Asad Mirza

Florida International University | FIU · Department of Biomedical Engineering

The Newtonian model has commonly been used to represent the viscosity of blood in the aorta, despite blood itself being a non-Newtonian fluid. This is justified where shear rates tend to be large. However, we hypothesized that using the Newtonian model to predict the hemodynamics on the aortic valve, particularly in those with severe calcifications...

Objective: The Newtonian assumption for blood has often been applied for aortic valve studies where high shear rates can be seen on the ventricularis side. However, in the presence of calcifications this assumption is suspect due to large flow disturbances, especially on the fibrosa side. Regions of low wall shear stress (WSS) have been known to le...

Objective: Critical calcific valve disease (CAVD) is a health condition that requires prosthetic valve replacement. Transcatheter valve replacement (TVR) is thought to be a safer treatment option for patients who are at high risk of undergoing open-heart surgery. TVR requires deployment of the prosthetic valve with the diseased valve displaced out...

Objective: Treatment options are extremely limited for children and older patients who are contra-indicated for receiving mechanical or bioprosthetic valves. The purpose of this study is to determine whether cylindrical porcine small intestinal submucosa (PSIS) bio-scaffold valves can facilitate robust valvular function in the tricuspid location. M...

Introduction: To investigate enhanced treatment options for critical mitral valve disease in children, we implanted a bio-scaffold mitral valve comprising of porcine small intestinal submucosa (PSIS) in a juvenile baboon model. Hypothesis: New tissue formation would be accelerated at physical connections between the replacement bio-scaffold valve a...

Support of somatic growth is a fundamental requirement of tissue-engineered valves. However, efforts thus far have been unable to maintain this support long term. A key event that will determine the valve's long-term success is the extent to which healthy host tissue remodeling can occur on the valve soon after implantation. The construct's phenoty...

In fabrication of cardiac tissue, an important factor is continuous measurement of its contraction features. A module that allows for a dynamic system capable of non-invasive and label-free monitoring of contraction profile under administering chemicals and drugs, is highly valuable for understanding accurate tissue mechanobiology. In this research...

The progression of calcific aortic valve disease (CAVD) is characterized by extracellular matrix (ECM) remodeling, leading to structural abnormalities and improper valve function. The focus of the present study was to relate aortic valve leaflet axial curvature changes as a function of elastin degradation, which has been associated with CAVD. Circu...