Arzu Yay

Arzu Yay
Erciyes Üniversitesi · Faculty of Medicine

PhD

About

112
Publications
10,394
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
780
Citations
Citations since 2017
70 Research Items
678 Citations
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150

Publications

Publications (112)
Preprint
Full-text available
Purpose Hesperidin is a flavonoid commonly found in citrus fruits. Studies have shown that hesperidin has anti-inflammatory, analgesic, and antimicrobial properties, as well as its effectiveness in carcinogenesis. In this paper, we aim to investigate the molecular mechanisms of hesperidin-induced apoptosis in MCF-7 and MDA-MB-231 cancer cells. Met...
Article
Purpose: The aim of this study was to investigate the role of Ganoderma lucidum (GL) in cell proliferation and autophagy in breast cancer cell lines. Materials and Methods: Cell lines were cultured in vitro and the appropriate dose was determined by the MTT method. In order to show the effect of GL on autophagy in MCF-7 and MDA-MB-231 breast cancer...
Article
Full-text available
Objectives: This study aimed to investigate the effect of TGF-B1-transfected adipose-derived mesenchymal stem cell (AD-MSC) conditional medium (TGF-B1-CM) on CD44 expression and biological activities in MCF-7 and MDA-MB-231 cells. Methods: In the study, the experimental groups were created as a standard medium, AD-MSC-CM, TGF-B1-CM, and TGF-B1 r...
Article
The goal of this work was to see how melatonin affected Bax and Bcl‐2 expression, as well as apoptosis and autophagy, in MCF‐7 and MDA‐MB‐231 breast cancer cell lines, which have distinct hormonal sensitivities. In this study, to investigate the IC50 value of melatonin, varied melatonin concentrations were administered to MCF‐7 and MDA‐MB‐231 breas...
Article
Amaç: Bu araştırmanın amacı, Melissa officinalis L. bitkisinin in vitro olarak MCF-7 meme kanseri hücrelerindeki ölüm yollarını nasıl etkilediğini görmektir. Gereç ve Yöntem: Melissa officinalis bitkisinin topraküstü kısımlarından hazırlanan %70 metanolik ekstrenin sitotoksik aktivitesi ve IC50 değerini belirlemek için MCF-7 meme kanseri hücre hatt...
Article
Objective: To evaluate the effects of photobiomodulation therapy (PBMT) at distinct energy levels on peri-implant bone healing in extra-short implants in a experimental rabbit model. Background: The effect of PBMT on peri-implant bone healing in short implants remains unclear. This explored the effect of PBMT on extra-short implants in terms of bon...
Article
We investigated using histochemistry and immunohistochemistry ovarian damage caused by nonylphenol (NP) and the protective effect of melatonin treatment of NP induced ovarian damage. We used 21 female rats divided randomly into three groups: control, NP and melatonin + NP. Histopathological examination of the ovaries, and counting and classificatio...
Article
Histopathological image analysis is used in the diagnosis of many diseases such as cancer, brain tumor, fatty liver and congenital heart diseases. In clinical practice, the time-consuming diagnostic process requires an expertise in the field, and disagreements can arise among pathologists at the decision stage. Machine learning methods can be used...
Article
Purpose: Although radiation is one of the basic methods commonly used in cancer treatment, it inevitably enters the field of treatment in healthy tissues and is adversely affected by the acute and chronic side effects of radiation. This study evaluated the possible protective effects of quercetin, an antioxidant agent, against liver and kidney dam...
Article
The anticancer drug, paclitaxel (PTX), is used to treat a variety of solid tumors, but its effects on normal tissues remain unclear. We investigated the effects of different doses of PTX and its vehicle, cremophor EL, on testis using histochemical, immunohistochemical and biochemical methods. We used 30 adult Wistar albino rats divided randomly int...
Article
Background: Although in vitro methods have disadvantages, they are still commonly used to measure nerve conduction velocity (NCV) in experimental studies. Therefore, this study was designed to demonstrate the effect of the surgical procedures required for in vitro methods on nerve fibers and the effect of in vivo and in vitro methods on the results...
Article
Background: Ionizing radiation poses a threat to the early embryo possibly leading to prenatal death, growth retardation, organ malformation, or mental retardation. It is important, assessment of any adverse effects of radiation upon the embryo. This study aimed to evaluate the outcomes of embryos irradiated with 1Gy doses in vitro and investigate...
Article
Purpose: To evaluate the effects of 2 different surface roughness values produced by sandblasted, large-grit, and acid-etched treatments at different loading conditions on the stability of mini-screws. Material and methods: A total of 56 mini-screws (Group 1; 28 with Ra value of 1 μm, Group 2; 28 with Ra value of 1.5 μm) were inserted into the t...
Article
Introduction In the study, it was aimed to investigate the possible protective effects of curcumin, a potent antioxidant, against the toxic effect of nonylphenol on bone development. Methods Thirty pregnant female Wistar albino rats were used. The rats were randomly divided into the following five groups; the control group, corn oil group (150 µl/...
Article
Full-text available
Background/aim: Acute lung injury (ALI) is a major cause of death in the intensive care unit. Lipopolysaccharide (LPS) induced lung injury is the most widely used experimental ALI model and provides opportunities for new targeting therapy. In this study, we investigated the effects of tocilizumab, adalimumab, and methylprednisolone in LPS-induced...
Article
Introduction: The ear, originates from the ectoderm, exhibits a complex structure that differs from species to species in terms of development. Objectives: This study was conducted to describe the prenatal and postnatal development process of the organ of Corti in the iner ear using light microscopy. Methods: In this study, Wistar Albino rats were...
Article
Objective We aimed to investigate the effects of umbilical cord-derived mesenchymal stem cells and erythropoietin on nerve regeneration in the sciatic nerve ‘crush injury’ in a rat model. Methods Experimental animals were randomly divided into 5 groups: Crush Injury, Sham, Crush Injury + Erythropoietin, Crush Injury + Mesenchymal Stem Cell, Crush...
Article
Purpose The sequelae of premature loss of ovarian function can undoubtedly have undesirable effects for a woman although radiotherapy is one of the most relevant treatment modalities for various types of malignancies. The aim of this study was to determine the effect of different doses of radiation on ovarian folliculogenesis, inflammation, and apo...
Article
Full-text available
Background Investigating the effects of 405-nm, 532-nm, 650-nm, and 950-nm wavelengths of LLLTs (low-level laser therapies) on the orthodontic tooth movement in rats by using histological and immunohistochemical methods. Forty-five Wistar albino rats were randomly divided into 5 groups: control group (positive control: the left maxillary 1st molar...
Article
Full-text available
Dimethoate is an organophosphorus pesticide used against agricultural insects, which causes oxidative stress and damage in many organs, including the reproductive ones. Cherry laurel ( Laurocerasus officinalis Roem.) fruit is rich in vitamins and phenolic compounds with antioxidant effect. The aim of this study was to investigate how effective its...
Article
Full-text available
This study aimed to evaluate the biological and clinical significance of apelin-36 in breast cancer and to compare apelin-36 expression and apoptotic index in both breast tissue and metastatic lymph nodes in patients with invasive breast carcinoma. In this study, both tumor tissue and metastatic lymph nodes of the same patient were collected from 6...
Article
Full-text available
Skeletal system and some organs development changes in rat fetuses with 30 and 60 mg/kg caffeine and melatonin’s (10 mg/kg) protective role against rat fetuses were investigated. Groups (n = 4) were formed as Control, LDC, HDC, LDC+melatonin, HDC+melatonin and melatonin. Fetuses were taken by cesarean section and stained using dual skeletal stainin...
Article
Full-text available
Objective: This study aimed to determine the effects of a natural diterpenoid, kirenol, on fracture healing in vivo in an experimental rat model of femur fracture and investigate its potential mechanism of action via the Wnt/β-catenin pathway. Methods: In this study, 64 male Wistar albino rats aged 5-7 weeks and weighing 261-348 g were randomly...
Article
Introduction: Cancer is the second most common cause of death in the world. Several natural products have been studied for anticancer activity and for prevention or repair of oxidative injury. Curcumin is one of the natural products of high medicinal interest. This study was performed to investigate effects of curcumin on lipid peroxidation and ant...
Article
Doxorubicin (DOX) is a widely used drug for the treatment of cancer,but its clinical use is limited by its liver toxicity. Administering DOX with an antioxidant has become a strategy for preventing the side effects of DOX. Although selenium (Se) is an important trace mineral, data concerning the effect of Se on DOX induced liver tissue are lacking....
Article
Full-text available
AIM: Cornus mas L is commonly used due to its anti-infl ammatory, anti-carcinogenic and anti-oxidant properties. In the study, the effects of C. mas L extract on a solid tumor were examined in the Ehrlich solid tumor model developed in Balb/C type mice. METHODS: Ehrlich acid tumor (EAT) cells (1x106 EAT cell) from the stock animal were injected sub...
Article
The purpose of this research was to investigate the possible protective effect of melatonin, as a potent antioxidant on I/R-induced renal injury in rats. Methods. We used 28 female Wistar albino rats weight 200-250g. The rats were randomly divided into 4 groups. Control Group (C): They were fed with only standard rat diet and tap water without drug...
Article
Purpose: The aim of this study was to evaluate how continuous heavy orthopedic forces affect the stability of sandblasted, large-grit, acid-etched (SLA)-surfaced miniscrew implants and surrounding bone tissue healing at three different loading periods with treatment of photobiomodulation and ozone therapy. Materials and methods: Miniscrew implan...
Article
Full-text available
Background/aim: Cisplatin is a highly effective chemotherapeutic agent used in the treatment of solid organ cancers. Besides its chemotherapeutic effectiveness, cisplatin administration was associated with numerous side effects. Of these, the most clinically significant and common effect is nephrotoxicity. Recent studies reported that oxidative st...
Article
Full-text available
The combination of an aging population and an increasing prevalence of diseases associated with impaired-wound healing, including obesity, peripheral vascular disease and diabetes, is likely to result in a dramatic increase in the incidence and prevalence of chronic skin wounds. Indeed, systemic reviews are now not only trying to establish both the...
Article
Full-text available
We investigated the myotoxic effects of bupivacaine, ropivacaine and levobupivacaine on rat skeletal muscle and compared its apoptotic activity and acute effects on pro-nflammatory cytokines. We divided 40 Wistar albino rats into four equal groups. Rats were injected intramuscularly with 0.5% bupivacaine (group B), 0.5% ropivacaine (group R), 0.5%...
Article
Background:: Bisphenol A (BPA) is one of the most commonly produced chemicals in the world. BPA is used in products such as food packaging, personal care products, detergents, and plastic bottles. This study was conducted to determine the effect of BPA on fetal bone development. Material and methods:: In this study, 16 pregnant female Sprague-Da...
Article
Introduction: The aim of this study was to evaluate the effects of platelet-rich plasma on orthodontic tooth movement in rats. Methods: We divided 48 Wistar male albino rats into 3 groups: control group, platelet-rich plasma group, and platelet-poor plasma group. The rats in all study groups had orthodontic tooth movement of their maxillary right f...
Article
Objectives: Recent studies reported that oxidative stress is an important mechanism that contributes to cisplatin induced cardiotoxicity. In the present study, the effects of N-acetylcysteine (NAC), which is an antioxidant, on cisplatin induced cardiotoxicity were investigated in a rat model. Methods: Thirty two rats were separated into 4 equal...
Article
Objective To investigate the effect of pretreatment with obestatin (OB), an endogenous hormone also found in mother's milk, in experimental necrotizing enterocolitis (NEC). Materials and Methods Pups were randomized into four groups: control, OB-control, NEC, and OB-NEC. NEC was induced by asphyxia and hypothermia in the NEC and OB-NEC groups. OB w...
Conference Paper
Possible Effects of Pseudoephedrine on Rat Fetal Corti Organ
Article
Full-text available
Background: A single dose injection or continuous infusion of local anesthetics into the joint space is considered to be a well-defined analgesia technique. The aim of this study was to investigate the chondrotoxic and apoptotic effects of single-dose intra-articular injection of levobupivacaine and bupivacaine on rabbit knee joint tissues. Mater...
Article
Background: Apart from role of progesterone in reproductive physiology, the protective role of exogenously administered progesterone was observed in various injuries, such as neurologic defects and acute kidney injury. Objectives: The aim of the present study was to investigate the effects of progesterone therapy on the immunoexpression of anti-...
Article
Full-text available
Background A single dose injection or continuous infusion of local anesthetics into the joint space is considered to be a well-defined analgesia technique. The aim of this study was to investigate the chondrotoxic and apoptotic effects of single-dose intra-articular injection of levobupivacaine and bupivacaine on rabbit knee joint tissues. Materia...
Article
Full-text available
Abstract: Background and Objectives: Contrast-induced nephropathy (CIN), is acute renal damage due to contrast agents. This study is conducted to evaluate serum and renal heterodimeric nuclear transcription factor (HIF)-2 alpha levels and its tissue expression in contrast-induced nephropathy, and in N-acetyl cysteine (NAC)-and Sildenafil-treated ra...
Article
Background: Body region-dependent hair follicle (HF) characteristics are concerned with follicular size and distribution, and have been demonstrated to have characteristics for each region of the body. Objectives: The aim of the present study was to investigate the expression patterns of the markers called cytokeratin 15 (K15), cytokeratin 6 (K6...
Preprint
Full-text available
Background and objectives: Contrast-induced nephropathy (CIN), is an acute renal damage due to contrast agents. This study is conducted to determine the potential diagnostic value of hypoxia-inducible factor 2-alpha (HIF2-α) and to evaluate the renal protective effects of N-acetyl cysteine (NAC) and sildenafil in a rat CIN model. Material/Methods:...
Article
Full-text available
Objective: The aim of the present study was to evaluate the effects of progesterone (PG) against ovarian ischemia-reperfusion (I/R) injury through evaluation of biochemical and histopathologic parameters. Material and methods: Twenty-one female Wistar albino rats were divided into three groups. Group 1: Sham; Group 2: I/R; Group 3: IR+PG (8 mg/k...
Article
Full-text available
Objective: Cisplatin (CDDP) has been known to be an effective antineoplastic drug; however, it has a cardiotoxic effect. Curcumin (CMN) and beta-carotene (BC) have been suggested to protect biological systems against CDDP-induced damage. The current study was conducted to evaluate the possible protective roles of CMN and BC on CDDP-induced cardiot...
Article
Full-text available
Background: The aim of the study was to investigate the effects of colchicine on cytokine production, apoptosis, alveolar bone loss, and oxidative stress in an experimental model of periodontitis in rats. Methods: Forty-eight rats were divided equally into four groups: healthy (H); periodontitis (P); periodontitis+colchicine low dose (CL, 30 μg/...
Article
Full-text available
Aim: The aim of this study is to determine the immunohistochemical properties of Ki-67, P53 expression and loss of P16, and to assess their relationship with both clinical parameters and patient survival in DLBCL. Method: Forty patients, diagnosed at the Pathology Department of our institute with nodal DLBCL were selected as the study group. The...
Article
Full-text available
Objective: The aim of study was to investigate anticancer effect of Viburnum opulus (VO) on Ehrlich ascites carcinoma (EAC) bearing mice that treated with different concentrations of VO. Materials and methods: For tumor transplantation; mice were inoculated with 1 × 106EAC cells intraperitoneally and than divided into five groups (n = 9). Two ho...
Article
Objective: This study aimed to investigate the therapeutic effect of ozone in combination with insulin on cranial and spinal neuropathy in rats with diabetes mellitus (DM). Materials and methods: Sixty adult male Sprague Dawley rats were randomly divided into the following six groups (n = 10): control (C), ozone (O), diabetic (D), ozone-treated...
Article
Effects of mesenchymal stem cells (MSCs) have been shown in several neurological diseases in human and several animal models. However, there is no study about the effectiveness of MSCs in chemotherapy induced neuropathy and neuropathic pain. We aimed to research the effects of bone marrow derived MSCs in neuropathic pain induced by cisplatin in rat...
Article
Dimethoate is one of the most important organophosphate insecticides and may cause oxidative stress leading to production of free radicals and alterations in antioxidants. The aim of this study was to investigate the protective effects of Laurocerasus officinalis Roem. fruit extract containing antioxidant compounds on dimethoate-induced hepatotoxic...
Article
Full-text available
Inflammatory bowel disease (IBD) is an inflammatory disorder involving colitis. Lycopene is a naturally occurring carotenoid that has attracted considerable attention as a potential chemopreventive agent. The impact of lycopene on colitis is currently unknown. The aim of this study was to investigate the protective effects of lycopene in a rat mode...
Presentation
Full-text available
Cross-Talk inhibition between 5-HT 7 and A2A receptors depends on severity of acute intermittent hypoxia Çağlar Karakaya1, Kemal Erdem Başaran2, Özlem Öz Gergin4, Safa Burakhan Kazancı3, Arzu Yay1 1Department of Histology and embryology, Erciyes University, Kayseri 2Department of physiology, Erciyes University, Kayseri 3Genome and Steam Cell Center...
Article
Inflammatory bowel disease (IBD) is an inflammatory disorder involving colitis. Lycopene is a naturally occurring carotenoid that has attracted considerable attention as a potential chemopreventive agent. The impact of lycopene on colitis is currently unknown. The aim of this study was to investigate the protective effects of lycopene in a rat mode...
Article
Some of the diseases like ulcerative colitis, Crohn disease and certain types of intestinal cancers are not treatable effectively. Our aim was to investigate the protective effects of 2-aminoethyl diphenylborinate (2-APB) on the rats with acetic acid induced colitis. Twenty four Sprague-Dawley rats were randomly divided into the following four grou...
Article
The aim of this study was to investigate whether cinnamon bark oil (CBO) has protective effect on taxanes-induced adverse changes in sperm quality, testicular and epididymal oxidant/antioxidant balance, testicular apoptosis, and sperm DNA integrity. For this purpose, 88 adult male rats were equally divided into 8 groups: control, CBO, docetaxel (DT...
Article
Selenium is shown to have beneficial effects on ischaemia-reperfusion (IR) injury. Our aim was to assess the effects of selenium on IR-induced testicular damage in terms of biochemical and histopathological evaluation. A total of 32 rats were randomised into four groups: control, IR, IR + selenium (IR + S) and S. Detorsion was applied after 3 h of...
Article
Full-text available
Background: Accelerated apoptosis plays a vital role in the development of diabetic vascular complications. Ozone may attenuate diabetic nephropathy by means of decreased apoptosis-related genes. The aim of our study was to investigate the effect of ozone therapy on streptozotocin-induced diabetic nephropathy in rats. Also the histopathological ch...
Article
Full-text available
Some of the diseases like ulcerative colitis, Crohn disease and certain types of intestinal cancers are not treatable effectively. Our aim was to investigate the protective effects of 2-aminoethyl diphenylborinate (2-APB) on the rats with acetic acid induced colitis. Twenty four Sprague-Dawley rats were randomly divided into the following four grou...
Article
Full-text available
Background: Investigate alterations in the expression and localization of carbohydrate units in rat retinal cells exposed to cisplatin toxicity. Aims: The aim of the study was to evaluate putative protective effects of selenium on retinal cells subjected to cisplatin. Study design: Animal experiment. Methods: Eighteen healthy Wistar rats wer...
Article
Objective: The aim of this study was to investigate the efficacy of anti-interleukin 6 (IL-6) therapy in the treatment of endometriosis in a rat model. Study design: After the peritoneal implantation of autologous endometrial tissue, 22 Wistar female rats were divided to create 2 intervention groups: the tocilizumab group (n = 13) and the contro...
Article
Full-text available
The aim of the study is to investigate the effects of the interleukin-6 (IL-6) blocker tocilizumab in a hyperstimulated rat model and compare it with ranibizumab, a gonadotropin-releasing hormone antagonist (GnRHA), and cabergoline. Forty-seven rats were randomly divided into the following seven groups: Group 1: OHS; Group 2: OHS+ GnRHA; Group 3: O...