Ashraf Sawafta

Ashraf Sawafta
An-Najah National University · Department of Biology

Ph.D In Molecular Genetics and Genetic Engineerin

About

16
Publications
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88
Citations

Publications

Publications (16)
Article
Full-text available
Two new Cu(II) complexes of type [Cu(dien)(N-N)] Br 2 (dien is diethlylenetriamine, C1 complex with N-N = diethlylenetriamine and C2 complex with N-N = propyl-1,3-diamine) were made valuable and in vitro screened for both cytostatic and cytotoxic activities against four cell lines: colon cancer (HCT), liver cancer (HepG2), prostate cancer (PC3) and...
Article
Full-text available
Camel milk is an important nutritional source that historically been used in the treatment of cancer. Therefore, the main aim of the present study is to determine the in vitro anticancer effect of both camel milk and whey against cervix cancer (HeLa) cells. To perform that, skimmed milk as well as whey immunoglobulins concentrate samples were prepa...
Article
Under mode of ultrasonic vibration, the neutral octahedral mononuclear [trans-CuBr2(N∩N)2]∙3H2O complex with N∩N=2,2-dimethylpropane-1,3-diamine was obtained. The structure of the desired complex was characterized by UV-Vis. spectroscopy, FT-IR, EDX, MS, SEM, TG/DTA and CHN-analysis. The octahedral-structure of the desired Cu(II) complex was proven...
Article
Two new hydrated monocationic Cu(II) complexes with 1,3-propylenediamine and 1,2-ethylenediamine of general formula [CuBr(N-N)2·H2O]Br were prepared. The complexes were identified by means of several spectroscopic tools (Uv-visible, IR and MS), thermally (TG/DTA) and CHN-elemental analysis. The three dimensional structure for complex A and B was pr...
Article
Asymmetrical Me2NCH2CH2NH2/copper(II)/bromide complex was synthesized in a good yield under ultrasonic vibration mode. The desired complex was characterized using, elemental EA, conductmetric, UV-Vis, FTIR, MS and EDX analysis. The thermal behaviour of the complex was performed by TG. DFT calculations were also performed in order to investigate the...
Article
Full-text available
Obesity escalates at an alarming rate worldwide. It is associated with chronic low-grade inflammation, which is implicated in the pathogenesis of type 2 diabetes and cardiovascular diseases. Adipose tissue is a primary site of obesity-induced pro-inflammatory factors such as leptin. Curcuminoids are potent anti-inflammatory agents; however, evidenc...
Poster
Full-text available
The irrigation of Mentha spicata with secondary treated effluent did not affect yield of essential oil quantity in the crop. The inhibitory activity of BuChE was similar of the essential oils under the two irrigation types collected in summer and fall, with IC50 of 9.67 and 9.51 mg/ml in summer for potable and effluent, respectively, and 6.72 and 6...
Article
Full-text available
Two dicationic water soluble mixed triamine/diamine copper (II) complexes, of general formula [Cu(dien)NN]Br2(1-2) [dien = diethelenetriamine and NN is en = ethylenediamine or Me4en = N,N’,N,N’-tetramethyletheylenediamine] were prepared under ultrasonic mode with a relatively high yield. These complexes were characterized by elemental microanalysis...
Article
Radionuclide activities (U238 and Th232) in the normal person kidney gallstone and another one with cancer disease have been determined experimentally by ɣ-ray spectroscopy and EDS measurements. U238 and Th232 concentrations were found to be very high in the kidney gallstone belonging to cancer patient indicating a strong radionuclide-cancer correl...
Article
Two new mixed-ligand copper(II) complexes, [Cu(dipn)(NN)]Br2(1-2) [dipn=dipropylenetriamine, NN=ethylenediamine (en) (1) and propylenediamine (pn) (2)], have been synthesized. These complexes were characterized by spectroscopic and thermal techniques. Crystal structure for 2 shows a distorted trigonal-bipyramidal geometry around Cu(II) ion with one...
Article
Full-text available
RNA interference is an attractive strategy to fight against viral diseases by targeting the mRNA of viral genes. Most studies have reported the transient delivery of small interfering RNA or small hairpin (shRNA) expression constructs. Here, we present the production of transgenic mice stably expressing shRNA or miRNA targeting the IE180 mRNA (imme...
Article
Full-text available
Fullerenes are a class of nanomaterials with unique electronic properties that can be harnessed for use in various applications. We have found their biologic function critically depends on the structure of the side chain moieties added to the core carbon cage. A therapeutic candidate termed C 70-Tetraglutamate (TGA), previously shown to have potent...
Article
Small interfering RNAs (siRNAs) are still rarely used in transgenic vertebrates to knockdown gene expression. Indeed, the in vitro highly efficient expression vectors for siRNA based on the use of polymerase III promoters as U6 or H1 gene promoters for expression in cells are often silenced in vivo. In this thesis, various shRNA expressing vectors...

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Projects (2)