Ashish Baldi

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Verified

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• Dr.
• Professor at Maharaja Ranjit Singh Punjab Technical University

Herbal and traditional medicines (H&TMs) form a significant part of healthcare practices worldwide, often perceived as safe alternatives to conventional treatments. However, this perception has led to challenges in ensuring the safety and efficacy of these products, highlighting the critical importance of pharmacovigilance for herbal medicines. Ove...

India is among the top 20 international markets for medical devices. With increasing economic growth, rising life expectancy, and rapid technological advancements, the healthcare needs of the population have surged. This is particularly evident with the rise in chronic diseases, growing healthcare awareness, and the growing demand for personalized...

Introduction Probiotics have proven to have a strong potential for treating and/or preventing a wide range of diseases and also aid in maintaining a healthy gut microbial ecology and are effective against pathogens that are resistant to many drugs. As a result, the probiotics industry is expanding fast on a global scale, and research to explore pro...

The process of pharmaceutical product development may be classified into four stages including preformulation, prototype development, scale-up studies and commercialisation of pharmaceutical formulations. Pharmaceutical product development begins with the estimation of physicochemical properties of new chemical entity with druggable properties. The...

Background: Inspite of extensive armamentarium available to treat fungal infections search of new compounds from herbal source is still on. Cassia occidentalis, also called as Kasunda, belongs to the Fabaceae family and is valued for its medicinal properties. These therapeutic effects are associated with existence of pharmacologically active compon...

The medical device industry has experienced a significant upsurge in the number, diversity, and complexity of devices over the last two decades. As the global demand for medical devices grows, regulatory frameworks across major economies, including the USA, Europe, India, China, and Australia, have evolved to ensure safety, quality, and efficacy. T...

The global nutraceuticals market has experienced substantial growth in recent years, attributed to increasing consumer awareness regarding the importance of nutritional supplementations for a healthy lifestyle. This market encompasses many products, including inorganic mineral supplements, vitamin supplements, digestive enzymes, dietary fibers, ant...

Artificial intelligence, an interdisciplinary approach that specializes in developing intelligent machines, has emerged as an authoritative tool in pharmaceutical product development cycle by offering numerous advantages over traditional trial-and-error approaches. Artificial intelligence-based techniques, such as machine learning, artificial neura...

Aim The aim of the current study was to explore nano-formulation for effective neuroprotection by auranofin. Background Currently, the treatment options for various CNS disorders, particularly neurodegenerative disorders, are greatly constrained. A significant obstacle in this pursuit is the blood-brain barrier, a shielding covering that hinders t...

As per World Health Organization, “health is a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity”. Balanced and healthy nutrition is important for the optimization of health status and overall quality of life. Suboptimal health status is the intermediate health state between disease and hea...

Traditional drug discovery approach is based on one drug-one target, that is associated with very lengthy timelines, high costs and very low success rates. Network pharmacology (NP) is a novel method of drug designing, that is based on a multiple-target approach. NP integrates systems such as biology, pharmacology and computational techniques to ad...

In response to the surging global demand for medicinal products, the herbal indus-try faces significant challenges in ensuring the quality of herbal formulations. Regulatory bod-ies, actively set wanted acceptance limits to different parameters and tries to uphold quality standards. However, the complexities of herbal manufacturing, characterized b...

Spices have one of the significant impact on mankind examining its historical, cultural, economic, and health importance. This research article shed light on the pressing problem of spice adulteration, with a specific emphasis on the difficulties encountered in case of cardamom, often referred to as the "Queen of Spices." The paper highlight the ab...

Medical devices play an essential role in the delivery of healthcare but its use is not entirely risk free. There are several instances where it causes mortality or morbidity among users. It is important to evaluate the risks involved at every stage of its application to bring improvement in the standard of healthcare. For the purpose Materiovigila...

Quality by design (QbD) is a systematic method for the development of product and process design to ensure quality and efficacy. In the fragrance and flavour industry, the design of delivery systems plays a crucial role in the overall product quality and consumer acceptance. This article analyses the current state‐of‐the‐art and future explorations...

Aim: In this study, we aimed to prepare enteric encapsulated spheroids containing inclusion complex using quality by design approach.Methods: A Box-Behnken design was employed to determine effects of variables on selected responses. Risk assessment was conducted using Ishikawa fishbone diagram. A model with a p-value was less than 0.5 for being a s...

Plastic surgery encompasses a wide array of specialties, including liposuction, facial cosmetic, breast surgery, maxillofacial surgery, body contouring, and skin grafting procedures. Given the critical need for biological safety in plastic surgery, biomaterials are extensively utilized due to their exceptional biocompatibility and biodegradability....

The study aimed to develop herbal anti-candida topical gel using ethanolic extract of leaves from the arid zone plant, Wrightia tinctoria, also known as Indrajau. This plant from the Apocynaceae family has been investigated for a wide range of medicinal uses, including pain relief, antifungal effects, inflammation reduction, parasite expulsion, ulc...

Alzheimer’s disease remains an unsolved neurological puzzle with no cure. Current therapies offer only symptomatic relief, hindered by limited uptake through the blood–brain barrier. Auranofin, an FDA-approved compound, exhibits potent antioxidative and anti-inflammatory properties targeting brain disorders. Yet, its oral bioavailability challenge...

Background: This research paper showcases the creation and assessment of a machine learning model utilizing the Efficient Net B4 architecture for the identification of cumin herbs and any potential adulterants. The research presents a comprehensive overview of the model's structure, emphasizing the different layers, their output dimensions, and the...

Hypertension, which stands as a leading global health challenge, demands a dynamic approach for its effective management. The traditional methods of managing hypertension, centered on periodic clinic visits for blood pressure measurement and pharmacological interventions, are increasingly being complemented and enhanced by digital technologies. The...

The adulteration of spices presents a substantial risk to public health and the authenticity of culinary customs. This article introduces a comprehensive interdisciplinary strategy to tackle this problem, by combining traditional and advanced techniques to authenticate spices in simple manner.The machine learning and artificial intelligence, has sh...

Background: Arteether (ART) is artemisinin derivatives drug used for resistant malaria. It has oral bioavailability of almost 0.98 %. AIM: ART loaded solid lipid nanoparticles (SLN) were developed with enhanced bioavailability using Quality by Design approach. Methodology: ART loaded SLNs were prepared by solvent emulsification/evaporation method u...

A quality control strategy for herbal materials, taking into account the alignment between process characteristics and material quality attributes. The application of this approach holds significant potential for ornamental the building of quality herbal products. The concept of Quality by Design (QbD) has emerged as a dominant framework in the pha...

Neurological disorders impose a significant burden on individuals, leading to disabilities and a reduced quality of life. However, recent years have witnessed remarkable advancements in pharmaceutical interventions aimed at treating these disorders. This review article aims to provide an overview of the latest innovations and breakthroughs in neuro...

Background: In Ayurvedic medicine, herbal, metallic, and herbometalic preparations gain recognition for treating physiological maladies. Aurothioglucose serves as a pharmaceutical intervention for the management of rheumatoid arthritis and can be potential as a potential pharmacological agent for mitigating neuronal toxicity. Objective: The current...

Respiratory disorders, such as tuberculosis, cystic fibrosis, chronic obstructive pulmonary disease, asthma, lung cancer, and pulmonary inflammation, are among the most prevalent ailments in today’s world. Dextran, an exopolysaccharide formed by Leuconostoc mesenteroides (slimeproducing bacteria), and its derivatives are investigated for several th...

Metabolic syndrome (MS) represents a complex cluster of medical conditions with profound implications for global public health. This constellation of disorders substantially increases the susceptibility to type 2 diabetes, obesity, thrombosis, cardiovascular disease, and hyperlipidemia. The drugs currently prescribed for managing MS offer limited e...

Spices and herbs play an important role in our day to day life with its application varying from flavouring the food to various medicinal uses. But the major limitations linked with these nature oriented spicesare individualized and restricted information about the identification and quality mapping. With increasing demands, adulteration of spices...

Farmers all across the world conduct experiments, and have done so for a long time, way before modern experimental science and its forerunners were acknowledged. Farmer techniques, based on their experience, have some advantages over agricultural specialists' field trials under the relevant local conditions, making documentation of successful agric...

In the aftermath of the COVID-19, India has witnessed an increase in the demand for immunity boosting plants. The Ministry of AYUSH, Government of India through National Medicinal Plants Board (NMPB) has decided to emerge medicinal plants as an attractive farming option in view of generating income for farmers. The aim of this work was to identify...

Objective: The aim of present study is to identify the breast cancer screening barriers among the women with breast cancer of Malwa region of Punjab, India. The study was conducted at three government hospitals representing almost all districts of Malwa region. Methods: The quantitative research design was followed using empirical research methods....

Lung diseases such as asthma, tuberculosis, cancer, cystic fibrosis, and diphtheria are few of the most common diseases that humans face in this decade. Pullulan, an exopolysaccharide produced by Aureobasidium pullulans, and its derivatives are explored for various therapeutic benefits in recent years. Pullulan-based drug delivery systems can becom...

Dextran is a biodegradable, nontoxic biological material commonly utilized in drug delivery systems. In this chapter, we brief the effect of dextran on lung diseases, different drug delivery systems with dextran, and their studies on affected lung. With more research and understanding of dextran and its derivatives, people will be able to more prec...

Background The deficiency of vitamin D is a global concern affecting individuals of all age groups. Insufficient exposure to sunlight and disease conditions can lead to cholecalciferol (vitamin D3) deficiency Objective Cholecalciferol is a lipophilic crystalline molecule, and it is highly susceptible to degradation under environmental conditions,...

Background: Atovaquone are important drugs that are used in the treatment of malaria and in combination with mefloquine hydrochloride increases the efficacy and potency. Present study covers the development of UV-spectrophotometry based analytical techniques for the simultaneous estimation of mefloquine HCl and atovaquone employing the Quality by D...

The inclusion complex of α, β-arteether with β-cyclodextrin was prepared. The ratio was selected by implementing the QbD approach to get the best host-guest complex ratio. Further, the formation of the best complex was compared with stability analysis. Also, the enhancement in dissolution profile, as well as solubility, was compared with the pure α...

α, β-Arteether (ART) antimalarial drug is used to treat chloroquine-resistant malaria and cerebral malaria. The drug’s solubility in water is relatively low (17 μg/mL), and 40% of the drug degrades in the stomach, resulting in poor bioavailability. This article discusses the quality by design technique used for formulation development and optimizat...

Atherosclerosis is a multifaceted inflammatory and cardiac disorder resulting from the deposition of lipid and fibrous material across the arterial walls. This eventually led to various cardiovascular, peripheral artery, and brain-related disorders. Various nanodrug delivery systems viz., nanoparticles, liposomes, and dendrimers have been investiga...

Background The development of effective, cost-effective, robust, sensitive, and specific analytical techniques for the analysis of drug(s), degradation product(s), and contaminants in dosage forms and biological samples is constantly required as part of the pharmaceutical product life-cycle. The adoption of systematic analytical development methodo...

Aim This study aimed to evaluate the potential of different hydrophilic polymers to increase Arteether's water solubility. Background Arteether is classified as a class II biopharmaceutical in the Biopharmaceutical Classification System (BCS), with low water solubility (17 g/mL) and dissolution rate, resulting in poor bioavailability. Objective T...

The present work is conducted to develop the innovative micro sized solid oral dosage forms of Arteether using a Quality by Design technique to increase the solubility and bioavailability. The quantity of oil and the co-surfactant-surfactant ratio was employed as parameters in DoE for drug-loaded SMEDDS optimization. The particle size and zeta pote...

Unorganized natural nutrient cycle and depleted soil health may prove major limitation on the growth and development of medicinal plants and therefore quality and final yield of the cultivation. Therefore, studies concerned with the restoration of normal fertility to the soil and make it rich with certain nutrients are of the fundamental interest f...

Osteoarthritis (OA), a chronic degenerative musculoskeletal disorder, progressively increases with old age. It is characterized by progressive loss of hyaline cartilage followed by subchondral bone remodelling and inflammaging. To counteract the inflammation, synovium pours various inflammatory and immune mediators along with metabolic intermediate...

Medicinal plants have regained popularity in recent years as a result of growing trust in traditional medicine, and the worldwide supply of medicinal plants sourced from the wild is resulting in a dwindling natural resource base. It is necessary to pursue a broad trend toward medicinal plant production, as well as vertical integration of commoditie...

In this book authors has explaned the detail treatment about the COVID-19 and Mucormycosis.

Unorganized natural nutrient cycle and depleted soil health may prove major limitation on the growth and development of medicinal plants and therefore quality and final yield of the cultivation. Therefore, studies concerned with the restoration of normal fertility to the soil and make it rich with certain nutrients are of the fundamental interest f...

Aim The study aims to enhance the permeability of pyridostigmine bromide by developing a self-double emulsifying drug delivery system (SDEDDS) and enteric-coated spheroids. Background Pyridostigmine bromide is a reversible anticholinesterase used to treat Myasthenia Gravis, reverse neuromuscular blockade, and prevent nerve gas (i.e., soman) poison...

Background: Global prevalence of scabies urge to develop phytochemicals based novel herbal dosage forms that can assist in treatment of scabies. Objective: Anti scabietic investigation of phytosomes assimilating acetone fraction of hydroalcoholic extract of Pistacia integerrima galls against Sarcoptes scabiei. Method: Flavonoids were screened in ac...

Understanding the constraints involved in the adoption of medicinal plant cultivation is the most important step to design future policies and action plans for effective outcomes. Keeping this in view, a model survey-based study involving medicinal plant cultivators by using a purposing sampling technique was carried out. Additionally, farmers iden...

Paediatric patients differ from adult in various aspects of pharmacotherapy, including the abilities of drug admistration, medicine related toxicity and taste partialities. It is very much important that paediatrics drugs should best fit the child's size, age, various physiologic conditions of the children. The objective of present study was to dev...

Witnessing an increase in the demand for immunity-booster plants especially in the aftermath of COVID-19, it becomes imperative to highlight suitable growing areas for Withania somnifera (L.) Dunal (Ashwagandha), and Ocimum sanctum L. (Tulsi) in Punjab. The scope of this work is to suggest market-driven immunity-booster plants that can act as a sub...

Background: The Ministry of AYUSH, Government of India has decided to emerge cultivation of medicinal plants as an attractive farming option due to a sharp increase in demand for medicinal plants. Punjab produces approximately twenty and nine percent of India's wheat and rice, respectively. At present, less than 1% of the state's land is under Medi...

The chapter is based on the insights related to the scale-up, preclinical and clinical status of Poly (Lactide-Co-Glycolide), and its copolymers-based drug delivery systems.

Objective Characterization, in vitro evaluation of antioxidant activity and ex vivo investigation of cytotoxic effect of phytosomes assimilating ethyl acetate fraction fractionated from hydro alcoholic extract of Cedrus deodara bark. Method Solvent fractions of hydro alcoholic extract were analyzed by HPTLC to identify taxifolin, using toluene: et...

Aim of the study The study aimed to investigate the impact of the patients' physical activity status and the type of cooking oil consumed by patients in their daily routine on glycemic profile, lipid profile, the hypertensive profile of the patients, and the length of stay, and overall cost of the treatment. Methods A prospective observational stu...

Background The global cases of Covid‐19 increasing day by day. On Nov. 25, 2020, a total of 59,850,910 cases reported globally with a 1,411,216 global death. In India, total cases in the country now stand at 91,77,841 including 86,04,955 recoveries and 4,38,667 active cases as on Nov. 24, 2020, as per the data issued by ICMR. A new generation of vo...

Extracellular vesicles (EVs) are the common designation for ectosomes, microparticles and microvesicles serving dominant roles in intercellular communication. Both viable and dying cells release EVs to the extracellular environment for transfer of cell, immune and infectious materials. Defined morphologically as lipid bi-layered structures EVs show...

A greenhouse and field experiment was conducted to investigate the effects of Azotobacter (Azotobacter chroococcum), Phosphate solubilizing bacteria (Pseudomonas fluorescens), and Arbuscular mycorrhiza-like fungi (Sebacinca vermifera) on seed germination, physiology, and essential oil production of dill (Anethum graveolens). The experimentation was...

The covid -19 pandemic has wreaked havoc on the global healthcare system and the economy. At present, no specific antiviral vaccine is available to combat this contagious virus. Traditional medicine has a long history of playing a significant role in managing several infectious diseases. In this context, scientists around the globe are also explori...

Sustainable plant production with the integration of eco-friendly agricultural practices, low chemical inputs, minimal deleterious effects on human health and low cost methods, is the need of the moment. In this direction, scientific/industrial community, continuously exploring novel and reliable methods. Plant growth promoting microbes are proving...

The SARS-CoV-2 global pandemic has seen rapid spread, disease mobidities and death associated with substantive social, economic and societal impact. Treatments rely on re-purposed antivirals and immune modulatory agents focusing on attenuating the acute respiratory distress syndrome. No curative therapies exist. Vaccines remain the best hope for di...

The SARS-CoV-2 global pandemic has seen rapid spread, disease mobidities and death associated with substantive social, economic and societal impact. Treatments rely on re-purposed antivirals and immune modulatory agents focusing on attenuating the acute respiratory distress syndrome. No curative therapies exist. Vaccines remain the best hope for di...

Introduction The coexistence of diabetes mellitus (DM) and hypertension (HTN) worsen clinical outcomes and contribute to increased morbidity and mortality. Objective This study aims to analyze the length of stay and healthcare costs by calculating the direct and indirect costs of diabetes with co‐existing hypertension in North India. Methods A pr...

Background: Diabetes mellitus with coexisting hypertension contributes to increased morbidity and mortality. The study aimed to investigate the impact of the patients’ physical activity status and the type of cooking oil consumed by patients in their daily routine on glycemic profile, lipid profile, the hypertensive profile of the patients, and the...

A 42-year-old male patient visited the outpatient department for follow-up with a history of respiratory tract infection and diabetes mellitus. His main symptom was peeling of his epidermal layer of skin, and bullous fixed drug eruption on the lower and upper limbs and bank region of the body. Following assessment, the patient was prescribed levoth...

Cancer represents one of the leading health-care issues around the globe. The overall life expectancy of cancer patients remains dismal regardless of enduring investigations and advances in the management of a disease. Thus the focus is always on the discovery of potential and less toxic alternatives of anticancer agents. Natural compounds from pla...

Introduction: The coexistence of diabetes mellitus (DM) and hypertension (HTN) worsen clinical outcomes and contribute to increased morbidity and mortality. Objective: This study aims to analyze the length of stay and healthcare costs by calculating the direct and indirect costs of diabetes with co-existing hypertension in North India. Methods: A p...

Background: The global cases of Covid-19 increasing day by day. On Nov. 25, 2020, a total of 59,850,910 cases reported globally with a 1,411,216 global death. In India, total cases in the country now stand at 91,77,841 including 86,04,955 recoveries and 4,38,667 active cases as of Nov. 24, 2020, as per data issued by ICMR. A new generation of voice...

Background: Diabetes mellitus with co-existing hypertension contributes to increased morbidity and mortality. The study aimed to investigate the impact of the patients' physical activity status and the type of cooking oil consumed by patients in their daily routine on glycemic profile, lipid profile, the hypertensive profile of the patients, and th...

Objective: The present study was designed to investigate phytopromotional effects of Sebacina vermifera on economically and medicinally important aromatic plant - Coriandrum sativum (coriander). Methods: Phytopromotional effects of Sebacina vermifera were evaluated on coriander, under greenhouse and field conditions. The evaluations were carried ou...