HCV in Egyptian patients with hepatocellular carcinoma (HCC) remains unknown. The current study was undertaken to estimate the risk of HCC in relation to HCV in Egypt. Thirty-three patients with HCC and 35 he...

Background: Egypt has one of the highest prevalence rates of hepatitis C virus (HCV) infection in the world; however, the risk and attribution related to HCV in Egyptian patients with hepatocellular carcinoma (HCC) remains unknown. Goals: The current study was undertaken to estimate the risk of HCC in relation to HCV in Egypt. Study: Thirty-three p...

Background: Although axillary lymph node metastasis is one of the most important determinants of breast carci- noma prognosis and adjuvant therapy, the patterns of axil- lary lymph node metastasis from breast cancer remain un- clear. Materials and methods: Fifty female patients with op- erable invasive breast cancer underwent complete axillary lymp...

Purpose: The aim of this study was to determine the morbidity, survival and patterns of failure for locally recurrent rectal cancer patients who underwent further surgery with the hope of cure. Evaluation of the accuracy of radiological imaging in early detection of local recur- rence was a second aim.