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Publications (24)
RNA-binding proteins (RBPs) are integral components of cellular machinery, playing crucial roles in the regulation of gene expression and maintaining genetic stability. Their interactions with RNA molecules govern critical processes such as mRNA splicing, stability, localization, and translation, which are essential for proper cellular function. Th...
BRCA1 and BRCA2 mutations significantly increase the risk of breast and ovarian cancers (OC) by affecting crucial cellular processes such as cell cycle regulation, DNA repair, and apoptosis. Despite understanding their broad impacts, the detailed effects on gene expression and signaling pathways in OC remain unclear. This study aims to elucidate th...
Bioinformatics, the interdisciplinary field that combines biology, computer
science, and data analysis, plays a pivotal role in advancing our understanding
of life sciences. In the African context, where the diversity of biological resources
and healthcare challenges is substantial, fostering bioinformatics literacy and
proficiency among students i...
Recent breakthroughs in the field of medicine and physiology have come through the application of bioinformatics and computational biology in experimental designs and in silico analyses. Genomics and proteomics-based strategies are currently used for data presentation, sequence analysis and alignment, primer designs, mapping and annotation of the e...
Recent breakthroughs in the feld of medicine and physiology have come through the application of bioinformatics and computational biology in experimental designs and in silico analyses. Genomics and proteomics-based strategies are currently used for data presentation, sequence analysis and alignment, primer designs, mapping and annotation of the en...
Wolbachia , an endosymbiotic bacterium, has a significant impact on the reproductive biology and pathogen transmission capabilities of various arthropods, including mosquitoes. This study aimed to assess the prevalence of Wolbachia in Culex molestus , a vector mosquito species, in South Korea. Mosquito samples were collected from different location...
The free hormone hypothesis postulates that the estimation of free circulating 25 (OH)D may be a better marker of vitamin D status and is of clinical importance compared to total vitamin D fraction. The unbound fraction is involved in biological activities since it is able to penetrate into the cell. Studies have shown that cathelicidin/LL-37 inhib...
Background
Genetic variants influence the distribution of vitamin D in circulation leading to vitamin D deficiency. The two extensively studied non-synonymous DBP single nucleotide polymorphisms (SNPs) rs7041 and rs4588 are found in different populations. The aim of this study was to determine the frequency distribution of DBPgene polymorphism andc...
The free hormone hypothesis postulates that the estimation of free circulating 25(OH)D may be a better marker of vitamin D status and is of clinical importance compared to total vitamin D levels because it is the fraction involved in biological activities. Studies have shown that cathelicidin inhibits the growth of Mycobacterium Tuberculosis in a v...
Background
Malaria is a global infectious (vector-borne: Anopheles mosquitoes) disease which is a leading cause of morbidity and mortality in Sub-Saharan Africa (SSA). Among all its parasitic (protozoan: Plasmodium sp. ) variants, Plasmodium falciparum (PF) is the most virulent and responsible for above 90% of global malaria deaths hence making it...
Genetic variants influence the distribution of vitamin D in circulation leading to vitamin D deficiency. This study aimed to determine the association between the DBP gene polymorphism with vitamin D bioavailability among active tuberculosis patients, latent Tuberculosis and with no Tuberculosis infection individuals. This was a cross-sectional stu...
We present the complete mitochondrial genome of a Malaria vector Mosquito Anopheles sinensis Wiedemann, 1828 from South Korea. The mitochondrial genome is about 15,421 bp long and contains 13 protein-coding genes (PCGs), 22 tRNA genes, two rRNA genes, and an A-T rich region. The present data were compared with those from China with respect to PCG s...
Methyl benzoate (MBe) is a volatile organic molecule found in various plants; it is used as an insect semiochem-ical. MBe also has a biorational insecticidal effect against various agricultural and urban arthropod pests. The present study was the first to assess the larvicidal potential of MBe against fourth-instar larvae of the mosquitoes Aedes al...
The fall armyworm, Spodoptera frugiperda, is an important agricultural pest native to tropical and subtropical regions of the Western Hemisphere, and has invaded Africa and further spread into most countries of Asia within two years. Here, we analyzed the genetic variation of invaded populations by comparing the nucleotide sequences of two genes: t...
A giant water bug Lethocerus deyrollei (Hemiptera: Belostomatidae) is a large, predatory, and nocturnal hemipteran insect, which has been considered threatened and thus enrolled as an endangered species in South Korea and Japan. Here, we characterized the complete mitochondrial genome of L. deyrollei, which has a circular form with 19,295 bp in len...
Bemisia tabaci is a species complex of at least 44 cryptic species with a worldwide distribution. It is a serious pest of many crop plants as well as a successful vector of at least 100 begomoviruses. Using B. tabaci collected from cassava and tomato fields in the southwestern and north central regions of Nigeria, we determined nucleotide sequences...
Effective control of mosquito requires adequate knowledge of not just the breeding sites but also the habitats and all other environmental factors relating to the Anopheline vector's life. This is not just to avoid the nuisance they cause but most importantly to curtail the spread of the diseases they transmit. This paper identified environmental f...