Åse Bjorvatn Sævik

Åse Bjorvatn Sævik
University of Bergen | UiB · Department of Clinical Medicine

MD, PhD Student

About

11
Publications
2,416
Reads
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64
Citations
Citations since 2016
11 Research Items
63 Citations
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Publications

Publications (11)
Article
Full-text available
Background Patients with primary adrenal insufficiency (PAI) suffer reduced quality of life (QoL), but comparisons with large-scale normative data are scarce. The clinical characteristics associated with reduced QoL are largely unknown. Methods Cross-sectional data on clinical characteristics and QoL scores from 494 patients were included. QoL was...
Article
Full-text available
Objective: Deciding the optimal doses of glucocorticoid (GC) replacement treatment in autoimmune Addison’s disease (AAD) is impeded by the lack of reliable biomarkers. This frequently results in over-treatment, with alarming and persistent side-effects, or under-replacement, which could be fatal. There is a need to think new in the quest for robust...
Article
Full-text available
Background No reliable biomarkers exist to guide glucocorticoid (GC) replacement treatment in autoimmune Addison’s disease (AAD), leading to overtreatment with alarming and persistent side-effects or undertreatment, which could be fatal. Objective To explore changes in gene expression following different GC replacement doses as a means of identify...
Article
Context Appropriate management of adrenal insufficiency (AI) in pregnancy can be challenging due to the rarity of the disease and lack of evidence-based recommendations to guide glucocorticoid- and mineralocorticoid dosage adjustment. Objective Multi-center survey on current clinical approaches in managing AI during pregnancy. Design Retrospectiv...
Article
Full-text available
Context Contrary to current dogma, growing evidence suggests that some patients with autoimmune Addison’s disease (AAD) produce corticosteroids even years after diagnosis. Objective Determine frequencies and clinical features of residual corticosteroid production in patients with AAD. Design Two-staged, cross-sectional clinical study in 17 center...
Article
Full-text available
Background: Early detection of autoimmune Addison's disease (AAD) is important as delay in diagnosis may result in a life-threatening adrenal crisis and death. The classical clinical picture of untreated AAD is well-described, but methodical investigations are scarce. Objective: Perform a retrospective audit of patient records with the aim of id...

Questions

Questions (2)
Question
I am doing a study on how a certain exposure may affect (change) biomarker profiles in human serum, i.e. at baseline compared to 1 hour after the exposure. In order to detect any change, I assume the biomarker half-lives should be short (at least less than 1 hour). Unfortunately, I struggle to find reliable and comprehensive sources (ideally a database) on half-lives of proteins/ biomarkers in human serum. (The manufacturer does not have this kind of information either).
I would be immensely grateful for any suggestions on how to find this kind of information! (without having to perform half-life experiments myself for the 150-200 proteins of interest)
Question
Hi,
I have biomarker data given in log2-scale, and I am looking into different approaches on how to present the results (differences between two groups). I have seen a paper (with similar data) present the difference as fold change, i.e. fold change of 1.5 for biomarker A for group X relative to group Y. However, I wonder whether this is an appropriate approach, as the difference between the given values already describe a ratio, i.e. a mean difference of 1 unit represents a doubling of protein concentration (as the unit is a log2 scale). In other words, calculating the fold change would be more appropriate if I had absolute values?

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